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Series GSE272 Query DataSets for GSE272
Status Public on Jan 29, 2003
Title T and B lymphocyte development profiles
Organism Mus musculus
Experiment type Expression profiling by array
Summary Expression profiles of seven consecutive stages of mouse thymocyte development were generated. Previously known expression patterns of several genes were confirmed. Ten percent (1,304 of more than 13,000) of the monitored genes were found with 99% confidence to be differentially expressed across all T cell developmental stages. When compared with 1,204 genes differentially expressed in five consecutive B lineage developmental stages of bone marrow, >40% (546 genes) appeared to be shared by both lineages. However, when four pools of functionally distinct cell stages were compared between B and T cell development, DJ-rearranged precursor cells and resting immature precursor cells before and after surface Ag receptor expression shared less than 10%, mature resting lymphocytes between 15 and 20%, and only cycling precursors responding to precursor lymphocyte receptor deposition shared >50% of these differentially expressed genes.
Keywords: other
 
 
Contributor(s) Hoffmann R, Bruno L, Seidl T, Rolink A, Melchers F, Rolink T, Neeb M
Citation(s) 12538694, 17890238
Submission date Jan 28, 2003
Last update date Jul 08, 2016
Contact name Reinhard Hoffmann
E-mail(s) reinhard.hoffmann@lrz.tum.de
Phone +49-89-4140-4155
Organization name Institute for medical microbiology
Street address Trogerstr. 30
City Munich
ZIP/Postal code 81675
Country Germany
 
Platforms (2)
GPL75 [Mu11KsubA] Affymetrix Murine 11K SubA Array
GPL76 [Mu11KsubB] Affymetrix Murine 11K SubB Array
Samples (138)
GSM610 Pre-BI cells 1
GSM611 Immature B cells 1
GSM612 Immature B cells 11
Relations
BioProject PRJNA84701

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