Similar studies for GEO DataSets (Select 3452) - GEO DataSets

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Items: 20

Select item 34521.

Nematode model of primary mitochondrial dysfunction: complex I mutants

Analysis of gas-1(fc21) electron transport chain complex I mutants. The gas-1(fc21) mutation affects the 49 kD subunit of complex I, decreasing the rate of complex I-dependent oxidative phosphorylation. Results provide insight into molecular mechanisms underlying primary mitochondrial disease .

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:: GPL200
Series:: GSE9896
10 Samples

Download data: CEL

DataSet

Accession:: GDS3452

ID:: 3452

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000099672.

Expression data from wildtype and C. elegan mutants

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array

Platform:: GPL200
20 Samples

Download data: CEL

Series

Accession:: GSE9967

ID:: 200009967

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000098973.

Expression data from 2 wildtype and 8 C. elegans ETC mutants

(Submitter supplied) Utilizing C. elegans as a model of mitochondrial dysfunction provides insight into cellular adaptations which occur as a consequence of genetic alterations causative of human disease. We characterized genome-wide expression profiles of hypomorphic C. ele Our goal was to detect concordant changes among clusters of genes that comprise defined metabolic pathways utilizing gene set enrichment analysis. more...

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array

Dataset:: GDS3453
Platform:: GPL200
10 Samples

Download data: CEL

Series

Accession:: GSE9897

ID:: 200009897

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000098964.

Expression data from wildtype and gas-1 mitochondrial mutant C. elegans

(Submitter supplied) Utilizing C. elegans as a model of mitochondrial dysfunction provides insight into cellular adaptations which occur as a consequence of genetic alterations causative of human disease. We characterized genome-wide expression profiles of hypomorhpic C. elegans mutants in nuclear-encoded subunits of respiratory chain complexes I, II and III. Our goal was to detect concordant changes among clusters of genes that comprise defined metabolic pathways utilizing gene set enrichment analysis. more...

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array

Dataset:: GDS3452
Platform:: GPL200
10 Samples

Download data: CEL

Series

Accession:: GSE9896

ID:: 200009896

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 34535.

Nematode models of primary mitochondrial dysfunction: complex I, II, and III mutants

Analysis of 8 different electron transport chain (ETC) subunit mutants (3 missense and 5 RNAi-induced) in complexes I, II, and III. Results from this validation set provide insight into the contributions of individual complexes or subunits to primary mitochondrial dysfunction.

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array, transformed count, 4 genotype/variation, 4 protocol sets

Platform:: GPL200
Series:: GSE9897
10 Samples

Download data: CEL

DataSet

Accession:: GDS3453

ID:: 3453

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000952406.

RNA-sequencing of C.elegans isp-1 mutant and superoxide dismutase-isp-1 double mutants

(Submitter supplied) isp-1;sod double mutants have decreased lifespan, increased resistance to oxidative stress and slow physiologic rates. We performed RNA sequencing to compare gene expression between isp-1 mutants and isp-1;sod-3 and isp-1;sod-5 double mutants

Organism:: Caenorhabditis elegans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19757
12 Samples

Download data: TXT

Series

Accession:: GSE95240

ID:: 200095240

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001109847.

Role of mitochondrial unfolded protein response transcription fatcor ATFS-1 in lifespan of long-lived mitochondrial mutants

(Submitter supplied) In this work, we examined the effect of the transcription factor ATFS-1 in the long lifespan of the nuo-6 mitochondrial mutant. We also examined the effect of the hypoxia transcription factor hif-1. We sequenced both atfs-1 deletion mutants and atfs-1 gain-of-function point mutants in which the mitochondrial localization sequence of ATFS-1 is disrupted. Note that sequencing batch 2 was previously uploaded as part of GSE93724.

Organism:: Caenorhabditis elegans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19757
43 Samples

Download data: TXT

Series

Accession:: GSE110984

ID:: 200110984

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000540248.

Expression Data of Reactive Oxygen Species Signalling in C. elegans

(Submitter supplied) We have shown that worms that possess mutations in two electron transport chain subunits live longer due to mtROS signalling. Wild type worms can also live longer by treatment with the pro-oxidant paraquat. Paraquat treatment is not additive to the mutations in the ETC subunits. We aimed to determine the underlying changes in gene expression that were common to both paraquat treatment and the two mutations. more...

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array

Datasets:: GDS5193 GDS5194 GDS5195
Platform:: GPL200
22 Samples

Download data: CEL

Series

Accession:: GSE54024

ID:: 200054024

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 51959.

nuo-6;ced-4 double mutation effect on young adults

Analysis of nuo-6;ced-4 double mutants. ced-4 mutation in the intrinsic apoptosis signaling pathway suppresses the longevity of electron transport chain mutant nuo-6. Results provide insight into molecular mechanisms underlying lifespan expansion.

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array, transformed count, 4 genotype/variation sets

Platform:: GPL200
Series:: GSE54024
13 Samples

Download data: CEL

DataSet

Accession:: GDS5195

ID:: 5195

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 519410.

isp-1;ced-4 double mutation effect on young adults

Analysis of isp-1;ced-4 double mutants. ced-4 mutation in the intrinsic apoptosis signaling pathway suppresses the longevity of electron transport chain mutant isp-1. Results provide insight into molecular mechanisms underlying lifespan expansion.

