Similar studies for GEO DataSets (Select 200133095) - GEO DataSets

Select item 2001330951.

Expression data from PDGF-B and EGFRvIII induced murine gliomas

(Submitter supplied) The trascription profiles of PDGF-B and EGFRvIII induced glioma models were compared. We show that both models converge towards a phenotype that resembles proneural glioblastoma subset.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
6 Samples

Download data: CEL, XLSX

Series

Accession:: GSE133095

ID:: 200133095

Select item 2001096142.

RNAseq of murine models of high-grade gliomas induced by overexpression of PDGF-B or EGFRvIII

(Submitter supplied) High grade glioma cells obtained by overexpression of PDGF-B in neural progenitors of Balb/c mice or by overexpression of EGFRvIII in neural progenitors of Ink/Arf -/- Balb/c mice and orthotopically transplanted in adult Balb/c mice.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL23479
7 Samples

Download data: TXT

Series

Accession:: GSE109614

ID:: 200109614

PubMed Similar studies SRA Run Selector

Select item 2000774243.

PDGF Engages an E2F-USP1 Signaling Pathway to Support ID2-mediated Survival of Proneural Glioma Cells.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL19441
12 Samples

Download data

Series

Accession:: GSE77424

ID:: 200077424

Select item 2000774234.

PDGF Engages an E2F-USP1 Signaling Pathway to Support ID2-mediated Survival of Proneural Glioma Cells.

(Submitter supplied) Identification of critical survival determinants of PDGF-driven proneural glioma. Results provided information about the genes and pathways that are regulated by PDGF signaling in PDGF-driven proneural glioma and led to the assessment of the importance of the USP1-ID2 axis in proneural glioma.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL19441
6 Samples

Download data: TXT

Series

Accession:: GSE77423

ID:: 200077423

Select item 2000774195.

PDGF Engages an E2F-USP1 Signaling Pathway to Support ID2-mediated Survival of Proneural Glioma Cells.

(Submitter supplied) Identification of critical survival determinants of PDGF-driven proneural glioma. Results provided information about the genes and pathways that are regulated by PDGF signaling in PDGF-driven proneural glioma and led to the assessment of the importance of the USP1-ID2 axis in proneural glioma.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL19441
6 Samples

Download data: TXT

Series

Accession:: GSE77419

ID:: 200077419

Select item 2000993616.

A recombinant lentiviral PDGF-driven mouse model of proneural GBM

(Submitter supplied) Informed by the genetic alterations observed in human GBM, we engineered a novel, lentiviral injection mediated, mouse model of proneural GBM.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL19441
8 Samples

Download data: TXT

Series

Accession:: GSE99361

ID:: 200099361

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000755927.

Core pathway mutations induce de-differentiation of murine astrocytes into glioblastoma stem cells that are sensitive to radiation, but resistant to temozolomide

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL19057
13 Samples

Download data: BW

Series

Accession:: GSE75592

ID:: 200075592

PubMed Full text in PMC Similar studies

Select item 2000755898.

Core pathway mutations induce de-differentiation of murine astrocytes into glioblastoma stem cells that are sensitive to radiation, but resistant to temozolomide (RNA-seq)

(Submitter supplied) Introduction: Glioma stem cells isolated from human glioblastomas are resistant to radiation and cytotoxic chemotherapy and may drive tumor recurrence. Treatment efficacy may depend on the presence of glioma stem cells, expression of DNA repair enzymes such as methylguanine methyltransferase (MGMT), or transcriptome subtype. Methods: To model genetic alterations in the core signaling pathways of human glioblastoma, we induced conditional Rb knockout, Kras activation, and Pten deletion mutations in cortical murine astrocytes. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
4 Samples

Download data: TXT

Series

Accession:: GSE75589

ID:: 200075589

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000732629.

Core pathway mutations induce de-differentiation of murine astrocytes into glioblastoma stem cells that are sensitive to radiation, but resistant to temozolomide (FAIRE-seq)

(Submitter supplied) Introduction: Glioma stem cells isolated from human glioblastomas are resistant to radiation and cytotoxic chemotherapy and may drive tumor recurrence. Treatment efficacy may depend on the presence of glioma stem cells, expression of DNA repair enzymes such as methylguanine methyltransferase (MGMT), or transcriptome subtype. Methods: To model genetic alterations in the core signaling pathways of human glioblastoma, we induced conditional Rb knockout, Kras activation, and Pten deletion mutations in cortical murine astrocytes. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL19057
9 Samples

Download data: BW

Series

Accession:: GSE73262

ID:: 200073262

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20005911610.

