Similar studies for GEO DataSets (Select 200045153) - GEO DataSets

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Items: 20

Select item 2000451531.

Tumor grafts derived from patients with head and neck squamous carcinoma.

(Submitter supplied) Head and neck squamous cell carcinoma (HNSCC) is a deadly and disfiguring disease for which better systemic therapy is desperately needed. The development of new therapies for HNSCC and the understanding of its biology both depend upon clinically relevant animal models. An increasingly promising xenograft model, the patient derived xenograft (PDX), is developed by surgically implanting tumor tissue directly from a patient into an immunocompromised mouse. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
31 Samples

Download data: CEL

Series

Accession:: GSE45153

ID:: 200045153

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001301602.

Patient-derived xenograft models of non-small cell lung cancer for evaluating targeted drug sensitivity and resistance

(Submitter supplied) Background: Patient-derived xenograft (PDX) models are a useful tool in cancer biology research. However, the number of lung cancer PDXs is limited Results: In the present study, we successfully established ten PDXs, including three adenocarcinoma (AD), six squamous cell carcinoma (SQ) and one large cell carcinoma (LA), from 30 patients with non-small cell lung cancer (NSCLC) (18 AD, 10 SQ, and 2 LA), mainly in SHO mice (Crlj:SHO-PrkdcscidHrhr). more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
12 Samples

Download data: TXT

Series

Accession:: GSE130160

ID:: 200130160

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Select item 2001027873.

Over-expression of BAG-1 in head and neck squamous cell carcinomas (HNSCC) is associated with cisplatin-resistance

(Submitter supplied) In order to improve therapy for head and neck squamous cell carcinoma (HNSCC), biomarkers associated with local and/or distant tumor relapses and cancer drug resistance are urgently needed. This study identified a potential biomarker, BAG-1 (Bcl-2 associated athanogene-1), that is implicated in HNSCC insensitive to cisplatin and tumor progression. Advanced HNSCC cells revealed resistant to cisplatin accompanied by increased expression of BAG-1 protein. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6480
18 Samples

Download data: TXT

Series

Accession:: GSE102787

ID:: 200102787

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Select item 2000563304.

Expression data of human hypopharyngeal tumor cells (FaDu)

(Submitter supplied) FaDu cells were infected with lentivirus containing sh-luciferase plasmid to compared with cells infected with sh-G9a containing lentivirus. We performed microarray analysis to identify the genes possibly regulated by G9a in FaDu cells

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
2 Samples

Download data: CEL, CHP

Series

Accession:: GSE56330

ID:: 200056330

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Select item 2000847135.

Gene expression data from head and neck cancer patient derived xenografts

(Submitter supplied) Head and neck cancer is a hetergeneous disease. Based on previoulsy defined molecular subtypes we associated gene expression with response to different compounds. We used microarry gene expression for molecular subtyping Cetuximab is the single targeted therapy approved for the treatment of head and neck cancer (SCCHN). Predictive biomarkers have not been established in the clinical setting and patient stratification based on molecular tumor profiles has not been possible. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
28 Samples

Download data: CEL

Series

Accession:: GSE84713

ID:: 200084713

Select item 2000478646.

The dual pathway inhibitor rigosertib is effective in direct-patient tumor xenografts of head and neck squamous cell carcinomas

(Submitter supplied) Rigosertib treatment of head and neck squamous cell cancer The dual pathway inhibitor rigosertib inhibits phosphoinositide 3-kinase (PI3K) pathway activation as well as polo-like kinase 1 (PLK1) activity across a broad spectrum of cancer cell lines. The importance of PIK3CA alterations in head and neck squamous cell cancer (HNSCC) has raised interest in exploring agents targeting PI3K, the product of PIK3CA. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
16 Samples

Download data: CEL

Series

Accession:: GSE47864

ID:: 200047864

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Select item 2002071827.

Transcriptomic Characterization of HPV+ and HPV- Head and Neck Cancer Patient-Derived Xenografts

(Submitter supplied) RNA-Seq was used to characterize a large cohort of HNSCC patient-derived xenografts (PDXs) at the transcriptional level.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
64 Samples

Download data: TXT

Series

Accession:: GSE207182

ID:: 200207182

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Select item 2001721158.

Differential RNA expression in human neck and squamous cell carcinoma cell lines (T-HEp3 and D-HEp3).

(Submitter supplied) We report the RNA expression profile in the tumorigenic (T-HEp3) and dormant (D-HEp3) HNSCC cell lines. T-HEp3 is a human epidermoid carcinoma, which grows on chorioallantoic membreane and metastasizes with high efficency into the organs of chick embryo. Upon serial paasage for more than 50 times in vitro , T-HEp3 loses tumorigenic and metastatic potential and termed as D-HEp3. This is an ideal cell line model system to study cancer dormancy.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
4 Samples

Download data: CSV

Series

Accession:: GSE172115

ID:: 200172115

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000517989.

