Similar studies for GEO DataSets (Select 200157396) - GEO DataSets

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Items: 20

Select item 2001573961.

Time dependence of volume overload on right ventricular remodeling during preadolescence

(Submitter supplied) We reported the RNAseq analyses of right ventricualr free wall myocardium in young volume overload (VO) C57/BL6 mice.VO was induced by the fistula between abdominal aorta and inferior vena cava (AVF) on postnatal day 7(P7). RNAseq analyses of RV free wall at P14 and P21from VO and sham-operated mice revealed that there were 981 differentially expressed genes between VO and sham group at P14, this number increased to 1907 at P21, there were 3012 differentially expressed genes between P21 and P14 sham group, and the number increased to 3470 at the presence of VO. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
12 Samples

Download data: TXT

Series

Accession:: GSE157396

ID:: 200157396

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2002101802.

Effect of neonatal right ventricular pressure overload on gene expression and regions of open chromatin during postnatal heart development

(Submitter supplied) To investigate the effect of pressure overload (PO) during postnatal right ventricular (RV) development, we established the RV PO model by conducting pulmonary artery banding (PAB) surgery on neonatal Sprague-Dawley (SD) rats. We then performed gene expression and chromatin openness profiling analysis using data obtained from RNA-seq and ATAC-seq of RV free walls from PO and sham-operated rats at postnatal day 21 (P21).

Organism:: Rattus norvegicus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL25947
12 Samples

Download data: TXT

Series

Accession:: GSE210180

ID:: 200210180

PubMed Full text in PMC Similar studies

Select item 2001869683.

Time dependence of volume overload on left ventricular remodeling during preadolescence

(Submitter supplied) We reported the RNAseq analyses of left ventricualr free wall myocardium in young volume overload (VO) C57/BL6 mice.VO was induced by the fistula between abdominal aorta and inferior vena cava (AVF) on postnatal day 7(P7). RNAseq analyses of LV free wall at P14 and P21from VO and sham-operated mice revealed that there were 378 differentially expressed genes between VO and sham group at P14, this number decreased to 184 at P21, there were 1374 differentially expressed genes between P21 and P14 sham group, and the number chenged to 1167 at the presence of VO. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
12 Samples

Download data: TXT

Series

Accession:: GSE186968

ID:: 200186968

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Select item 2001806434.

Effect of volume overload on right ventricular remodeling in neonatal SD rats

(Submitter supplied) We reported the RNAseq analyses of right ventricualr free wall myocardium in neonatal volume overload (VO) SD rat. VO was induced by the fistula between abdominal aorta and inferior vena cava (AVF) within 24 hours postnatally (P1). RNAseq analyses of RV free wall at P7 from VO and sham-operated rat revealed that there were 454 differentially expressed genes between VO and sham group at P7. GO analysis showed that in the VO and sham comparison, the upregulated genes mainly mediated immune system response and the downregulated genes mainly mediated apoptotic process at P7. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL25947
6 Samples

Download data: TXT

Series

Accession:: GSE180643

ID:: 200180643

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Select item 2001395615.

Pressure overload greatly promotes neonatal right ventricular cardiomyocyte proliferation - a new model for heart regeneration study

(Submitter supplied) Background: Current mammalian model for heart regeneration research is limited in apex amputation or myocardium infarction, both of which are controversy. Moreover, RNAseq demonstrated there were a very limited set of differential expressed genes between sham and operation heart in the myocardium infarction model. Here we investigated whether pressure overload in the right ventricle(RV), a common phenomenon in congenital heart disease children, could be a better animal model for heart regeneration study when consider cardiomyocyte(CM) proliferation as the most important index. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18694
12 Samples

Download data: TXT

Series

Accession:: GSE139561

ID:: 200139561

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Select item 2001862476.

The difference of right and left ventricular remodeling caused by volume overload in neonatal SD rats

(Submitter supplied) We reported the RNAseq analyses of right ventricle (RV) and left ventricle (LV) in neonatal volume overload (VO) and sham-operated SD rat. VO was induced by the fistula between abdominal aorta and inferior vena cava (AVF) within 24 hours postnatally (P1). RNAseq analyses of RV and LV free wall of P7 from VO and sham-operated rat. It demonstrated that the 1806 differentially expressed genes (DEGs) between RV and LV at the neonatal stage were primarily enriched in GTPase mediating signal transduction, insulin signaling pathway and thyroid hormone signaling pathway. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL25947
12 Samples

Download data: XLS

Series

Accession:: GSE186247

ID:: 200186247

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Select item 2002325947.

