Similar studies for GEO DataSets (Select 200146849) - GEO DataSets

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Items: 20

Select item 2001468491.

Chromatin state maintains human myeloid leukemia by regulating m6A demethylase ALKBH5 expression [Ribo-seq]

(Submitter supplied) ALKBH5 is the RNA N(6)-methyladenosine (m6A) demethylase. To understhand the function and mechnism of ALKBH5 in human acute myeloid leukemia, we compared the translational efficiency in wild-type and ALKBH5-knock-down THP1 cells.

Organism:: Homo sapiens

Type:: Other

Platform:: GPL20795
8 Samples

Download data: XLSX

Series

Accession:: GSE146849

ID:: 200146849

Select item 2001468742.

Chromatin state maintains human myeloid leukemia by regulating m6A demethylase ALKBH5 expression [Slam-seq]

(Submitter supplied) ALKBH5 is the RNA N(6)-methyladenosine (m6A) demethylase. To understhand the function and mechnism of ALKBH5 in human acute myeloid leukemia, we compared the RNA decay rate in wild-type and ALKBH5-knock-down THP1 cells.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20795
16 Samples

Download data: CSV

Series

Accession:: GSE146874

ID:: 200146874

PubMed Similar studies SRA Run Selector

Select item 2001468313.

Chromatin state maintains human myeloid leukemia by regulating m6A demethylase ALKBH5 expression [ATAC-seq]

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL24676
2 Samples

Download data: BW, NARROWPEAK

Series

Accession:: GSE146831

ID:: 200146831

PubMed Similar studies SRA Run Selector

Select item 2001285754.

Chromatin state maintains human myeloid leukemia by regulating m6A demethylase ALKBH5 expression

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Other

Platforms:: GPL24676 GPL20795
38 Samples

Download data: BIGWIG, BW, NARROWPEAK, TSV

Series

Accession:: GSE128575

ID:: 200128575

PubMed Similar studies

Select item 2001285745.

Chromatin state maintains human myeloid leukemia by regulating m6A demethylase ALKBH5 expression [RNA-Seq]

(Submitter supplied) ALKBH5 is the RNA N(6)-methyladenosine (m6A) demethylase. To under sthand the function and mechnism of ALKBH5 in human acute myeloid leukemia, we compared the m6A profiling in wild-type, ALKBH5-knock-down, and ALKBH5 rescue THP1 cells.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20795
6 Samples

Download data: TSV

Series

Accession:: GSE128574

ID:: 200128574

Select item 2001285206.

Chromatin state maintains human myeloid leukemia by regulating m6A demethylase ALKBH5 expression [m6A-seq]

(Submitter supplied) ALKBH5 is the RNA N(6)-methyladenosine (m6A) demethylase. To under sthand the function and mechnism of ALKBH5 in human acute myeloid leukemia, we compared the m6A profiling in wild-type, ALKBH5-knock-down, and ALKBH5 rescue THP1 cells.

Organism:: Homo sapiens

Type:: Other

Platform:: GPL20795
6 Samples

Download data: BIGWIG

Series

Accession:: GSE128520

ID:: 200128520

Select item 2001449847.

ALKBH5 regulates AML development and LSC as an m6A eraser

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
28 Samples

Download data: BW

Series

Accession:: GSE144984

ID:: 200144984

PubMed Full text in PMC Similar studies

Select item 2001449688.

Sequencing of mRNA in AML cells upon ALKBH5 knockdown

(Submitter supplied) To identify the potential mRNA targets of ALKBH5, we conducted RNA-seq of mRNA samples enriched from AML cells with ALKBH5 knockdown

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
8 Samples

Download data: TXT

Series

Accession:: GSE144968

ID:: 200144968

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2001449639.

Sequencing of RNA fragments immunoprecipitated by anti-Flag in ALKBH5 overexpression NOMO1 cells

(Submitter supplied) To identify the direct mRNA targets of ALKBH5, we conducted RIP-seq with total RNA samples from ALKBH5 overexpression NOMO1 cells

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
4 Samples

Download data: TXT

Series

Accession:: GSE144963

ID:: 200144963

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20014495910.

Sequencing of mRNA in AML cells upon ALKBH5 knockdown and actinomycin D treatment for different time

(Submitter supplied) To evaluate the effects of ALKBH5 KD on the mRNA stability, we conducted RNA-seq of mRNA samples enriched from AML cells with ALKBH5 knockdown and actinomycin D treatment for different time

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
12 Samples

Download data: TXT

Series

Accession:: GSE144959

ID:: 200144959

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20013476311.

Sequencing of mRNA with N6-methyladenosine (m6A) modification in AML cells upon ALKBH5 knockdown or overexpression

(Submitter supplied) To identify the potential mRNA targets of ALKBH5, we conducted m6A-seq with mRNA samples enriched from AML cells with ALKBH5 knockdown or overexpression

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
4 Samples

Download data: BW

Series

Accession:: GSE134763

ID:: 200134763

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Select item 20016948412.

