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Items: 20

1.

Host metabolic reprogramming during immune activation promotes intracellular bacterial survival (glycerol or succinate)

(Submitter supplied) Intracellular pathogens, such as Salmonella enterica serovar Typhimurium (S.Tm), are able to sense and respond to a changing host cell environment. Macrophages exposed to microbial products undergo metabolic changes that are increasingly understood to drive a productive inflammatory response. However, the role of macrophage metabolic reprogramming in bacterial adaptation to the intracellular environment has not been explored. more...
Organism:
Salmonella enterica subsp. enterica serovar Typhimurium
Type:
Expression profiling by high throughput sequencing
Platform:
GPL27640
6 Samples
Download data: TXT
Series
Accession:
GSE139207
ID:
200139207

PubMed Similar studies SRA Run Selector

2.

Host succinate is a signal for activation of Salmonella virulence during intracellular infection

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus; Salmonella enterica subsp. enterica serovar Typhimurium
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL19057 GPL27640 GPL24107
72 Samples
Download data: TXT
Series
Accession:
GSE139208
ID:
200139208

PubMed Similar studies

3.

Host metabolic reprogramming during immune activation promotes intracellular bacterial survival (2DG)

(Submitter supplied) Intracellular pathogens, such as Salmonella enterica serovar Typhimurium (S.Tm), are able to sense and respond to a changing host cell environment. Macrophages exposed to microbial products undergo metabolic changes that are increasingly understood to drive a productive inflammatory response. However, the role of macrophage metabolic reprogramming in bacterial adaptation to the intracellular environment has not been explored. more...
Organism:
Salmonella enterica subsp. enterica serovar Typhimurium
Type:
Expression profiling by high throughput sequencing
Platform:
GPL27640
12 Samples
Download data: TXT
Series
Accession:
GSE139206
ID:
200139206

PubMed Similar studies SRA Run Selector

4.

Host metabolic reprogramming during immune activation promotes intracellular bacterial survival (host and bacteria)

(Submitter supplied) Intracellular pathogens, such as Salmonella enterica serovar Typhimurium (S.Tm), are able to sense and respond to a changing host cell environment. Macrophages exposed to microbial products undergo metabolic changes that are increasingly understood to drive a productive inflammatory response. However, the role of macrophage metabolic reprogramming in bacterial adaptation to the intracellular environment has not been explored. more...
Organism:
Salmonella enterica subsp. enterica serovar Typhimurium; Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL24107 GPL19057
54 Samples
Download data: TXT
Series
Accession:
GSE139205
ID:
200139205

PubMed Similar studies SRA Run Selector

5.

Salmonella persisters undermine host immune defences during antibiotic treatment

(Submitter supplied) Many bacterial infections are hard to treat and tend to relapse, possibly due to the presence of antibiotic-tolerant persisters that are considered dormant cells when bacteria are grown in laboratory medium. Non-growing persisters also form following uptake of Salmonella by macrophages but their nature is little understood. Here we show that Salmonella persisters arising during macrophage infection maintain an active state. more...
Organism:
Salmonella enterica subsp. enterica serovar Typhimurium; Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL21220 GPL19057 GPL24107
18 Samples
Download data: TXT
Series
Accession:
GSE104785
ID:
200104785

PubMed Similar studies SRA Run Selector

6.

Search for genes affected by MgtC overexpression in Salmonella enterica serovar Typhimurium 14028s

(Submitter supplied) A set of genes are differentially regulated in the presence of extra copy of the mgtC gene. Provide a hint of potental target of the MgtC protein.
Organism:
Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S
Type:
Expression profiling by high throughput sequencing
Platform:
GPL23619
4 Samples
Download data: TXT
Series
Accession:
GSE103153
ID:
200103153

PubMed Full text in PMC Similar studies SRA Run Selector

7.

Paired single-cell host profiling with multiplex-tagged bacterial mutants reveals intracellular virulence-immune networks [CEL-Seq]

(Submitter supplied) Encounters between host cells and intracellular bacterial pathogens lead to complex phenotypes that determine the outcome of infection. Single-cell RNA-sequencing (scRNA-seq) are increasingly used to study the host factors underlying diverse cellular phenotypes. But current approaches do not permit the simultaneous unbiased study of both host and bacterial factors during infection. Here, we developed scPAIR-seq, an approach to analyze both host and pathogen factors during infection by combining multiplex-tagged mutant bacterial library with scRNA-seq to identify mutant-specific changes in host transcriptomes. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
21 Samples
Download data: TXT
Series
Accession:
GSE230533
ID:
200230533

PubMed Full text in PMC Similar studies

8.

