Similar studies for GEO DataSets (Select 200059793) - GEO DataSets

Links from GEO DataSets

Items: 20

Select item 2000597931.

Dynamic profiling of the protein life cycle in response to pathogens

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Protein profiling by Mass Spec

Platforms:: GPL18998 GPL17021
116 Samples

Download data

Series

Accession:: GSE59793

ID:: 200059793

PubMed Full text in PMC Similar studies

Select item 2000597922.

Dynamic profiling of the protein life cycle in response to pathogens (protein)

(Submitter supplied) Protein expression is regulated by production and degradation of mRNAs and proteins, but their specific relationships remain unknown. We combine measurements of protein production and degradation and mRNA dynamics to build a quantitative genomic model of the differential regulation of gene expression in LPS stimulated mouse dendritic cells. Changes in mRNA abundance play a dominant role in determining most dynamic fold changes in protein levels. more...

Organism:: Mus musculus

Type:: Protein profiling by Mass Spec

Platform:: GPL18998
88 Samples

Download data: TXT

Series

Accession:: GSE59792

ID:: 200059792

PubMed Full text in PMC Similar studies

Select item 2000597843.

Dynamic profiling of the protein life cycle in response to pathogens (RNA-seq)

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
28 Samples

Download data: TXT

Series

Accession:: GSE59784

ID:: 200059784

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000412654.

Single-cell transcriptomics reveals widespread heterogeneity in gene regulation and RNA processing in stimulated immune cells

(Submitter supplied) Here, we used single-cell RNA-Seq to discover extensive cell-to-cell variability – in transcript expression levels, cell state, circuit usage, and alternative splicing – between stimulated immune cells

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
24 Samples

Download data: TXT

Series

Accession:: GSE41265

ID:: 200041265

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000254325.

Temporal response of DCs to LPS stimulation: 4sU_sequencing

(Submitter supplied) Regulation of RNA levels is critical for the response to external stimuli and determined through the interplay between RNA production, processing and degradation. Despite the centrality of these processes, most global studies of RNA regulation do not distinguish their separate contributions and relatively little is known about how they are temporally integrated. Here, we combine metabolic labeling of RNA with advanced RNA quantification assays and computational modeling to estimate RNA transcription and degradation during the response of immune dendritic cells (DCs) to pathogens, a critical and tightly regulated step in innate immunity. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL9250
6 Samples

Download data: SAM

Series

Accession:: GSE25432

ID:: 200025432

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000524516.

Translational regulation of specific mRNAs controls feedback inhibition and survival during macrophage activation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Expression profiling by array

Platforms:: GPL13112 GPL17940
38 Samples

Download data: CEL

Series

Accession:: GSE52451

ID:: 200052451

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000524497.

Translational regulation of specific mRNAs controls feedback inhibition and survival during macrophage activation [array]

(Submitter supplied) When macrophages encounter pathogens, they transiently induce an orchestrated cascade of pro- and anti-inflammatory genes. We systematically analyzed the contribution of translational regulation to the early phase of macrophage activation. While the expression of most cytokines is regulated by changes in mRNA levels, de-repression of translation was found to permit expression of many feedback inhibitors of the inflammatory response. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL17940
30 Samples

Download data: CEL

Series

Accession:: GSE52449

ID:: 200052449

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000523208.

High temporal resolution of mRNA expression patterns during the early macrophage response to LPS [RNA_Seq]

(Submitter supplied) When macrophages encounter pathogens, they transiently induce an orchestrated cascade of pro- and anti-inflammatory genes. To obtain a precise picture of transcriptome-wide mRNA expression patterns, we performed RNA-Seq of total RNA at a high temporal resolution during the first two hours of macrophage activation. We systematically analyzed the contribution of translational regulation to the early phase of macrophage activation. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
8 Samples

Download data: TXT

Series

Accession:: GSE52320

ID:: 200052320

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000199389.

Expression data from mouse collecting duct cell, mpkCCD, in response to a peptide hormone vasopressin analog, dDAVP

(Submitter supplied) Vasopressin is the major hormone that regulates renal water excretion. It does so by binding to a receptor in renal collecting duct cells, triggering signaling pathways that ultimately regulate the abundance, location, and activity of the water channel protein aquaporin 2. We took an advantage of quantitative large scale proteomic technologies and oligonucleotide microarrays to quantify steady state changes in protein and transcript abundances in response to vasopressin in a collecting duct cell line, mpkCCD clone 11 (Yu et al. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
6 Samples

Download data: CEL, CHP

Series

Accession:: GSE19938

ID:: 200019938

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20010833310.

Mettl3-mediated mRNA m6A methylation promotes dendritic cell activation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Other

Platforms:: GPL17021 GPL21493
30 Samples

Download data

Series

Accession:: GSE108333

ID:: 200108333

PubMed Full text in PMC Similar studies

Select item 20010833211.

Next Generation Sequencing Facilitates Quantitative Analysis of mRNA expression of Wild Type and Mettl3-/- mice

(Submitter supplied) Considering m6A modification in mRNA was reported to be important in many biology processes, like cell fate decision and embryonic development and was closely connected to human diseases such as metabolic diseases, neuron disorders and cancer. We wondered how Mettl3 affect dendritic cell development.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21493
4 Samples

Download data: XLS

Series

Accession:: GSE108332

ID:: 200108332

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20010833112.

Next Generation Sequencing Facilitates Quantitative Analysis of mRNA translation efficiency of Wild Type and Mettl3-/- mice

(Submitter supplied) Considering m6A modification in mRNA was reported to be intensively corelated with RNA metabolism like RNA decay and RNA translation, we wonderd whether deleting Mettl3, the main catalzing enzyme, affect the RNA translation efficiency of mouse dendritic cells.

