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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Jan 29, 2003 |
| Title |
T and B lymphocyte development profiles |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Expression profiles of seven consecutive stages of mouse thymocyte development were generated. Previously known expression patterns of several genes were confirmed. Ten percent (1,304 of more than 13,000) of the monitored genes were found with 99% confidence to be differentially expressed across all T cell developmental stages. When compared with 1,204 genes differentially expressed in five consecutive B lineage developmental stages of bone marrow, >40% (546 genes) appeared to be shared by both lineages. However, when four pools of functionally distinct cell stages were compared between B and T cell development, DJ-rearranged precursor cells and resting immature precursor cells before and after surface Ag receptor expression shared less than 10%, mature resting lymphocytes between 15 and 20%, and only cycling precursors responding to precursor lymphocyte receptor deposition shared >50% of these differentially expressed genes.
Keywords: other
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| Contributor(s) |
Hoffmann R, Bruno L, Seidl T, Rolink A, Melchers F, Rolink T, Neeb M |
| Citation(s) |
12538694, 17890238 |
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| Submission date |
Jan 28, 2003 |
| Last update date |
Jul 08, 2016 |
| Contact name |
Reinhard Hoffmann |
| E-mail(s) |
reinhard.hoffmann@lrz.tum.de
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| Phone |
+49-89-4140-4155
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| Organization name |
Institute for medical microbiology
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| Street address |
Trogerstr. 30
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| City |
Munich |
| ZIP/Postal code |
81675 |
| Country |
Germany |
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| Platforms (2) |
| GPL75 |
[Mu11KsubA] Affymetrix Murine 11K SubA Array |
| GPL76 |
[Mu11KsubB] Affymetrix Murine 11K SubB Array |
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| Samples (138)
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| Relations |
| BioProject |
PRJNA84701 |
| Supplementary data files not provided |
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