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| Status |
Public on Sep 22, 2006 |
| Title |
Regulation of sexual development of Plasmodium by translational repression. |
| Organism |
Plasmodium berghei |
| Experiment type |
Expression profiling by array
|
| Summary |
Translational repression of messenger RNAs (mRNAs) plays an important role in sexual differentiation and gametogenesis in multicellular eukaryotes. Translational repression and mRNA turnover were shown to influence stage-specific gene expression in the protozoan Plasmodium. The DDX6-class RNA helicase, DOZI (development of zygote inhibited), is found in a complex with mRNA species in cytoplasmic bodies of female, blood-stage gametocytes. These translationally repressed complexes are normally stored for translation after fertilization. Genetic disruption of pbdozi inhibits the formation of the ribonucleoprotein complexes, and instead, at least 370 transcripts are diverted to a degradation pathway.
Keywords: P. berghei, gene expression
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| Overall design |
mRNA abundance was compared between dozy mutana nd wt parasite strains.
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| Contributor(s) |
Mair GR, Braks JA, Garver LS, Wiegant JC, Hall N, Dirks RW, Khan SM, Dimopoulos G, Janse CJ, Waters AP |
| Citation(s) |
16888139 |
| Submission date |
Sep 20, 2006 |
| Last update date |
Mar 16, 2012 |
| Contact name |
George Dimopoulos |
| E-mail(s) |
gdimopo1@jhu.edu
|
| Phone |
443 28 70128
|
| Organization name |
Johns Hopkins School of Public Health
|
| Department |
Molecular Microbiology and Immunology
|
| Street address |
615 N. Wolfe Street
|
| City |
Baltimore |
| State/province |
MD |
| ZIP/Postal code |
21205 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL3824 |
Oligo array for Plasmodium berghei |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA97313 |
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