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Links from GEO DataSets

Items: 20

1.

Molecular homology and difference between spontaneous canine mammary cancer and human breast cancer.

(Submitter supplied) Spontaneously occurring canine mammary cancer represents an excellent model of human breast cancer, but is greatly understudied. To better use this valuable resource, we performed whole-genome sequencing, whole-exome sequencing, RNA-seq, and/or high-density arrays on twelve canine mammary cancer cases, including seven simple carcinomas and four complex carcinomas. Canine simple carcinomas, which histologically match human breast carcinomas, harbor extensive genomic aberrations, many of which faithfully recapitulate key features of human breast cancer. more...
Organism:
Canis lupus familiaris
Type:
Genome variation profiling by genome tiling array
Platform:
GPL9314
12 Samples
Download data: PAIR, TXT
Series
Accession:
GSE54535
ID:
200054535
2.

Metastatic Canine Mammary Carcinomas

(Submitter supplied) [original title] Metastatic Canine Mammary Carcinomas can be Identified by a Gene Expression Profile that partly Overlaps with Human Breast Cancer Profiles. Introduction: Similar to human breast cancer mammary tumors of the female dog are commonly associated with a fatal outcome due to the development of distant metastases. However, the molecular defects leading to metastasis are largely unknown and the value of canine mammary carcinoma as a model for human breast cancer is unclear. more...
Organism:
Canis lupus familiaris
Type:
Expression profiling by array
Platform:
GPL3738
27 Samples
Download data: CEL
Series
Accession:
GSE20718
ID:
200020718
3.

RNA-seq data of canine mammary tumors and normal samples

(Submitter supplied) Canine mammary gland tumors (CMTs) have been suggested as promising cancer models to human breast cancer due to their many biological and clinical similarities. Here, we collected 222 samples consist of 158 tumor samples and 64 matched normal samples of CMTs. Fresh tissue samples were transferred in to RNAlater, and refrigerated overnight at 4°C and then stored at -80°C. Total RNA was extracted from tissues using RNeasy mini kit. more...
Organism:
Canis lupus familiaris
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20988
222 Samples
Download data: CSV
Series
Accession:
GSE119810
ID:
200119810
4.

Metastatic Cascade is Reflected in the Gene Expression of Metastatic Canine Mammary Carcinomas Similar to Human Breast Cancer

(Submitter supplied) Proliferation, dedifferentiation, loss of cell-cell contacts and angiogenesis are among the first steps of the metastasis cascade. The complex molecular pathways associated with these events in canine mammary tumors are mostly unknown and the value of this spontaneous canine tumor as a comparative model for human breast cancer is therefore still under debate. Messenger RNA profiles of lymph-node positive canine mammary carcinomas and normal mammary glands of the same dogs were compared by microarray analysis to elucidate molecular pathways associated with metastatic progression. more...
Organism:
Canis lupus familiaris
Type:
Expression profiling by array
Platform:
GPL3738
25 Samples
Download data: CEL
Series
Accession:
GSE22516
ID:
200022516
5.

Next-generation RNA sequencing of FFPE subsections reveals highly conserved stromal reprogramming between canine and human mammary carcinoma

(Submitter supplied) Cancer-associated stroma (CAS) and matched normal stroma (NS) samples from 15 cases of canine mammary carcinoma (mCA).
Organism:
Canis lupus familiaris
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24229
30 Samples
Download data: CSV
Series
Accession:
GSE135183
ID:
200135183
6.

Investigating stromal reprogramming in canine mammary adenoma using next-generation RNA sequencing of FFPE subsections

(Submitter supplied) Cancer-associated stroma (CAS) and matched normal stroma (NS) samples from 13 cases of canine mammary adenoma
Organism:
Canis lupus familiaris
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24229
26 Samples
Download data: CSV
Series
Accession:
GSE135454
ID:
200135454
7.

