Similar studies for GEO DataSets (Select 200107417) - GEO DataSets

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Items: 20

Select item 2001074171.

LincU Preserves Naive Pluripotency by Restricting ERK Activity in Embryonic Stem Cells [overexpression]

(Submitter supplied) While the functional roles of long non-coding RNAs (lncRNAs) have been increasingly identified, few lncRNAs that control the naive state of embryonic stem cells (ESCs) are known. Here, we report a naive-state-associated lncRNA, lincU, which is intrinsically activated by NANOG in naive mESCs. LincU-deficient mESCs exhibit a primed-like pluripotent state and potentiate the transition from naive state to primed state, whereas ectopic lincU expression maintains mESCs in the naive state. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
2 Samples

Download data: CEL, PDF

Series

Accession:: GSE107417

ID:: 200107417

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001074182.

LincU Preserves Naive Pluripotency by Restricting ERK Activity in Embryonic Stem Cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array

Platforms:: GPL21163 GPL1261
4 Samples

Download data: CEL, TXT

Series

Accession:: GSE107418

ID:: 200107418

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Select item 2001074163.

LincU Preserves Naive Pluripotency by Restricting ERK Activity in Embryonic Stem Cells [knockdown]

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL21163
2 Samples

Download data: PDF, TXT

Series

Accession:: GSE107416

ID:: 200107416

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Select item 2001119294.

Long noncoding RNA CCDC144NL-AS1 knockdown induces naïve-like state conversion of human pluripotent stem cells

(Submitter supplied) Human naïve pluripotency state cells can be derived from direct isolation of inner cell mass or primed-to-naïve resetting of human embryonic stem cells (hESCs) through different combinations of transcription factors, small molecular inhibitors and growth factors. Long noncoding RNAs (lncRNAs) have been identified to be crucial in diverse biological processes, including pluripotency regulatory circuit of mouse pluripotent stem cells (PSCs), but few are involved in human PSCs’ regulation of pluripotency and naïve pluripotency derivation. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL24676 GPL20301
28 Samples

Download data: BED, CSV

Series

Accession:: GSE111929

ID:: 200111929

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Select item 2001434965.

Species-specific processing of long noncoding RNAs contributes to non-conserved functions in human and mouse stem cells

(Submitter supplied) Subcellular RNA-seq datasets are used for genome-wide RNA localization analysis. We find different subcellular localization of lncRNAs in human and mouse stem cells. FAST, one of conserved lncRNAs with different localizations, is validated to be important for stem cell pluripotency. Futher, splicing factor PPIE is revealed to regulate RNA processing and localization.

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by high throughput sequencing; Other

Platforms:: GPL21273 GPL20795 GPL18573
25 Samples

Download data: BW, TXT

Series

Accession:: GSE143496

ID:: 200143496

PubMed Similar studies SRA Run Selector

Select item 2000597556.

Expression data from mouse embryonic stem cells across a time course of Erk stimulation

(Submitter supplied) Fgf signaling via Erk activation has been associated with both neural induction and the generation of a primed state for the differentiation of embryonic stem cells (ESCs) to all somatic lineages. To dissect the role of Erk in both ESC self-renewal and lineage specification we explore the requirements for this pathway in various in vitro differentiation settings. A combination of pharmacological inhibition of Erk signaling and genetic loss of function experiments reveal a role for Erk signaling in suppressing endodermal differentiation, but not neural specification. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL13912
16 Samples

Download data: TXT

Series

Accession:: GSE59755

ID:: 200059755

Select item 2000467307.

Transcriptome Analysis of LincRNA TUNA Knockdown in Mouse Embryonic Stem Cells

(Submitter supplied) Globel gene expression was analyzed by RNA-seq to study the role of lincRNA TUNA in pluripotent mouse embryonic stem cells.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
12 Samples

Download data: TXT

Series

Accession:: GSE46730

ID:: 200046730

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001166028.

The Long Noncoding RNA Lncenc1 Regulates Glycolysis in Naive Mouse ES Cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
8 Samples

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Series

Accession:: GSE116602

ID:: 200116602

PubMed Full text in PMC Similar studies

Select item 2001164629.

The Long Noncoding RNA Lncenc1 Regulates Glycolysis in Naive Mouse ES Cells II

(Submitter supplied) The naive embryonic stem cells (nESCs) display unique characteristics mirroring naive pluripotency in vivo, but the molecular mechanisms underlying the self-renewal of nESCs remain incompletely understood. Here we analyzed stranded transcriptomes in mouse nESCs and epiblast-like cells (EpiLCs), and identified 135 long non-coding RNAs (lncRNAs) preferentially expressed in nESCs. We further investigated the functions of Lncenc1, a highly abundant lncRNA in mouse nESCs. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
4 Samples

Download data: TXT

Series

Accession:: GSE116462

ID:: 200116462

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20011645810.