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array, transformed count, 4 genotype/variation sets

Platform:: GPL200
Series:: GSE54024
13 Samples

Download data: CEL

DataSet

Accession:: GDS5194

ID:: 5194

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 519311.

isp-1 and nuo-6 mutants and paraquat-treated wildtype young adults

Analysis of wildtype worms treated with the pro-oxidant paraquat and electron transport chain mutants isp-1 and nuo-6. Results provide insight into common molecular mechanisms underlying the increased longevity in all three conditions.

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array, transformed count, 3 genotype/variation, 3 protocol sets

Platform:: GPL200
Series:: GSE54024
13 Samples

Download data: CEL

DataSet

Accession:: GDS5193

ID:: 5193

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 20016850212.

CEST-2.2 stimulates lipid metabolism and promotes longevity in mitochondrial mutant animals

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Caenorhabditis elegans

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL19757
19 Samples

Download data: BW, TSV

Series

Accession:: GSE168502

ID:: 200168502

PubMed Full text in PMC Similar studies

Select item 20016850113.

CEST-2.2 stimulates lipid metabolism and promotes longevity in mitochondrial mutant animals (RNA-Seq)

(Submitter supplied) Intestine-specific transcriptome of wild-type. gas-1(fc21) and gas-1(fc21); cest-2.2 OE Caenorhaditis elegans in order to gain insight into how cest-2.2 overexpression ameliorates Complex I deficiency

Organism:: Caenorhabditis elegans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19757
15 Samples

Download data: FA, TSV, TXT, XLSX

Series

Accession:: GSE168501

ID:: 200168501

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20016850014.

CEST-2.2 stimulates lipid metabolism and promotes longevity in mitochondrial mutant animals (ChIP-Seq)

(Submitter supplied) ChIP-Seq of H3.3 loading on promoters of genes in short-lived and long-lived mitochondrial mutant nematodes identifies genes which could potentially regulate longevity

Organism:: Caenorhabditis elegans

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL19757
4 Samples

Download data: BW

Series

Accession:: GSE168500

ID:: 200168500

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20000176215.

C. elegans daf2 mutant adults

(Submitter supplied) Analysis of gene expression in long-lived daf-2 mutants for the insulin/IGF-1 receptor. daf-2(e1370) and daf-2(m577) alleles each examined as single and as double mutations with the daf-16(df50) allele. DAF-2 regulates DAF-16, a transcription factor. Results provide insight into longevity. Keywords: other

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array

Dataset:: GDS770
Platform:: GPL200
20 Samples

Download data

Series

Accession:: GSE1762

ID:: 200001762

Select item 77016.

Long-lived daf-2 insulin/IGF-1 receptor mutant expression profiling

Analysis of gene expression in long-lived daf-2 mutants for the insulin/IGF-1 receptor. daf-2(e1370) and daf-2(m577) alleles each examined as single and as double mutations with the daf-16(df50) allele. DAF-2 regulates DAF-16, a transcription factor. Results provide insight into longevity.

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array, transformed count, 4 genotype/variation sets

Platform:: GPL200
Series:: GSE1762
20 Samples

Download data

DataSet

Accession:: GDS770

ID:: 770

Select item 20009857617.

Global transcriptional responce in C.elegans on a high glucose diet

(Submitter supplied) We compared differential gene expression in C. elegans on a regular and 2% glucose supplemented diet.

Organism:: Caenorhabditis elegans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19757
6 Samples

Download data: DIFF, FPKM_TRACKING

Series

Accession:: GSE98576

ID:: 200098576

PubMed Full text in PMC Similar studies

Select item 20004298618.

Transcriptome profiling in human primary mitochondrial respiratory chain disease

(Submitter supplied) Primary mitochondrial respiratory chain (RC) diseases are heterogeneous in etiology and manifestations but collectively impair cellular energy metabolism. To identify a common cellular response to RC disease, systems biology level transcriptome investigations were performed in human RC disease skeletal muscle and fibroblasts. Global transcriptional and post-transcriptional dysregulation in a tissue-specific fashion was identified across diverse RC complex and genetic etiologies. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL16240
53 Samples

Download data: CEL

Series

Accession:: GSE42986

ID:: 200042986

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20022749919.

SIN3 acts in distinct complexes to regulate the germline transcriptional program in C. elegans

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Caenorhabditis elegans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL22765
14 Samples

Download data: TSV

Series

Accession:: GSE227499

ID:: 200227499

PubMed Full text in PMC Similar studies

Select item 20022749820.

SIN3 acts in distinct complexes to regulate the germline transcriptional program in C. elegans [sin-3(tm1276)]

(Submitter supplied) The SIN3 transcriptional coregulator influences gene expression through multiple interactions that include histone deacetylases (HDACs). Haploinsufficiency and mutations in SIN3 are the underlying cause of Witteveen-Kolk syndrome and related intellectual disability (ID)/autism syndromes, emphasizing its key role in development. However, little is know on its complexity of interactions and functions in developmental processes. more...

Organism:: Caenorhabditis elegans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL22765
6 Samples

Download data: CSV, TSV

Series

Accession:: GSE227498

ID:: 200227498

PubMed Full text in PMC Similar studies

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