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Links from GEO DataSets

Items: 20

1.
Full record GDS3787

CXC chemokine ligand 4 effect on monocyte-derived macrophages

Analysis of blood monocytes differentiated to macrophages (MP) with CXC Chemokine Ligand 4 (CXCL4) and macrophage colony-stimulation factor (M-CSF). In atherosclerotic arteries, monocytes differentiate to MPs in the presence of growth factors, such as M-CSF, and chemokines, such as CXCL4.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 agent sets
Platform:
GPL570
Series:
GSE20484
4 Samples
Download data: CEL
2.

CXCL4 induces a unique transcriptome in monocyte-derived macrophages

(Submitter supplied) Human blood monocytes were differentiated over six days with either 100 ng/ml M-CSF or 1 umol/l CXCL4 In atherosclerotic arteries, blood monocytes differentiate to macrophages in the presence of growth factors like macrophage colony-stimulation factor (MCSF) and chemokines like platelet factor 4 (CXCL4). To compare the gene expression signature of CXCL4-induced macrophages with MCSF-induced macrophages or macrophages polarized with IFN-γ/LPS (M1) or IL-4 (M2), we cultured primary human peripheral blood monocytes for six days. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS3787
Platform:
GPL570
4 Samples
Download data: CEL
Series
Accession:
GSE20484
ID:
200020484
3.

Expression Data from Macrophage Maturation and Polarization Experiment

(Submitter supplied) Monocytes were induced to mature to macrophages with M-CSF. Cells were then activated with Interferon gamma and LPS or IL-4.
Organism:
Homo sapiens
Type:
Expression profiling by array
Datasets:
GDS2429 GDS2430
Platforms:
GPL97 GPL96
30 Samples
Download data: CEL
Series
Accession:
GSE5099
ID:
200005099
4.
Full record GDS2430

Monocyte differentiation to macrophage and subsequent polarization (HG-U133B)

Analysis of monocytes (MCs) treated with M-CSF to induce differentiation into macrophages (MPs), and mature MPs treated with either IFN-gamma and LPS or IL-4 to induce polarization to M1 or M2 cells, respectively. Results provide insight into MC to MP differentiation and polarized activation.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 5 development stage sets
Platform:
GPL97
Series:
GSE5099
15 Samples
Download data: CEL
DataSet
Accession:
GDS2430
ID:
2430
5.
Full record GDS2429

Monocyte differentiation to macrophage and subsequent polarization (HG-U133A)

Analysis of monocytes (MCs) treated with M-CSF to induce differentiation into macrophages (MPs), and mature MPs treated with either IFN-gamma and LPS or IL-4 to induce polarization to M1 or M2 cells, respectively. Results provide insight into MC to MP differentiation and polarized activation.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 5 development stage sets
Platform:
GPL96
Series:
GSE5099
15 Samples
Download data: CEL
DataSet
Accession:
GDS2429
ID:
2429
6.

Expression Data From HCMV-Infected Human Monocytes Study 2

(Submitter supplied) Human cytomegalovirus induces a pro-inflammatory monocyte following infection. To begin to address how HCMV induces these rapid changes in infected monocytes, we examined the transcriptome of infected monocytes. Global transcriptional profiling using cDNA microarrays revealed a significant number of pro-inflammatory genes were upregulated within 4 hours post infection. Keywords: Disease State
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL8300
12 Samples
Download data: CEL, CHP
Series
Accession:
GSE11408
ID:
200011408
7.

Human monocyte-derived macrophages polarized by GM-CSF or M-CSF

(Submitter supplied) Identification of genes differentially expressed between human monocyte-macrophages generated in the presence of either GM-CSF (termed M1) or M-CSF (termed M2)
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL11010
6 Samples
Download data: TXT
Series
Accession:
GSE27792
ID:
200027792
8.

Homogeneous monocytes and macrophages from hES cells following coculture-free differentiation in M-CSF and IL-3.

