GEO DataSets

(Submitter supplied) Cell-based models of many neurological and psychiatric diseases, established by reprogramming patient somatic cells into human induced pluripotent stem cells (hiPSCs), have now been reported. While numerous reports have demonstrated that neuronal cells differentiated from hiPSCs are electrophysiologically active mature neurons, the “age” of these cells relative to cells in the human brain remains unresolved. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6244

24 Samples

Download data: CEL, TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array; Expression profiling by high throughput sequencing

Platforms:

GPL25480 GPL16791

5718 Samples

Download data

(Submitter supplied) Integration of in silico and in vitro approaches to design and conduct transcriptomic drug screening in patient-derived neural cells, in order to survey novel pathologies and points of intervention in schizophrenia.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL16791

44 Samples

Download data: TXT

(Submitter supplied) Integration of in silico and in vitro approaches to design and conduct transcriptomic drug screening in patient-derived neural cells, in order to survey novel pathologies and points of intervention in schizophrenia.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL25480

380 Samples

Download data

(Submitter supplied) Integration of in silico and in vitro approaches to design and conduct transcriptomic drug screening in patient-derived neural cells, in order to survey novel pathologies and points of intervention in schizophrenia.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL25480

380 Samples

Download data

(Submitter supplied) Integration of in silico and in vitro approaches to design and conduct transcriptomic drug screening in patient-derived neural cells, in order to survey novel pathologies and points of intervention in schizophrenia.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL25480

380 Samples

Download data

(Submitter supplied) Integration of in silico and in vitro approaches to design and conduct transcriptomic drug screening in patient-derived neural cells, in order to survey novel pathologies and points of intervention in schizophrenia.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL25480

380 Samples

Download data

(Submitter supplied) Integration of in silico and in vitro approaches to design and conduct transcriptomic drug screening in patient-derived neural cells, in order to survey novel pathologies and points of intervention in schizophrenia.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL25480

380 Samples

Download data

(Submitter supplied) Integration of in silico and in vitro approaches to design and conduct transcriptomic drug screening in patient-derived neural cells, in order to survey novel pathologies and points of intervention in schizophrenia.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL25480

378 Samples

Download data

(Submitter supplied) Integration of in silico and in vitro approaches to design and conduct transcriptomic drug screening in patient-derived neural cells, in order to survey novel pathologies and points of intervention in schizophrenia.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL25480

378 Samples

Download data

(Submitter supplied) Integration of in silico and in vitro approaches to design and conduct transcriptomic drug screening in patient-derived neural cells, in order to survey novel pathologies and points of intervention in schizophrenia.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL25480

377 Samples

Download data

(Submitter supplied) Integration of in silico and in vitro approaches to design and conduct transcriptomic drug screening in patient-derived neural cells, in order to survey novel pathologies and points of intervention in schizophrenia.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL25480

378 Samples

Download data

(Submitter supplied) Integration of in silico and in vitro approaches to design and conduct transcriptomic drug screening in patient-derived neural cells, in order to survey novel pathologies and points of intervention in schizophrenia.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL25480

378 Samples

Download data

(Submitter supplied) Integration of in silico and in vitro approaches to design and conduct transcriptomic drug screening in patient-derived neural cells, in order to survey novel pathologies and points of intervention in schizophrenia.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL25480

377 Samples

Download data

(Submitter supplied) Integration of in silico and in vitro approaches to design and conduct transcriptomic drug screening in patient-derived neural cells, in order to survey novel pathologies and points of intervention in schizophrenia.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL25480

378 Samples

Download data

(Submitter supplied) Integration of in silico and in vitro approaches to design and conduct transcriptomic drug screening in patient-derived neural cells, in order to survey novel pathologies and points of intervention in schizophrenia.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL25480

377 Samples

Download data

(Submitter supplied) Integration of in silico and in vitro approaches to design and conduct transcriptomic drug screening in patient-derived neural cells, in order to survey novel pathologies and points of intervention in schizophrenia.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL25480

379 Samples

Download data

(Submitter supplied) Integration of in silico and in vitro approaches to design and conduct transcriptomic drug screening in patient-derived neural cells, in order to survey novel pathologies and points of intervention in schizophrenia.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL25480

374 Samples

Download data

(Submitter supplied) Schizophrenia (SCZD) is a debilitating neurological disorder with a world-wide prevalence of 1%; there is a strong genetic component, with an estimated heritability of 80–85%1. Although post-mortem studies have revealed reduced brain volume, cell size, spine density and abnormal neural distribution in the prefrontal cortex and hippocampus of SCZD brain tissue2 and neuropharmacological studies have implicated dopaminergic, glutamatergic and GABAergic activity in SCZD3, the cell types affected in SCZD and the molecular mechanisms underlying the disease state remain unclear. more...

Organism:

Homo sapiens

Type:

Genome variation profiling by genome tiling array

Platform:

GPL10815

4 Samples

Download data: PAIR, TXT

(Submitter supplied) Schizophrenia is a debilitating neurological disorder for which no cure exists. Few defining characteristics of schizophrenic neurons have been identified and the molecular mechanisms responsible for schizophrenia are not well understood, in part due to the lack of patient material for study. Human induced pluripotent stem cells (hiPSCs) offer a new strategy for studying schizophrenia. We have created the first cell-based human model of a complex genetic psychiatric disease by generating hiPSCs from schizophrenic patients and subsequently differentiating these cells to hiPSC-derived neurons in vitro. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3938

Platform:

GPL6244

24 Samples

Download data: CEL, TXT