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Nephrosis

MedGen UID:
10223
Concept ID:
C0027720
Disease or Syndrome
Synonym: Nephroses
 
Monarch Initiative: MONDO:0002331

Definition

Pathological processes of the KIDNEY without inflammatory or neoplastic components. Nephrosis may be a primary disorder or secondary complication of other diseases. It is characterized by the NEPHROTIC SYNDROME indicating the presence of PROTEINURIA and HYPOALBUMINEMIA with accompanying EDEMA. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNephrosis

Professional guidelines

PubMed

Ellison B, Cader R, Willcocks L
Br J Hosp Med (Lond) 2024 Jul 30;85(7):1-11. doi: 10.12968/hmed.2024.0044. PMID: 39078905
Tseng MH, Lin SH, Fan WL, Wu TW, Lin SP, Ding JJ, Tsai IJ, Tsai JD
J Formos Med Assoc 2024 Jun;123(6):647-654. Epub 2023 Oct 14 doi: 10.1016/j.jfma.2023.10.003. PMID: 37845138
Couser WG
Clin J Am Soc Nephrol 2017 Jun 7;12(6):983-997. Epub 2017 May 26 doi: 10.2215/CJN.11761116. PMID: 28550082Free PMC Article

Recent clinical studies

Etiology

Watts AJB, Keller KH, Lerner G, Rosales I, Collins AB, Sekulic M, Waikar SS, Chandraker A, Riella LV, Alexander MP, Troost JP, Chen J, Fermin D, Yee JL, Sampson MG, Beck LH Jr, Henderson JM, Greka A, Rennke HG, Weins A
J Am Soc Nephrol 2022 Jan;33(1):238-252. Epub 2021 Nov 3 doi: 10.1681/ASN.2021060794. PMID: 34732507Free PMC Article
Medjeral-Thomas NR, Lawrence C, Condon M, Sood B, Warwicker P, Brown H, Pattison J, Bhandari S, Barratt J, Turner N, Cook HT, Levy JB, Lightstone L, Pusey C, Galliford J, Cairns TD, Griffith M
Clin J Am Soc Nephrol 2020 Feb 7;15(2):209-218. Epub 2020 Jan 17 doi: 10.2215/CJN.06180519. PMID: 31953303Free PMC Article
Meyrier A, Niaudet P
Kidney Int 2018 Nov;94(5):861-869. Epub 2018 Jul 3 doi: 10.1016/j.kint.2018.04.024. PMID: 29980292
Floege J, Amann K
Lancet 2016 May 14;387(10032):2036-48. Epub 2016 Feb 25 doi: 10.1016/S0140-6736(16)00272-5. PMID: 26921911
Tsimihodimos V, Elisaf M
Curr Opin Lipidol 2011 Aug;22(4):262-9. doi: 10.1097/MOL.0b013e328345ebb0. PMID: 21464714

Diagnosis

Gomez AC, Gibson KL, Seethapathy H
Adv Kidney Dis Health 2024 Jul;31(4):267-274. doi: 10.1053/j.akdh.2024.02.002. PMID: 39084752
Ellison B, Cader R, Willcocks L
Br J Hosp Med (Lond) 2024 Jul 30;85(7):1-11. doi: 10.12968/hmed.2024.0044. PMID: 39078905
Campbell RE, Thurman JM
Clin J Am Soc Nephrol 2022 Dec;17(12):1823-1834. Epub 2022 Oct 5 doi: 10.2215/CJN.07180622. PMID: 36198505Free PMC Article
Ahn W, Bomback AS
Am J Kidney Dis 2020 Jun;75(6):955-964. Epub 2020 Apr 21 doi: 10.1053/j.ajkd.2019.12.019. PMID: 32331832
Vivarelli M, Massella L, Ruggiero B, Emma F
Clin J Am Soc Nephrol 2017 Feb 7;12(2):332-345. Epub 2016 Dec 9 doi: 10.2215/CJN.05000516. PMID: 27940460Free PMC Article

Therapy

Ellison B, Cader R, Willcocks L
Br J Hosp Med (Lond) 2024 Jul 30;85(7):1-11. doi: 10.12968/hmed.2024.0044. PMID: 39078905
Azukaitis K, Palmer SC, Strippoli GF, Hodson EM
Cochrane Database Syst Rev 2022 Mar 1;3(3):CD001537. doi: 10.1002/14651858.CD001537.pub5. PMID: 35230699Free PMC Article
Medjeral-Thomas NR, Lawrence C, Condon M, Sood B, Warwicker P, Brown H, Pattison J, Bhandari S, Barratt J, Turner N, Cook HT, Levy JB, Lightstone L, Pusey C, Galliford J, Cairns TD, Griffith M
Clin J Am Soc Nephrol 2020 Feb 7;15(2):209-218. Epub 2020 Jan 17 doi: 10.2215/CJN.06180519. PMID: 31953303Free PMC Article
Vivarelli M, Massella L, Ruggiero B, Emma F
Clin J Am Soc Nephrol 2017 Feb 7;12(2):332-345. Epub 2016 Dec 9 doi: 10.2215/CJN.05000516. PMID: 27940460Free PMC Article
Ruggenenti P, Ruggiero B, Cravedi P, Vivarelli M, Massella L, Marasà M, Chianca A, Rubis N, Ene-Iordache B, Rudnicki M, Pollastro RM, Capasso G, Pisani A, Pennesi M, Emma F, Remuzzi G; Rituximab in Nephrotic Syndrome of Steroid-Dependent or Frequently Relapsing Minimal Change Disease Or Focal Segmental Glomerulosclerosis (NEMO) Study Group
J Am Soc Nephrol 2014 Apr;25(4):850-63. Epub 2014 Jan 30 doi: 10.1681/ASN.2013030251. PMID: 24480824Free PMC Article