The Long Noncoding RNA Lncenc1 Regulates Glycolysis in Naive Mouse ES Cells I

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
4 Samples

Download data: TXT

Series

Accession:: GSE116458

ID:: 200116458

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20007058111.

BMP signaling in mouse embryonic stem cells (ESCs) in the naïve and primed pluripotent states

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL11002
11 Samples

Download data: BED, BW

Series

Accession:: GSE70581

ID:: 200070581

PubMed Full text in PMC Similar studies

Select item 20007057912.

BMP signaling in mouse embryonic stem cells (ESCs) in the naïve and primed pluripotent states [ChIP-Seq]

(Submitter supplied) Carrying out both RNA-seq and Smad1/5 genome-wide chromatin immunoprecipitation and sequencing (ChIP-seq) analyses of mESCs in the naïve or primed states, we revisit the roles of BMP signaling in mESCs.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL11002
6 Samples

Download data: BED, BW

Series

Accession:: GSE70579

ID:: 200070579

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20007057813.

BMP signaling in mouse embryonic stem cells (ESCs) in the naïve and primed pluripotent states [RNA-Seq]

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11002
5 Samples

Download data: BW, TXT

Series

Accession:: GSE70578

ID:: 200070578

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20006521414.

Global DNA CpG methylation profiling of human embryonic stem cells, fibroblast iPSC, and low passage stromal primed myeloid iPSC before and after conversion to the naïve state

(Submitter supplied) Global DNA CpG methylation profiling of human embryonic stem cells, fibroblast iPSC, and low passage stromal primed myeloid iPSC before and after conversion to the naïve state

Organism:: Homo sapiens

Type:: Methylation profiling by array

Platform:: GPL13534
24 Samples

Download data: TXT

Series

Accession:: GSE65214

ID:: 200065214

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20006521115.

Global gene expression analysis of human embryonic stem cells, fibroblast iPSC, and low passage stromal primed myeloid iPSC before and after conversion to the naïve state

(Submitter supplied) Global gene expression analysis of human embryonic stem cells, fibroblast iPSC, and low passage stromal primed myeloid iPSC before and after conversion to the naïve state

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10904
24 Samples

Download data: TXT

Series

Accession:: GSE65211

ID:: 200065211

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20004443016.

Comprehensive microarray analysis of reprogramming fidelity in a library of non-integrated induced pluripotent stem cell lines prepared with various derivation methods

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Methylation profiling by array

4 related Platforms
207 Samples

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Series

Accession:: GSE44430

ID:: 200044430

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Select item 20004442717.

Global gene expression analysis of donor cells, low passage episomal stromal and non-stromal primed myeloid iPSC, and hESC

(Submitter supplied) Global gene expression analysis of (a) human embryonic stem cells, (b) low passage episomal stromal-primed iPSC derived from growth-factor activated CD34+ myeloid progenitors from cord blood or GCSF mobilized peripheral blood, and (d) samples of donor fibroblasts or myeloid progenitors

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10904
29 Samples

Download data: TXT

Series

Accession:: GSE44427

ID:: 200044427

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Select item 20004442518.

Global gene expression analysis of human embryonic stem cells, adult fibroblasts, and CD34+ cord blood (CB) cells before, during, and after generation of stromal primed and non-stromal primed episomal induction of pluripotency

(Submitter supplied) Global gene expression analysis of (a) human embryonic stem cells, (b) adult fibroblasts with and without nucleofection of SOKM, (c) CD34+ cord blood cells at various time points during induction of pluripotency with SOKM, with or without co-culture with bone marrow stromal cells (BMSC), and (d) resulting stromal primed and non-stromal primed cord blood CD34+ myeloid iPSC

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10904
46 Samples

Download data: TXT

Series

Accession:: GSE44425

ID:: 200044425

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20004442419.

Global CpG Methylation profiling of donor cells, induced pluripotent stem cells, and human embryonic stem cells

(Submitter supplied) Global CpG methylation profiling using Illumina 27k Infinium platform of (a) human embryonic stem cells, (b) low passage episomal stromal-primed myeloid iPSC, (c) intermediate passage fibroblast iPSC, and (d) samples of corresponding donor cells.

Organism:: Homo sapiens

Type:: Methylation profiling by array

Platform:: GPL8490
43 Samples

Download data: TXT

Series

Accession:: GSE44424

ID:: 200044424

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20004442120.

Global gene expression analysis of donor cells, low passage episomal stromal-primed myeloid iPSC, and intermediate passage fibroblast iPSC.

(Submitter supplied) Global gene expression analysis of (a) human embryonic stem cells, (b) low passage episomal stromal-primed myeloid iPSC, (c) intermediate passage fibroblast iPSC, and (d) samples of corresponding donor cells.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL16700
41 Samples

Download data: TXT

Series

Accession:: GSE44421

ID:: 200044421

PubMed Full text in PMC Similar studies Analyze with GEO2R

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