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Links from GEO DataSets

Items: 14

1.

MAFG is a transcriptional repressor of bile acid synthesis and metabolism (ChIP-seq)

(Submitter supplied) Specific bile acids are potent signaling molecules that modulate metabolic pathways affecting lipid, glucose and bile acid homeostasis, and the microbiota. Bile acids are synthesized from cholesterol in the liver, and the key enzymes involved in bile acid synthesis (Cyp7a1, Cyp8b1) are regulated transcriptionally by the nuclear receptor FXR. We have identified an FXR-regulated pathway upstream of a transcriptional repressor that controls multiple bile acid metabolism genes. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL17021
4 Samples
Download data: TXT
Series
Accession:
GSE77529
ID:
200077529

PubMed Full text in PMC Similar studies SRA Run Selector

2.

MAFG is a transcriptional repressor of bile acid synthesis and metabolism

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by array
Platforms:
GPL17021 GPL6885
10 Samples
Download data
Series
Accession:
GSE77559
ID:
200077559

PubMed Full text in PMC Similar studies Analyze with GEO2R

3.

Differential gene expression following MafG overexpression

(Submitter supplied) Specific bile acids are potent signaling molecules that modulate metabolic pathways affecting lipid, glucose and bile acid homeostasis, and the microbiota. Bile acids are synthesized from cholesterol in the liver, and the key enzymes involved in bile acid synthesis (Cyp7a1, Cyp8b1) are regulated transcriptionally by the nuclear receptor FXR. We have identified an FXR-regulated pathway upstream of a transcriptional repressor that controls multiple bile acid metabolism genes. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
6 Samples
Download data: TXT
Series
Accession:
GSE77507
ID:
200077507

PubMed Full text in PMC Similar studies Analyze with GEO2R

4.

FXR cistrome in mouse liver

(Submitter supplied) FXR ChIP-seq was performed using the liver from adult male C57Bl6 mice
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL17021
4 Samples
Download data: BIGWIG
Series
Accession:
GSE87866
ID:
200087866

PubMed Full text in PMC Similar studies SRA Run Selector

5.

A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens; Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL21103 GPL17021 GPL20301
73 Samples
Download data
Series
Accession:
GSE121346
ID:
200121346

PubMed Full text in PMC Similar studies

6.

A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism: RNA profiles of metabolically active tissues.

(Submitter supplied) Obesity and type 2 diabetes mellitus are global emergencies and long noncoding RNAs (lncRNAs) are regulatory transcrips with elusive functions in metabolism. Here we report that an unexpectedly high fraction of lncRNAs, but not protein-coding mRNAs, is repressed during diet-induced obesity (DIO) and refeeding, whilst nutrient deprivation specifically induced lncRNAs in mouse liver. Similarly, lncRNAs were lost in diabetic humans. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
7 Samples
Download data: TXT
Series
Accession:
GSE121345
ID:
200121345

PubMed Full text in PMC Similar studies SRA Run Selector

7.

A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism: Liver RNA profiles of lean non-diabetic, obese non-diabetic as well as obese diabetic humans.

(Submitter supplied) Obesity and type 2 diabetes mellitus are global emergencies and long noncoding RNAs (lncRNAs) are regulatory transcrips with elusive functions in metabolism. Here we report that an unexpectedly high fraction of lncRNAs, but not protein-coding mRNAs, is repressed during diet-induced obesity (DIO) and refeeding, whilst nutrient deprivation specifically induced lncRNAs in mouse liver. Similarly, lncRNAs were lost in diabetic humans. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20301
12 Samples
Download data: XLSX
Series
Accession:
GSE121344
ID:
200121344

PubMed Full text in PMC Similar studies Analyze with GEO2RSRA Run Selector

8.

A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism: Liver RNA profiles of mice injected with control, Mafg and LncIRS2 LNA.

(Submitter supplied) Obesity and type 2 diabetes mellitus are global emergencies and long noncoding RNAs (lncRNAs) are regulatory transcrips with elusive functions in metabolism. Here we report that an unexpectedly high fraction of lncRNAs, but not protein-coding mRNAs, is repressed during diet-induced obesity (DIO) and refeeding, whilst nutrient deprivation specifically induced lncRNAs in mouse liver. Similarly, lncRNAs were lost in diabetic humans. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21103
24 Samples
Download data: XLSX
Series
Accession:
GSE121343
ID:
200121343

PubMed Full text in PMC Similar studies SRA Run Selector

9.