Paired single-cell host profiling with multiplex-tagged bacterial mutants reveals intracellular virulence-immune networks

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus; synthetic construct
Type:
Expression profiling by high throughput sequencing; Other
4 related Platforms
136 Samples
Download data: TXT
Series
Accession:
GSE198728
ID:
200198728

PubMed Full text in PMC Similar studies

9.

Paired single-cell host profiling with multiplex-tagged bacterial mutants reveals intracellular virulence-immune networks VI

(Submitter supplied) Encounters between host cells and intracellular bacterial pathogens lead to complex phenotypes that determine the outcome of infection. Single-cell RNA-sequencing (scRNA-seq) are increasingly used to study the host factors underlying diverse cellular phenotypes. But current approaches do not permit the simultaneous unbiased study of both host and bacterial factors during infection. Here, we developed scPAIR-seq, an approach to analyze both host and pathogen factors during infection by combining multiplex-tagged mutant bacterial library with scRNA-seq to identify mutant-specific changes in host transcriptomes. more...
Organism:
synthetic construct
Type:
Other
Platform:
GPL26967
26 Samples
Download data: TXT
Series
Accession:
GSE198727
ID:
200198727

PubMed Full text in PMC Similar studies

10.

Paired single-cell host profiling with multiplex-tagged bacterial mutants reveals intracellular virulence-immune networks V

(Submitter supplied) Encounters between host cells and intracellular bacterial pathogens lead to complex phenotypes that determine the outcome of infection. Single-cell RNA-sequencing (scRNA-seq) are increasingly used to study the host factors underlying diverse cellular phenotypes. But current approaches do not permit the simultaneous unbiased study of both host and bacterial factors during infection. Here, we developed scPAIR-seq, an approach to analyze both host and pathogen factors during infection by combining multiplex-tagged mutant bacterial library with scRNA-seq to identify mutant-specific changes in host transcriptomes. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
34 Samples
Download data: TXT
Series
Accession:
GSE198726
ID:
200198726

PubMed Full text in PMC Similar studies

11.

Paired single-cell host profiling with multiplex-tagged bacterial mutants reveals intracellular virulence-immune networks IV

(Submitter supplied) Encounters between host cells and intracellular bacterial pathogens lead to complex phenotypes that determine the outcome of infection. Single-cell RNA-sequencing (scRNA-seq) are increasingly used to study the host factors underlying diverse cellular phenotypes. But current approaches do not permit the simultaneous unbiased study of both host and bacterial factors during infection. Here, we developed scPAIR-seq, an approach to analyze both host and pathogen factors during infection by combining multiplex-tagged mutant bacterial library with scRNA-seq to identify mutant-specific changes in host transcriptomes. more...
Organism:
synthetic construct
Type:
Expression profiling by high throughput sequencing
Platform:
GPL26967
38 Samples
Download data: TXT
Series
Accession:
GSE198724
ID:
200198724

PubMed Full text in PMC Similar studies

12.

Paired single-cell host profiling with multiplex-tagged bacterial mutants reveals intracellular virulence-immune networks III

(Submitter supplied) Encounters between host cells and intracellular bacterial pathogens lead to complex phenotypes that determine the outcome of infection. Single-cell RNA-sequencing (scRNA-seq) are increasingly used to study the host factors underlying diverse cellular phenotypes. But current approaches do not permit the simultaneous unbiased study of both host and bacterial factors during infection. Here, we developed scPAIR-seq, an approach to analyze both host and pathogen factors during infection by combining multiplex-tagged mutant bacterial library with scRNA-seq to identify mutant-specific changes in host transcriptomes. more...
Organism:
synthetic construct
Type:
Other
Platform:
GPL26967
4 Samples
Download data: TXT
Series
Accession:
GSE198448
ID:
200198448

PubMed Full text in PMC Similar studies

13.

Paired single-cell host profiling with multiplex-tagged bacterial mutants reveals intracellular virulence-immune networks II

(Submitter supplied) Encounters between host cells and intracellular bacterial pathogens lead to complex phenotypes that determine the outcome of infection. Single-cell RNA-sequencing (scRNA-seq) are increasingly used to study the host factors underlying diverse cellular phenotypes. But current approaches do not permit the simultaneous unbiased study of both host and bacterial factors during infection. Here, we developed scPAIR-seq, an approach to analyze both host and pathogen factors during infection by combining multiplex-tagged mutant bacterial library with scRNA-seq to identify mutant-specific changes in host transcriptomes. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
12 Samples
Download data: TXT
Series
Accession:
GSE198436
ID:
200198436

PubMed Full text in PMC Similar studies

14.