Transcriptional dissection of pancreatic tumors engrafted in mice

(Submitter supplied) Engraftment of primary pancreas ductal adenocarcinomas (PDAC) in mice to generate patient derived xenograft (PDX) models is a promising platform to for biological and therapeutic studies in this disease. However, these models are still incompletely characterized. Here, we measured the impact of the murine environment on the gene expression of the engrafted human tumoral cells. We have analyzed gene expression profiles from 35 new PDX models and compared them with previously published microarray data from PDAC and hepatocellular carcinoma (HCC). more...

Organism:: Homo sapiens

Type:: Expression profiling by array; Third-party reanalysis

Platform:: GPL570
37 Samples

Download data: CEL, TXT

Series

Accession:: GSE51798

ID:: 200051798

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Select item 20000959910.

Coordinated over-expression of genes in the EGFR pathway predicts sensitivity to EGFR inhibition in pancreatic cancer

(Submitter supplied) Tumors from pancreatic cancer specimens obtained at surgery were used for efficacy testing and biologic analysis Keywords: Pharmacogenetics

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
36 Samples

Download data: CEL

Series

Accession:: GSE9599

ID:: 200009599

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Select item 20023035211.

Gene expression profiles of a non-gestational choriocarcinoma and its corresponding patient-derived xenograft tumor

(Submitter supplied) Non-gestational choriocarcinoma (NGC) is a rare subtype of malignant germ cell tumor. We established a patient-derived xenograft (PDX) model using tumor tissue from an 18-year-old patient with NGC. Then, we performed mRNA-seq analysis using the fresh-frozen tissues of the original tumor and the PDX model.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL28038
2 Samples

Download data: TXT

Series

Accession:: GSE230352

ID:: 200230352

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Select item 20010012312.

Phenotype-driven precision oncology in patient-derived tumor models predict therapeutic response in squamous cell carcinoma [expression]

(Submitter supplied) Gene expression analysis of patient metastatic tumor derived cell lines.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL21061
9 Samples

Download data: TXT

Series

Accession:: GSE100123

ID:: 200100123

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Select item 20009247913.

Open chromatin profile of primary and lymph node oral cancer cells

(Submitter supplied) We employed FAIRE-seq to identify open chromatin in head and neck squamous cell carcinoma (HNSCC) patient-derived primary and lymph node cell lines. We further analysed this data to identify differential open chromatin between primary and metastatic cells.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL16791
4 Samples

Download data: BED, WIG

Series

Accession:: GSE92479

ID:: 200092479

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20008467614.

Phenotype-driven precision oncology in patient-derived tumor models predict therapeutic response in squamous cell carcinoma

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Genome variation profiling by genome tiling array

Platforms:: GPL22194 GPL21061
15 Samples

Download data: BW, JPG, PDF, TIFF, TXT

Series

Accession:: GSE84676

ID:: 200084676

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Select item 20008467415.

Array-CGH for cell lines derived from paired primary and metastatic tumor

(Submitter supplied) Characterization of DNA copy number changes in cell line derived from patient using DNA microarray-based comparative genomic hybridization method. Our study identified genomic alterations between primary and metastatic tumor within a single individual

Organism:: Homo sapiens

Type:: Genome variation profiling by genome tiling array

Platform:: GPL22194
2 Samples

Download data: BW, PDF, TXT

Series

Accession:: GSE84674

ID:: 200084674

PubMed Full text in PMC Similar studies

Select item 20008467316.

Gene expression analysis of patient (HN137) primary and metastatic tumor derived cell lines

(Submitter supplied) Comparison of copy number variations and gene expression profiles of cell lines obtained from the primary and lymph node metastatic tumors from a single patient.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL21061
4 Samples

Download data: JPG, PDF, TIFF, TXT

Series

Accession:: GSE84673

ID:: 200084673

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Select item 20010332217.

Single cell RNA-seq analysis of head and neck cancer

(Submitter supplied) To understand the diversity of expression states within head and neck cancers, we profiled 5902 single cells from 18 patients with oral cavity tumors by single cell RNA-seq

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
5901 Samples

Download data: TXT

Series

Accession:: GSE103322

ID:: 200103322

PubMed Full text in PMC Similar studies

Select item 20015749418.

Improved patient-derived tumor models in pancreatic ductal adenocarcinoma employing orthotopic implantation

(Submitter supplied) Pancreatic ductal adenocarcinoma has a very poor prognosis, and new therapies and preclinical models are urgently needed. We developed patient-derived xenografts (PDXs), established PDX-derived cell lines (PDCLs), and generated cell line-derived xenografts (CDXs), and integrated these to create 13 matched trios, as systematic models for this cancer. Orthotopic implantation (OI) of PDCLs showed tumorigenesis and metastases to the liver and peritoneum. more...