GEO DataSets

(Submitter supplied) Single-cell RNA-sequencing was performed in the mouse and naked mole-rat immune systems in order to map and compare their immune cell repertoirs and their cell-specific gene-expression responses to LPS challenge

Organism:

Heterocephalus glaber; Mus musculus

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL21103 GPL26775

63 Samples

Download data: CSV

(Submitter supplied) Deep sequencing of mRNA from naked mole rat

Organism:

Heterocephalus glaber

Type:

Expression profiling by high throughput sequencing

Platform:

GPL13793

13 Samples

Download data: BEDGRAPH

(Submitter supplied) Naked mole-rats are a mammalian model organism of exceptional longevity. We mapped the hematopoietic hierarchy and used functional characterizations to define a purified stem and progenitor cell (HSPC) compartment similar to mouse LIN-/Sca-1+/Kit+ HSPCs or human LIN-/CD34+/CD38lo HSPCs.

Organism:

Heterocephalus glaber

Type:

Expression profiling by high throughput sequencing

Platform:

GPL30845

7 Samples

Download data: RDATA

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus; Heterocephalus glaber

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL24247 GPL30845

42 Samples

Download data

(Submitter supplied) Naked mole-rats are a mammalian model organism of exceptional longevity. We mapped the T cell developmental landscape in Naked mole-rats and showed

Organism:

Mus musculus; Heterocephalus glaber

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL24247 GPL30845

14 Samples

Download data: RDATA

(Submitter supplied) Heathly naked mole-rats kept under normal housing conditions harbor either a small or enlarged spleen. The aim of the study is to compare RNAseq of naked mole-rat (NM-R) small and enlarged spleens between them and to compare them with RNAseq of mouse spleen.

Organism:

Heterocephalus glaber; Mus musculus

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL21195 GPL17021

9 Samples

Download data: TXT

(Submitter supplied) Deep sequencing of mRNA from Fukomys damarensis to uncover the reproduce regulation

Organism:

Fukomys damarensis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17710

16 Samples

Download data: BEDGRAPH, TXT

(Submitter supplied) The goal was to find genes which are differentially expressed between the naked mole-rat (Heterocephalus glaber) and the wild-type mice liver tissue. The genes which are most differentially expressed may provide a clue for the remarkable differences between naked mole-rat and mouse in terms of longevity, cancer resistance and adaptation to subterranean environments.

Organism:

Heterocephalus glaber; Mus musculus

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL9185 GPL13940

2 Samples

Download data: TXT

(Submitter supplied) Mammals differ more than 100-fold in maximum lifespan. Here, we conducted comparative transcriptomics on 26 species with diverse lifespans. We identified thousands of genes with expression levels negatively or positively correlated with a species' maximum lifespan (Neg- or Pos-MLS genes). Neg-MLS genes are primarily involved in energy metabolism and inflammation. Pos-MLS genes show enrichment in DNA repair, microtubule organization, and RNA transport. more...

Organism:

Peromyscus maniculatus; Ondatra zibethicus; Hydrochoerus hydrochaeris; Ellobius lutescens; Cuniculus paca; Cricetulus barabensis; Mesocricetus auratus; Mus musculus; Sciurus carolinensis; Tamias striatus; Neotoma cinerea; Condylura cristata; Fukomys damarensis; Blarina brevicauda; Tamiasciurus hudsonicus; Rattus rattus; Myocastor coypus; Heterocephalus glaber; Castor canadensis; Acomys russatus; Marmota monax; Cavia porcellus; Octodon degus; Chinchilla lanigera; Scalopus aquaticus

Type:

Expression profiling by high throughput sequencing

25 related Platforms

522 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens; Mus musculus; Nannospalax ehrenbergi; Rattus norvegicus

Type:

Expression profiling by high throughput sequencing; Methylation profiling by genome tiling array; Methylation profiling by high throughput sequencing

5 related Platforms

110 Samples

Download data: IDAT, TXT

(Submitter supplied) Blind mole rats (BMRs) are small rodents, characterized by exceptionally long lifespan (> 21 years) and resistance to both spontaneous and induced tumorigenesis. Here we report that cancer resistance in the BMR is mediated by retrotransposable elements (RTEs). BMR cells and tissues express very low levels of DNA methyltransferase 1 (DNMT1). Upon cell hyperplasia, the BMR genome DNA loses methylation, resulting in activation of RTEs. more...

Organism:

Nannospalax ehrenbergi; Mus musculus

Type:

Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing

4 related Platforms

90 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Cavia porcellus; Heterocephalus glaber

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL22346 GPL21195

476 Samples

Download data

(Submitter supplied) Comparison of gene expression level by Illumina sequencing of naked mole-rat liver from breeders and non-breeders.

Organism:

Heterocephalus glaber

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21195

23 Samples

Download data: XLS

(Submitter supplied) Comparison of gene expression level by Illumina sequencing of nine different naked mole-rat tissue from breeders and non-breeders.

Organism:

Heterocephalus glaber

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21195

215 Samples

Download data: XLS

(Submitter supplied) Comparison of gene expression level by Illumina sequencing of ten different guinea pig tissue from breeders and non-breeders.

Organism:

Cavia porcellus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL22346

238 Samples

Download data: XLS

(Submitter supplied) We compared RNA-seq expression patterns in liver, an organ with high oxidative metabolism and abundant spontaneous DNA damage, from humans, naked mole rats, and mice, differing in maximum lifespan over a range of ~100, 30, and 3 years, respectively, for 130 genes involved in DNA repair. The results show that the longer-lived species, human and naked mole rat, share higher expression of these DNA repair genes, including core genes in several DNA repair pathways. more...

Organism:

Mus musculus; Heterocephalus glaber; Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL16791 GPL17021 GPL21195

9 Samples

Download data: CSV

(Submitter supplied) The immune system consists of a network of specialized cells and processes that protect the organism from diseases and regulates tissue repair. Natural killer (NK) cells and the αβ and γδ T cells comprise the cytotoxic arm of the immune system and have evolved to detect and eradicate cells infected with pathogens and affected by malignancies, in order to prevent their spread and subsequent tissue damage. more...

Organism:

Mus musculus; Heterocephalus glaber

Type:

Expression profiling by high throughput sequencing

4 related Platforms

66 Samples

Download data: MTX, TSV

(Submitter supplied) Changes in gene regulation have long been though to underlie most phenotypic differences between species. Subterranean rodents, and in particular the naked mole-rat (NMR), have attracted substantial attention due to their proposed phenotypic adaptations, which include hypoxia tolerance, metabolic changes and cancer resistance. However, it is largely unknown what regulatory changes may associate with these phenotypic traits, and whether these are unique to the NMR, the mole-rat clade or also present in other mammals. more...

Organism:

Cavia porcellus; Heterocephalus glaber; Mus musculus; Fukomys damarensis

Type:

Genome binding/occupancy profiling by high throughput sequencing; Other

13 related Platforms

160 Samples

Download data: NARROWPEAK, WIG