GEO DataSets

(Submitter supplied) Why is metamorphosis so pervasive? Does it facilitate the independent (micro)evolution of quantitative traits in distinct life-stages, like it does for discrete characters such as limbs and organs? We tested this hypothesis by measuring the expression of 6400 genes in 41 Drosophila melanogaster inbred lines at larval and adult stages. Only 32% of the genes showed significant genetic correlations between larval and adult expression. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17275

164 Samples

Download data: CSV

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Platform:

GPL6799

88 Samples

Download data: GPR

(Submitter supplied) Drosophila melanogaster undergoes a complete metamorphosis, during which time the larval male and female forms transition into sexually dimorphic, reproductive adult forms. To understand this complex morphogenetic process at a molecular-genetic level, we performed whole genome microarray analyses. Genes were identified that were expressed during metamorphosis in both somatic and germline tissues of males and females. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Platform:

GPL6799

60 Samples

Download data: GPR

(Submitter supplied) Drosophila melanogaster undergoes a complete metamorphosis, during which time the larval male and female forms transition into sexually dimorphic, reproductive adult forms. To understand this complex morphogenetic process at a molecular-genetic level, we performed whole genome microarray analyses. In somatic tissues at 48 hour After Puparium Formation (APF), 173 sex-biased transcripts that likely function downstream of the doublesex (dsx) branch of the sex determination hierarchy were identified. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Platform:

GPL6799

28 Samples

Download data: GPR

(Submitter supplied) This RNAseq study has been performed in the framework of a project using experimental evolution to understand the consequences of genetically-based adaptation to juvenile undernutrition for adult gene metabolism. Six "Selected" populations of Drosophila melanogaster had been maintained on a very poor larval diet (3.2 g yeast / liter w/v) for 14 years (about 250 generations). Six "Control" populations of the same origin had been maintained in parallel on the standard diet (12.5 g yeast/liter). more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21306

24 Samples

Download data: TSV, TXT

(Submitter supplied) In order to test the hypothesis that adult hybrid misexpression results from the cascading effect of earlier-expressed developmentally important improperly regulated genes, as well as address whether Von Baer’s 3rd law (suggesting that earlier stages of development should be more similar between species than later stages) holds at the level of gene expression, we conducted whole-transcriptome Drosophila melanogaster cDNA microarray-based expression profiling of males of D. more...

Organism:

Drosophila melanogaster; Drosophila sechellia; Drosophila simulans; Drosophila sechellia x Drosophila simulans

Type:

Expression profiling by array

Dataset:

GDS3835

Platform:

GPL3598

48 Samples

Download data

Analysis of males of 3 species (melanogaster, sechellia, simulans) and D. sechellia x D. simulans F1 hybrids during 4 developmental stages. Results within and between pure species and hybrids provide insight into both the evolution of gene regulation in the context of development and speciation.

Organism:

Drosophila melanogaster; Drosophila sechellia; Drosophila simulans; Drosophila sechellia x Drosophila simulans

Type:

Expression profiling by array, log2 ratio, 4 development stage, 4 species sets

Platform:

GPL3598

Series:

GSE17535

48 Samples

Download data

(Submitter supplied) MicroRNAs (miRNAs) are endogenous RNA molecules that contribute to the regulation of gene expression post-transcriptionally. Recently, patterns of sequence evolution and evolutionary emergence of miRNAs have been analyzed in detail. However, the extent to which miRNA expression levels vary within and between species, the role of stabilizing selection versus other evolutionary mechanisms in shaping the temporal dynamics of these changes, and how this variation might unveil the interplay between miRNAs and mRNAs remain poorly understood. more...

Organism:

Drosophila simulans; Drosophila melanogaster; Drosophila yakuba

Type:

Non-coding RNA profiling by high throughput sequencing

Platforms:

GPL11000 GPL9394 GPL9058

12 Samples

Download data: TXT, XLS

(Submitter supplied) We found two lines of evidence suggesting that miRNA abundance has been shaped by different evolutionary regimes at the two developmental stages. Attributed to functional constraints, which points to mechanisms more subtle and diverse than previously thought.

Organism:

Drosophila melanogaster; Drosophila simulans; Drosophila yakuba

Type:

Non-coding RNA profiling by array

Platform:

GPL18365

72 Samples

Download data: TXT

(Submitter supplied) We found two lines of evidence suggesting that miRNA abundance has been shaped by different evolutionary regimes at the two developmental stages attributed to functional constraints, which points to mechanisms more subtle and diverse than previously thought.

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Platform:

GPL14007

24 Samples

Download data: PAIR

(Submitter supplied) The process of metamorphosis relies on choreography of temporal and spatial cues that mediate, in which inappropriate activation of many of these genes results in growth defects, developmental delay and death. Using RNA interference, we have unraveled an essential role for the insect specific dopamine 1(D1)-like receptor Dop1R2 at the late larval/prepupal stage. We used microarrays to evaluate differentially expressed genes during the early/pale pupal stage and identified up-regulation of families of functionally related genes, including ecdysone induced genes, stress and defense/immune response genes, and those that underlie tissue morphogenesis.

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Platform:

GPL72

4 Samples

Download data: CEL, CHP