Similar studies for GEO DataSets (Select 5289) - GEO DataSets

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Items: 17

Select item 52891.

Lung eosinophil response to allergen challenge

Analysis of lung eosinophils of sensitized animals exposed intranasally to ovalbumin to induce eosinophilia. Eosinophilia, higher than normal eosinophil count, is a feature of allergic asthma. Results provide insight into the molecular response of eosinophils to allergen challenge.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 2 agent sets

Platform:: GPL6246
Series:: GSE57757
7 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS5289

ID:: 5289

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000577572.

Expression profiles of sorted murine lung Eosinophils following allergen challenge

(Submitter supplied) The eosinophil transcriptome analysis indicated a robust transcription change in eosinophils following allergen challenge in the lung.

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS5289
Platform:: GPL6246
7 Samples

Download data: CEL, CHP, TXT

Series

Accession:: GSE57757

ID:: 200057757

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2002204533.

Eosinophils promote effector functions of lung ILC2s in allergic airway inflammation in mice

(Submitter supplied) We investigated reciprocal interactions between cocultures of isolated populations of eosinophils and ILC2s and found these cells promote changes in gene expression as compared to being cultured alone.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
12 Samples

Download data: TXT

Series

Accession:: GSE220453

ID:: 200220453

PubMed Full text in PMC Similar studies

Select item 2000154294.

Expression of survivin in lung eosinophils is associated with pathology in a mouse model of allergic asthma

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array

Platforms:: GPL3069 GPL8331
20 Samples

Download data: SPOT

Series

Accession:: GSE15429

ID:: 200015429

Select item 2000154145.

Expression of survivin in lung eosinophils is associated with pathology in a mouse model of allergic asthma 2

(Submitter supplied) Humans vary markedly in their propensity to develop asthma, despite often being exposed to similar environmental stimuli. Similarly, mouse strains vary in susceptibility to airways pathology in experimental asthma. Sensitization and aerosol challenge with ovalbumin (OVA) induces eosinophil accumulation, mucus production and airways obstruction in BALB/c and C57BL/6 mice. In contrast, CBA/Ca mice show relatively little pathology. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL8331
8 Samples

Download data: SPOT

Series

Accession:: GSE15414

ID:: 200015414

Select item 2000153456.

Expression of survivin in lung eosinophils is associated with pathology in a mouse model of allergic asthma 1

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL3069
12 Samples

Download data: SPOT

Series

Accession:: GSE15345

ID:: 200015345

Select item 2000462387.

Sputum cell gene expression following allergen challenge

(Submitter supplied) Sputum cells collected before (visit 2) and after (visit 4) allergen challenge in asthma patients were isolated and RNA purified for analysis on gene expression arrays. Human subject recruitment part of NIH sponsored protocol as part of the Eosinophil Program Project Grant (PI: Dr. Nizar Jarjour)

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL14550
12 Samples

Download data: TXT

Series

Accession:: GSE46238

ID:: 200046238

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000461598.

Segmental Allergen Challenge Regulates Gene Expression In Bronchoalveolar Lavage (BAL) Cells From Atopic and Mild Asthmatic Subjects

(Submitter supplied) Segmental allergen challenge increases the percentage of eosinophils in bronchoalveolar lavage (BAL) cells. Mepolizumab, an anti-IL-5 therapeutic antibody, decreases the number of eosinophils in bronchoalveolar lavages (BAL). The use of both procedures allows to define genes that are either expressed by eosinophils or dependent on eosinophil presence in the airways.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
8 Samples

Download data: CEL

Series

Accession:: GSE46159

ID:: 200046159

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001503479.

Lung eosinophil RNA-Seq for P2ry14-deficient and wild-type mice

(Submitter supplied) Transcriptome analysis of P2ry14-sufficient and P2ry14-deficient mouse lung eosinophils in protease model of asthma.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
10 Samples

Download data: BIGWIG, TXT

Series

Accession:: GSE150347

ID:: 200150347

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20005629210.

