Similar studies for GEO DataSets (Select 200134263) - GEO DataSets

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Items: 20

Select item 2001342631.

Natural killer cells suppress T cell tumor immune evasion [B16-F10 CRISPR/Cas9 MHC I low]

(Submitter supplied) Investigation of tumor genes which are involved in the upregulation of MHC I expression through a genome-wide in vitro CRISPR/Cas9 screen

Organism:: Mus musculus

Type:: Other

Platform:: GPL19057
2 Samples

Download data: TXT

Series

Accession:: GSE134263

ID:: 200134263

PubMed Similar studies SRA Run Selector

Select item 2001342652.

Natural killer cells suppress T cell tumor immune evasion

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Other

Platform:: GPL19057
35 Samples

Download data

Series

Accession:: GSE134265

ID:: 200134265

PubMed Similar studies

Select item 2001342643.

Natural killer cells suppress T cell tumor immune evasion [Supernatant treated control or Jak1 sgRNA B16-F10 RNA Seq]

(Submitter supplied) Investigation of the transcriptional response in Jak1 depleted tumor cells upon NK-derived cytokine presence using 3’ RNA sequencing

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
24 Samples

Download data: TXT

Series

Accession:: GSE134264

ID:: 200134264

PubMed Similar studies SRA Run Selector

Select item 2001342624.

Natural killer cells suppress T cell tumor immune evasion [B16-F10 CRISPR/Cas9 NK cell screen]

(Submitter supplied) Investigation of tumor genes which limit sensitivity to killing by NK cells through a genome-wide in vitro CRISPR/Cas9 screen

Organism:: Mus musculus

Type:: Other

Platform:: GPL19057
3 Samples

Download data: TXT

Series

Accession:: GSE134262

ID:: 200134262

PubMed Similar studies SRA Run Selector

Select item 2001342615.

Natural killer cells suppress T cell tumor immune evasion [NK treated B16-F10 RNA Seq]

(Submitter supplied) Investigation of the tumor transcriptional response upon NK cell attack using 3’ RNA sequencing

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
6 Samples

Download data: TXT

Series

Accession:: GSE134261

ID:: 200134261

PubMed Similar studies SRA Run Selector

Select item 2000968846.

Affymetrix SNP array data of melanoma cell lines II

(Submitter supplied) Genetic alterations lead to resistance to immunotherapy

Organism:: Homo sapiens

Type:: SNP genotyping by SNP array

Platform:: GPL16131
14 Samples

Download data: CEL, CYCHP

Series

Accession:: GSE96884

ID:: 200096884

PubMed Full text in PMC Similar studies

Select item 2001122537.

Tumor immune evasion arises through loss of TNF sensitivity

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
52 Samples

Download data

Series

Accession:: GSE112253

ID:: 200112253

PubMed Similar studies

Select item 2001122528.

Tumor immune evasion arises through loss of TNF sensitivity [MC38]

(Submitter supplied) Investigation of the transcriptional response to TNF and Interferon gamma or T cells

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
28 Samples

Download data: CSV

Series

Accession:: GSE112252

ID:: 200112252

PubMed Similar studies SRA Run Selector

Select item 2001122519.

Tumor immune evasion arises through loss of TNF sensitivity [Ado]

(Submitter supplied) Investigation of the transcriptional response of wild type or Ado knockout MC38 cells to TNF

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
24 Samples

Download data: CSV

Series

Accession:: GSE112251

ID:: 200112251

PubMed Similar studies SRA Run Selector

Select item 20013931310.

Genome-wide CRISPR screen reveals cancer cell resistance to NK cells induced by NK-derived IFN-gamma

(Submitter supplied) The anti-leukemia activity of NK cells helps to prevent relapse during hematopoietic stem cell transplantation in leukemia patients. However, the factors that determine sensitivity or resistance of leukemia cells in the context of NK-mediated cytotoxicity are not well established. Here we performed a genome-wide CRIPSR screen in the human chronic-myelogenous-leukemia (CML) cell line K562 to identify genes that regulate vulnerability of leukemia cells to killing by primary human NK cells. more...

Organism:: Homo sapiens

Type:: Other

Platform:: GPL18573
7 Samples

Download data: TXT

Series

Accession:: GSE139313

ID:: 200139313

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20003701211.

Gene expression profiling upon knockdown of JAK1 in IM9 cells

(Submitter supplied) Natural Killer (NK) cells are primary effectors of innate immunity directed against transformed cells. In response, tumor cells have developed mechanisms to evade NK cell-mediated lysis but the molecular basis for target cell resistance is not well understood. In the present study, we used a lentiviral shRNA library targeting more than 1000 human genes to identify 83 genes that promote target cell resistance to human NK cells. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL15401
8 Samples

Download data: CEL, TXT

Series

Accession:: GSE37012

ID:: 200037012

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20026162612.

IFNγ mediates the resistance of tumor cells to distinct NK cell subsets.