(Submitter supplied) In the present study we aimed at producing homogeneous populations of monocytes and macrophages from human embryonic stem (hES) cells. Human embryonic stem cell lines KCL001, KCL002, and HUES-2 were differentiated into monocytes by coculture-free differentiation with two growth factors using a three-step method. The method involved embryoid body (EB) formation in hES media, directed differentiation with macrophage colony-stimulating factor and interleukin (IL)-3, and harvest of nonadherent monocytes from the culture supernatants. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6244
9 Samples
Download data: CEL
Series
Accession:
GSE15791
ID:
200015791
9.

Colony Stimulating Factor 1 (CSF-1) responses in human monocyte derived macrophages

(Submitter supplied) Although the role of macrophage colony stimulating factor (M-CSF/CSF-1) in homeostasis and disease processes has been studied extensively in mice, little is known of the impact of this cytokine on differentiated human macrophages. Here we show that, in contrast to its effects on mouse bone marrow-derived macrophages (BMM), CSF-1 did not induce expression of urokinase plasminogen activator mRNA, repress expression of apolipoprotein E mRNA, or prime LPS-induced TNF secretion in human monocyte-derived macrophages (HMDM) from several independent donors. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS3686
Platform:
GPL2507
6 Samples
Download data: TXT
Series
Accession:
GSE11061
ID:
200011061
10.
Full record GDS3686

Colony stimulating factor 1 effect on monocyte derived macrophage

Analysis of mature monocyte derived macrophages treated with colony stimulating factor 1 (CSF-1) in vitro for 6 hours. CSF-1 supports the proliferation and differentiation of monocytes and macrophages. Results provide insight into the effect of CSF-1 stimulation on mature monocytes.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 agent, 3 individual sets
Platform:
GPL2507
Series:
GSE11061
6 Samples
Download data: TXT
DataSet
Accession:
GDS3686
ID:
3686
11.

Inflammatory Expression Profiles in Monocyte to Macrophage Differentiation amongst Patients with Systemic Lupus Erythematosus and Healthy Controls with and without an Atherosclerosis Phenotype

(Submitter supplied) To examine mononuclear cell gene expression profiles in patients with and without SLE and subsets with and without atherosclerosis
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
72 Samples
Download data: TXT
Series
Accession:
GSE37356
ID:
200037356
12.

Transcriptional effects of IL-10 neutralization on LPS-activated M-CSF-derived macrophages

(Submitter supplied) Analysis of the role of IL-10 on the transcriptional signature of LPS-activated human M-CSF-dependent monocyte-derived macrophages. Methods: Human Peripheral Blood Mononuclear Cells (PBMC) were isolated from buffy coats from donors over a Lymphoprep gradient according to standard procedures. Monocytes were purified from PBMC by magnetic cell sorting using anti-CD14 microbeads (>95% CD14+ cells). Monocytes from three independent donors (0.5 x 106 cells/ml, >95% CD14+ cells) were cultured in RPMI 1640 supplemented with 10% fetal bovine serum (FBS) at 37°C in a humidified atmosphere with 5% CO2 and 21% O2 for 7 days in the presence of 1000 U/ml M-CSF, with cytokine addition every two days. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL23227
6 Samples
Download data: TXT
13.

Transcriptional effects of siRNA-mediated STAT3 knockdown on LPS-activated M-CSF-derived macrophages

(Submitter supplied) Analysis of the role of STAT3 on the transcriptional signature of LPS-activated human M-CSF-dependentmonocyte-derived macrophages. Methods: Human Peripheral Blood Mononuclear Cells (PBMC) were isolated from buffy coats from donors over a Lymphoprep gradient according to standard procedures.monocytes were purified from PBMC by magnetic cell sorting using anti-CD14 microbeads (>95% CD14+ cells).monocytes from three independent donors (0.5 x 106 cells/ml, >95% CD14+ cells) were cultured in RPMI 1640 supplemented with 10% fetal bovine serum (FBS) at 37°C in a humidified atmosphere with 5% CO2 and 21% O2 for 5 days in the presence of 1000 U/ml M-CSF, with cytokine addition every two days. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL23227
12 Samples
Download data: TXT
14.

