GEO DataSets

Temporal analysis of microdissected distal nephron convoluted/connecting tubules (DCT/CNT) or cortical collecting ducts (CCD). Renal excretion of water and major electrolytes exhibits a significant circadian rhythm. Results provide insight into the role of molecular clock in renal function.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 6 time, 2 tissue sets

Platform:

GPL1261

Series:

GSE17739

24 Samples

Download data: CEL

(Submitter supplied) Renal excretion of water and major electrolytes exhibits a significant circadian rhythm. This functional periodicity is believed to result, at least in part, from circadian changes in secretion/reabsorption capacities of the distal nephron and collecting ducts. Here, we studied the molecular mechanisms underlying circadian rhythms in the distal nephron segments, i.e. distal convoluted tubule (DCT) and connecting tubule (CNT) and, the cortical collecting duct (CCD). more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4023

Platform:

GPL1261

24 Samples

Download data: CEL

(Submitter supplied) Investigation of RNA transcript abundance in aortic tissue of BMAL-/- versus BMAL+/+ control mice at ZT14 Keywords: Differential RNA abundance in genetic mutant

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

9 Samples

Download data

(Submitter supplied) Investigation of RNA transcript abundance in aortic tissue of NPAS2 mutant versus wild type mice at ZT14 Keywords: Differential RNA abundance in genetic mutant

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

10 Samples

Download data

(Submitter supplied) Molecular analysis of circadian rhythm in mice. Liver tissue of wildtype, Clock mutant and Cry deficient C57BL/6 8- to 10-week-old male mice examined. Keywords = circadian rhythm Keywords: other

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS413

Platform:

GPL81

6 Samples

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Identification of CLOCK and CRY-regulated genes expressed in circadian manner in liver. Wild-type, Clock mutant and Cry-deficient C57BL/6 8-10 week old male mice examined at circadian times (CT) 14 and 2.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 strain, 2 time sets

Platform:

GPL81

Series:

GSE454

6 Samples

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(Submitter supplied) A cardinal symptom of Major Depressive Disorder (MDD) is the disruption of circadian patterns. Yet, to date, there is no direct evidence of circadian clock dysregulation in the brains of MDD patients. Circadian rhythmicity of gene expression has been observed in animals and peripheral human tissues, but its presence and variability in the human brain was difficult to characterize. Here we applied time-of-death analysis to gene expression data from high-quality postmortem brains, examining 24-hour cyclic patterns in six cortical and limbic regions of 55 subjects with no history of psychiatric or neurological illnesses ('Controls') and 34 MDD patients. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17027

670 Samples

Download data: CEL

(Submitter supplied) In diabetes, the kidney contributes to the development of diabetic hyperglycemia by increasing glucose reabsorption from the primary urine and by upregulating gluconeogenesis in the proximal tubule. However, these two processes are also controlled by the circadian clock, a mechanism that synchronizes a large number of specific renal functions with environmental daily cycles. Here, we investigated the (patho)physiological role of intrinsic renal tubule circadian clocks in the diabetic kidney. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17021

36 Samples

Download data: TXT

(Submitter supplied) Hair follicles undergo recurrent cycling of controlled growth (anagen), regression (catagen), and relative quiescence (telogen) with a defined periodicity. Taking a genomics approach to study gene expression during synchronized mouse hair follicle cycling, we discovered that, in addition to circadian fluctuation, CLOCK-regulated genes are also modulated in phase with the hair growth cycle. During telogen and early anagen, circadian clock genes are prominently expressed in the secondary hair germ, which contains precursor cells for the growing follicle. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6246

6 Samples

Download data: CEL, CHP

(Submitter supplied) Hair follicles undergo recurrent cycling of controlled growth (anagen), regression (catagen), and relative quiescence (telogen) with a defined periodicity. Taking a genomics approach to study gene expression during synchronized mouse hair follicle cycling, we discovered that, in addition to circadian fluctuation, CLOCK-regulated genes are also modulated in phase with the hair growth cycle. During telogen and early anagen, circadian clock genes are prominently expressed in the secondary hair germ, which contains precursor cells for the growing follicle. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

