GEO DataSets

Analysis of embryonic day 19 fetal lung type II epithelial cells exposed to mechanical strain for 16 hours. Mechanical forces are essential for normal fetal lung development. Results provide insight into the mechanisms regulating lung development in response to mechanical forces.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 stress sets

Platform:

GPL341

Series:

GSE3541

6 Samples

Download data: CEL, EXP

(Submitter supplied) Mechanical forces are essential for normal fetal lung development. However, the cellular and molecular mechanisms regulating this process remain largely unknown. In the present study, we used oligonucleotide microarray technology to investigate gene expression profile in cultured E19 rat fetal lung type II epithelial cells exposed to a level of mechanical strain similar to that observed in utero. Significance Analysis of Microarrays (SAM) identified 92 genes differentially expressed by strain. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS2225

Platform:

GPL341

6 Samples

Download data: CEL, EXP

(Submitter supplied) d-serine is naturally present throughout the human body. It is also used as add-on therapy for treatment-refractory schizophrenia. d-Serine interacts with the strychnine-insensitive glycine binding site of NMDA receptor, and this interaction could lead to potentially toxic activity (i.e., excitotoxicity) in brain tissue. The transcriptomic changes that occur in the brain after d-serine exposure have not been fully explored. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3643

Platform:

GPL1355

24 Samples

Download data: CEL

Analysis of forebrains of animals treated with up to 500 mg/kg D-serine for 96 hours. D-serine is involved in many physiological processes through its interaction with the glycine binding site of the NMDA receptor. Results provide insight into the impact of D-serine exposure on neuronal functions.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent, 6 dose sets

Platform:

GPL1355

Series:

GSE10748

24 Samples

Download data: CEL

(Submitter supplied) The mechanical effect of raised intraocular pressure is a recognised stimulus for optic neuropathy in primary open angle glaucoma (POAG). Characteristic extra-cellular matrix (ECM) remodelling accompanies axonal damage in the lamina cribrosa (LC) of the optic nerve head in POAG. Glial cells in the lamina cribrosa may play a role in this process but the precise cellular responses to mechanical forces in this region are unknown. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

2 Samples

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(Submitter supplied) Mammalian lung development is a complex morphogenetic process, which initiates near mid-gestation and continues through early postnatal life. The lung arises as two lateral buds that emerge from the ventral foregut endoderm at ~ 9 days after fertilization (in mouse) and undergo numerous rounds of dichotomous branching to form the bronchial tree. This stage of development is referred to as the pseudoglandular phase, histologically characterized by loose mesenchyme surrounding undifferentiated epithelial tubes. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS3447 GDS3448

Platforms:

GPL76 GPL75

22 Samples

Download data: CEL, EXP

Analysis of lungs from embryonic day 12 to adulthood. Results provide insight into the molecular mechanisms governing normal lung development.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 11 age sets

Platform:

GPL76

Series:

GSE10889

11 Samples

Download data: CEL, EXP

Analysis of lungs from embryonic day 12 to adulthood. Results provide insight into the molecular mechanisms governing normal lung development.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 11 age sets

Platform:

GPL75

Series:

GSE10889

11 Samples

Download data: CEL, EXP

(Submitter supplied) Lung alveolarization is a complex process that involves interactions between several cell types and leads to considerable increase in gas-exchange surface area. The step designated secondary septation includes elastogenesis from interstitial fibroblasts. We used microarrays to detail the global programme of fibroblast gene expression that underly secondary septation, and identified numerous genes that undergo signficant changes in expression Keywords: Time course

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

9 Samples

Download data: CEL

(Submitter supplied) Prolonged use of glucocorticoids can lead to the formation of a cataract, however the mechanism is not known. We recently reported the presence of the functional glucocorticoid receptor in immortalized cultured mammalian lens epithelial cells (Gupta & Wagner, Invest Ophthalmol Vis Sci 2003), but the short term biological effect of glucocorticoid action in lens epithelial cells is not known. This study seeks to examine glucocorticoid induced changes in global gene expression in LECs. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1353

Platform:

