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Series GSE33785 Query DataSets for GSE33785
Status Public on Jul 24, 2012
Title Gene expression in the chronic ethanol-treated rat liver during liver regeneration
Organism Rattus norvegicus
Experiment type Expression profiling by array
Summary In this study, we analyzed the effects of chronic alcohol consumption on liver repair and regeneration after partial hepatectomy (PHx). Rats were fed a liquid diet containing 36% of total calories derived from ethanol for 5 weeks; corresponding pair-fed calorie-matched controls were fed diets in which ethanol calories were replaced either by carbohydrate or by fat. After 5 weeks, rats were subjected to 70% PHx and liver samples were collected at 1, 6 and 24h after the surgery. The excised liver samples at t=0 served as within-animal controls. We used Affymetrix Rat Gene 1.0 ST  arrays to obtain global gene expression data from each liver sample (n=4 replicate rats, 72 arrays total).
 
Overall design Gene expression was profiled in the chronic ethanol-fed (EtOH) and carbohydrate control pair-fed (CHO) liver prior to (control) and 1 h, 6 h, 12 h, and 24 h after partial hepatectomy (PHx).
 
Contributor(s) Dippold R, Vadigepalli R, Hoek JB
Citation(s) 22790595, 27012785
Submission date Nov 17, 2011
Last update date Sep 14, 2016
Contact name Egle Juskeviciute
Organization name Thomas Jefferson University
Department Pathology
Street address 1020 Locust st. JAH 527
City Philadelphia
State/province PA
ZIP/Postal code 19107
Country USA
 
Platforms (1)
GPL6247 [RaGene-1_0-st] Affymetrix Rat Gene 1.0 ST Array [transcript (gene) version]
Samples (72)
GSM835578 EtOH_1h_ctrl, biological rep1
GSM835579 EtOH_1h_phx, biological rep1
GSM835580 EtOH_1h_ctrl, biological rep2
Relations
BioProject PRJNA148049

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE33785_RAW.tar 268.7 Mb (http)(custom) TAR (of CEL)
GSE33785_batch_corrected.txt.gz 6.8 Mb (ftp)(http) TXT
GSE33785_outliers_removed.txt.gz 5.9 Mb (ftp)(http) TXT
Processed data included within Sample table
Processed data are available on Series record
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