Similar studies for GEO DataSets (Select 200087866) - GEO DataSets

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Items: 11

Select item 2000878661.

FXR cistrome in mouse liver

(Submitter supplied) FXR ChIP-seq was performed using the liver from adult male C57Bl6 mice

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17021
4 Samples

Download data: BIGWIG

Series

Accession:: GSE87866

ID:: 200087866

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001137072.

Postprandial FGF19 signaling-induced phosphorylation of FXR by Src modulates its activity in bile acid homeostasis

(Submitter supplied) Farnesoid-X-Receptor (FXR) plays a central role in maintaining bile acid (BA) homeostasis by transcriptional control of numerous enterohepatic genes, including intestinal FGF19, a hormone that strongly represses hepatic BA synthesis. How activation of the FGF19 receptor at the membrane is transmitted to the nucleus for transcriptional regulation of BA levels and whether FGF19 signaling posttranslationally modulates function of FXR remain largely unknown. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
6 Samples

Download data: TXT

Series

Accession:: GSE113707

ID:: 200113707

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000038093.

Gene expression profiling of livers from cafestol-fed APOE3Leiden mice

(Submitter supplied) Unfiltered coffee markedly increases serum lipid levels in humans and mice. The responsible compounds are the fat-soluble diterpenes cafestol and kahweol. Cafestol is responsible for more than 80% of the effect on serum lipids and is the most potent cholesterol-elevating compound known in the human diet. Aim of these microarray studies was to identify novel genes and regulatory pathways determining the cholesterol raising effect of cafestol by genome-wide expression studies. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL3239
16 Samples

Download data

Series

Accession:: GSE3809

ID:: 200003809

Select item 2001135754.

The nuclear Bile Acid Receptor FXR is a PKA- and FOXA2- sensitive Activator of Fasting Hepatic Gluconeogenesis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL16570
32 Samples

Download data: CEL

Series

Accession:: GSE113575

ID:: 200113575

Select item 2001135495.

The nuclear Bile Acid Receptor FXR is a PKA- and FOXA2- sensitive Activator of Fasting Hepatic Gluconeogenesis [modulated FOXA2/FXR]

(Submitter supplied) Identified genes deregulated in mouse primary hepatocytes after modulation of expression/activity of FOXA2 and FXR in glucagon or insulin state

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL16570
24 Samples

Download data: CEL

Series

Accession:: GSE113549

ID:: 200113549

Select item 2001135266.

The nuclear Bile Acid Receptor FXR is a PKA- and FOXA2- sensitive Activator of Fasting Hepatic Gluconeogenesis [glucacon/GW4064]

(Submitter supplied) Identified genes deregulated in mouse primary hepatocytes after glucagon and /or GW4064 treatment

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL16570
8 Samples

Download data: CEL

Series

Accession:: GSE113526

ID:: 200113526

Select item 2000775597.

MAFG is a transcriptional repressor of bile acid synthesis and metabolism

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by array

Platforms:: GPL6885 GPL17021
10 Samples

Download data

Series

Accession:: GSE77559

ID:: 200077559

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000775298.

MAFG is a transcriptional repressor of bile acid synthesis and metabolism (ChIP-seq)

(Submitter supplied) Specific bile acids are potent signaling molecules that modulate metabolic pathways affecting lipid, glucose and bile acid homeostasis, and the microbiota. Bile acids are synthesized from cholesterol in the liver, and the key enzymes involved in bile acid synthesis (Cyp7a1, Cyp8b1) are regulated transcriptionally by the nuclear receptor FXR. We have identified an FXR-regulated pathway upstream of a transcriptional repressor that controls multiple bile acid metabolism genes. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17021
4 Samples

Download data: TXT

Series

Accession:: GSE77529

ID:: 200077529

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000775079.

Differential gene expression following MafG overexpression

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6885
6 Samples

Download data: TXT

Series

Accession:: GSE77507

ID:: 200077507

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20017357010.

Fxr signaling and microbial metabolism of bile salts in the zebrafish intestine

(Submitter supplied) The purpose of this study was to elucidate potential effects of fxr mutation on the functional specification of intestinal epithelial cells. To do this, we sorted GFP-positive cells from TgBAC(cldn15la:GFP) transgenics of either fxr+/+ or fxr-/- fish larvae and subjected them to 10X Genomics single-cell RNA-seq. Our results uncovered the requirement of fxr in gene expression and differentiation among multiple intestinal epithelial cell types.