Core pathway mutations induce de-differentiation of murine astrocytes into glioblastoma stem cells that are sensitive to radiation but resistant to temozolomide.

(Submitter supplied) BACKGROUND: Glioma stem cells (GSCs) from human glioblastomas (GBMs) are resistant to radiation and chemotherapy and may drive recurrence. Treatment efficacy may depend on GSCs, expression of DNA repair enzymes such as methylguanine methyltransferase (MGMT), or transcriptome subtype. METHODS: To model genetic alterations in human GBM core signaling pathways, we induced Rb knockout, Kras activation, and Pten deletion mutations in cortical murine astrocytes. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL11202
37 Samples

Download data: TXT

Series

Accession:: GSE59116

ID:: 200059116

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20002945811.

Expression data from PDGF driven mouse tumors

(Submitter supplied) Background Tumor heterogeneity is a major obstacle for finding effective treatment of Glioblastoma (GBM). Based on global expression analysis, GBM can be classified into distinct subtypes: Proneural, Neural, Classical and Mesenchymal. The signatures of these different tumor subtypes may reflect the phenotypes of cells giving rise to them. However, the experimental evidence connecting any specific subtype of GBM to particular cells of origin is lacking. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
23 Samples

Download data: CEL

Series

Accession:: GSE29458

ID:: 200029458

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20005961212.

MRI-localized biopsies reveal subtype-specific differences in molecular and cellular composition at the margins of glioblastoma

(Submitter supplied) We obtained radiographically-localized biopsies during glioma resection surgeries to sample the tumor core and margins from multiple glioma patients. We also procured fresh, non-neoplastic brain tissue specimens from multiple patients having procedures to relieve epilespy symptoms or to place shunts to treat normal pressure hydrocephalus. We then used RNA-Seq to compare expression patterns between geographically distinct regions of gliomas and computational deconvolution to estimate cell type-specific expression patterns in different disease subtypes.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
92 Samples

Download data: TXT

Series

Accession:: GSE59612

ID:: 200059612

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Select item 20004926913.

Progression from low- to high-grade astrocytoma is characterized by transcriptomal heterogeneity and genomic number copy alterations

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array; Genome variation profiling by genome tiling array

Platforms:: GPL11202 GPL15076 GPL7202
172 Samples

Download data: TXT

Series

Accession:: GSE49269

ID:: 200049269

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Select item 20004926814.

Progression from low- to high-grade astrocytoma is characterized by transcriptomal heterogeneity and genomic number copy alterations (part 4)

(Submitter supplied) We used genetically-engineered mice (GEM) to target constitutive RTK effector pathway (KrasG12D and/or Pten deletion) mutations in G1/S checkpoint-defective adult mouse astrocytes. Genetic lineage tracing showed that these mutations potentiated tumor initiation in cortical, diencephalic, brainstem, and olfactory bulb astrocytes, producing low-grade astrocytomas (LGA). LGA lacked copy number abnormalities (CNA), but showed oncogenic driver- and astrocyte location-specific transcriptome profiles, suggesting that both driver mutations and cellular origin contribute to LGA genomic heterogeneity. more...

Organism:: Mus musculus

Type:: Genome variation profiling by genome tiling array

Platform:: GPL15076
41 Samples

Download data: TXT

Series

Accession:: GSE49268

ID:: 200049268

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20004926715.

Progression from low- to high-grade astrocytoma is characterized by transcriptomal heterogeneity and genomic number copy alterations (part 3)

(Submitter supplied) We used genetically-engineered mice (GEM) to target constitutive RTK effector pathway (KrasG12D and/or Pten deletion) mutations in G1/S checkpoint-defective adult mouse astrocytes. Genetic lineage tracing showed that these mutations potentiated tumor initiation in cortical, diencephalic, brainstem, and olfactory bulb astrocytes, producing low-grade astrocytomas (LGA). LGA lacked copy number abnormalities (CNA), but showed oncogenic driver- and astrocyte location-specific transcriptome profiles, suggesting that both driver mutations and cellular origin contribute to LGA genomic heterogeneity. more...

