Similar studies for GEO DataSets (Select 200113895) - GEO DataSets

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Items: 20

Select item 2001138951.

Cardiac-specific developmental and epigenetic functions of Jarid2 during embryonic development

(Submitter supplied) Jarid2 cooperates with PRC2 for H3K27me3 accumulation on a subset of Jarid2 target genes in the developing heart, which contributes to repress differentiation of other lineages such as neural differentiation, and to guide normal myocardial development. Jarid2 forms a functional complex with PRC2 to increase or maintain H3K27me3 levels on the specific promoters in the developing heart.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by genome tiling array

Platform:: GPL16605
3 Samples

Download data: FTR, TXT

Series

Accession:: GSE113895

ID:: 200113895

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000299972.

Ezh2 and H3K27me3 in cardiomyocytes

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL13112
5 Samples

Download data: GFF, TXT

Series

Accession:: GSE29997

ID:: 200029997

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Select item 2000299943.

ChIP-seq of Ezh2 and H3K27me3 in E12.5 heart apex

(Submitter supplied) Ezh2 and H3K27me3 binding sites in E12.5 heart apex

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL13112
3 Samples

Download data: GFF, TXT

Series

Accession:: GSE29994

ID:: 200029994

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Select item 2000299924.

Genome-wide profiling of E12.5 cardiomyocytes RNA expression in both heterozygous control and mutant

(Submitter supplied) Congenital heart disease is among the most frequent major birth defects. Epigenetic marks are crucial for organogenesis, but their role in heart development is poorly understood. Polycomb Repressive Complex 2 (PRC2) trimethylates histone H3 at lysine 27, establishing H3K27me3 repressive epigenetic marks that promote tissue-specific differentiation by silencing ectopic gene programs. We studied the function of the catalytic subunit of PRC2, EZH2, in murine heart development. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
2 Samples

Download data: TXT

Series

Accession:: GSE29992

ID:: 200029992

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Select item 2001285715.

E11.5 Hand1 myocardial knockout RNA-Seq

(Submitter supplied) Aims: To examine the role of the basic Helix-loop-Helix (bHLH) transcription factor HAND1 in embryonic and adult myocardium. Methods and Results: Hand1 is expressed within the cardiomyocytes of the left ventricle (LV) and myocardial cuff between embryonic days (E) 9.5-13.5. Hand gene dosage plays an important role in ventricular morphology and the contribution of Hand1 to congenital heart defects requires further interrogation. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
7 Samples

Download data: XLSX

Series

Accession:: GSE128571

ID:: 200128571

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Select item 2001559976.

MTF2 and JARID2 function in ESC differentiation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Other

Platform:: GPL19057
81 Samples

Download data

Series

Accession:: GSE155997

ID:: 200155997

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Select item 2001494097.

LncRNA HBL1 Recruits Polycomb Repressive Complex 2 on Essential Cardiogenic Genes to Orchestrate Human Cardiogenesis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL20301 GPL24676
22 Samples

Download data: BROADPEAK, BW, NARROWPEAK

Series

Accession:: GSE149409

ID:: 200149409

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Select item 2001494088.

Total RNA-seq revealed function of HBL1 lncRNA during cardiac differentiation from hiPSCs.

(Submitter supplied) We reported loss of HBL1 lncRNA promoted cardiogenesis. Here we wanted to know the genomewide gene expression profiles caused by HBL1 KO during cardiac differentiation.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
9 Samples

Download data: TXT

Series

Accession:: GSE149408

ID:: 200149408

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Select item 2001493519.

Genome-wide maps of EED binding genes in WT and JARID2 KO human embryonic stem cells (hESCs)

(Submitter supplied) We wanted to know whether JARID2 KO in hESCs could affect EED occupancy on chromatin.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL20301
3 Samples

Download data: BW, NARROWPEAK

Series

Accession:: GSE149351

ID:: 200149351

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Select item 20014932310.

Genome-wide maps of EED and H3K27me3 binding genes in WT and HBL1 KO human induced pluripotent stem cells (hiPSCs).

(Submitter supplied) We reported loss of HBL1 lnRNA promoted cardiogenesis and the interaction of HBL1-EED in hiPSCs. Here we used specific EED and H3K27me3 antibodies to pull down their binding genomic DNAs in hiPSCs, respectively, which let us know the potential genes regulated by HBL1-EED-H3K27me3 during cardiogenesis. 1% Input samples were collected from the same samples after chromatin shearing.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL20301
7 Samples

Download data: BROADPEAK, BW, NARROWPEAK

Series

Accession:: GSE149323

ID:: 200149323

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Select item 20014928811.

Genome-wide maps of JARID2 binding genes in WT and HBL1 KO human pluripotent stem cells (hPSCs).