Rat mammary normal - tumor

(Submitter supplied) Rat mammary tumors induced by N-methyl-N-nitrosurea (NMU) and normal mammary gland Keywords = breast cancer Keywords = rat mammary tumor Keywords = NMU Keywords = animal model. Keywords: other
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS1363
Platform:
GPL341
35 Samples
Download data: CEL
Series
Accession:
GSE1872
ID:
200001872
8.
Full record GDS1363

N-methyl-N-nitrosourea-induced breast cancer model

Analysis of N-methyl-N-nitrosourea (NMU)- induced primary mammary tumors from Wistar-Furth females. Results compared to expression profiles of human breast carcinomas, and found similar to profiles of ER-positive, low to intermediate grade breast cancer.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 2 disease state sets
Platform:
GPL341
Series:
GSE1872
35 Samples
Download data: CEL
DataSet
Accession:
GDS1363
ID:
1363
9.

ATF3-induced mammary tumors exhibit molecular features of human basal-like breast cancer

(Submitter supplied) Transcriptional profiling of mammary tumors that occurs in parous, BK5.ATF3 mice, compared to adjacent normal mammary tissue
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
6 Samples
Download data: TXT
Series
Accession:
GSE162804
ID:
200162804
10.

BK5.ATF3-induced mammary tumors compared to normal mammary glands

(Submitter supplied) Transcriptional profiling of mammary tumors that occur in parous, BK5.ATF3 mice, compared to normal mammary tissue
Organism:
Mus musculus; Murid betaherpesvirus 1; Murid gammaherpesvirus 4
Type:
Non-coding RNA profiling by array
Platform:
GPL29478
7 Samples
Download data: GPR
Series
Accession:
GSE162793
ID:
200162793
11.

cDNA microarray profiles of canine mammary tumour cell lines reveal deregulated pathways pertaining to their phenotype

(Submitter supplied) Mammary cancer is the most common type of cancer in female dogs with a lifetime risk of over 24% when dogs are not spayed. The elucidation of the complete canine genome opens new areas for development of cancer therapies. These should be tested first by in vitro models such as cell lines. However, to date, no canine mammary cell lines have been characterized by expression profiling. In this study, canine mammary tumour cell lines with histologically distinct primary tumours of origin were characterized using a newly developed canine cDNA microarray. more...
Organism:
Canis lupus familiaris
Type:
Expression profiling by array
Platform:
GPL5117
15 Samples
Download data
Series
Accession:
GSE7659
ID:
200007659
12.

Gene expression profiling of human and dog breast cancers

(Submitter supplied) Spontaneous tumors in dog have been demonstrated to share many features with their human counterparts, including relevant molecular targets, histological appearance, genetics, biological behavior and response to conventional treatments. Mammary tumors in dog therefore provide an attractive alternative to more classical mouse models, such as transgenics or xenografts, where the tumour is artificially induced. more...
Organism:
Homo sapiens; Canis lupus familiaris
Type:
Expression profiling by array
Platforms:
GPL7198 GPL3991
162 Samples
Download data
Series
Accession:
GSE14999
ID:
200014999
13.

Gene expression profile of cancer cells growing as a co-culture with carcinoma-associated fibroblasts (CAF)

(Submitter supplied) Molecular mechanisms of the cancer cells-carcinoma associated fibroblasts (CAF) interactions growing in vitro conditions as a co-culture. The five canine mammary cancer cell lines were cultured with CAF (isolated from canine mammary cancer) for 72hrs. Then, the cancer cells and CAFs were sorted and the gene expression analysis was conducted. The control for each co-cultured cell line was the same cell line growing as a single culture.
Organism:
Canis lupus familiaris
Type:
Expression profiling by array
Platform:
GPL13661
10 Samples
Download data: TXT
Series
Accession:
GSE29601
ID:
200029601
14.

