Similar studies for GEO DataSets (Select 200217337) - GEO DataSets

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Items: 20

Select item 2002173371.

Genome-wide methylation studies in nasal epithelial cells.

(Submitter supplied) We performed an epigenome-wide association study (EWAS) of allergic sensitization using nasal epithelial cell DNA from 280 subjects.

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL21145
280 Samples

Download data: IDAT, TXT

Series

Accession:: GSE217337

ID:: 200217337

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Select item 2002675952.

Genome-wide methylation studies in nasal epithelial cells using a custom Asthma&Allergy DNAm array

(Submitter supplied) We performed an epigenome-wide association study (EWAS) of allergic sensitization using nasal epithelial cell DNA from 474 subjects.

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL32946
474 Samples

Download data: IDAT, TXT

Series

Accession:: GSE267595

ID:: 200267595

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Select item 2002208743.

Genome-wide methylation studies in nasal epithelial cells using a custom Asthma&Allergy DNAm array.

(Submitter supplied) We performed an epigenome-wide association study (EWAS) of allergic sensitization using nasal epithelial cell DNA from 280 subjects.

Organism:: Homo sapiens

Type:: Methylation profiling by array

Platform:: GPL32946
280 Samples

Download data: IDAT, TXT

Series

Accession:: GSE220874

ID:: 200220874

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Select item 2001455054.

Endotype of Allergic Asthma with Airway Obstruction in Urban Children

(Submitter supplied) In the first decade of life, high-asthma risk urban children develop stable phenotypes of respiratory health versus disease that link early life environmental exposures to childhood allergic sensitization and asthma. Moreover, unique patterns of nasal gene expression demonstrate how specific molecular pathways underlie distinct respiratory phenotypes, including allergic and non-allergic asthma.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
353 Samples

Download data: CSV

Series

Accession:: GSE145505

ID:: 200145505

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Select item 2002401555.

Characterization of DNA methylation changes induced by albuterol in airway epithelial cultures

(Submitter supplied) Albuterol is the first-line asthma medication used in diverse populations. Although DNA methylation (DNAm) is an epigenetic mechanism involved in asthma and bronchodilator drug response (BDR), no study has assessed whether albuterol could induce changes in the airway epithelial methylome. We aimed to characterize albuterol-induced changes in DNAm in airway epithelial cells and assess the potential functional consequences and biological pathways implicated. more...

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL21145
200 Samples

Download data: IDAT, TXT

Series

Accession:: GSE240155

ID:: 200240155

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Select item 2001529236.

Comparison of Methylation Capture Sequencing and Infinium EPIC Methylation Array in Peripheral Blood Mononuclear Cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array; Methylation profiling by high throughput sequencing

Platforms:: GPL21145 GPL24676
16 Samples

Download data: COV, IDAT

Series

Accession:: GSE152923

ID:: 200152923

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Select item 2001529227.

Comparison of Methylation Capture Sequencing and Infinium EPIC Methylation Array in Peripheral Blood Mononuclear Cells [MC-seq]

(Submitter supplied) Background: Epigenome-wide association studies (EWAS) have been widely applied to identify methylation CpG sites associated with human disease. To date, the Infinium Methylation EPIC array (EPIC) is commonly used for high-throughput DNA methylation profiling. However, the EPIC array covers only 30% of the human methylome. Methylation Capture bisulfite sequencing (MC-seq) captures target regions of methylome and has advantages of extensive coverage in the methylome at an affordable price. more...

Organism:: Homo sapiens

Type:: Methylation profiling by high throughput sequencing

Platform:: GPL24676
12 Samples

Download data: COV

Series

Accession:: GSE152922

ID:: 200152922

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Select item 2001522458.

Comparison of Methylation Capture Sequencing and Infinium EPIC Methylation Array in Peripheral Blood Mononuclear Cells [EPIC array]

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL21145
4 Samples

Download data: IDAT, TXT

Series

Accession:: GSE152245

ID:: 200152245

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Select item 2000346399.

