Similar studies for GEO DataSets (Select 200100115) - GEO DataSets

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Items: 20

Select item 2001001151.

Time-course global miRNA expression profiling on lung fibroblasts isolated from untreated, bleomycin-treated and silica-treated mice

(Submitter supplied) Lung fibroblasts play a pivotal role in pulmonary fibrosis, a devastating lung diseases, by producing extracellular matrix. MicroRNAs (miRNAs) suppress a lot of genes posttranscriptionally, but the dynamics and the role of miRNAs in activated lung fibroblasts in fibrotic lung has been poorly understood. To elucidate these problems, we performed global miRNA expression profiling of lung fibroblasts of bleomycin- and silica-induced fibrotic lungs

Organism:: Mus musculus

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL16331
7 Samples

Download data: TXT

Series

Accession:: GSE100115

ID:: 200100115

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001001472.

Global miRNA expression profiling of lung fibroblasts identifies miR-19a-19b-20a subcluster as a suppressor of TGF-beta-associated fibroblast activation in murine pulmonary fibrosis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Non-coding RNA profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:: GPL18635 GPL16331
13 Samples

Download data: TXT

Series

Accession:: GSE100147

ID:: 200100147

PubMed Full text in PMC Similar studies

Select item 2001001163.

Transcriptomic analysis of miR-19a-19b-20a subcluster-overexpressed fibroblasts in bleomycin-induced lung fibrosis

(Submitter supplied) Lung fibroblasts play a pivotal role in pulmonary fibrosis, a devastating lung diseases, by producing extracellular matrix. MicroRNAs (miRNAs) suppress a lot of genes posttranscriptionally, but the dynamics and the role of miRNAs in activated lung fibroblasts in fibrotic lung has been poorly understood. We found miR-19a, 19b and 20a subcluster expression increased in activated lung fibroblasts as the fibrosis progression. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18635
6 Samples

Download data: TXT

Series

Accession:: GSE100116

ID:: 200100116

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Select item 2001251834.

Next Generation Sequencing Analysis of miRNA profiling in fibroblast or myofibroblast

(Submitter supplied) We reported the application of next generation sequencing technology for high-throughput profiling of miRNA expression in human primary lung fibroblast Cells with undifferentiated (fibroblast) or differentiated (myofibroblast) status. By comparation the expression aboundence of known miRNAs between undifferentiated and differentiated type human primary lung fibroblast cells, we found both upregulated and downregulated miRNAs in fibroblast cells during differentiation. more...

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL18573
8 Samples

Download data: TXT

Series

Accession:: GSE125183

ID:: 200125183

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Select item 2000186515.

miR-29 targets in human fetal lung fibroblast IMR-90 cells

(Submitter supplied) TGFβ is one of most intensively studied regulators of extracellular matrix formation, and has been implicated in the development of pulmonary fibrosis in different models. However, little is know about the role of miRNAs in TGFβ mediated fibrogenic gene regulation. By using miRNA qRT-PCR array, we have identified miRNAs whose expression are regulated by TGFβ in IMR-90 cells. Among those down-regulated miRNAs are miR-29 family members. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
9 Samples

Download data: CEL

Series

Accession:: GSE18651

ID:: 200018651

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Select item 2000348186.

MiR-199a-5p determines fibroblast activation and pulmonary fibrogenesis

(Submitter supplied) Idiopathic pulmonary fibrosis (IPF) is a chronic and often fatal pulmonary disorder characterized by fibroblast proliferation and the excess deposit of extracellular matrix proteins. The etiology of IPF is unknown, but a central role for microRNAs (miRNAs), a class of small non-coding regulatory RNAs, has been recently suggested. We report the upregulation of miR-199a-5p in mouse lungs undergoing bleomycin-induced fibrosis and also in human biopsies from IPF patients. more...

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by array; Non-coding RNA profiling by array

Platforms:: GPL13607 GPL7686 GPL13912
48 Samples

Download data: GPR, TXT

Series

Accession:: GSE34818

ID:: 200034818

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Select item 2000348157.