Mouse tumors: Chaos3 Mammary Tumors (MTs) vs. Controls

(Submitter supplied) CNV profiling of tumors obtained from our Chaos3 mouse model for spontaneous breast cancer. The goal of this experiment was to determine copy number variations that were specific to MTs derived from this mouse model, when comapared to non-MTs.
Organism:
Mus musculus
Type:
Genome variation profiling by genome tiling array
Platform:
GPL10448
15 Samples
Download data: TXT
Series
Accession:
GSE81967
ID:
200081967
15.

Next Generation Sequencing of 23116 MT (low Arid1a expression) vs AB-C1 and AB-C2 (high Arid1a expression) Transcriptomes

(Submitter supplied) The goal of this study was to identify important genetic pathways that are altered in mammary tumor cells upon over-expression of the tumor suppressor gene Arid1a. The results of this experiment revealed that Arid1a helps regulate key cell-cycle checkpoint and growth regulatory pathways, either directly or indirectly. This helped explain in part the significant decrease in cell proliferation and tumor growth phenotypes observed both in vitro and in vivo, when comparing the same samples analyzed here by RNA-seq (untransduced replicates vs. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
4 Samples
Download data: DIFF, TXT
Series
Accession:
GSE81575
ID:
200081575
16.

Canine Spontaneous Head and Neck Squamous Cell Carcinomas Represent Their Human Counterparts at the Molecular Level.

(Submitter supplied) Spontaneous canine head and neck squamous cell carcinoma (HNSCC) represents an excellent model of human HNSCC but is greatly understudied. To better understand and utilize this valuable resource, we performed a pilot study that represents its first genome-wide characterization by investigating 12 canine HNSCC cases, of which 9 are oral, via high density array comparative genomic hybridization and RNA-seq. more...
Organism:
Canis lupus familiaris
Type:
Genome variation profiling by genome tiling array
Platform:
GPL9314
13 Samples
Download data: PAIR, TXT
Series
Accession:
GSE61231
ID:
200061231
17.

Expression profiling of murine DCIS and invasive ductal breast carcinoma

(Submitter supplied) Murine healthy tissue samples, DCIS and invasive mammary tumors were analyzed in order to identify marker genes which show enhanced expresssion in DCIS and invasive ductal carcinomas. Using this approach, we were able to identify a set of genes which might allow a better detection of DCIS and invasive carcinomas in the future.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
40 Samples
Download data: CEL, TXT
Series
Accession:
GSE21444
ID:
200021444
18.

Expression profiling of human DCIS and invasive ductal breast carcinoma

(Submitter supplied) Human healthy tissue samples, DCIS and invasive mammary tumors were analyzed in order to identify marker genes which show enhanced expresssion in DCIS and invasive ductal carcinomas. Using this approach, we were able to identify a set of genes which might allow a better detection of DCIS and invasive carcinomas in the future.
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS3853
Platform:
GPL570
19 Samples
Download data: CEL
Series
Accession:
GSE21422
ID:
200021422
19.
Full record GDS3853

Ductal carcinoma in situ: mammary gland

Analysis of ductal carcinoma in situ (DCIS) of mammary gland. DCIS represents an early, pre-invasive stage in development of invasive breast carcinoma. These results, together with results from a rodent model of DCIS development, provide insight into molecular basis of early stages of breast cancer.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 3 disease state sets
Platform:
GPL570
Series:
GSE21422
19 Samples
Download data: CEL
20.

Radiation-specific DNA copy number aberration in rat mammary carcinoma.

(Submitter supplied) Breast cancer ranks top in the incidence among the main sites of female cancer in Japan. The epidemiological study on atomic bomb survivors has suggested that the excess relative risk for breast cancer is higher than any other sites. Little is known, however, about the molecular mechanisms of breast cancer induction by radiation. Therefore, we analyzed here the genome-wide copy number aberration of radiation-induced rat mammary carcinomas using microarray-based comparative genomic hybridization (array-CGH). more...
Organism:
Rattus norvegicus
Type:
Genome variation profiling by array
Platform:
GPL21556
21 Samples
Download data: TXT
Series
Accession:
GSE16128
ID:
200016128
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