Methylation data from CD4+ cells at birth and 12 months from a cohort of children who were diagnosed with IgE food allergy to either egg milk or peanut at 12 months (n=12) and healthy controls (n=12).

(Submitter supplied) DNA methylation data derived from total CD4+ T-cells from a cohort of paediatric food allergy. There are 12 food allergic samples (6 activated and matched control), 12 non-allergic samples (6 activated and matched control) collected at birth and resample at 12-months, total 48 samples. Mononuclear cells were either activated with anti-CD3 (0.5 ug/mL) + IL2(20U) or rested in media alone for 24 hours. more...

Organism:: Homo sapiens

Type:: Methylation profiling by array

Platform:: GPL13534
48 Samples

Download data: TXT

Series

Accession:: GSE34639

ID:: 200034639

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Select item 20006989410.

Mapping of variable DNA methylation across multiple cell types defines a dynamic regulatory landscape of the human genome

(Submitter supplied) DNA methylation is an important epigenetic modification involved in many biological processes and diseases. Many studies have mapped DNA methylation changes associated with embryogenesis, cell differentiation and cancer at a genome-wide scale. Our understanding of genome-wide DNA methylation changes in a developmental or disease-related context has been steadily growing. However, the investigation of which CpGs are variably methylated in different normal cell or tissue types is still limited. more...

Organism:: Homo sapiens

Type:: Methylation profiling by high throughput sequencing; Third-party reanalysis

Platforms:: GPL9115 GPL11154
31 Samples

Download data: TXT

Series

Accession:: GSE69894

ID:: 200069894

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Select item 20004467811.

Effect of allergen sensitization on gene expression in dendritic cells from neonates of asthmatic vs control mothers

(Submitter supplied) This study aims to demonstrate the link between epigenome-wide methylation aberrations at birth and genomic transcriptional changes upon allergen sensitization that occur in the neonatal dendritic cells (DC) due to maternal asthma. In an in vivo model reproducing human epidemiology findings, maternal but not paternal asthma predisposes the neonate to increased asthma risk, the effect is allergen-independent and is not genetic or environmental. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL8321
24 Samples

Download data: CEL

Series

Accession:: GSE44678

ID:: 200044678

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Select item 20003785312.

DNA Methylation Profiles of Airway Epithelial Cells and PBMCs from Healthy, Atopic and Asthmatic Children.

(Submitter supplied) DNA methylation profiling of airway epithelial cells (AECs) and peripheral blood mononuclear cells (PBMCs) from normal, atopic and asthmatic subjects. The Illumina GoldenGate Methylation Cancer Panel I was used to obtain DNA methylation profiles across approximately 1505 CpGs in AECs and PBMCs. Samples included 7 healthy, 9 atopic, 4 atopic asthmatic and 5 non-atopic asthmatic subjects. Please note that only some of the samples are matched (i.e. more...

Organism:: Homo sapiens

Type:: Methylation profiling by array

Platform:: GPL9183
41 Samples

Download data: TXT

Series

Accession:: GSE37853

ID:: 200037853

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Select item 20008522813.

Neonatal DNA methylation distinguishes children who will and will not become asthmatic by age 9 years

(Submitter supplied) Background The timing and mechanisms of asthma inception remain imprecisely defined. Although epigenetic mechanisms likely contribute to asthma pathogenesis, little is known about their role in asthma inception. Objective To assess whether the trajectory to asthma begins already at birth and epigenetic mechanisms, specifically DNA methylation, contribute to asthma inception. Methods We used a combination of methyl binding protein-dependent DNA capture and microarrays to survey DNA methylation in cord blood mononuclear cells (CBMC) from 36 children (18 non-asthmatic, 18 asthmatic by age 9) from the Infant Immune Study (IIS), an unselected birth cohort closely monitored for asthma for a decade. more...

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platforms:: GPL22289 GPL22288
36 Samples

Download data: PAIR, TXT

Series

Accession:: GSE85228

ID:: 200085228

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Select item 20008359514.

