Similar studies for GEO DataSets (Select 200206668) - GEO DataSets

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Items: 20

Select item 2002066681.

Single cell transcriptomics of the tumor immune microenvironment from checkpoint blockade-treated KPC tumors

(Submitter supplied) Single cell transcriptomes of CD45+ cells from KPC tumor subcutaneous allografts, either treated with PD-1+CTLA-4 checkpoint blockade or treatment-naïve.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
8 Samples

Download data: H5

Series

Accession:: GSE206668

ID:: 200206668

PubMed Similar studies

Select item 2002064432.

Transcriptomics effects of IFNb and IFNg stimulation on murine cancer cell lines

(Submitter supplied) To measure the transcriptomic changes in response to IFNb and IFNg stimulation, we collected RNAseq of various cell lines that were stimulated or unstimulated by interferon for 48 hours

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
70 Samples

Download data: TXT

Series

Accession:: GSE206443

ID:: 200206443

PubMed Similar studies

Select item 2001342653.

Natural killer cells suppress T cell tumor immune evasion

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Other

Platform:: GPL19057
35 Samples

Download data

Series

Accession:: GSE134265

ID:: 200134265

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Select item 2001342644.

Natural killer cells suppress T cell tumor immune evasion [Supernatant treated control or Jak1 sgRNA B16-F10 RNA Seq]

(Submitter supplied) Investigation of the transcriptional response in Jak1 depleted tumor cells upon NK-derived cytokine presence using 3’ RNA sequencing

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
24 Samples

Download data: TXT

Series

Accession:: GSE134264

ID:: 200134264

PubMed Similar studies SRA Run Selector

Select item 2001342635.

Natural killer cells suppress T cell tumor immune evasion [B16-F10 CRISPR/Cas9 MHC I low]

(Submitter supplied) Investigation of tumor genes which are involved in the upregulation of MHC I expression through a genome-wide in vitro CRISPR/Cas9 screen

Organism:: Mus musculus

Type:: Other

Platform:: GPL19057
2 Samples

Download data: TXT

Series

Accession:: GSE134263

ID:: 200134263

PubMed Similar studies SRA Run Selector

Select item 2001342626.

Natural killer cells suppress T cell tumor immune evasion [B16-F10 CRISPR/Cas9 NK cell screen]

(Submitter supplied) Investigation of tumor genes which limit sensitivity to killing by NK cells through a genome-wide in vitro CRISPR/Cas9 screen

Organism:: Mus musculus

Type:: Other

Platform:: GPL19057
3 Samples

Download data: TXT

Series

Accession:: GSE134262

ID:: 200134262

PubMed Similar studies SRA Run Selector

Select item 2001342617.

Natural killer cells suppress T cell tumor immune evasion [NK treated B16-F10 RNA Seq]

(Submitter supplied) Investigation of the tumor transcriptional response upon NK cell attack using 3’ RNA sequencing

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
6 Samples

Download data: TXT

Series

Accession:: GSE134261

ID:: 200134261

PubMed Similar studies SRA Run Selector

Select item 2001122538.

Tumor immune evasion arises through loss of TNF sensitivity

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
52 Samples

Download data

Series

Accession:: GSE112253

ID:: 200112253

PubMed Similar studies

Select item 2001122529.

Tumor immune evasion arises through loss of TNF sensitivity [MC38]

(Submitter supplied) Investigation of the transcriptional response to TNF and Interferon gamma or T cells

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
28 Samples

Download data: CSV

Series

Accession:: GSE112252

ID:: 200112252

PubMed Similar studies SRA Run Selector

Select item 20011225110.

Tumor immune evasion arises through loss of TNF sensitivity [Ado]

(Submitter supplied) Investigation of the transcriptional response of wild type or Ado knockout MC38 cells to TNF

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
24 Samples

Download data: CSV

Series

Accession:: GSE112251

ID:: 200112251

PubMed Similar studies SRA Run Selector

Select item 20014576611.

