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Solid tumor

MedGen UID:
124697
•Concept ID:
C0280100
•
Neoplastic Process
Synonyms: Solid neoplasm; Solid tumors

Definition

A benign or malignant neoplasm arising from tissues that do not include fluid areas. Representative examples include epithelial neoplasms (e.g. lung carcinoma, prostate carcinoma, breast carcinoma, colon carcinoma), and neoplasms arising from the soft tissues and bones (e.g. leiomyosarcoma, liposarcoma, chondrosarcoma, osteosarcoma). Neoplasms originating from the blood or bone marrow (leukemias and myeloproliferative disorders) are not considered solid tumors. [from NCI]

Professional guidelines

PubMed

CAR-cell therapy in the era of solid tumor treatment: current challenges and emerging therapeutic advances.
Maalej KM, Merhi M, Inchakalody VP, Mestiri S, Alam M, Maccalli C, Cherif H, Uddin S, Steinhoff M, Marincola FM, Dermime S
Mol Cancer 2023 Jan 30;22(1):20. doi: 10.1186/s12943-023-01723-z. PMID: 36717905Free PMC Article
Radiation-Induced Lung Injury: Assessment and Management.
Hanania AN, Mainwaring W, Ghebre YT, Hanania NA, Ludwig M
Chest 2019 Jul;156(1):150-162. Epub 2019 Apr 15 doi: 10.1016/j.chest.2019.03.033. PMID: 30998908Free PMC Article
Testicular Cancer: Diagnosis and Treatment.
Baird DC, Meyers GJ, Hu JS
Am Fam Physician 2018 Feb 15;97(4):261-268. PMID: 29671528

Recent clinical studies

Etiology

Uncovering the mode of action of engineered T cells in patient cancer organoids.
Dekkers JF, Alieva M, Cleven A, Keramati F, Wezenaar AKL, van Vliet EJ, Puschhof J, Brazda P, Johanna I, Meringa AD, Rebel HG, Buchholz MB, Barrera Román M, Zeeman AL, de Blank S, Fasci D, Geurts MH, Cornel AM, Driehuis E, Millen R, Straetemans T, Nicolasen MJT, Aarts-Riemens T, Ariese HCR, Johnson HR, van Ineveld RL, Karaiskaki F, Kopper O, Bar-Ephraim YE, Kretzschmar K, Eggermont AMM, Nierkens S, Wehrens EJ, Stunnenberg HG, Clevers H, Kuball J, Sebestyen Z, Rios AC
Nat Biotechnol 2023 Jan;41(1):60-69. Epub 2022 Jul 25 doi: 10.1038/s41587-022-01397-w. PMID: 35879361Free PMC Article
Characterizing the tumor microenvironment of metastatic ovarian cancer by single-cell transcriptomics.
Olalekan S, Xie B, Back R, Eckart H, Basu A
Cell Rep 2021 May 25;35(8):109165. doi: 10.1016/j.celrep.2021.109165. PMID: 34038734
Update on neuroblastoma.
Newman EA, Abdessalam S, Aldrink JH, Austin M, Heaton TE, Bruny J, Ehrlich P, Dasgupta R, Baertschiger RM, Lautz TB, Rhee DS, Langham MR Jr, Malek MM, Meyers RL, Nathan JD, Weil BR, Polites S, Madonna MB; APSA Cancer committee
J Pediatr Surg 2019 Mar;54(3):383-389. Epub 2018 Sep 19 doi: 10.1016/j.jpedsurg.2018.09.004. PMID: 30305231
Tumor-derived spheroids: Relevance to cancer stem cells and clinical applications.
Ishiguro T, Ohata H, Sato A, Yamawaki K, Enomoto T, Okamoto K
Cancer Sci 2017 Mar;108(3):283-289. doi: 10.1111/cas.13155. PMID: 28064442Free PMC Article
Epidemiology of Brain Tumors.
McNeill KA
Neurol Clin 2016 Nov;34(4):981-998. doi: 10.1016/j.ncl.2016.06.014. PMID: 27720005