5 Samples

Download data: CEL, CHP

(Submitter supplied) Hair follicles undergo recurrent cycling of controlled growth (anagen), regression (catagen), and relative quiescence (telogen) with a defined periodicity. Taking a genomics approach to study gene expression during synchronized mouse hair follicle cycling, we discovered that, in addition to circadian fluctuation, CLOCK-regulated genes are also modulated in phase with the hair growth cycle. During telogen and early anagen, circadian clock genes are prominently expressed in the secondary hair germ, which contains precursor cells for the growing follicle. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

33 Samples

Download data: CEL

(Submitter supplied) One hundred ninety wildtype male C57BL/6J mice age 7-10 weeks were purchased from Jackson Laboratory and entrained to a 12:12 light:dark cycle for 2 weeks. Mice were placed in light-tight boxes on a 12:12 LD cycle for 4 weeks, then released into constant darkness. Starting 30 hours after entry into DD (CT18), tissues from 5 (skeletal muscle) or 10 (liver or SCN) wildtype mice were collected every 4 hours for 48 hours, for a total of 12 timepoints. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1073

76 Samples

Download data: CEL

(Submitter supplied) One hundred ninety wildtype male C57BL/6J mice age 7-10 weeks were purchased from Jackson Laboratory and entrained to a 12:12 light:dark cycle for 2 weeks. Mice were placed in light-tight boxes on a 12:12 LD cycle for 4 weeks, then released into constant darkness. Starting 30 hours after entry into DD (CT18), tissues from 5 (skeletal muscle) or 10 (liver or SCN) wildtype mice were collected every 4 hours for 48 hours, for a total of 12 timepoints. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1073

38 Samples

Download data: CEL

(Submitter supplied) One hundred ninety wildtype male C57BL/6J mice age 7-10 weeks were purchased from Jackson Laboratory and entrained to a 12:12 light:dark cycle for 2 weeks. Mice were placed in light-tight boxes on a 12:12 LD cycle for 4 weeks, then released into constant darkness. Starting 30 hours after entry into DD (CT18), the left leg muscle from 5 wildtype mice, and the right leg muscle from the same wildtype mice were collected every 4 hours for 48 hours, for a total of 12 timepoints. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1073

38 Samples

Download data: CEL

(Submitter supplied) The oscillation status of the circadian clock during late gestation is not clear. To gain a better understanding on the oscillation state of the clock and possible influences by maternal cues, we performed transcriptome analyses on the fetal liver tissue during late gestation. Fetal liver transcriptome data were analyzed and compared to adult mouse data in the public database: GSE11923 and GSE13093 (only samples GSM327130 to GSM327141). more...

Organism:

Mus musculus

Type:

Expression profiling by array; Third-party reanalysis

Platform:

GPL8321

24 Samples

Download data: CEL, TXT

(Submitter supplied) The aim of the current study is to create a transcriptional profile of genes regulated by the circadian gene NPAS2, using a human binding ChIP-on-chip analysis of NPAS2 in MCF-7 cells.

Organism:

Homo sapiens

Type:

Genome binding/occupancy profiling by array

Platforms:

GPL4125 GPL4124

4 Samples

Download data

(Submitter supplied) High-temporal resolution profiling was performed on U2OS fibroblasts to detect rhythmic transcripts Keywords: time course

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6244

48 Samples

Download data: CEL, CHP

(Submitter supplied) We report differential gene expression analysis of brain tissue (dorsal hippocampus) in adult mice over-expressing mouse hepatic leukemia factor (AAV-2/8-hSyn1-mHLf) in dentate gyrus neurons.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21103

14 Samples

Download data: CSV

(Submitter supplied) This dataset constitutes the first RNA-Seq study of gene expression following sleep deprivation in wildtype and Shank3 exon 21 mutant mice

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17021

20 Samples

Download data: BEDGRAPH, TXT

(Submitter supplied) The mammalian circadian clock system is made up of individual cell and tissue clocks that function as a coherent network, however it remains unclear which rhythmic functions of the liver clock are autonomous or rely on clocks in other tissues. Here, using mice which only have a functioning liver clock, we investigate the autonomous vs non-autonomous reatures of the liver clock and diurnal rhythmicity in the liver

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17021

54 Samples

Download data: TSV