(Submitter supplied) Tumor resistance to immune cells remains a major obstacle for successful treatment. NK cells are emerging tools for cancer therapy. However, due to differential and subset-specific expression of inhibitory NK cell receptors, often only subsets of NK cells exert reactivity against particular cancer types. Using a genome-wide CRISPR/Cas9 knockout (KO) screen in melanoma, we revealed resistance factors against NK cell attack and evaluated their differential impact on NK cell subpopulations. more...

Organism:: Homo sapiens

Type:: Other

Platform:: GPL21697
3 Samples

Download data: TXT

Series

Accession:: GSE261626

ID:: 200261626

PubMed Full text in PMC Similar studies

Select item 20012457413.

CD56dim NK cell gene signature in melanoma patients with better and worse clinical outcomes

(Submitter supplied) Natural killer (NK) cells are innate cytotoxic and immunoregulatory lymphocytes that have a central role in anti-tumor immunity and play a critical role in mediating cellular immunity in advanced cancer immunotherapies, such as dendritic cell (DC) vaccines. Our group recently tested a novel recombinant adenovirus-transduced autologous DC-based vaccine that simultaneously induces T cell responses against three melanoma-associated antigens for advanced melanoma patients. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL25998
41 Samples

Download data: RCC, TXT

Series

Accession:: GSE124574

ID:: 200124574

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20016149614.

Differential expression genes analysis of knocking down Prmt1 and Ripk1 in MC38/gp100 cell line

(Submitter supplied) Despite approval of immunotherapy for a wide range of cancers, the majority of patients fail to respond to immunotherapy or relapse following initial response. These failures may be attributed to immunosuppressive mechanisms co-opted by tumor cells. However, it is challenging to utilize conventional methods to systematically evaluate the potential of tumor intrinsic factors to act as immune regulators in cancer patients. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
3 Samples

Download data: XLSX

Series

Accession:: GSE161496

ID:: 200161496

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20007940915.

CIS is a potent checkpoint in NK cell-mediated tumour immunity

(Submitter supplied) Natural killer (NK) cells have evolved to detect and kill aberrant cells with this activity being governed by the cytokine interleukin (IL)-15 and foreign and self-ligands. We have identified CIS (Cytokine-inducible SH2-containing protein; Cish gene) as the critical negative regulator of IL-15 signalling in NK cells. Cish was rapidly induced in response to IL-15 and deletion of Cish rendered NK cells hypersensitive to IL-15, as evidenced by superior proliferation, survival, IFN-γ production and cytotoxicity towards tumours. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
8 Samples

Download data: TXT

Series

Accession:: GSE79409

ID:: 200079409

PubMed Similar studies SRA Run Selector

Select item 20009929916.

Cytokine Stimulation of PTPN2-deleted cancer cells

(Submitter supplied) PTPN2 was deleted from a selection of murine and human cancer cells using CRISPR/Cas9. The loss-of-function phenotype was assessed in vitro with cytokine stimulation or vehicle control.

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL21697 GPL21626
81 Samples

Download data: TXT

Series

Accession:: GSE99299

ID:: 200099299

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20020666817.

Single cell transcriptomics of the tumor immune microenvironment from checkpoint blockade-treated KPC tumors

(Submitter supplied) Single cell transcriptomes of CD45+ cells from KPC tumor subcutaneous allografts, either treated with PD-1+CTLA-4 checkpoint blockade or treatment-naïve.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
8 Samples

Download data: H5

Series

Accession:: GSE206668

ID:: 200206668

PubMed Similar studies

Select item 20020644318.

Transcriptomics effects of IFNb and IFNg stimulation on murine cancer cell lines

(Submitter supplied) To measure the transcriptomic changes in response to IFNb and IFNg stimulation, we collected RNAseq of various cell lines that were stimulated or unstimulated by interferon for 48 hours

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
70 Samples

Download data: TXT

Series

Accession:: GSE206443

ID:: 200206443

PubMed Similar studies

Select item 20016210519.

Next Generation Sequencing Facilitates Quantitative Analysis of Renca and B16 Murine Cancer Line Transcriptomes

(Submitter supplied) Renca, a murine renal cell carcinoma, and B16F10, a murine melanoma, were transcriptionally profiled in a study designed to accompany an in vivo CRISPR screen to identify novel immunotherapy dependencies.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
5 Samples

Download data: TXT

Series

Accession:: GSE162105

ID:: 200162105

PubMed Similar studies SRA Run Selector

Select item 20012569820.

Gene expression in B16.SIY tumor cells deficient in IFN-g signaling

(Submitter supplied) We performed RNASeq on purified tumor cells from wild-type, IFNgR2-, and Jak1-mutant tumors on day 7 after tumor engraftment. To investigate whether IFN-g-insensitive tumor cells showed decreased expression of a negative immune regulatory factor, RNASeq was performed on purified tumor cells from WT, IFNgR2-, and Jak1-mutant tumors on day 7 after tumor engraftment. Compared to wild-type, we found 375 and 305 differentially expressed genes in IFNgR2- and Jak1-mutant tumor cells respectively. more...