Diagnosis

From patterns to patients: Advances in clinical machine learning for cancer diagnosis, prognosis, and treatment.
Swanson K, Wu E, Zhang A, Alizadeh AA, Zou J
Cell 2023 Apr 13;186(8):1772-1791. Epub 2023 Mar 10 doi: 10.1016/j.cell.2023.01.035. PMID: 36905928
Folate Receptor as a Biomarker and Therapeutic Target in Solid Tumors.
Young O, Ngo N, Lin L, Stanbery L, Creeden JF, Hamouda D, Nemunaitis J
Curr Probl Cancer 2023 Feb;47(1):100917. Epub 2022 Nov 17 doi: 10.1016/j.currproblcancer.2022.100917. PMID: 36508886
Mediastinal neuroblastoma, ganglioneuroblastoma, and ganglioneuroma: Pathology review and diagnostic approach.
Choi JH, Ro JY
Semin Diagn Pathol 2022 Mar;39(2):120-130. Epub 2021 Jun 15 doi: 10.1053/j.semdp.2021.06.007. PMID: 34167847
Pediatric Neuro-Oncology.
Malbari F
Neurol Clin 2021 Aug;39(3):829-845. Epub 2021 Jun 10 doi: 10.1016/j.ncl.2021.04.005. PMID: 34215389
Detection of Solid Tumor Molecular Residual Disease (MRD) Using Circulating Tumor DNA (ctDNA).
Chin RI, Chen K, Usmani A, Chua C, Harris PK, Binkley MS, Azad TD, Dudley JC, Chaudhuri AA
Mol Diagn Ther 2019 Jun;23(3):311-331. doi: 10.1007/s40291-019-00390-5. PMID: 30941670Free PMC Article

Therapy

Pembrolizumab in Patients With Microsatellite Instability-High Advanced Endometrial Cancer: Results From the KEYNOTE-158 Study.
O'Malley DM, Bariani GM, Cassier PA, Marabelle A, Hansen AR, De Jesus Acosta A, Miller WH Jr, Safra T, Italiano A, Mileshkin L, Xu L, Jin F, Norwood K, Maio M
J Clin Oncol 2022 Mar 1;40(7):752-761. Epub 2022 Jan 6 doi: 10.1200/JCO.21.01874. PMID: 34990208Free PMC Article
Targeting CD47 for cancer immunotherapy.
Jiang Z, Sun H, Yu J, Tian W, Song Y
J Hematol Oncol 2021 Oct 30;14(1):180. doi: 10.1186/s13045-021-01197-w. PMID: 34717705Free PMC Article
Multidisciplinary standards of care and recent progress in pancreatic ductal adenocarcinoma.
Grossberg AJ, Chu LC, Deig CR, Fishman EK, Hwang WL, Maitra A, Marks DL, Mehta A, Nabavizadeh N, Simeone DM, Weekes CD, Thomas CR Jr
CA Cancer J Clin 2020 Sep;70(5):375-403. Epub 2020 Jul 19 doi: 10.3322/caac.21626. PMID: 32683683Free PMC Article
MET-dependent solid tumours - molecular diagnosis and targeted therapy.
Guo R, Luo J, Chang J, Rekhtman N, Arcila M, Drilon A
Nat Rev Clin Oncol 2020 Sep;17(9):569-587. Epub 2020 Jun 8 doi: 10.1038/s41571-020-0377-z. PMID: 32514147Free PMC Article
Antibody-Drug Conjugate-Based Therapeutics: State of the Science.
Birrer MJ, Moore KN, Betella I, Bates RC
J Natl Cancer Inst 2019 Jun 1;111(6):538-549. doi: 10.1093/jnci/djz035. PMID: 30859213

Prognosis

Pembrolizumab in Patients With Microsatellite Instability-High Advanced Endometrial Cancer: Results From the KEYNOTE-158 Study.
O'Malley DM, Bariani GM, Cassier PA, Marabelle A, Hansen AR, De Jesus Acosta A, Miller WH Jr, Safra T, Italiano A, Mileshkin L, Xu L, Jin F, Norwood K, Maio M
J Clin Oncol 2022 Mar 1;40(7):752-761. Epub 2022 Jan 6 doi: 10.1200/JCO.21.01874. PMID: 34990208Free PMC Article
Epidemiology and Prevention of Prostate Cancer.
Gandaglia G, Leni R, Bray F, Fleshner N, Freedland SJ, Kibel A, Stattin P, Van Poppel H, La Vecchia C
Eur Urol Oncol 2021 Dec;4(6):877-892. Epub 2021 Oct 26 doi: 10.1016/j.euo.2021.09.006. PMID: 34716119
Herpes Zoster Risk in Immunocompromised Adults in the United States: A Systematic Review.
McKay SL, Guo A, Pergam SA, Dooling K
Clin Infect Dis 2020 Oct 23;71(7):e125-e134. doi: 10.1093/cid/ciz1090. PMID: 31677266Free PMC Article
Update on neuroblastoma.
Newman EA, Abdessalam S, Aldrink JH, Austin M, Heaton TE, Bruny J, Ehrlich P, Dasgupta R, Baertschiger RM, Lautz TB, Rhee DS, Langham MR Jr, Malek MM, Meyers RL, Nathan JD, Weil BR, Polites S, Madonna MB; APSA Cancer committee
J Pediatr Surg 2019 Mar;54(3):383-389. Epub 2018 Sep 19 doi: 10.1016/j.jpedsurg.2018.09.004. PMID: 30305231
Testicular cancer.
Cheng L, Albers P, Berney DM, Feldman DR, Daugaard G, Gilligan T, Looijenga LHJ
Nat Rev Dis Primers 2018 Oct 5;4(1):29. doi: 10.1038/s41572-018-0029-0. PMID: 30291251