Organism:: Mus musculus

Type:: Genome variation profiling by genome tiling array

Platform:: GPL15076
10 Samples

Download data: TXT

Series

Accession:: GSE49267

ID:: 200049267

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20004926616.

Progression from low- to high-grade astrocytoma is characterized by transcriptomal heterogeneity and genomic number copy alterations (part 2)

(Submitter supplied) We used genetically-engineered mice (GEM) to target constitutive RTK effector pathway (KrasG12D and/or Pten deletion) mutations in G1/S checkpoint-defective adult mouse astrocytes. Genetic lineage tracing showed that these mutations potentiated tumor initiation in cortical, diencephalic, brainstem, and olfactory bulb astrocytes, producing low-grade astrocytomas (LGA). LGA lacked copy number abnormalities (CNA), but showed oncogenic driver- and astrocyte location-specific transcriptome profiles, suggesting that both driver mutations and cellular origin contribute to LGA genomic heterogeneity. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL11202
43 Samples

Download data: TXT

Series

Accession:: GSE49266

ID:: 200049266

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20004926517.

Progression from low- to high-grade astrocytoma is characterized by transcriptomal heterogeneity and genomic number copy alterations (part 1)

(Submitter supplied) We used genetically-engineered mice (GEM) to target constitutive RTK effector pathway (KrasG12D and/or Pten deletion) mutations in G1/S checkpoint-defective adult mouse astrocytes. Genetic lineage tracing showed that these mutations potentiated tumor initiation in cortical, diencephalic, brainstem, and olfactory bulb astrocytes, producing low-grade astrocytomas (LGA). LGA lacked copy number abnormalities (CNA), but showed oncogenic driver- and astrocyte location-specific transcriptome profiles, suggesting that both driver mutations and cellular origin contribute to LGA genomic heterogeneity. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL7202
78 Samples

Download data: TXT

Series

Accession:: GSE49265

ID:: 200049265

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20011336118.

Bivalent chromatin domains in glioblastoma multiforme reveal an epigenetic signature of early neural development mediated by SHH and Wnt signaling

(Submitter supplied) We performed ChIP-seq for H3K27me3 and H3K4me3 to identify bivalent chromatin regions in T98G Glioblastoma multiforme cells.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL16791
5 Samples

Download data: BED9

Series

Accession:: GSE113361

ID:: 200113361

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20004587419.

Human non-GCIMP gioblastoma subtypes evolve from a common proneural-like precursor glioma

(Submitter supplied) In order to understand the relationships between the human non-GCIMP glioblastoma subgroups, we performed computational analysis of human genomic data to predict the temporal sequence in which the driver events arise during tumorigenesis. The order of evolutionary events for non-GCIMP GBM is 1) chr 7 gain and loss of chr 10, followed by 2) CDKN2A loss and/or TP53 mutation, and 3) alterations canonical for specific subtypes such as NF1 loss or focal amplification of PDGFRα or EGFR. more...

Organism:: Mus musculus; Homo sapiens

Type:: Expression profiling by array

Platforms:: GPL10558 GPL6887
144 Samples

Download data

Series

Accession:: GSE45874

ID:: 200045874

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20001269420.

Cooperative actions of p53 and Pten in normal and neoplastic progenitor cell renewal and differentiation

(Submitter supplied) Glioblastoma (GBM) is a highly lethal brain tumor presenting as one of two subtypes with distinct clinical histories and molecular profiles. The primary GBM subtype presents acutely as high-grade disease that typically harbors EGFR, PTEN and Ink4a/Arf mutations, and the secondary GBM subtype evolves from the slow progression of low-grade disease that classically possesses PDGF and p53 events1. Here, we show that concomitant CNS-specific deletion of p53 and Pten in the mouse CNS generates a penetrant acute-onset high-grade malignant glioma phenotype with striking clinical, pathological and molecular resemblance to primary GBM in humans. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
5 Samples

Download data: CEL

Series

Accession:: GSE12694

ID:: 200012694

PubMed Full text in PMC Similar studies Analyze with GEO2R

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