Prognosis

Gomez AC, Gibson KL, Seethapathy H
Adv Kidney Dis Health 2024 Jul;31(4):267-274. doi: 10.1053/j.akdh.2024.02.002. PMID: 39084752
Zhang Y, Yang L
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2024 Mar 28;49(3):377-384. doi: 10.11817/j.issn.1672-7347.2024.230377. PMID: 38970511Free PMC Article
Zhao M, Veeranki SP, Magnussen CG, Xi B
BMJ 2020 Jul 1;370:m2031. doi: 10.1136/bmj.m2031. PMID: 32611588Free PMC Article
AlYousef A, AlSahow A, AlHelal B, Alqallaf A, Abdallah E, Abdellatif M, Nawar H, Elmahalawy R
BMC Nephrol 2020 May 18;21(1):186. doi: 10.1186/s12882-020-01836-3. PMID: 32423387Free PMC Article
Sadowski CE, Lovric S, Ashraf S, Pabst WL, Gee HY, Kohl S, Engelmann S, Vega-Warner V, Fang H, Halbritter J, Somers MJ, Tan W, Shril S, Fessi I, Lifton RP, Bockenhauer D, El-Desoky S, Kari JA, Zenker M, Kemper MJ, Mueller D, Fathy HM, Soliman NA; SRNS Study Group, Hildebrandt F
J Am Soc Nephrol 2015 Jun;26(6):1279-89. Epub 2014 Oct 27 doi: 10.1681/ASN.2014050489. PMID: 25349199Free PMC Article

Clinical prediction guides

Ma X, Fang L, Sheng L, Zhou X, Bai S, Zang X, Wang Y, Li M, Lv Z, Zhong Q, Yang X, Wang Y, Hu Y, Yan D, Shi Y, Chen H, Li J, Tao M, Zhuang S, Wang Y, Liu N
Ren Fail 2023 Dec;45(1):2237124. doi: 10.1080/0886022X.2023.2237124. PMID: 37482915Free PMC Article
Campbell RE, Thurman JM
Clin J Am Soc Nephrol 2022 Dec;17(12):1823-1834. Epub 2022 Oct 5 doi: 10.2215/CJN.07180622. PMID: 36198505Free PMC Article
Warejko JK, Tan W, Daga A, Schapiro D, Lawson JA, Shril S, Lovric S, Ashraf S, Rao J, Hermle T, Jobst-Schwan T, Widmeier E, Majmundar AJ, Schneider R, Gee HY, Schmidt JM, Vivante A, van der Ven AT, Ityel H, Chen J, Sadowski CE, Kohl S, Pabst WL, Nakayama M, Somers MJG, Rodig NM, Daouk G, Baum M, Stein DR, Ferguson MA, Traum AZ, Soliman NA, Kari JA, El Desoky S, Fathy H, Zenker M, Bakkaloglu SA, Müller D, Noyan A, Ozaltin F, Cadnapaphornchai MA, Hashmi S, Hopcian J, Kopp JB, Benador N, Bockenhauer D, Bogdanovic R, Stajić N, Chernin G, Ettenger R, Fehrenbach H, Kemper M, Munarriz RL, Podracka L, Büscher R, Serdaroglu E, Tasic V, Mane S, Lifton RP, Braun DA, Hildebrandt F
Clin J Am Soc Nephrol 2018 Jan 6;13(1):53-62. Epub 2017 Nov 10 doi: 10.2215/CJN.04120417. PMID: 29127259Free PMC Article
Ruggenenti P, Ruggiero B, Cravedi P, Vivarelli M, Massella L, Marasà M, Chianca A, Rubis N, Ene-Iordache B, Rudnicki M, Pollastro RM, Capasso G, Pisani A, Pennesi M, Emma F, Remuzzi G; Rituximab in Nephrotic Syndrome of Steroid-Dependent or Frequently Relapsing Minimal Change Disease Or Focal Segmental Glomerulosclerosis (NEMO) Study Group
J Am Soc Nephrol 2014 Apr;25(4):850-63. Epub 2014 Jan 30 doi: 10.1681/ASN.2013030251. PMID: 24480824Free PMC Article
Tsimihodimos V, Elisaf M
Curr Opin Lipidol 2011 Aug;22(4):262-9. doi: 10.1097/MOL.0b013e328345ebb0. PMID: 21464714

Recent systematic reviews

Horvit AM, Molony DA
Environ Res 2024 May 1;248:118224. Epub 2024 Jan 17 doi: 10.1016/j.envres.2024.118224. PMID: 38242418
Ekrikpo UE, Obiagwu PN, Udo AI, Chukwuonye II, Noubiap JJ, Okpechi-Samuel US, Udoudo UN, Tannor EK, Ngoka SC, Mbah IO, Bello AK, Okpechi IG
Pan Afr Med J 2023;45:153. Epub 2023 Aug 9 doi: 10.11604/pamj.2023.45.153.40741. PMID: 37869232Free PMC Article
Azukaitis K, Palmer SC, Strippoli GF, Hodson EM
Cochrane Database Syst Rev 2022 Mar 1;3(3):CD001537. doi: 10.1002/14651858.CD001537.pub5. PMID: 35230699Free PMC Article
Morello W, Vianello FA, Proverbio E, Peruzzi L, Pasini A, Montini G
Pediatr Nephrol 2022 Apr;37(4):757-764. Epub 2021 Oct 23 doi: 10.1007/s00467-021-05330-2. PMID: 34687377Free PMC Article
Hansrivijit P, Cheungpasitporn W, Thongprayoon C, Ghahramani N
BMC Nephrol 2020 Apr 15;21(1):134. doi: 10.1186/s12882-020-01797-7. PMID: 32293308Free PMC Article

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