Effect of volume overload on gene expression of right atrium during postnatal heart development

(Submitter supplied) To investigate the effect of volume overload (VO) during postnatal right atrium (RA) development, we established the RA VO model by conducting the fistula between abdominal aorta and inferior vena cava (ACF) on postnatal day 7(P7) C57/BL6 mice. We then performed gene expression analysis using data obtained from RNA-seq of RA from VO and sham-operated mice at postnatal day 21 (P21).

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
6 Samples

Download data: TXT

Series

Accession:: GSE232594

ID:: 200232594

PubMed Full text in PMC Similar studies

Select item 2001208528.

Wipi1 is a Genetic Hub that Mediates Right Ventricular Failure

(Submitter supplied) Right ventricular dysfunction (RVD) independently predicts worse outcomes in both heart failure (HF) and pulmonary hypertension (PH), irrespective of their etiologies. Yet no evidence-based therapies exist for RVD and progression towards RV failure (RVF) can occur in spite of optimal medical treatment of HF or PH. This disparity reflects our insufficient understanding of the molecular pathophysiology of RVF. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
30 Samples

Download data: CSV

Series

Accession:: GSE120852

ID:: 200120852

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2000478149.

Right ventricular failure due to pulmonary banding

(Submitter supplied) Right ventricular failure was induced thourgh pulmonary banding in 11 pigs. Right ventricular failure was defined as a SRVP >50 mmHg during two hours. After right ventricular failure was induced, half the pigs were treated with a Glenn-shunt combined with pulmonary banding for one hour, and the other half served as control group with pulmonary banding only. The aim was to study the change in global gene expression during right ventricular failure due to pulmonary banding, and the effect of volume unloading during pulmonary banding.

Organism:: Sus scrofa

Type:: Expression profiling by array

Platform:: GPL3533
33 Samples

Download data: CEL

Series

Accession:: GSE47814

ID:: 200047814

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20013390410.

The Right Ventricular Fibroblast Secretome Drives Cardiomyocyte Dedifferentiation

(Submitter supplied) Rationale: In virtually all models of heart failure, prognosis is determined by right ventricular (RV) function; thus, understanding the cellular mechanisms contributing to RV dysfunction is critical. Whole organ remodeling is associated with cell-specific changes, including cardiomyocyte dedifferentiation and activation of cardiac fibroblasts (Cfib) which in turn is linked to disorganization of cytoskeletal proteins and loss of sarcomeric structures. more...

Organism:: Bos taurus; Rattus norvegicus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL15749 GPL22396
12 Samples

Download data: CSV

Series

Accession:: GSE133904

ID:: 200133904

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Select item 20020697211.

Postnatal lung development under the influence of pulmonary hypoperfusion

(Submitter supplied) We reported the RNAseq analyses of lungs tissues in neonatal SD rats with or without reduced pulmonary blood flow. Lung hypoperfution was induced by causing the supravalvular pulmonary stenosis through performing pulmonary artery banding surgery within 24 hours postnatally (P1). RNAseq analyses of the upper lobe of the right lung tissues was generated at P7 from 5 sham-operated rats and 4 pulmonary artery banding rats (1 rat dead before sample collection). more...

Organism:: Rattus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL32253
9 Samples

Download data: TXT

Series

Accession:: GSE206972

ID:: 200206972

PubMed Full text in PMC Similar studies

Select item 20020152212.

Congenital heart disease associated bronchopulmonary dysplasia and its underlying mechanisms

(Submitter supplied) We reported the RNAseq analyses of lungs tissues in neonatal SD rats with or without reduced pulmonary blood flow(RPF). RPF was induced by causing the supravalvular pulmonary stenosis through pulmonary artery banding within 24 hours postnatally (P1). RNAseq analyses of the upper lobe of the right lung tissues was generated at P14 from 5 sham-operated rats and 5 PAB rats. The results revealed that there were 2013 differentially expressed genes between PAB and sham group at P7, among which 936 were upregulated and 1077 were downregulated. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL25947
10 Samples

Download data: TXT

Series

Accession:: GSE201522

ID:: 200201522

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Select item 20015996913.