Impact of miR-199-5p overexpression and CAV1 silencing on human lung fibroblasts

(Submitter supplied) To identify putative novel specific targets of mir-199-5p, we overexpressed miR-199a-5p as well as miR-21 and a siRNA targeted against CAV1 in human HFL1 pulmonary fibroblasts (CCL-153) by transfecting them with synthetic pre-miRNAs or a synthetic “negative” pre-miRNA as control (miR-Neg). RNA samples were harvested at 48 hours post-transfection and 2 independent experiments were carried out. Additional samples correspond to HFL1 cells treated or not with 10ng/ml TGFbeta for 48 hours in the absence of serum (2 independent experiments).

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13607
14 Samples

Download data: TXT

Series

Accession:: GSE34815

ID:: 200034815

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Select item 2000348148.

mRNA reponse to bleomycin instillation

(Submitter supplied) Gene expression analysis of C57BL/6 mice challenged by intratracheal bleomycin instillation: mRNA expression profiles were established from lungs following a 14-days PBS or bleomycin administration.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL13912
10 Samples

Download data: TXT

Series

Accession:: GSE34814

ID:: 200034814

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000348129.

miRNA reponse to bleomycin instillation

(Submitter supplied) Comparison of C57BL/6 (sensitive) and BALB/c (resistant) mice challenged by intratracheal bleomycin instillation: miRNA expression profiles were established from lungs derived from the two strains, following a 7- or 14-days PBS or bleomycin administration.

Organism:: Mus musculus; Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL7686
24 Samples

Download data: GPR

Series

Accession:: GSE34812

ID:: 200034812

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Select item 20004399210.

miRNA in human lung fibroblasts

(Submitter supplied) By employing miRCURY™ LNA array, we have identified a subset (79) of the total number of miRNAs that are differentially expressed in TGF beta1-treated human lung fibroblasts MRC-5 cells, as compared to untreated control cells

Organism:: Homo sapiens; Human betaherpesvirus 5; Murid gammaherpesvirus 4; Betapolyomavirus hominis; human gammaherpesvirus 4; Human gammaherpesvirus 8; Mus musculus cytomegalovirus 2; Betapolyomavirus macacae; Mus musculus; Human alphaherpesvirus 1; Human alphaherpesvirus 2; Rattus norvegicus; JC polyomavirus; Human immunodeficiency virus 1; Merkel cell polyomavirus

Type:: Non-coding RNA profiling by array

Platform:: GPL11432
9 Samples

Download data: TXT

Series

Accession:: GSE43992

ID:: 200043992

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Select item 20011104311.

Comparison between steady-state fibroblasts and myofibroblasts in mouse lungs

(Submitter supplied) This analysis aimed to identify significantly up-regulated genes in myofibroblasts, compared with steady-state fibroblasts.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL21810
6 Samples

Download data: TXT

Series

Accession:: GSE111043

ID:: 200111043

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Select item 20012912612.

microRNA expression profiles in Idiopathic Pulmonary Fibrosis (IPF)

(Submitter supplied) Idiopathic pulmonary fibrosis (IPF) is a lethal fibrotic lung disease characterized by enhanced fibroblast proliferation, collagen synthesis, extracellular matrix deposition. We obtained 28 IPF patient lung tissue samples from the Lung Tissue Research Consortium (LTRC). Here we determined the miRNA expression profiles in these IPF lung samples.

Organism:: Mus musculus; Rattus norvegicus; Homo sapiens

Type:: Expression profiling by array

Platform:: GPL26371
29 Samples

Download data: GPR

Series

Accession:: GSE129126

ID:: 200129126

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Select item 20008618613.

miRNA expression data before and after TGF-β treatment and Ago2-associated transcripts in lung fibroblasts

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: synthetic construct; Homo sapiens

Type:: Other; Non-coding RNA profiling by array

Platforms:: GPL21185 GPL8786
34 Samples

Download data: CEL

Series

Accession:: GSE86186

ID:: 200086186

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Select item 20008618514.

miRNA expression data in unstimulated and TGF-β1-stimulated lung fibroblasts

(Submitter supplied) Lung fibroblasts play an important role in extracellular matrix homeostasis and this process is mainly regulated by transforming growth factor-beta (TGF-β). Hence, lung fibroblasts are postulated to play a crucial role in aberrant lung tissue repair and remodeling, which is a main factor in lung diseases like COPD. In this study, the effect of TGF-β1 on the miRNA expression in parenchymal lung fibroblasts is investigated.