Clinical prediction guides

T-cell-engaging antibodies for the treatment of solid tumors: challenges and opportunities.
Baeuerle PA, Wesche H
Curr Opin Oncol 2022 Sep 1;34(5):552-558. Epub 2022 Jul 28 doi: 10.1097/CCO.0000000000000869. PMID: 35880455Free PMC Article
Prediction of prognosis in elderly patients with sepsis based on machine learning (random survival forest).
Zhang L, Huang T, Xu F, Li S, Zheng S, Lyu J, Yin H
BMC Emerg Med 2022 Feb 11;22(1):26. doi: 10.1186/s12873-022-00582-z. PMID: 35148680Free PMC Article
TRPS1: a highly sensitive and specific marker for breast carcinoma, especially for triple-negative breast cancer.
Ai D, Yao J, Yang F, Huo L, Chen H, Lu W, Soto LMS, Jiang M, Raso MG, Wang S, Bell D, Liu J, Wang H, Tan D, Torres-Cabala C, Gan Q, Wu Y, Albarracin C, Hung MC, Meric-Bernstam F, Wistuba II, Prieto VG, Sahin AA, Ding Q
Mod Pathol 2021 Apr;34(4):710-719. Epub 2020 Oct 3 doi: 10.1038/s41379-020-00692-8. PMID: 33011748
A multicenter study of romiplostim for chemotherapy-induced thrombocytopenia in solid tumors and hematologic malignancies.
Al-Samkari H, Parnes AD, Goodarzi K, Weitzman JI, Connors JM, Kuter DJ
Haematologica 2021 Apr 1;106(4):1148-1157. doi: 10.3324/haematol.2020.251900. PMID: 32499239Free PMC Article
Detection of Solid Tumor Molecular Residual Disease (MRD) Using Circulating Tumor DNA (ctDNA).
Chin RI, Chen K, Usmani A, Chua C, Harris PK, Binkley MS, Azad TD, Dudley JC, Chaudhuri AA
Mol Diagn Ther 2019 Jun;23(3):311-331. doi: 10.1007/s40291-019-00390-5. PMID: 30941670Free PMC Article

Recent systematic reviews

Is antibody-drug conjugate a rising star for clinical treatment of solid tumors? A systematic review and meta-analysis.
Zhang L, Shen D, Yu L, Yan Y, Wasan HS, Yu J, Zhang S, Sun L
Crit Rev Oncol Hematol 2022 Sep;177:103758. Epub 2022 Jul 20 doi: 10.1016/j.critrevonc.2022.103758. PMID: 35868498
Primary Sjögren's syndrome is associated with increased risk of malignancies besides lymphoma: A systematic review and meta-analysis.
Zhong H, Liu S, Wang Y, Xu D, Li M, Zhao Y, Zeng X
Autoimmun Rev 2022 May;21(5):103084. Epub 2022 Mar 24 doi: 10.1016/j.autrev.2022.103084. PMID: 35341972
Relationship Between Progression-Free Survival, Objective Response Rate, and Overall Survival in Clinical Trials of PD-1/PD-L1 Immune Checkpoint Blockade: A Meta-Analysis.
Ye J, Ji X, Dennis PA, Abdullah H, Mukhopadhyay P
Clin Pharmacol Ther 2020 Dec;108(6):1274-1288. Epub 2020 Jul 18 doi: 10.1002/cpt.1956. PMID: 32564368Free PMC Article
Herpes Zoster Risk in Immunocompromised Adults in the United States: A Systematic Review.
McKay SL, Guo A, Pergam SA, Dooling K
Clin Infect Dis 2020 Oct 23;71(7):e125-e134. doi: 10.1093/cid/ciz1090. PMID: 31677266Free PMC Article
Risks and Benefits of Chimeric Antigen Receptor T-Cell (CAR-T) Therapy in Cancer: A Systematic Review and Meta-Analysis.
Grigor EJM, Fergusson D, Kekre N, Montroy J, Atkins H, Seftel MD, Daugaard M, Presseau J, Thavorn K, Hutton B, Holt RA, Lalu MM
Transfus Med Rev 2019 Apr;33(2):98-110. Epub 2019 Feb 14 doi: 10.1016/j.tmrv.2019.01.005. PMID: 30948292

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