GEO DataSets

Analysis of pancreatic islet cells deficient for the von Hippel-Lindau tumor suppressor protein from 18 to 26 wk-old animals. Loss of Vhlh in beta-cells leads to impaired glucose tolerance and to abnormal insulin secretion. Results provide insight into the role of Vhlh in pancreatic beta cells.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 age, 2 gender, 2 genotype/variation sets

Platform:

GPL1261

Series:

GSE11484

6 Samples

Download data: CEL, CHP

(Submitter supplied) Understanding the nature of the various glucose-derived signals for insulin secretion (both triggering and amplifying) is essential for gaining insight into the functional failure of the beta-cells in diabetes and the development of drugs for correcting this problem. The beta-cells uniquely couple changes in cellular metabolism to electrical activity and thus insulin release. In mice, beta-cell specific deletion of the von Hippel-Lindau (VHL) tumor suppressor protein leads to the activation of a HIF transcription program that includes genes involved in glycolysis, suppression of mitochondrial activity and lactate production. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3800

Platform:

GPL1261

6 Samples

Download data: CEL, CHP

(Submitter supplied) To unravel the potential cooperative roles of oxygen-regulated signaling pathways; von Hippel-Lindau (VHL) tumor suppressor protein and hypoxia-inducible factor (HIF) transcription factors, we have generated mutant mice with; Vhlh, Vhlh/Hif1α, Vhlh/Hif2α and Vhlh/Hif1α/Hif2α gene alleles floxed. Subsequently primary kidney cells were isolated, cultured and infected with Adenoviruses bearing either Cre/GFP or GFP expression only. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL10333

13 Samples

Download data: TXT