A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism: Liver RNA profiles of mice treated with adenoviruses expressing either Mafg cDNA or empty vector.

(Submitter supplied) Obesity and type 2 diabetes mellitus are global emergencies and long noncoding RNAs (lncRNAs) are regulatory transcrips with elusive functions in metabolism. Here we report that an unexpectedly high fraction of lncRNAs, but not protein-coding mRNAs, is repressed during diet-induced obesity (DIO) and refeeding, whilst nutrient deprivation specifically induced lncRNAs in mouse liver. Similarly, lncRNAs were lost in diabetic humans. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21103
6 Samples
Download data: XLSX
Series
Accession:
GSE121342
ID:
200121342

PubMed Full text in PMC Similar studies SRA Run Selector

10.

A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism: Liver RNA seq profiles of mice fed different feeding regimes.

(Submitter supplied) Obesity and type 2 diabetes mellitus are global emergencies and long noncoding RNAs (lncRNAs) are regulatory transcrips with elusive functions in metabolism. Here we report that an unexpectedly high fraction of lncRNAs, but not protein-coding mRNAs, is repressed during diet-induced obesity (DIO) and refeeding, whilst nutrient deprivation specifically induced lncRNAs in mouse liver. Similarly, lncRNAs were lost in diabetic humans. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21103
12 Samples
Download data: XLSX
Series
Accession:
GSE121341
ID:
200121341

PubMed Full text in PMC Similar studies SRA Run Selector

11.

A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism: Liver RNA profiles of obese and lean mice.

(Submitter supplied) Obesity and type 2 diabetes mellitus are global emergencies and long noncoding RNAs (lncRNAs) are regulatory transcrips with elusive functions in metabolism. Here we report that an unexpectedly high fraction of lncRNAs, but not protein-coding mRNAs, is repressed during diet-induced obesity (DIO) and refeeding, whilst nutrient deprivation specifically induced lncRNAs in mouse liver. Similarly, lncRNAs were lost in diabetic humans. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
12 Samples
Download data: XLSX
Series
Accession:
GSE121340
ID:
200121340

PubMed Full text in PMC Similar studies SRA Run Selector

12.

Expression data in Hepa1c1c7 cells treated with Nrf2 activator, diethyl maleate (DEM)

(Submitter supplied) To examine the gene expression profile of Hepa1c1c7 cells in response to DEM, we performed microarray analysis.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL4134
4 Samples
Download data: TXT
Series
Accession:
GSE38350
ID:
200038350

PubMed Full text in PMC Similar studies Analyze with GEO2R

13.

Gene expression profiling from pooled samples of liver tissue of liver MyD88 WT mice and MyD88 liver specific KO mice fed either with a control diet or a high-fat diet.

(Submitter supplied) Mice wild type or knocked-out for the MyD88 gene specifically in liver, were recruited for this expression profiling experiment. Each group of mice (WT versus LKO) were fed with a control diet or a high fat diet. Then mice were sacrificed and liver samples form were processed for RNA extraction. Total liver RNA of each sample was then pooled with those of the same group and treatment for microarray hybridization.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL16570
4 Samples
Download data: CEL
Series
Accession:
GSE73489
ID:
200073489

PubMed Full text in PMC Similar studies Analyze with GEO2R

14.

Liver gene expression profile _ wild type_ CYP7A1 transgenic

(Submitter supplied) Bile acids are not only physiological detergents facilitating nutrient absorption, but also signaling molecules regulating metabolic homeostasis. We reported recently that transgenic expression of CYP7A1 in mice stimulated bile acid synthesis and prevented Western diet-induced obesity, insulin resistance and hepatic steatosis. The aim of this experiment is to determine the impact of induction of hepatic bile acid synthesis on liver metabolism by determining hepatic gene expression profile in CYP7A1 transgenic mice. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
16 Samples
Download data: TXT
Series
Accession:
GSE38872
ID:
200038872

PubMed Full text in PMC Similar studies Analyze with GEO2R

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