Me-RIP- Sequencing Analysis of normal and senescent nucleus pulposus cells Transcriptomes

(Submitter supplied) N6-methyladenosine (m6A) is the most prevalent modification of eukaryotic cells st post-transcriptional level. The goals of this study are to compare the N6-methyladenosine modification of transcripts in normal and senescent nucleus pulposus cells using Me-RIP-seq

Organism:: Homo sapiens

Type:: Other

Platform:: GPL24676
12 Samples

Download data: TXT

Series

Accession:: GSE169484

ID:: 200169484

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20016793113.

Next Generation Sequencing analysis at single-cell level of normal and degenerated nucleus pulposus cells transcriptomes

(Submitter supplied) Purpose: Next-generation sequencing (NGS) has revolutionized systems-based analysis of cellular pathways. The goals of this study are to compare NGS-derived retinal transcriptome profiling (RNA-seq) to microarray and quantitative reverse transcription polymerase chain reaction (qRT–PCR) methods and to evaluate protocols for optimal high-throughput data analysis

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL20795
9 Samples

Download data: TXT

Series

Accession:: GSE167931

ID:: 200167931

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20019414814.

TimeLapse-seq reveals that ALKBH5 modulates RNA stability of metabolic transcripts

(Submitter supplied) N6-methyadenosine (m6A) RNA modification controls numerous cellular processes through regulation of RNA stability and translational efficiency. Whether the RNA m6A modification regulates energy metabolism process by posttranscriptional regulation is unknown. We here show that loss of the m6A demethylase ALKBH5 results in instability of oxogluatarate-dehydrogenase (Ogdh) messenger RNA and transcripts of other metabolic enzymes.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
8 Samples

Download data: BEDGRAPH, CSV

Series

Accession:: GSE194148

ID:: 200194148

PubMed Full text in PMC Similar studies

Select item 20009305415.

Gene expression in GSCs with shALKBH5

(Submitter supplied) Knocking down ALKBH5 in Glioma Stem Cells resulted in an altered gene expression profile N6-methyl-adenosine (m6A) is the most prevalent internal chemical modification of mRNAs in eukaryotes. In mammals, m6A installed by m6A methyltransferases METTL3 and METTL14 is erased by two members of the AlkB family of nonheme Fe(II)/a-ketoglutarate (a-KG)-dependent dioxygenases, fat-mass and obesity associated protein (FTO) or ALKBH5. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL16686
4 Samples

Download data: CEL, CHP

Series

Accession:: GSE93054

ID:: 200093054

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20008751516.

The m6A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-Like Cells by Sustaining FOXM1 Expression and Cell Proliferation Programing

(Submitter supplied) The dynamic and reversible N6-methyladenosine (m6A) RNA modification installed and erased by N6-methyltransferases and demethylases regulates gene expression and cell fate. Here, we show that the m6A demethylase ALKBH5 is highly expressed in glioblastoma stem-like cells (GSCs). Silencing ALKBH5 suppresses the proliferation of patient-derived GSCs in vitro and in vivo. Integrated transcriptome and m6A-seq analyses revealed altered expression of select ALKBH5 target genes, including FOXM1, a critical transcription factor for the ALKBH5-dependent cell cycle gene expression. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Other

Platform:: GPL16791
8 Samples

Download data: XLSX

Series

Accession:: GSE87515

ID:: 200087515

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Select item 20014220317.

ALKBH5 K235 acetylation regulates the RNA m6A profiles

(Submitter supplied) We performed the transcripome-wild m6A-sequencing to compare the m6A profiles of negative control (NC) HeLa cells and ALKBH5 KO HeLa cells stably re-expressing wild type ALKBH5 (WT) or its mutant K235R (K235R)

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
6 Samples

Download data: XLSX

Series

Accession:: GSE142203

ID:: 200142203

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Select item 20018588818.

ALKBH5 promotes tumor progression by decreasing RIG-I expression mediated by N6-methyladenosine-dependent HNRNPC binding in HNSCC

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing

Platform:: GPL20301
12 Samples

Download data

Series

Accession:: GSE185888

ID:: 200185888

PubMed Full text in PMC Similar studies

Select item 20018588619.

ALKBH5 promotes tumor progression by decreasing RIG-I expression mediated by N6-methyladenosine-dependent HNRNPC binding in HNSCC [RNA-seq]

(Submitter supplied) To determine the targets underlying ALKBH5 during head and neck squamouse cell carcinoma progression, Methylated RNA immunoprecipitation (MeRIP) with an m6A specific antibody followed by RNA sequencing (MeRIP-seq) and next generation sequencing were combined to screen the potential targets haboring m6A modificatios and mRNA level alteration after ALKBH5 knockdown in a HNSCC cell line.