Similar studies for GEO DataSets (Select 200098576) - GEO DataSets

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Items: 12

Select item 2000985761.

Global transcriptional responce in C.elegans on a high glucose diet

(Submitter supplied) We compared differential gene expression in C. elegans on a regular and 2% glucose supplemented diet.

Organism:: Caenorhabditis elegans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19757
6 Samples

Download data: DIFF, FPKM_TRACKING

Series

Accession:: GSE98576

ID:: 200098576

PubMed Full text in PMC Similar studies

Select item 2000952402.

RNA-sequencing of C.elegans isp-1 mutant and superoxide dismutase-isp-1 double mutants

(Submitter supplied) isp-1;sod double mutants have decreased lifespan, increased resistance to oxidative stress and slow physiologic rates. We performed RNA sequencing to compare gene expression between isp-1 mutants and isp-1;sod-3 and isp-1;sod-5 double mutants

Organism:: Caenorhabditis elegans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19757
12 Samples

Download data: TXT

Series

Accession:: GSE95240

ID:: 200095240

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000099673.

Expression data from wildtype and C. elegan mutants

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array

Platform:: GPL200
20 Samples

Download data: CEL

Series

Accession:: GSE9967

ID:: 200009967

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000098974.

Expression data from 2 wildtype and 8 C. elegans ETC mutants

(Submitter supplied) Utilizing C. elegans as a model of mitochondrial dysfunction provides insight into cellular adaptations which occur as a consequence of genetic alterations causative of human disease. We characterized genome-wide expression profiles of hypomorphic C. ele Our goal was to detect concordant changes among clusters of genes that comprise defined metabolic pathways utilizing gene set enrichment analysis. more...

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array

Dataset:: GDS3453
Platform:: GPL200
10 Samples

Download data: CEL

Series

Accession:: GSE9897

ID:: 200009897

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000098965.

Expression data from wildtype and gas-1 mitochondrial mutant C. elegans

(Submitter supplied) Utilizing C. elegans as a model of mitochondrial dysfunction provides insight into cellular adaptations which occur as a consequence of genetic alterations causative of human disease. We characterized genome-wide expression profiles of hypomorhpic C. elegans mutants in nuclear-encoded subunits of respiratory chain complexes I, II and III. Our goal was to detect concordant changes among clusters of genes that comprise defined metabolic pathways utilizing gene set enrichment analysis. more...

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array

Dataset:: GDS3452
Platform:: GPL200
10 Samples

Download data: CEL

Series

Accession:: GSE9896

ID:: 200009896

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 34536.

Nematode models of primary mitochondrial dysfunction: complex I, II, and III mutants

Analysis of 8 different electron transport chain (ETC) subunit mutants (3 missense and 5 RNAi-induced) in complexes I, II, and III. Results from this validation set provide insight into the contributions of individual complexes or subunits to primary mitochondrial dysfunction.

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array, transformed count, 4 genotype/variation, 4 protocol sets

Platform:: GPL200
Series:: GSE9897
10 Samples

Download data: CEL

DataSet

Accession:: GDS3453

ID:: 3453

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 34527.

Nematode model of primary mitochondrial dysfunction: complex I mutants

Analysis of gas-1(fc21) electron transport chain complex I mutants. The gas-1(fc21) mutation affects the 49 kD subunit of complex I, decreasing the rate of complex I-dependent oxidative phosphorylation. Results provide insight into molecular mechanisms underlying primary mitochondrial disease .

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:: GPL200
Series:: GSE9896
10 Samples

Download data: CEL

DataSet

Accession:: GDS3452

ID:: 3452

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2001829818.

Next Generation Sequencing Facilitates Quantitative Analysis of Wild Type animal fed normal and high glucose diets at different age

(Submitter supplied) Metabolic diseases are strongly associated with endoplasmic reticulum (ER) stress. Upon ER stress, the unfolded protein response (UPR) is activated to limit cellular damage. However, escalating cellular UPR response weakens with age. Here, we show that 5-day-old Caenorhabditis elegans fed a bacteria diet with 2% glucose (high glucose diet, HGD-5) extend their lifespan while shortening the lifespan of 1-day-old (HGD-1) animals. more...

Organism:: Caenorhabditis elegans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL22765
18 Samples

Download data: CSV

Series

Accession:: GSE182981

ID:: 200182981

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000548539.

RNA-seq of C.elegans and M.musculus in the presence and absence of D-Glucosamine (GlcN)

(Submitter supplied) D-Glucosamine (2-amino-2-deoxy-D-glucose, C.A.S.# 3416-24-8) (GlcN) is a freely available and commonly used dietary supplement possibly promoting cartilage health in humans which also acts as an inhibitor of glycolysis. We here find that GlcN extends C. elegans lifespan by impairing glucose metabolism to activate AMP-activated protein kinase (AMPK/AAK2) leading to increased mitochondrial biogenesis. more...

Organism:: Caenorhabditis elegans; Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL13112 GPL13657
24 Samples

Download data: XLS

Series

Accession:: GSE54853

ID:: 200054853

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20003969910.

gene expression signatures of Akt1 +/- mice at 8weeks and 35weeks

(Submitter supplied) To know the difference of transcriptome between Wild type and Akt1+/- mice, 8weeks and 35weeks female mice were subjected to microarray analysis.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL7202
42 Samples

Download data: TXT

Series

Accession:: GSE39699

ID:: 200039699

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Select item 20011143411.

Genome wide gene expression analysis of acutely injured primary mouse neurons

(Submitter supplied) We aimed at identifying a common transcriptional response of neurons to acute injury by conducting a RNA-Seq analysis on primary mouse neurons. We performed parallel damaging of cultured neurons by applying oxygen-glucose deprivation (OGD) as model for cerebral ischemia as well as excitotoxicity induced by the glutamate receptor agonist kainic acid (KA) as an in vitro model amyotrophic lateral sclerosis and epilepsy. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
12 Samples

Download data: XLS

Series

Accession:: GSE111434

ID:: 200111434

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20014166812.

Transcriptional analysis effect of excess sugar and lipid on the growth and development of Caenorhabditis elegan

(Submitter supplied) Purpose：We used transcriptome sequencing to study the mechanism of sugar and lipid excesses on nematode growth and development. Methods：Nematodes grew to L4 phase and collected nematodes from different treatment groups, including control group without any treatment, 400 mM sucrose, 500 ug/ml stearic acid, co-treatment with sucrose and stearic acid, and co-treatment with resveratrol-sucrose-stearic acid, 3 replicates per group. more...