GEO DataSets

Analysis of GM5659 skin fibroblasts treated with ascorbic acid or the stable vitamin C derivative, ascorbic acid 2-phosphate. Vitamin C is an important water-soluble free radical scavenger and an essential cofactor for collagen synthesis by dermal fibroblasts.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 3 agent sets

Platform:

GPL570

Series:

GSE11919

9 Samples

Download data: CEL

(Submitter supplied) The skin is a protective barrier against external insults and any lesion must be rapidly and efficiently repaired. Dermal fibroblasts are the major source of extracellular connective tissue matrix and play an important role in wound healing. Vitamin C is an important water-soluble free radical scavenger and an essential cofactor for collagen synthesis by dermal fibroblasts and, consequently, may contribute to the maintenance of healthy skin. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3635

Platform:

GPL570

9 Samples

Download data: CEL

(Submitter supplied) In order to test the hypothesis that fibroblasts from different tissues are phenotypically distinct from one another, we have subjected tendon, skin and corneal fibroblasts of fetal mouse to mechanical stimulation by fluid flow and analyzed the transcriptional responses of the cells using Affymetrix MOE430 chip set containing two arrays MOE430A and MOE430B. Keywords: cell type comparison, stress response

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS1500 GDS1501

Platforms:

GPL339 GPL340

36 Samples

Download data: CEL, EXP

Expression profiling of fetal fibroblasts from tendon, skin, and cornea following mechanical stimulation by fluid flow. Fibroblasts isolated from embryos at 19 days post conception. Results provide insight into differences among fibroblasts from different tissues and response to linear shear stress.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 3 cell line, 2 stress sets

Platform:

GPL340

Series:

GSE3486

18 Samples

Download data: CEL, EXP

Expression profiling of fetal fibroblasts from tendon, skin, and cornea following mechanical stimulation by fluid flow. Fibroblasts isolated from embryos at 19 days post conception. Results provide insight into differences among fibroblasts from different tissues and response to linear shear stress.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 3 cell line, 2 stress sets

Platform:

GPL339

Series:

GSE3486

18 Samples

Download data: CEL, EXP

(Submitter supplied) Wound healing within the oral mucosa results in minimal scar formation compared to wounds within the skin. We have recently demonstrated distinct differences in the ageing profiles of cells (oral mucosal and patient-matched skin fibroblasts) isolated from these tissues. We hypothesize that the increased replicative potential of oral mucosal fibroblasts may confer upon them preferential wound healing capacities. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3856

Platform:

GPL96

15 Samples

Download data: CEL, CHP

Temporal analysis of oral mucosal (OM) fibroblasts and patient-matched skin fibroblasts following serum starvation/induction. OM fibroblasts exhibit a preferential wound-healing response compared to that of dermis. Results provide insight into molecular basis of OM fibroblast wound healing response.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 cell type, 4 individual, 2 protocol, 2 time sets

Platform:

GPL96

Series:

GSE21648

15 Samples

Download data: CEL, CHP

(Submitter supplied) Responses of the Human Airway Epithelium Transcriptome to In Vivo Injury To identify genes participating in repair of the human airway epithelium following injury, we used bronchoscopy and brushing to denude the airway epithelium of healthy individuals, sequentially sampled the same region 7 and 14 days later, and assessed the recovered epithelium for relative levels of gene expression using Affymetrix high-density oligonucleotide microarrays with TaqMan PCR confirmation. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS2495

Platform:

GPL570

22 Samples

Download data: CEL

Analysis of airway epithelia from healthy individuals 7 and 14 days following injury by epithelial denudation. Results provide insight into the molecular mechanisms underlying airway epithelial repair.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 9 individual, 2 other, 2 stress, 3 time sets

Platform:

GPL570

Series:

GSE5372

22 Samples

Download data: CEL

(Submitter supplied) Clone (Whirly) of human BJhTERT (human foreskin cell line) cells exposed to PC3 mRFP cells

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL11532

2 Samples

Download data: CEL

(Submitter supplied) In order to gain insight into the molecular pathogenesis of collagen VI defects we have performed gene expression microarray analysis of dermal fibroblasts. We have compared the transcriptome of fibroblasts, treated or untreated with ascorbic acid, from UCMD patients (n = 6) and aged-matched healthy children (n = 5).

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL13667

23 Samples

Download data: CEL

(Submitter supplied) The present study reports the temporal transcriptional response of THP-1 cells to physiological levels (100 μM) of vit C treatment. An extensive modulation of gene expression occurs from early to late time-points, which is reflected in a gamut of functional responses regulated by vit C, as determined by enrichment analysis. The study reveals the pleiotropic activity of vit C with diverse implications on biological processes. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL13252

19 Samples

Download data: TXT

(Submitter supplied) Fibroblasts synthesize the extracellular matrix of connective tissue and play an essential role in maintaining tissue integrity. We have previously shown that mouse skin connective tissue, the dermis, is comprised of functionally distinct fibroblast lineages. However, the extent of fibroblast heterogeneity in human skin is unknown. Here, using a combination of spatial transcriptional profiling of human and mouse dermis and single cell transcriptional profiling of human dermal fibroblasts, we show that there are at least four distinct fibroblast populations in adult human skin. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL16791 GPL11154

190 Samples

Download data: CSV

(Submitter supplied) Expression data from P2 mouse fibroblasts sorted for CD26, Sca1 and Dlk1. We have sorted mouse fibroblasts using the different lineages markers In this dataset, we include 3 biological replicates for CD26+, Sca1+Dlk1-, Sca1+Dlk1+ and Sca1-Dlk1+, a total of 12 samples

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL16570

12 Samples

Download data: CEL

(Submitter supplied) The temporal program of gene expression during a model physiological response of human cells, the response of fibroblasts to serum, was explored with a complementary DNA microarray representing about 8600 different human genes. Genes could be clustered in groups on the basis of their temporal patterns of expression in this program. Many features of the transcriptional program appeared to be related to the physiology of wound repair suggesting that fibroblasts play a larger and richer role in this complex multicellular response than had previously been appreciated. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS85 GDS86

Platforms:

GPL169 GPL168

18 Samples

Download data

(Submitter supplied) The transcriptional program in the response of human fibroblasts to serum control group. This study is described more fully in Iyer VR, et al. 1999. Science 283:83-7 Keywords: other

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL169

2 Samples

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(Submitter supplied) The transcriptional program in the response of human fibroblasts to serum. Serum was added to fibroblasts in the presence of cycloheximide. This study is described more fully in Iyer VR, et al. 1999. Science 283:83-7 Keywords: time-course

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS145

Platform:

GPL169

4 Samples

Download data

(Submitter supplied) The transcriptional program in the response of human fibroblasts to serum. Serum was added to fibroblasts, and samples were taken. This study is described more fully in Iyer VR, et al. 1999. Science 283:83-7 Keywords: time-course

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL168 GPL169

12 Samples

Download data

Analysis of the transcriptional program in the response of human fibroblasts to serum. Serum added to fibroblasts in the presence of cycloheximide and samples taken at 0, 0.5, 2 and 4 hours.

Organism:

Homo sapiens

Type:

Expression profiling by array, log ratio, 4 time sets

Platform:

GPL169

Series:

GSE56

4 Samples

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Analysis of a temporal transcriptional program in the response of primary fibroblast cultures to serum. Samples taken at 15 minutes and 2 hours.

Organism:

Homo sapiens

Type:

Expression profiling by array, log ratio, 2 time sets

Platform:

GPL168

Series:

GSE58

2 Samples

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