Transcriptomic analysis reveals autophagy flux variation within mouse pancreatic cancer organoids

(Submitter supplied) Murine pancreatic cancer cells (HY15549 cells) established from genetically engineered mouse models (GEMM) of PDAC (p48-Cre+, KrasLSL-G12D/+, Trp53lox/+; KPC mice) were transfected with the GFP-LC3-RFP autophagy flux reporter from Mizushima lab, wherein reduction in the GFP/RFP ratio indicates increase in autophagy flux. Organoids derived from these cells were dissociated into single cells and sorted into autophagy-high (AThi) and autophagy-low (ATlo) populations according to GFP/RFP signal ratio. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
5 Samples

Download data: CSV, XLSX

Series

Accession:: GSE145766

ID:: 200145766

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20016210512.

Next Generation Sequencing Facilitates Quantitative Analysis of Renca and B16 Murine Cancer Line Transcriptomes

(Submitter supplied) Renca, a murine renal cell carcinoma, and B16F10, a murine melanoma, were transcriptionally profiled in a study designed to accompany an in vivo CRISPR screen to identify novel immunotherapy dependencies.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
5 Samples

Download data: TXT

Series

Accession:: GSE162105

ID:: 200162105

PubMed Similar studies SRA Run Selector

Select item 20021580313.

Parallel Genome-Wide CRISPR Screens Clarify Executors of Epithelial-Mesenchymal Transition Mediated Immune resistance to CD8+ T cells

(Submitter supplied) To investigate the role of tumor epithelial-to-mesenchymal plasticity in CD8+ T cell cytotoxicity, we generated two types of tumor cells with epithelial-like (Epi) or mesenchymal-like (Mes) features through an inducible EMT system. The parental KPC3-OVA cells were transduced with constitutively kinase active ALK5 cDNA (ALK5 CA) in doxycycline-induced system by Nakao et al. and Itoh et al, which initiated TGF-β signaling induced EMT. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL28457
18 Samples

Download data: CSV

Series

Accession:: GSE215803

ID:: 200215803

PubMed Full text in PMC Similar studies

Select item 20015122714.

CRISPR-GEMM pooled mutagenic screening identifies KMT2D as a major modulator of immune checkpoint blockade

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL17021 GPL24247
18 Samples

Download data: NARROWPEAK, TSV

Series

Accession:: GSE151227

ID:: 200151227

PubMed Full text in PMC Similar studies

Select item 20015122615.

CRISPR-GEMM pooled mutagenic screening identifies KMT2D as a major modulator of immune checkpoint blockade (ATAC-Seq)

(Submitter supplied) Immune checkpoint blockade (ICB) has shown remarkable clinical efficacy across multiple cancer types. However, only a fraction of patients respond to ICB. Here, we performed pooled mutagenic screening with CRISPR-mediated genetically engineered mouse models (CRISPR-GEMMs) in ICB settings, and identified KMT2D as a major modulator of ICB response across multiple cancer types. Kmt2d encodes a histone H3K4 methyltransferase and is among the most frequently mutated genes in cancer patients. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL24247
12 Samples

Download data: NARROWPEAK, TXT

Series

Accession:: GSE151226

ID:: 200151226

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20015122516.

CRISPR-GEMM pooled mutagenic screening identifies KMT2D as a major modulator of immune checkpoint blockade (RNA-Seq)

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
6 Samples

Download data: TSV, TXT

Series

Accession:: GSE151225

ID:: 200151225

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20014982617.

Therapeutic decoupling of MHC-I and PD-L1 expression increases the efficacy of immune checkpoint blockade

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Other; Expression profiling by high throughput sequencing

Platform:: GPL17021
56 Samples

Download data: BED

Series

Accession:: GSE149826

ID:: 200149826

PubMed Full text in PMC Similar studies

Select item 20014982518.

Therapeutic decoupling of MHC-I and PD-L1 expression increases the efficacy of immune checkpoint blockade (SMAC_RNAseq)

(Submitter supplied) Immune checkpoint blockade (ICB) therapy has revolutionized the treatment of multiple cancers, but the majority of patients remain refractory due to impaired MHC-I expression. Although the combination of immunotherapy with existing anti-cancer treatments has shown synergy in multiple scenarios, the immunomodulatory effects of conventional therapies remain poorly understood. Here, we integrated CRISPR-mediated genetic screens and data mining of perturbation associated gene expression data to identify drugs that can specifically up-regulate MHC-I without inducing PD-L1. more...