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Links from GEO DataSets

Items: 6

1.

Effect of Anaplasma phagocytophilum infection on the micro RNA profile of Ixodes scapularis tick cells

(Submitter supplied) Ticks are blood feeding arthropod ectoparasites that transmit pathogens, which cause diseases in humans and animals worldwide. In the past ten decades, the continuous human exploitation of environmental resources and the increase in human outdoor activities has promoted contact with arthropod vectors normally present in the wild, resulting in increased transmission of vector-borne pathogens. In addition, vector populations are expanding in response to climate change and human interventions that impact reservoir host movement and human exposure to infected vectors. more...
Organism:
Ixodes scapularis
Type:
Non-coding RNA profiling by high throughput sequencing; Expression profiling by high throughput sequencing
Platform:
GPL21603
4 Samples
Download data: GTF
Series
Accession:
GSE79324
ID:
200079324
2.

Integrated metabolomics, transcriptomics and proteomics identifies metabolic pathways affected by Anaplasma phagocytophilum infection in tick cells

(Submitter supplied) Anaplasma phagocytophilum is an emerging zoonotic pathogen that causes human granulocytic anaplasmosis. These intracellular bacteria establish infection by affecting cell function in both the vertebrate host and the tick vector, Ixodes scapularis. Previous studies have characterized the tick transcriptome and proteome in response to A. phagocytophilum infection. However, in the post-genomic era, the integration of omics datasets through a systems biology approach allows network-based analyses to describe the complexity and functionality of biological systems such as host-pathogen interactions and the discovery of new targets for prevention and control of infectious diseases. more...
Organism:
Ixodes scapularis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18496
4 Samples
Download data: GTF
Series
Accession:
GSE68881
ID:
200068881
3.

Tick-borne Pathogens Induce Differential Expression of Genes Promoting Cell Survival and Host Resistence in Ixodes ricinus Cells

(Submitter supplied) There has been an emergence and expansion of tick-borne diseases in Europe, Asia and North America in recent years, including Lyme disease, tick-borne encephalitis, and human anaplasmosis. The primary tick vectors implicated are hard ticks of the Ixodes genera. Although much is known about the host response to these bacterial and viral pathogens, there is limited knowledge of the cellular responses to infection within the tick vector. more...
Organism:
Ixodes ricinus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21340
6 Samples
Download data: FPKM_TRACKING
Series
Accession:
GSE85300
ID:
200085300
4.

Tissue-specific signatures in the transcriptional response to Anaplasma phagocytophilum infection of Ixodes scapularis and Ixodes ricinus tick cell lines

(Submitter supplied) We report differential gene expression with tissue-specific signatures in tick cell lines infected with Anaplasma phagocytophilum - transcriptional response to infection of I. scapularis ISE6 cells resembled that of tick hemocytes while the response in I. ricinus IRE/CTVM20 cells resembles that of tick midguts.
Organism:
Ixodes ricinus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21340
4 Samples
Download data: FPKM_TRACKING
Series
Accession:
GSE76906
ID:
200076906
5.

Differential expression of inflammatory and immune response genes in sheep infected with Anaplasma phagocytophilum.

(Submitter supplied) Anaplasma phagocytophilum is the causative agent of tick-borne fever (TBF) in ruminants and human, equine and canine granulocytic anaplasmosis. A. phagocytophilum modifies host gene expression and immune response. The objective of this work was to analyze differential gene expression in A. phagocytophilum-infected sheep using microarray hybridization and real-time RT-PCR in experimentally and naturally infected animals. more...
Organism:
Sus scrofa; Ovis aries; Bos taurus
Type:
Expression profiling by array
Platform:
GPL4456
2 Samples
Download data: GPR
Series
Accession:
GSE10286
ID:
200010286
6.

Gene expression profiles of European wild boar naturally infected with Anaplasma phagocytophilum.

(Submitter supplied) Anaplasma phagocytophilum infects a wide variety of host species and causes the diseases granulocytic anaplasmosis in humans, horses and dogs and tick-borne fever in ruminants. The objective of this research was to characterize differential gene expression in wild boar naturally infected with A. phagocytophilum by microarray hybridization using the GeneChip® Porcine Genome Array
Organism:
Sus scrofa
Type:
Expression profiling by array
Platform:
GPL3533
5 Samples
Download data: CEL
Series
Accession:
GSE15766
ID:
200015766
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