Expression profiling by high throughput sequencing

(Submitter supplied) Innate immune cells control acute eosinophilic lung inflammation induced by cystein proteases. Here we characterize the dynamic change of gene expression profile in basophils, natural helper cells and eosinophils during lung inflammation via cystein protease

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18480
15 Samples

Download data: TXT

Series

Accession:: GSE56292

ID:: 200056292

PubMed Similar studies SRA Run Selector

Select item 20011201011.

Transcriptional profiling of eosinophil subsets in Interleukin-5 transgenic mice

(Submitter supplied) Eosinophils are important in fighting parasitic infections and are implicated in the pathogenesis of asthma and allergy. Interleukin-5 (IL-5) is a critical regulator of eosinophil development, controlling proliferation, differentiation and maturation of the lineage. Mice that constitutively express IL-5 have more than 10 fold more eosinophils in the haematopoietic organs than their wild type counterparts. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platforms:: GPL6105 GPL6887
32 Samples

Download data: TXT

Series

Accession:: GSE112010

ID:: 200112010

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20012432512.

Epithelial Vegfa specifies a distinct endothelial population in the mouse lung

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
15 Samples

Download data: CLOUPE

Series

Accession:: GSE124325

ID:: 200124325

PubMed Full text in PMC Similar studies

Select item 20012432413.

Epithelial Vegfa specifies a distinct endothelial population in the mouse lung [bulk RNA-seq]

(Submitter supplied) The lung microvasculature is essential for gas exchange and commonly considered homogeneous. We show that Vascular endothelial growth factor A (Vegfa) from the epithelium specifies a distinct endothelial cell (EC) population in the postnatal mouse lung. Vegfa is predominantly expressed by alveolar type 1 (AT1) cells and locally required to specify a subset of ECs. Single cell RNA-seq identified 15~20% lung ECs as transcriptionally distinct and marked by Carbonic anhydrase 4 (Car4), which are specifically lost upon epithelial Vegfa deletion. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
6 Samples

Download data: XLSX

Series

Accession:: GSE124324

ID:: 200124324

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20012432314.

Epithelial Vegfa specifies a distinct endothelial population in the mouse lung [scRNA-seq]

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
9 Samples

Download data: CLOUPE

Series

Accession:: GSE124323

ID:: 200124323

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20018921315.

Transcriptional profiling of mouse eosinophils identifies distinct gene signatures following cellular activation

(Submitter supplied) Purpose: we aimed to characterized the transcriptional profile of mouse eosinophils in response to stimuli that are associated with Type 1 and Type 2 environments Methods: Eosinophils were purified from the peritoneal cavity of Il5Tg mice and stimulated with IL-4 (i.e. type 2 activated eosinophils), IFN-γ, and a combination of lipopolysaccharide (LPS, i.e. type 1 activated eosinophils) in the presence of IFN-γ. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21626
18 Samples

Download data: TSV

Series

Accession:: GSE189213

ID:: 200189213

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20020322516.

Mouse resident lung eosinophils are dependent on IL-5

(Submitter supplied) Purpose: we aimed to characterized eosinophils in the murine model of asthma Methods: Eosinophils were sorted from the lung of naïve and and HDM-induced asthma mice. There after RNA was extracted from the sorted eosinophils and subjected to RNAseq. Results:we demonstrated that resident lung eosinophils require IL-5 for their survival and that the expression of Siglec-F, is regulated by IL-5 . Conclusion: Our data suggest that the distinct eosinophil populations in the asthmatic lung represent a continuum of activation states rather than distinct eosinophil subsets.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL30172
8 Samples

Download data: TXT

Series

Accession:: GSE203225

ID:: 200203225

PubMed Full text in PMC Similar studies

Select item 20019565817.

IL-13 signaling via epithelial cell-expressed type II IL-4 receptor mediates eosinophilic esophagitis II

(Submitter supplied) Purpose: We aimed to define the molecular pathways and the transcriptome signature of experimental EoE treated WT mice Methods: 1cm piece of the middle part from the esophagus of OXA or Vehicle treated WT mice was obtained for RNA extraction using TRIZOL . Thereafter, RNA samples were prepared for sequencing using the CEL-Seq2 protocol, with minor modifications. Briefly, purified RNA (2 ng) was taken as input for library preparation. more...