GPL96

12 Samples

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Analysis of cultured immortalized lens epithelial cells (LEC) 4 and 16 hours after treatment with 1 uM dexamethasone, a glucocorticoid steroid hormone. Long-term glucocorticoid use can induce cataract formation. Results identify glucocorticoid targets and short-term effects of glucocorticoid on LECs

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent, 2 time sets

Platform:

GPL96

Series:

GSE3040

12 Samples

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(Submitter supplied) Fetal lung development is a complex biological process, which involves temporal and spatial regulations of many genes. To understand molecular mechanisms of this process, we investigated gene expression profiling of lungs at gestational day 18, 19, 20, 21, new born, and adult rats using in-house rat DNA microarray containing 6,000 known genes and 4,000 ESTs. 1,512 genes passed SAM test and 583 genes (402 known genes and 181 ESTs) had a 2-fold change at least at one time point. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1699

54 Samples

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(Submitter supplied) Studies of human fetal lung in explant culture and in isolated epithelial cells have demonstrated that both glucocorticoids and cyclic AMP promote differentiated alveolar type II cell phenotype as assessed by ultrastructural morphology and surfactant production. This project profiles changes in gene expression associated with hormone induced differentiation. Undifferentiated human fetal lung (13-20 wk) epithelial cells were cultured in serum-free medium (control) or with dexamethasone/8-Bromo cyclic AMP/isobutylmethylxanthine (DCI) to promote type II cell differentiation. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1405

Platform:

GPL96

10 Samples

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Analysis of epithelial cells isolated from 13 fetal lungs (13-20 wks old) and cultured in dexamethasone/cyclic AMP/isobutylmethylxanthine (DCI) for 72 hrs to promote type II cell differentiation. Mature alveolar type II cells that produce surfactant are critical for adaptation to extrauterine life.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent sets

Platform:

GPL96

Series:

GSE3306

10 Samples

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(Submitter supplied) Amniotic fluid is critical for the development of foetus, which provides the appropriate conditions for foetus growth. Besides its presumed traditional roles of providing movement place and protecting from crushing, amniotic fluid is considered to have more important roles in the nervous development of foetus respecting nervous related compositions and close contact with the skin of foetus. Peripheral nervous sensory system is the feeling basis for the body with neuritis anchoring on the surface of skin. more...

Organism:

Mus musculus

Type:

Non-coding RNA profiling by array

Platform:

GPL20632

3 Samples

Download data: GPR

(Submitter supplied) Developmental gene expression profiling of mammalian, fetal orofacial tissue Keywords = orofacial Keywords = embryo Keywords = development Keywords: time-course

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS739

Platform:

GPL81

9 Samples

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Developmental gene expression profiling of fetal orofacial tissue from gestation day (GD) 12-14 embryos.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 development stage sets

Platform:

GPL81

Series:

GSE1624

9 Samples

Download data

(Submitter supplied) Maturation of lung cell types occurs during late gestation to ensure lung function and optimal gas exchange at birth. The pulmonary lymphatic endothelium is an understudied cell type and is essential for immune regulation and interstitial fluid removal. Here we provide the first characterization of the pulmonary lymphatic endothelium during late gestation prior to birth. We used microarrays to detail the global transcriptional programme underlying maturation of pulmonary lymphatic endothelium and identified 1,281 genes with significant changes in gene expression over time. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL17791

9 Samples

Download data: CEL

(Submitter supplied) We decompose the genome-wide expression patterns in 38 embryonic human lung (53-154 days post conception/dpc) into their independent, dominant directions of transcriptomic sample variation in order togain global insight of the developing human lung transcriptome.The characteristic genes and their corresponding bio–ontologic attribute profile for the latter were identified. We noted the over–representation of lung specific attributes (e.g., surfactant proteins) traditionally associated with later developmental stages, and highly ranked attributes (e.g., chemokine–immunologic processes) not previously reported nor immediately apparent in an early lung development context. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4930

Platform:

GPL570

38 Samples

Download data: CEL

Analysis of lung tissues at 53 to 154 days post conception. Results provide insight into the molecular regulation of lung development.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 29 time sets

Platform:

GPL570

Series:

GSE14334

38 Samples

Download data: CEL