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Links from GEO DataSets

Items: 10

1.

Ascending colon-derived mucin-type O-glycans form key mucus layers encapsulating microbiota in the colon

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus; mouse gut metagenome
Type:
Expression profiling by high throughput sequencing; Other
Platforms:
GPL21493 GPL22735
60 Samples
Download data
Series
Accession:
GSE133257
ID:
200133257

PubMed Full text in PMC Similar studies

2.

Ascending colon-derived mucin-type O-glycans form key mucus layers encapsulating microbiota in the colon (16S rNA-seq)

(Submitter supplied) The colon contains a dense metabolically potent microbiota. The colonic O-glycan-rich mucus has been recognized as a key barrier to prevent microbial intrusion, but how this system forms and functions remains unclear. Here, we discovered that the colon mucus is mainly forged by microbiota-dependent secretion of O-glycosylated Muc2 by goblet cells in the ascending colon, where it seamlessly encapsulates the fecal materials including the microbiota. more...
Organism:
mouse gut metagenome
Type:
Other
Platform:
GPL22735
30 Samples
Download data: TXT
Series
Accession:
GSE133256
ID:
200133256

PubMed Full text in PMC Similar studies SRA Run Selector

3.

Ascending colon-derived mucin-type O-glycans form key mucus layers encapsulating microbiota in the colon (RNA-seq)

(Submitter supplied) The colon contains a dense metabolically potent microbiota. The colonic O-glycan-rich mucus has been recognized as a key barrier to prevent microbial intrusion, but how this system forms and functions remains unclear. Here, we discovered that the colon mucus is mainly forged by microbiota-dependent secretion of O-glycosylated Muc2 by goblet cells in the ascending colon, where it seamlessly encapsulates the fecal materials including the microbiota. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21493
30 Samples
Download data: TXT
Series
Accession:
GSE133174
ID:
200133174

PubMed Full text in PMC Similar studies SRA Run Selector

4.

Mouse intestinal epithelial cells in the deficiency of Foxo1

(Submitter supplied) Mucus produced by goblet cells in the gastrointestinal (GI) tract forms a biological barrier that protects the intestine from invasion by commensals and pathogens. However, the host-derived regulatory network that controls mucus secretion and thereby changing gut microbiota has not been well studied. We found Forkhead box protein O1 (Foxo1) regulates mucus secretion by goblet cells and determines intestinal homeostasis. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
6 Samples
Download data: TXT
Series
Accession:
GSE178650
ID:
200178650

PubMed Full text in PMC Similar studies SRA Run Selector

5.

Microbiota facilitates dietary heme-induced epithelial hyperproliferation and hyperplasia by breaking the mucus barrier

(Submitter supplied) Colorectal cancer risk is associated with diets high in red meat. Heme, the pigment of red meat, induces cytotoxicity of colonic contents and elicits epithelial damage and compensatory hyperproliferation, leading to hyperplasia. Here we explore the possible causal role of the gut microbiota in heme-induced hyperproliferation. To this end, mice were fed a purified control or heme diet (0.5 μmol/g heme) with or without broad-spectrum antibiotics for 14 d. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11533
18 Samples
Download data: CEL
Series
Accession:
GSE40670
ID:
200040670

PubMed Full text in PMC Similar studies Analyze with GEO2R

6.

To determine transcriptome of gnotobiotic mice fed fiber-rich and fiber-free diets

(Submitter supplied) Despite accepted health benefits of dietary fiber, little is known about the mechanisms by which fiber deprivation impacts the gut microbiota and alters disease risk. Using a gnotobiotic model, in which mice were colonized with a synthetic human gut microbiota, we elucidated the functional interactions between dietary fiber, the gut microbiota and the colonic mucus barrier, which serves as a primary defence against pathogens. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL17400
7 Samples
Download data: CEL
Series
Accession:
GSE79067
ID:
200079067

PubMed Full text in PMC Similar studies Analyze with GEO2R

7.

Aging-induced decline in mucus thickness in mice is associated with changes in microbiota composition and immunity and is sex dependent

(Submitter supplied) A mucus layer covers and protects the intestinal epithelial cells from direct contact with microbes. This mucus layer not only prevents inflammation but also plays an essential role in microbiota colonization, indicating the complex interplay between mucus composition-microbiota and intestinal health. However, it is unknown whether the mucus layer is influenced by age or sex and whether this contributes to reported differences in intestinal diseases in males and females or with ageing. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11533
26 Samples
Download data: CEL
Series
Accession:
GSE94515
ID:
200094515

PubMed Full text in PMC Similar studies Analyze with GEO2R

8.

Gene expression profiles in the epithelial cells from the different parts of the colon in mice

(Submitter supplied) We investigated the difference of gene expression profiles in the epithelial cells between the different parts of the colon in C57BL/6J mice.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
6 Samples
Download data: TXT
Series
Accession:
GSE214866
ID:
200214866

PubMed Similar studies

9.

Gene expression profiles in the colonic epithelial cells from mice deficient in the function of St6galnac6, B3galt5 and B3gnt7

(Submitter supplied) To investigate the effect of deficiency of glycosyltransferases on the intestinal epithelial cells, we analyzed the gene expression profiles in colonic epithelial cells of mice deficient in the function of St6galnac6, B3galt5 and B3gnt7.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
8 Samples
Download data: TXT
Series
Accession:
GSE214864
ID:
200214864

PubMed Similar studies

10.

The ATP-hydrolyzing ectoenzyme E-NTPD8 attenuates colonic inflammation through regulation of P2X4 receptor-dependent metabolism in myeloid cells [F0536]

(Submitter supplied) Extracellular adenosine triphosphate (ATP) released by mucosal immune cells and by microbiota in the intestinal lumen elicits diverse immune responses that mediate the intestinal homeostasis via P2 purinergic receptors, while overactivation of the ATP signaling leads to disruption of mucosal immune system linked to pathogenesis of intestinal inflammation. In the small intestine, hydrolysis of luminal ATP by E-NTPD7 in epithelial cells is essential for control of the number of Th17 cells. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
3 Samples
Download data: CSV
Series
Accession:
GSE160379
ID:
200160379

PubMed Full text in PMC Similar studies SRA Run Selector

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