Similar studies for GEO DataSets (Select 200077245) - GEO DataSets

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Items: 20

Select item 2000772451.

Gene expression analysis of miR-210 over-expressing flies at ZT0 and ZT12

(Submitter supplied) Single microRNAs are usually associated with hundreds of putative target genes that can influence multiple phenotypic traits in Drosophila, ranging from development to behaviour. We investigated the function of Drosophila miR-210 in circadian behaviour by misexpressing it within circadian clock cells. Manipulation of miR-210 expression levels in the PDF (pigment dispersing factor) positive neurons affected the phase of locomotor activity, under both light-dark conditions and constant darkness. more...

Organism:: Drosophila melanogaster

Type:: Expression profiling by array

Platform:: GPL18767
16 Samples

Download data: TXT

Series

Accession:: GSE77245

ID:: 200077245

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000772332.

Gene expression analysis of miR-210 over-expressing flies at ZT12.

(Submitter supplied) MicroRNAs (miRNAs) are a novel class of small RNAs which act as modulators of gene expression either by inhibiting the translation or by inducing the degradation of their target mRNAs. Several studies suggest a role for miRNAs as regulators of the circadian clock in mammals and Drosophila. Based on computational predictions of target mRNAs of clock (or clock related) genes, we have selected the miR-210 as a putative regulator of the period clock gene. more...

Organism:: Drosophila melanogaster

Type:: Expression profiling by array

Platform:: GPL18767
8 Samples

Download data: TXT

Series

Accession:: GSE77233

ID:: 200077233

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000760993.

Gene expression analysis of miR-210 over-expressing flies at ZT0.

Organism:: Drosophila melanogaster

Type:: Expression profiling by array

Platform:: GPL18767
8 Samples

Download data: TXT

Series

Accession:: GSE76099

ID:: 200076099

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000188084.

A methyl transferase links the circadian clock to the regulation of alternative splicing

(Submitter supplied) Study on differential gene expression and splicing between wildtype and clock mutants. This study is part of a comparative analysis of the role of Protein Methyltransferase 5 in the regulation of transcriptional and post-transcriptional processes simultaneously in Arabidopsis and Drosophila. Circadian rhythms allow organisms to time biological processes to the most appropriate phases of the day/night cycle1. more...

Organism:: Arabidopsis thaliana; Drosophila melanogaster

Type:: Expression profiling by array; Expression profiling by genome tiling array

Platforms:: GPL198 GPL1979 GPL6882
18 Samples

Download data: CEL

Series

Accession:: GSE18808

ID:: 200018808

Select item 2000223085.

Circadian expression profiling of purified clock neurons in adult Drosophila

(Submitter supplied) To compare circadian gene expression within highly discrete neuronal populations, we separately purified and characterized two adjacent but distinct groups of Drosophila adult circadian neurons: the 8 small and 10 large PDF (pigment-dispersing factor)-expressing ventral lateral neurons (s-LNvs and l-LNvs, respectively). The s-LNvs are the principal circadian pacemaker cells, whereas recent evidence indicates that the l-LNvs are involved in sleep and light-mediated arousal. more...

Organism:: Drosophila melanogaster

Type:: Expression profiling by array

Platform:: GPL1322
24 Samples

Download data: CEL

Series

Accession:: GSE22308

ID:: 200022308

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Select item 2000774516.

RNA-seq analysis of Drosophila clock and non-clock neurons reveals neuron-specific cycling and novel candidate neuropeptides

(Submitter supplied) LNd, LNv, DN1 and TH neurons were manually sorted from dissociated Drosophila brains. RNA was extracted and transcriptomes analyzed via RNA-seq.

Organism:: Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13304
48 Samples

Download data: TXT

Series

Accession:: GSE77451

ID:: 200077451

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000807387.

Achilles is a circadian clock controlled gene that regulates innate immune function in Drosophila

(Submitter supplied) RNAseq transcriptional profiling of Drosophila heads from Achilles RNAi or control animals

Organism:: Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16479
14 Samples

Download data: TXT, XLSX

Series

Accession:: GSE80738

ID:: 200080738

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000178038.

