Similar studies for GEO DataSets (Select 4794) - GEO DataSets

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Items: 20

Select item 47941.

Analysis of 23 clinical small cell lung cancer (SCLC) samples from patients undergoing pulmonary resection and 42 normal tissue samples including the lung. SCLC is a lung cancer subtype with poor prognosis. Results provide insight into the molecular mechanisms underlying SCLC.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 disease state, 43 tissue sets

Platform:: GPL570
Series:: GSE43346
65 Samples

Download data: CEL

DataSet

Accession:: GDS4794

ID:: 4794

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000993162.

Gene repression and ChIP-seq in Human Small Cell Lung Cancer

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

4 related Platforms
75 Samples

Download data: BED, CEL

Series

Accession:: GSE99316

ID:: 200099316

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000993123.

PRC2 overexpression and PRC2-target gene repression relating to poorer prognosis in small cell lung cancer

(Submitter supplied) Small cell lung cancer (SCLC) is a subtype of lung cancer with poor prognosis. Expression array analysis of 23 SCLC cases and 42 normal tissues revealed that EZH2 and other PRC2 members were highly expressed in SCLC. ChIP-seq for H3K27me3 suggested that genes with H3K27me3(+) in SCLC were extended not only to PRC2-target genes in ES cells but also to other target genes such as cellular adhesion-related genes. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL10999
5 Samples

Download data: BED

Series

Accession:: GSE99312

ID:: 200099312

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000433464.

Gene repression with H3K27me3 modification in human small cell lung cancer

(Submitter supplied) Small cell lung cancer (SCLC) is a subtype of lung cancer with poor prognosis due to early dissemination and rapid growth. We here analyze gene expression profile of 23 clinical SCLC samples. EZH2 was found to be highly expressed in SCLC samples compared to 42 normal tissues including the normal lung, and other PRC2 members, SUZ12 and EED, were also highly expressed in SCLC. To obtain target genes of PRC2 in SCLC, H3K27me3 mark was mapped in three SCLC cell lines, Lu130, H209 and DMS53, and compared to normal small airway epithelial cells (SAEC). more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4794
Platforms:: GPL96 GPL97 GPL570
70 Samples

Download data: CEL

Series

Accession:: GSE43346

ID:: 200043346

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000412395.

Gene expression profiling of two DLBCL cell lines upon shRNA mediated knockdown of EZH2

(Submitter supplied) We studied transcriptional changes by Affymetrix human microarrays in 2 DLBCL cell lines as a result of shRNA mediated knockdown of EZH2. In eukaryotes, epigenetic post-translational modification of histones is critical for regulation of chromatin structure and gene expression. EZH2 is the catalytic subunit of the Polycomb Repressive Complex 2 (PRC2) and is responsible for repressing target gene expression through methylation of histone H3 on lysine 27 (H3K27). more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
6 Samples

Download data: CEL

Series

Accession:: GSE41239

ID:: 200041239

Select item 2000409726.

EZH2 Inhibition as a Therapeutic Strategy for Lymphoma with EZH2 Activating Mutations

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by array

Platforms:: GPL570 GPL9115
52 Samples

Download data: BED, CEL

Series

Accession:: GSE40972

ID:: 200040972

Select item 2000409717.

Gene expression profiling of EZH2 mutant and wild type DLBCL cell lines treated with EZH2 inhibitor

(Submitter supplied) We studied transcriptional changes by Affymetrix human microarrays in DLBCL cell lines as a result of treatment with GSK126, a potent, highly-selective, SAM-competitive, small molecule inhibitor of EZH2 In eukaryotes, epigenetic post-translational modification of histones is critical for regulation of chromatin structure and gene expression. EZH2 is the catalytic subunit of the Polycomb Repressive Complex 2 (PRC2) and is responsible for repressing target gene expression through methylation of histone H3 on lysine 27 (H3K27). more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
40 Samples

Download data: CEL

Series

Accession:: GSE40971

ID:: 200040971

Select item 2000409708.

ChIP-seq analysis of H3K27me3 histone modification in EZH2 mutant and wild type DLBCL cell lines

(Submitter supplied) In eukaryotes, epigenetic post-translational modification of histones is critical for regulation of chromatin structure and gene expression. EZH2 is the catalytic subunit of the Polycomb Repressive Complex 2 (PRC2) and is responsible for repressing target gene expression through methylation of histone H3 on lysine 27 (H3K27). Over-expression of EZH2 is implicated in tumorigenesis and correlates with poor prognosis in multiple tumor types. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL9115
6 Samples

Download data: BED

Series

Accession:: GSE40970

ID:: 200040970

PubMed Similar studies SRA Run Selector

Select item 2000303159.

DMSO control and DZNep treated MOLM-14 cells

(Submitter supplied) We demonstrated that 3-Deazaneplanocin A (DZNep), a histone methyltransferase inhibitor, induce robust apoptosis in AML cells through increased ROS production and ER stress. We identified a core gene signature including TXNIP, a major redox control molecule which is crucial in DZNep-induced apoptosis.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
4 Samples

Download data: CEL

Series

Accession:: GSE30315

ID:: 200030315

Select item 20005661710.