Paired single-cell host profiling with multiplex-tagged bacterial mutants reveals intracellular virulence-immune networks I

(Submitter supplied) Encounters between host cells and intracellular bacterial pathogens lead to complex phenotypes that determine the outcome of infection. Single-cell RNA-sequencing (scRNA-seq) are increasingly used to study the host factors underlying diverse cellular phenotypes. But current approaches do not permit the simultaneous unbiased study of both host and bacterial factors during infection. Here, we developed scPAIR-seq, an approach to analyze both host and pathogen factors during infection by combining multiplex-tagged mutant bacterial library with scRNA-seq to identify mutant-specific changes in host transcriptomes. more...
Organism:
synthetic construct
Type:
Other
Platform:
GPL19424
1 Sample
Download data: TXT
Series
Accession:
GSE198433
ID:
200198433

PubMed Full text in PMC Similar studies

15.

Switch from LB pH7 to M9 pH5

(Submitter supplied) Salmonella must express and deploy a type III secretion system located in Salmonella pathogenicity island 2 (SPI-2) in order to survive in host phagocytic vacuoles and to cause systemic infection in mouse models of typhoid fever. A genome-wide approach to screening for Salmonella genes that are transcriptionally co-regulated in vitro with SPI-2 genes was used to identify bacterial loci that might function in a mouse model of systemic disease. more...
Organism:
Salmonella enterica subsp. enterica serovar Typhimurium
Type:
Expression profiling by array
Platform:
GPL3048
13 Samples
Download data
Series
Accession:
GSE3735
ID:
200003735

PubMed Similar studies Analyze with GEO2R

16.

RNA-seq analysis determined the effect of pat or cobB mutation on transcriptional levels in Salmonella Typhimurium 14028s.

(Submitter supplied) Salmonella causes a range of diseases in different hosts, including enterocolitis and systemic infection. Lysine acetylation regulates many eukaryotic cellular processes, but its function in prokaryotes is largely unknown. Reversible acetylation in Salmonella Typhimurium depends on acetyltransferase Pat and nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase CobB. Here, we used cell and animal models to evaluate the virulence of pat and cobB deletion mutants in S. more...
Organism:
Salmonella enterica subsp. enterica serovar Typhimurium str. ATCC 14028
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20792
3 Samples
Download data: TXT
Series
Accession:
GSE71907
ID:
200071907

PubMed Similar studies SRA Run Selector

17.

Intra-macrophage transcriptome of Salmonella enterica serovar Typhimurium 4/74 using strand-specific RNA-seq

(Submitter supplied) Bacterial transcription is controlled by many transcription factors and promoters. Currently many promoters are mapped only in in vitro conditions. We use an intra-macrophage model to map the promoters and their expression in vivo. InSPI2 is an in vitro growth condition mimicking intra-macrophage condition. We also characterize the transcriptome of Salmonella during growth in an in vitro intra-macrophage growth condition.
Organism:
Salmonella enterica subsp. enterica serovar Typhimurium str. ST4/74
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17562
6 Samples
Download data: GR
Series
Accession:
GSE59945
ID:
200059945

PubMed Full text in PMC Similar studies SRA Run Selector

18.

Single cell RNA Seq data of BMDM from mouse infected with Salmonella [dilution; CEL-Seq2]

(Submitter supplied) The interaction between a pathogen and a host is a highly dynamic process in which both agents activate complex programs. Here, we introduce a single-cell RNA-Seq method (scDual-Seq) that simultaneously captures both host and pathogen transcriptomes and use it to study the process of infection of individual mouse macrophages with the intracellular pathogen Salmonella typhimurium. Among the infected macrophages, we found three subpopulations and we show evidence for a linear progression through these subpopulations, supporting a model in which these three states correspond to consecutive stages of infection.
Organism:
Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344; Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24092
5 Samples
Download data: XLSX
Series
Accession:
GSE104678
ID:
200104678

PubMed Full text in PMC Similar studies SRA Run Selector

19.

Single cell RNA Seq data of BMDM from mouse infected with Salmonella

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344; Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL17021 GPL19729 GPL24092
511 Samples
Download data
Series
Accession:
GSE102163
ID:
200102163

PubMed Full text in PMC Similar studies

20.

Single cell RNA Seq data of BMDM from mouse infected with Salmonella [stat log]

(Submitter supplied) The interaction between a pathogen and a host is a highly dynamic process in which both agents activate complex programs. Here, we introduce a single-cell RNA-Seq method (scDual-Seq) that simultaneously captures both host and pathogen transcriptomes and use it to study the process of infection of individual mouse macrophages with the intracellular pathogen Salmonella typhimurium. Among the infected macrophages, we found three subpopulations and we show evidence for a linear progression through these subpopulations, supporting a model in which these three states correspond to consecutive stages of infection.
Organism:
Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19729
6 Samples
Download data: XLSX
Series
Accession:
GSE102162
ID:
200102162

PubMed Full text in PMC Similar studies SRA Run Selector

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