(Submitter supplied) We reported loss of HBL1 lnRNA promoted cardiogenesis and the interaction of HBL1-JARID2 in hPSCs. Here we used specific JARID2 antibody to pull down their binding genomic DNAs in hPSCs, respectively, which let us know the potential genes regulated by HBL1-JARID2 during cardiogenesis. 1% Input samples were collected from the same samples after chromatin shearing.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL20301
3 Samples

Download data: BW, NARROWPEAK

Series

Accession:: GSE149288

ID:: 200149288

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Select item 20001877612.

Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells

(Submitter supplied) We report on mechanism of interaction between PRC2 complex and Jarid2 and their role in pluripotent cells

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL9185
5 Samples

Download data: BED

Series

Accession:: GSE18776

ID:: 200018776

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Select item 20007723813.

Expression profiling of E15.5 pancreases from pancreas-specific Jarid2 knockout (KO) embryos.

(Submitter supplied) Jarid2, a member of the Jumanji family of proteins, is a developmental regulator that is necessary for proper mouse development and stem cell differentiation. To investigate the specific functions of Jarid2 during pancreas development, we generated pancreas-specific Jarid2 mutants. We used microarrays to determine gene expression changes resulting from deletion of the Jarid2 gene in the pancreas.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
6 Samples

Download data: CEL

Series

Accession:: GSE77238

ID:: 200077238

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Select item 20001793614.

Nkx2.5 regulates Jarid2 during outflow tract morphogenesis

(Submitter supplied) The transcription factor Nkx2.5 is required for specification of pharyngeal arch second heart field (SHF) progenitors that contribute to outflow tract (OFT) and right ventricle (RV) formation. Multiple sets of microarray data were analyzed to identify genes that are candidate targets of Nkx2.5 in the second heart field. These sets are: 1) publicly available data for cardiothoracic tissue from E9.5 Nkx2.5 wild-type, heterozygous and homozygous embryos; 2) an analysis of mouse E10.5 pharyngeal arch tissue; 3) an analysis of mouse E12.5 heart tissue; and 4) a temporal analysis of the cardiogenic cell line P19CL6. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Datasets:: GDS3802 GDS3803
Platforms:: GPL1261 GPL339
26 Samples

Download data: CEL, CHP

Series

Accession:: GSE17936

ID:: 200017936

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Select item 20001793515.

Gene expression in mouse embryonic heart

(Submitter supplied) This study was conducted to examine normal gene expression in the heart during mouse embryonic development.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL339
5 Samples

Download data: CEL, CHP

Series

Accession:: GSE17935

ID:: 200017935

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Select item 20001793416.

Analysis of gene expression in the mouse embryo pharyngeal arch

(Submitter supplied) This study was conducted to examine normal gene expression in the pharyngeal arch during mouse embryonic development

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL339
5 Samples

Download data: CEL, CHP

Series

Accession:: GSE17934

ID:: 200017934

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Select item 20001791017.

In vitro differentiation of P19CL6 cardiogenic embryonic carcinoma cells

(Submitter supplied) Pluripotent P19CL6 embryonic carcinoma cells can be differentiated to a cardiac lineage by culture in the presence of DMSO. The goal of this study was to characterize temporal gene expression patterns associated with cardiogenic differentiation. Gene expression analysis was conducted on differentiating P19CL6 cells at several time points following induction with 1% DMSO. Samples were processed for analysis by Affymetrix GeneChip.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
16 Samples

Download data: CEL, CHP

Series

Accession:: GSE17910

ID:: 200017910

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Select item 380318.

Embryonic pharyngeal arch and embryonic heart

Analysis of second heart field (SHF)-containing pharyngeal arch from E10.5 embryos and heart from E12.5 embryos. These results, together with results from P19CL6 cells induced to differentiate into a cardiac lineage, provide insight into Nkx2.5 target genes relevant specifically to the SHF.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 age, 2 tissue sets

Platform:: GPL339
Series:: GSE17936
10 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS3803

ID:: 3803

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 380219.

P19CL6 cardiogenic embryonal carcinoma cell differentiation into a cardiac lineage: time course

Temporal analysis of P19CL6 cells induced to differentiate into a cardiac lineage in the presence of DMSO. These results, together with results from E10.5 second heart field (SHF)-containing pharyngeal arch and E12.5 heart, provide insight into Nkx2.5 target genes relevant specifically to SHF.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 2 growth protocol, 6 time sets

Platform:: GPL1261
Series:: GSE17936
16 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS3802

ID:: 3802

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 20010211620.

Novel Form of JARID2 is Required to Regulate Differentiation in Keratinocytes.

(Submitter supplied) Polycomb repressive complex-2 (PRC2) is a group of proteins that play important role during development and in cell differentiation. PRC2 is a histone-modifying complex that catalyses methylation of lysine 27 of histone H3 (H3K27me3) at differentiation genes leading to their transcriptional repression. JARID2 is a co-factor of PRC2 and is important for targeting PRC2 to chromatin as well as modulating its activity. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
8 Samples

Download data: DIFF

Series

Accession:: GSE102116

ID:: 200102116

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

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