RNA-sequencing analysis gene expression changes in response to neonatal pulmonary artery banding

(Submitter supplied) The goal of this study is to investigate the molecular mechanisms of cardiomyocyte hyperplasia and hypertrophy in response to the pressure overload

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21273
11 Samples

Download data: TXT

Series

Accession:: GSE159969

ID:: 200159969

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20016513414.

Transcriptional characterization of cardiomyocyte nuclei from neonatal mice with volume overload

(Submitter supplied) Expression analysis of cardiomyocytes from 12 day old mice with and without left ventricular volume overload

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
9 Samples

Download data: XLSX

Series

Accession:: GSE165134

ID:: 200165134

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20011953015.

RNA expression in postnatal mouse ventricular tissue

(Submitter supplied) Mammals lose the ability to regenerate their hearts within one week after birth. During this regenerative window, cardiac energy metabolism shifts from glycolysis to fatty acid oxidation, and recent evidence suggests that metabolism may participate in controlling cardiomyocyte cell cycle. However, the molecular mechanisms mediating the loss of postnatal cardiac regeneration are not fully understood. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
12 Samples

Download data: TXT

Series

Accession:: GSE119530

ID:: 200119530

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20003042816.

Identification of right heart-enriched genes in a murine model of chronic outflow tract obstruction

(Submitter supplied) The right ventricle (RV) differs in several aspects from the left ventricle (LV) including its embryonic origin, physiological role and anatomical design. In contrast to LV hypertrophy, little is known about the molecular circuits, which are activated upon RV hypertrophy (RVH). We established a highly reproducible model of RVH in mice using pulmonary artery clipping (PAC), which avoids detrimental RV pressure overload and thus allows long-term survival of operated mice. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS4545
Platform:: GPL6246
12 Samples

Download data: CEL

Series

Accession:: GSE30428

ID:: 200030428

Select item 454517.

Cardiac right ventricle hypertrophy model

Analysis of right ventricle (RV) from C57BL/6 males subjected to hemoclip installation around the pulmonary artery (PA) for up to 6 weeks. PA clipping induces RV hypertrophy (RVH) while avoiding detrimental RV pressure overload. Results provide insight into the molecular basis of RV remodeling.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 3 protocol, 3 time, 2 tissue sets

Platform:: GPL6246
Series:: GSE30428
12 Samples

Download data: CEL

DataSet

Accession:: GDS4545

ID:: 4545

Select item 20001705018.

Gene expression profiling in Wistar male rat left ventricle with chronic and severe aortic valve regurgitation

(Submitter supplied) Aortic valve regurgitation (AR) imposes a severe volume overload to the left ventricle (LV) which results in dilation, eccentric hypertrophy and eventually loss of function. Little is known about the impact of AR on LV gene expression. We therefore conducted a gene expression profiling study in the LV of male Wistar rats with chronic (9 months) and severe AR.

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platform:: GPL6101
10 Samples

Download data: TXT

Series

Accession:: GSE17050

ID:: 200017050

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20014534619.

RNA sequencing analysis of pig neonatal left ventricular tissues

(Submitter supplied) The goal of this study is to examine transcriptomic changes in the left ventricles during the transition from a regenerative to a non-regenerative state in the pig neonatal heart. RNA was isolated from pig left ventricular tissue at postnatal day (P)0, P7, and P15, to compare the regeneration-capable P0 cardiac transcriptomic environment to the non-regenerative timepoints of P7 and P15, in pig hearts.

Organism:: Sus scrofa

Type:: Expression profiling by high throughput sequencing

Platform:: GPL26351
9 Samples

Download data: TXT

Series

Accession:: GSE145346

ID:: 200145346

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20006262920.

Comparative DNA methylation and gene expression analysis identifies novel genes for structural congenital heart diseases

(Submitter supplied) The most common congenital heart disease (CHD) is the ventricular septal defect (VSD), which is also a subfeature of Tetralogy of Fallot (TOF) representing the most common form of cyanotic CHD. The underlying causes for the majority of CHDs are still unclear and most probably consist of combinations of genetic, epigenetic and environmental factors. DNA methylation is the most widely studied epigenetic modification and several cardiac regulators have already been shown to be differentially methylated in CHD patients. more...

Organism:: Homo sapiens

Type:: Methylation profiling by high throughput sequencing

Platform:: GPL11154
23 Samples

Download data: TXT

Series

Accession:: GSE62629

ID:: 200062629

PubMed Similar studies SRA Run Selector

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