Organism:: Mus musculus

Type:: Other

Platforms:: GPL17021 GPL21493
8 Samples

Download data: XLS

Series

Accession:: GSE108331

ID:: 200108331

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20010833013.

Next Generation Sequencing Facilitates Quantitative Analysis of mRNA lifetime of Wild Type and Mettl3-/- mice

(Submitter supplied) Considering m6A modification in mRNA was reported to be intensively correlated with RNA decay, for example, T cells and neurone cells. We wondered whether deleting Mettl3, the main catalzing enzyme, affect the RNA stability of mouse dendritic cells.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21493
6 Samples

Download data: XLS

Series

Accession:: GSE108330

ID:: 200108330

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20010027314.

Methylated RNA Immunoprecipitation Sequencing of dendritic cells in different development stages

(Submitter supplied) Using m6A immunoprecipitation together with high-throughput sequencing (meRIP-seq), we potrayed the dynamic distribution pattern of m6A modification in the mRNA transcripts of immature DC, mature DC and regulatory DC, aiming to explored the funcion and mechanisms of m6A during DC maturation, activation and differentiation , or maybe other important processes like migration and antigen presentation. This may shed light on the function of m6A in innate and adaptive immune system in an epigenic transcriptome level.

Organism:: Mus musculus

Type:: Other

Platform:: GPL17021
12 Samples

Download data: XLS

Series

Accession:: GSE100273

ID:: 200100273

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20001575915.

NFAT-mediated gene expression response to LPS in murine dendritic cells and macrophages

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL8321
36 Samples

Download data: CEL, CHP

Series

Accession:: GSE15759

ID:: 200015759

Select item 20001572116.

Gene expression in macrophages stimulated with LPS in conditions allowing or inhibiting NFAT activation

(Submitter supplied) Macrophages and dendritic cells (DCs) differently contribute to the generation of coordinated immune system responses against infectious agents. They interact with microbes through germline-encoded pattern-recognition receptors (PRRs), which recognize molecular patterns expressed by various microorganisms. Upon antigen binding, PRRs instruct DCs for the appropriate priming of natural killer cells, followed by specific T-cell responses. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL8321
8 Samples

Download data: CEL, CHP

Series

Accession:: GSE15721

ID:: 200015721

Select item 20001572017.

Apoptosis genes specifically modulated by NFAT in LPS-activated dendritic cells

(Submitter supplied) Dendritic cells (DCs) are a special class of leukocytes able to activate both innate and adaptive immune responses. They interact with microbes through germline-encoded pattern-recognition receptors (PRRs), which recognize molecular patterns expressed by various microorganisms. Upon antigen binding, PRRs instruct DCs for the appropriate priming of natural killer cells, followed by specific T-cell responses. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL8321
10 Samples

Download data: CEL, CHP

Series

Accession:: GSE15720

ID:: 200015720

Select item 20001571818.

Gene expression in dendritic cells stimulated with LPS in conditions allowing or inhibiting NFAT activation

(Submitter supplied) Interleukin-2 (IL-2) is one of the molecules produced by mouse dendritic cells (DCs) after stimulation by Toll like receptor (TLR) agonists. By analogy with the events following T-cell receptor (TCR) engagement leading to IL-2 production we have observed that DC stimulation with lipopolysaccharide (LPS) induces Src-family kinase and phospholipase C (PLC)γ2 activation, influx of extracellular Ca2+ and calcineurin-dependent nuclear NFAT translocation. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL8321
18 Samples

Download data: CEL, CHP

Series

Accession:: GSE15718

ID:: 200015718

Select item 20010080219.

Genome-wide profiling of RNAs reveals novel insights into the immune response between infectious bronchitis virus and avian dendritic cells

(Submitter supplied) Background: Avian infectious bronchitis virus (IBV) was an major respiratory disease-causing agents that lead to significant losses in birds. Dendritic cells (DCs), an major antigen-presenting cells, influence viruses pathogenicity as well as host immune response. Expression of host non-coding mRNA changes markedly during infectious bronchitis virus (IBV) infection of avian, but their role in regulating host immune function to defend IBV infection has not been explored. more...

Organism:: Gallus gallus

Type:: Expression profiling by array

Platform:: GPL21649
2 Samples

Download data: GPR

Series

Accession:: GSE100802

ID:: 200100802

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20000131620.

IL-10-conditioned dendritic cells elicit innate inflammatory gene products in response to danger signals

(Submitter supplied) IL-10-Conditioned Dendritic Cells, Decommissioned for Recruitment of Adaptive Immunity, Elicit Innate Inflammatory Gene Products in Response to Danger Signals Dendritic cells (DCs) are the professional APCs of the immune system, enabling T cells to perceive and respond appropriately to potentially dangerous microbes, while also being able to maintain T cell tolerance toward self. In part, such tolerance can be determined by IL-10 released from certain types of regulatory T cells. more...

Organism:: Mus musculus

Type:: Expression profiling by SAGE

Platforms:: GPL11 GPL1349
26 Samples

Download data

Series

Accession:: GSE1316

ID:: 200001316

PubMed Similar studies

GEO DataSets

Functional Genomics Studies

Result Filters

Entry type

Organism

Study type

Author

Attribute name

Publication dates

Custom date range

Additional filters

Send to:

Links from GEO DataSets

Items: 20

Send to:

Supplemental Content

Find related data

Important Links

Recent activity