Transcriptional effects of activation stimuli on M-CSF-derived macrophages

(Submitter supplied) Analysis of the effect of various activation stimuli on the transcriptional signature of human M-CSF-dependent monocyte-derived macrophages. Methods: Human Peripheral Blood Mononuclear Cells (PBMC) were isolated from buffy coats from donors over a Lymphoprep gradient according to standard procedures. Monocytes were purified from PBMC by magnetic cell sorting using anti-CD14 microbeads (>95% CD14+ cells). more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL23227
63 Samples
Download data: TXT
15.

MAPKs control the expression of a novel gene set that defines de activation of human anti-inflammatory macrophages

(Submitter supplied) LPS treatment is considered as the paradigmatic stimulus for acquisition of the classical macrophage polarization/activation state. However, this definition does not take into account the influence that other macrophage differentiating/priming factors might have on the LPS response. In spite of the pathophysiological relevance of the response of M-CSF-dependent anti-inflammatory human macrophages (M-MØ) to endogenous and pathogenic stimuli, detailed analysis of the gene signature of activated anti-inflammatory M-CSF-dependent macrophages remained to be determined. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13497
12 Samples
Download data: TXT
Series
Accession:
GSE99056
ID:
200099056
16.

Single cell RNA sequencing of aortic CX3CR1-derived monocyte/macrophage from atherosclerotic aorta during progression and regression

(Submitter supplied) In atherosclerosis progression and regression, monocytes or monocyte-derived macrophages are the major immune cells in the plaque. It is important to understand the fate and characteristics of monocyte/macrophage during the plaque progression and regression. To characterize the fate of monocytes/macrophages, we performed single cell RNA sequencing of fate-mapped aortic CX3CR1-derived monocytes/macrophages from Cx3cr1CreERT2-IRES-YFP/+Rosa26floxed-tdTomato/+ mice with AAV-PCSK9 injection and fed a Western Diet. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21103
2 Samples
Download data: MTX, TSV
Series
Accession:
GSE123587
ID:
200123587
17.

Mesenchymal stromal cells perturb human monocyte in vitro differentiation into dendritic cells

(Submitter supplied) Monocytes cultured in media containing GM-CSF and IL4 for 5 days normally differentiate into immature dendritic cells which, upon further stimulation with LPS for an additional 2 days, acquire a mature phenotype. In the present study, we evaluated the effect of human cord-blood mesenchymal stem cells (MSC) on human monocyte differentiation into immature and mature DCs by examining the trancriptional profile of the cells that were obtained after both the differentiation and maturation stages.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6480
18 Samples
Download data: TXT
Series
Accession:
GSE68962
ID:
200068962
18.

5hmC and m6a modification and Translatomes of monocytes and macrophages

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Other
Platforms:
GPL15456 GPL16791
52 Samples
Download data: BW, NARROWPEAK
Series
Accession:
GSE213207
ID:
200213207
19.

m6A modification of monocytes and macrophages

(Submitter supplied) RNA modifications are essential for the establishment of cellular identity. Although increasing evidence indicates that RNA modifications control the innate immune response, their role in monocyte-to-macrophage differentiation and polarisation is unclear. We profile m6A epitranscriptomes of monocytes and macrophages at resting, pro- and anti-inflammatory states.
Organism:
Homo sapiens
Type:
Other
Platform:
GPL16791
16 Samples
Download data: BW, NARROWPEAK
Series
Accession:
GSE213206
ID:
200213206
20.

Translatomes of monocytes and macrophages

(Submitter supplied) RNA modifications are essential for the establishment of cellular identity. Although increasing evidence indicates that RNA modifications control the innate immune response, their role in monocyte-to-macrophage differentiation and polarisation is unclear. We profile translatomes of monocytes and macrophages at resting, pro- and anti-inflammatory states.
Organism:
Homo sapiens
Type:
Other
Platform:
GPL16791
12 Samples
Download data: BW, TXT
Series
Accession:
GSE213204
ID:
200213204
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