Dynamics of Genomic H3K27me3 Domains and Role of EZH2 during Pancreatic Endocrine Specification

(Submitter supplied) Endoderm cells undergo a sequence of fate choices to generate insulin-secreting β cells. Studies of chromatin transitions during this process have been limited to the pancreatic progenitor stage that can be reconstituted from stem cells in vitro, with a gap in understanding the induction of endocrine cells. To address this, we established conditions for isolating endoderm cells, pancreatic progenitors, and endocrine cells from different staged embryos and performed genome wide analysis of the H3K27me3 mark of the repressive Polycomb complex. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL14602
10 Samples

Download data: BED, BW, XLSX

Series

Accession:: GSE56617

ID:: 200056617

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20003143311.

Gene expression change in Skov3 after EZH2 knockdown

(Submitter supplied) To identify genes whose expression was suppressed by EZH2, we performed gene expression microarray analysis in control and EZH2 knockdown human SKOV3 EOC cells. Two individual short hairpin RNAs to the human EZH2 gene (shEZH2) were used to limit potential off-target effects.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6480
9 Samples

Download data: TXT

Series

Accession:: GSE31433

ID:: 200031433

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20004161012.

mRNA expression after siRNA-mediated knock down of Enhancer of zeste homolog 2 (Ezh2) in human umbilical vein endothelial cells

(Submitter supplied) mRNA expression after Ezh2 knock down was analyzed to identify genes regulated by Ezh2.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6480
3 Samples

Download data: TXT

Series

Accession:: GSE41610

ID:: 200041610

Select item 20013986813.

TTF-1/NKX2-1 and ASCL1 binding regions in NCI-H209 and NKX2-1 binding regions in NCI-H441, replicate 2

(Submitter supplied) Although Thyroid transcription factor-1 (TTF-1, encoded by NKX2-1 gene) is highly expressed in small cell lung carcinoma (SCLC) and lung adenocarcinoma (LADC), difference in the functional roles of TTF-1 between SCLC and LADC remains to be elucidated. The aim of this study was to clarify the differences in the TTF-1 binding regions and functional roles in SCLC and LADC. Employing chromatin immunoprecipitation-sequencing (ChIP-seq) , here we compared the genome-wide TTF-1-binding profiles and the TTF-1-mediated transcriptional programs in a SCLC and a LADC cell lines. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17303
5 Samples

Download data: BED, BW

Series

Accession:: GSE139868

ID:: 200139868

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20012934114.

Comparative Analysis of TTF-1 Binding DNA Regions in Small Cell Lung Cancer and Non-Small Cell Lung Cancer

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17303
17 Samples

Download data: BED, BW

Series

Accession:: GSE129341

ID:: 200129341

PubMed Full text in PMC Similar studies

Select item 20012934015.

RNA-seq transcriptome analysis in NCI-H209 and NCI-H441 cells transfected with TTF-1/NKX2-1 or ASCL1 siRNAs.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17303
9 Samples

Download data: BW, FPKM_TRACKING

Series

Accession:: GSE129340

ID:: 200129340

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20012931216.

TTF-1/NKX2-1 and ASCL1 binding regions in a small cell lung carcinoma cell line, NCI-H209

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17303
3 Samples

Download data: BED, BW

Series

Accession:: GSE129312

ID:: 200129312

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20012317417.

EZH2 Variants Differentially Regulate Polycomb Repressive Complex 2 in Histone Methylation and Cell Differentiation

(Submitter supplied) Background: Polycomb repressive complex 2 (PRC2) is responsible for establishing and maintaining histone H3K27 methylation during cell differentiation and proliferation. H3K27 can be mono-, di-, or tri-methylated, resulting in differential gene regulation. However, it remains unknown how PRC2 specifies the degree and biological effects of H3K27 methylation within a given cellular context. One way to determine PRC2 specificity may be through alternative splicing of Ezh2, PRC2’s catalytic subunit, during cell differentiation and tissue maturation. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL13112
10 Samples

Download data: BED, BROADPEAK, TXT

Series

Accession:: GSE123174

ID:: 200123174

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20006157718.

Bap1 loss results in EZH2 dependent transformation

(Submitter supplied) Analysis of sorted granulocyte macrophage progenitors (GMPs) in control and Bap1-deficient bone marrow cells. Loss of Bap1 in the hematopoietic compartments results in an MDS-like disease. These data allow for the examination of the genetic underpinnings of Bap1 loss in disease.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18635
6 Samples

Download data: TXT

Series

Accession:: GSE61577

ID:: 200061577

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20006136019.

Bap1 loss results in EZH2 dependent transformation

(Submitter supplied) BAP1 and ASXL1 interact to form a polycomb deubiquitinase complex that removes monoubiquitin from histone H2A lysine 119 (H2AK119Ub). However, BAP1 and ASXL1 are mutated in distinct cancer types, consistent with independent roles in regulating epigenetic state and malignant transformation. Here we demonstrate that Bap1 loss results in increased trimethylated histone H3 lysine 27 (H3K27me3), elevated Ezh2 expression, and enhanced repression of Polycomb Repressive Complex 2 (PRC2) targets. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL13112
11 Samples

Download data: BW

Series

Accession:: GSE61360

ID:: 200061360

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20009272320.

Transcriptome analysis for KDM6A mutated urothelial bladder carcinoma and EZH2 inhibitor treated KDM6A mutated urothelial bladder carcinoma

(Submitter supplied) Purpose: The goals of this study are to compare 1. The transcription profile in KDM6A wildtype and KDM6A mutated urothelial bladder carcinoma. 2. The transcriptional changes in KDM6A mutated urothelial bladder carcinoma upon EZH2 inhibitor treatment.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
50 Samples

Download data: TXT

Series

Accession:: GSE92723

ID:: 200092723

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