GEO DataSets

(Submitter supplied) Osteosarcoma in dogs is a spontaneously occurring disease with a global tumor gene expression signature indistinguishable from human pediatric tumors and clinical progression is remarkably similar. Unlike human OS, canine OS is a highly heritable disease with some large and giant dog breeds at >10x increased risk. We did a genome wide association study of osteosarcoma using the Illumina CanineHD genotyping array in three breeds: greyhound (mortality from OS = 26%), rottweiler (17%) and Irish wolfhound (IWH, 21%) and identified 33 inherited risk loci explaining 55 to 85% of phenotype variance in each breed.

Organism:

Canis lupus familiaris

Type:

SNP genotyping by SNP array

Platform:

GPL17481

278 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Canis lupus familiaris

Type:

SNP genotyping by SNP array

Platform:

GPL17481

570 Samples

Download data

(Submitter supplied) Osteosarcoma in dogs is a spontaneously occurring disease with a global tumor gene expression signature indistinguishable from human pediatric tumors and clinical progression is remarkably similar. Unlike human OS, canine OS is a highly heritable disease with some large and giant dog breeds at >10x increased risk. We did a genome wide association study of osteosarcoma using the Illumina CanineHD genotyping array in three breeds: greyhound (mortality from OS = 26%), rottweiler (17%) and Irish wolfhound (IWH, 21%) and identified 33 inherited risk loci explaining 55 to 85% of phenotype variance in each breed.

Organism:

Canis lupus familiaris

Type:

SNP genotyping by SNP array

Platform:

GPL17481

147 Samples

Download data: TXT

(Submitter supplied) Osteosarcoma in dogs is a spontaneously occurring disease with a global tumor gene expression signature indistinguishable from human pediatric tumors and clinical progression is remarkably similar. Unlike human OS, canine OS is a highly heritable disease with some large and giant dog breeds at >10x increased risk. We did a genome wide association study of osteosarcoma using the Illumina CanineHD genotyping array in three breeds: greyhound (mortality from OS = 26%), rottweiler (17%) and Irish wolfhound (IWH, 21%) and identified 33 inherited risk loci explaining 55 to 85% of phenotype variance in each breed.

Organism:

Canis lupus familiaris

Type:

SNP genotyping by SNP array

Platform:

GPL17481

145 Samples

Download data: TXT

(Submitter supplied) This was a prospective clinical trial testing the ability of gene expression models of drug sensitivity that were developed in human and canine cell lines and applied to outcomes in dogs treated with adjuvant carboplatin and/or doxorubicin. Tumor samples were collected prospectively, and gene expression analysis was conducted using Affymetrix Canine Genome 2.0 Arrays.

Organism:

Canis lupus familiaris

Type:

Expression profiling by array

Platform:

GPL3738

109 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Canis lupus familiaris

Type:

Expression profiling by array

Platform:

GPL3738

62 Samples

Download data: CEL

(Submitter supplied) The recently developed COXEN method (PMID: 17666531) has been used to successfully extrapolate gene signatures of drug sensitivity across different tumor histotypes. We wanted to explore the utility of COXEN to predict chemosensitivity in canine cancer, specifically if we could extrapolate gene signatures identified in human datasets over to canine osteosarcoma tumors. This dataset of canine osteosarcoma tumor samples has available clinical outcome data after patients had infected limbs amputated and were treated with doxorubicin and/or carboplatin. more...

Organism:

Canis lupus familiaris

Type:

Expression profiling by array

Platform:

GPL3738

33 Samples

Download data: CEL

(Submitter supplied) Well-defined, closed breeding populations coupled with excessive disease predispositions among purebred domestic dog breeds offer unique advantages to genetic studies of disease susceptibility. Advantages offered by canine population substructure, combined with similarity to human disease in terms of clinical presentation and response to treatment, make the dog a particularly attractive system for finding genes associated with cancer. more...

Organism:

Canis lupus familiaris

Type:

SNP genotyping by SNP array

Platform:

GPL15578

474 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Canis lupus familiaris

Type:

Genome binding/occupancy profiling by high throughput sequencing; SNP genotyping by SNP array

Platforms:

GPL17481 GPL28490

335 Samples

Download data: IDAT, NARROWPEAK

(Submitter supplied) Multi-omics approach identifies germline regulatory variants associated with hematopoietic malignancies in dogs

Organism:

Canis lupus familiaris

Type:

SNP genotyping by SNP array

Platform:

GPL17481

311 Samples

Download data: IDAT, TXT

(Submitter supplied) Identification of canine regulatory regions in peripheral blood mononuclear cells from purebred dogs.

Organism:

Canis lupus familiaris

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL28490

24 Samples

Download data: NARROWPEAK

(Submitter supplied) 22 plexiform neurofibromas from 18 unrelated neurofibromatosis-type 1 patients were screened with a high resolution array-CGH. Each PNF DNA (somatic tumor DNA) was individually hybridized on Agilent whole human genome 244K microarrays (Platform GPL4091) using the matched genomic constitutional DNA (lymphocytes DNA) from the corresponding patient as reference, in order to detect tumor-specific aberrations.

Organism:

Homo sapiens

Type:

Genome variation profiling by genome tiling array

Platform:

GPL4091

22 Samples

Download data: TXT

(Submitter supplied) Despite significant advances in cancer diagnosis and treatment, osteosarcoma (OSA), an aggressive primary bone tumor, has eluded attempts at improving patient survival for many decades. The difficulty in managing OSA lies in its extreme genetic complexity, drug-resistance, and heterogeneity, making it improbable that a single-target treatment would be beneficial for the majority of affected individuals. more...

Organism:

Canis lupus familiaris

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24229

14 Samples

Download data: CSV

(Submitter supplied) Thymic epithelial tumors are a group of neoplasms with heterogeneous histological features and clinical behavior. The identification of markers useful to predict patient prognosis and molecular targets for therapies is limited by a very little understanding of the biology of these neoplasms. We evaluated the copy number (CN) aberrations of genes involved in normal thymus development in thymic epithelial tumors, following the intriguing idea that the ectopic deregulation of genes relevant for proliferation and differentiation of embryonic cells, can contribute to tumor growth. more...

Organism:

Homo sapiens

Type:

Genome variation profiling by genome tiling array

Platforms:

GPL4093 GPL10123

62 Samples

Download data: TXT

(Submitter supplied) Osteosarcoma is a rare maligancy seen in pediatric human patients but frequently seen in canine patients. Because of the increased frequecy of osteosarcoma in canines it is becoming recognized as an informative model for human osteosarcoma. Therefore in a better effort to understand the moclular features common to both human and canine osteosracoma a transcriptional mRNA seq dataset of 186 canine osteosarcoma primary tumors

Organism:

Canis lupus familiaris

Type:

Expression profiling by high throughput sequencing

Platform:

GPL25760

186 Samples

Download data: CSV