Gene expression dissection of the circadian neuronal circuit of Drosophila identifies novel circadian genes

(Submitter supplied) Gene expression profiling of distinct members of a neuronal circuit has the potential to identify candidate molecules and mechanisms that underlie the formation, organization and function of the circuit. To this end, we report here the application of a novel method to characterize RNAs from small numbers of specific Drosophila brain neurons, which belong to the circadian circuit. We identified three different sets of mRNAs enriched in different subclasses of clock neurons: one is enriched in all clock neurons, a second is enriched in PDF-positive clock neurons and a third is enriched in PDF-negative clock neurons. more...

Organism:: Drosophila melanogaster

Type:: Expression profiling by array

Platform:: GPL1322
23 Samples

Download data: CEL

Series

Accession:: GSE17803

ID:: 200017803

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000176299.

Circadian analysis of miRNAs and their targets

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Drosophila melanogaster

Type:: Expression profiling by array; Expression profiling by genome tiling array

Platforms:: GPL1322 GPL5919
28 Samples

Download data: BAR, CEL, TXT

Series

Accession:: GSE17629

ID:: 200017629

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Select item 20001762710.

AGO 1 IMMUNOPRECIPITATION MICROARRAYS

(Submitter supplied) Little is known about the contribution of translational control to circadian rhythms. To address this issue and in particular translational control by microRNAs (miRNAs), we knocked down the miRNA biogenesis pathway in Drosophila circadian tissues. In combination with an increase in circadian-mediated transcription, this severely affected Drosophila behavioral rhythms, indicating that miRNAs function in circadian timekeeping. more...

Organism:: Drosophila melanogaster

Type:: Expression profiling by array

Platform:: GPL1322
27 Samples

Download data: CEL

Series

Accession:: GSE17627

ID:: 200017627

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Select item 20012992211.

Circadian gene variants and the skeletal muscle circadian clock contribute to the evolutionary divergence in longevity across Drosophila populations

(Submitter supplied) Organisms use endogenous clocks to adapt to the rhythmicity of the environment and to synchronize social activities. Although circadian rhythms have been implicated in multiple aspects of aging, it remains uncertain whether evolutionary selection of circadian cycle gene variants contributes to changes in longevity and aging traits within animal populations. We have sequenced the genomes of Drosophila melanogaster strains with exceptional longevity that were obtained via multiple rounds of selection for reduced senescence from a parental strain. more...

Organism:: Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13304
72 Samples

Download data: TXT

Series

Accession:: GSE129922

ID:: 200129922

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20018607612.

Next generation sequencing of isolated R5 ellipsoid body neurons of Drosophila in the morning and evening with and without sleep deprivation

(Submitter supplied) Purpose: After identifying a difference in the response to sleep deprivation between the morning and evening, we assayed gene expression in a key homeostatic circuit in the Drosophila brain: the R5 ellipsoid body neurons. We sought to identify changes in gene expression in this circuit that are critical for the behavioral output. Methods: Flies expressing GFP via a restrictive R5 driver were entrained to a 12:12 light:dark paradigm at 25C. more...

Organism:: Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing

Platform:: GPL25244
12 Samples

Download data: CSV, H5

Series

Accession:: GSE186076

ID:: 200186076

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20012406513.

Chronic Circadian Misalignment Results in Reduced Longevity and Large-Scale Changes in Gene Expression in Drosophila

(Submitter supplied) We investigated the consequences of chronic circadian misalignment (CCM) in the powerful model system of the fruit fly, Drosophila melanogaster. We subjected flies to daily 4-hr phase delays in the light-dark schedule and used the Drosophila Activity Monitoring (DAM) system to continuously track locomotor activity and sleep while simultaneously monitoring fly lifespan. Consistent with previous results, we find that exposing flies to CCM leads to a ~15% reduction in median lifespan in both male and female flies. more...