“Same Difference”: Comprehensive evaluation of four DNA methylation measurement platforms

(Submitter supplied) DNA methylation in CpG context is fundamental to the epigenetic regulation of gene expression in high eukaryotes. Disorganization of methylation status is implicated in many diseases, cellular differentiation, imprinting, and other biological processes. Techniques that enrich for biologically relevant CpG-rich genomic regions are desired since, depending on the size of an oragnism's methylome, the depth of sequencing required to cover all CpGs can be prohibitively expensive. more...

Organism:: Homo sapiens

Type:: Methylation profiling by high throughput sequencing

Platform:: GPL16791
7 Samples

Download data: TXT

Series

Accession:: GSE83595

ID:: 200083595

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Select item 20015137315.

A cord blood multi-omic analysis of birthweight reveals new underlying mechanisms related to cholesterol metabolism [gene expression]

(Submitter supplied) Birthweight reflects in utero exposures and later health evolution. Despite existing studies employing high-dimensional molecular measurements, the understanding of underlying mechanisms of birthweight remains limited. To investigate the systems biology of birthweight, we cross-sectionally integrated the methylome, the transcriptome, the metabolome and a set of inflammatory proteins measured in cord blood samples, collected from four birth-cohorts (n=489). more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL17077
194 Samples

Download data: TXT

Series

Accession:: GSE151373

ID:: 200151373

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Select item 20015104216.

A cord blood multi-omic analysis of birthweight reveals new underlying mechanisms related to cholesterol metabolism

Organism:: Homo sapiens

Type:: Methylation profiling by array

Platform:: GPL13534
492 Samples

Download data: IDAT, TXT

Series

Accession:: GSE151042

ID:: 200151042

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Select item 20013143317.

Epigenome-wide Association study of individuals conceived by Assisted Reproduction Technologies at birth and adulthood

(Submitter supplied) Genome wide DNA methylation profiling of whole blood at birth (Guthrie blood spots) and adulthood of individuals conceived by assisted reproductive technology (ART) and matched non-ART controls. The Illumina Infinium MethylationEPIC BeadChip was used to obtain DNA methylation profiles across approximately 850,000 CpGs in guthrie cards and whole adult blood.

Organism:: Homo sapiens

Type:: Methylation profiling by array

Platform:: GPL21145
440 Samples

Download data: CSV, IDAT

Series

Accession:: GSE131433

ID:: 200131433

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Select item 20006520518.

Childhood Atopic Asthma

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Methylation profiling by array

Platforms:: GPL14550 GPL13534
141 Samples

Download data: IDAT, TXT

Series

Accession:: GSE65205

ID:: 200065205

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Select item 20006520419.

The Nasal Gene Expression and Childhood Atopic Asthma

(Submitter supplied) We compared genomic DNA methylation patterns and gene expression in African American children with persistent atopic asthma versus healthy controls. We identified 119 differentially methylated regions (DMRs) and 118 differentially methylated probes (DMPs) after adjustment for age, gender, race/ethnicity, batch effects, inflation, and multiple comparisons (false discovery rate-adjusted q<0.05). Genes differentially methylated include those with established roles in asthma and atopy, components of the extracellular matrix, genes related to immunity, cell adhesion, epigenetic regulation, and airway obstruction. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL14550
69 Samples

Download data: TXT

Series

Accession:: GSE65204

ID:: 200065204

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Select item 20006516320.

The Nasal Methylome and Childhood Atopic Asthma

(Submitter supplied) Background: Nasal epithelia are emerging as a proxy measure of gene expression of the airway epithelium in asthma. We hypothesized that epigenetic marks regulate gene expression of the nasal epithelia and consequently may provide a novel target for allergic asthma. Methods: We compared genomic DNA methylation patterns and gene expression in African American children with persistent atopic asthma [N=36] versus healthy controls [N=36]. more...

Organism:: Homo sapiens

Type:: Methylation profiling by array

Platform:: GPL13534
72 Samples

Download data: IDAT

Series

Accession:: GSE65163

ID:: 200065163

PubMed Full text in PMC Similar studies Analyze with GEO2R

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