Organism:: synthetic construct; Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL8786
18 Samples

Download data: CEL

Series

Accession:: GSE86185

ID:: 200086185

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Select item 20008618315.

mRNA expression profiling after Ago2-immunoprecipitation (IP) in unstimulated and TGF-β1-stimulated primary parenchymal lung fibroblasts of two control subjects

(Submitter supplied) To identify the target gene repertoire of miRNAs (i.e. the miRNA-targetome) of unstimulated and TGF-β1-stimulated primary parenchymal lung fibroblasts, Ago2-IP was performed followed by mRNA expression profiling.

Organism:: Homo sapiens

Type:: Other

Platform:: GPL21185
16 Samples

Download data: TXT

Series

Accession:: GSE86183

ID:: 200086183

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Select item 20002812216.

Development and Preclinical Efficacy of Novel Transforming Growth Factor-β1 (TGFβ1) siRNAs for Pulmonary Fibrosis

(Submitter supplied) Idiopathic pulmonary fibrosis is a chronic devastating disease of unknown etiology. No therapy is currently available. A growing body of evidence supports the role of TGFβ1 as the major player in the pathogenesis of the disease. This study designed novel human- and mouse-specific siRNAs and siRNA/DNA chimeras targeting both human and mouse common sequences and evaluated their inhibitory activity in pulmonary fibrosis induced by bleomycin and lung-specific transgenic expression of human TGFβ1. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL13285
9 Samples

Download data: GPR

Series

Accession:: GSE28122

ID:: 200028122

Select item 20016132217.

RNA-sequencing comparison of pneumonectomy and bleomycin reveals novel anti-fibrotic mechanisms and regulators

(Submitter supplied) Fibroblast activation is transient in successful wound repair, but persistent in fibrotic pathologies. Understanding fibroblast deactivation during successful wound healing may provide new approaches to therapeutically reverse fibrogenic cell activation. To characterize the gene programs that accompany fibroblast activation and reversal during lung fibrosis resolution, we used RNA-seq analysis of flow-sorted Col1α1-GFP positive and CD45, CD31, and CD326 negative cells isolated from the lungs of young mice exposed to bleomycin and pneumonectomy. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21493
13 Samples

Download data: CSV

Series

Accession:: GSE161322

ID:: 200161322

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20015847818.

Inhibitory effect of a human microRNA, miR-6133-5p, on the fibrotic activity of hepatic stellate cells in culture

(Submitter supplied) Purpose: We recently identified 39 human microRNAs, which effectively suppress hepatitis B virus (HBV) replication in hepatocytes. Because chronic HBV infection often results in active, hepatitis-related liver fibrosis, we assessed whether any of these microRNAs have anti-fibrotic potential and predicted that miR-6133-5p may target several fibrosis-related genes. Methods: The hepatic stellate cell line LX-2 was transfected with miR-6133-5p mimic and subsequently treated with TGF-β. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
4 Samples

Download data: TXT

Series

Accession:: GSE158478

ID:: 200158478

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Select item 20011282719.

Impact of Dnm3os silencing on bleomycin-induced lung fibrosis

(Submitter supplied) To assess the impact of Dnm3os silencing on lung fibrogenesis, anti-Dnm3os gapmers (5mg/kg, 2 distinct designs: GP DNM3OS-1 and GP DNM3OS-3) or control gapmer (5mg/kg, GP Ctrl) formulated for in vivo delivery was instilled intratracheally 4 days and 2 days before intratracheal administration of bleomycin (1 unit/kg) or PBS as well as 4 days after bleomycin or PBS treatment.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL13912
24 Samples

Download data: TXT

Series

Accession:: GSE112827

ID:: 200112827

Select item 20009783420.

The DNM3OS lncRNA is a reservoir of fibromiRs with major functions in fibroblast response to TGF-beta and fibrogenesis

(Submitter supplied) RATIONALE: Given the paucity of effective treatments for Idiopathic Pulmonary Fibrosis (IPF), new insights into the deleterious mechanisms controlling lung fibroblast activation, the key cell type driving the fibrogenic process, are essential to develop new therapeutic strategies. Transforming growth factor β (TGF-β) is the main pro-fibrotic factor, but its inhibition is associated with severe side effects due to its pleiotropic role. more...

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by array; Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing

Platforms:: GPL13912 GPL18573 GPL17077
92 Samples

Download data: TXT

Series

Accession:: GSE97834

ID:: 200097834

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