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Solid tumor

MedGen UID:
124697
•Concept ID:
C0280100
•
Neoplastic Process
Synonyms: Solid neoplasm; Solid tumors

Definition

A benign or malignant neoplasm arising from tissues that do not include fluid areas. Representative examples include epithelial neoplasms (e.g. lung carcinoma, prostate carcinoma, breast carcinoma, colon carcinoma), and neoplasms arising from the soft tissues and bones (e.g. leiomyosarcoma, liposarcoma, chondrosarcoma, osteosarcoma). Neoplasms originating from the blood or bone marrow (leukemias and myeloproliferative disorders) are not considered solid tumors. [from NCI]

Professional guidelines

PubMed

CAR-cell therapy in the era of solid tumor treatment: current challenges and emerging therapeutic advances.
Maalej KM, Merhi M, Inchakalody VP, Mestiri S, Alam M, Maccalli C, Cherif H, Uddin S, Steinhoff M, Marincola FM, Dermime S
Mol Cancer 2023 Jan 30;22(1):20. doi: 10.1186/s12943-023-01723-z. PMID: 36717905Free PMC Article
Radiation-Induced Lung Injury: Assessment and Management.
Hanania AN, Mainwaring W, Ghebre YT, Hanania NA, Ludwig M
Chest 2019 Jul;156(1):150-162. Epub 2019 Apr 15 doi: 10.1016/j.chest.2019.03.033. PMID: 30998908Free PMC Article
Testicular Cancer: Diagnosis and Treatment.
Baird DC, Meyers GJ, Hu JS
Am Fam Physician 2018 Feb 15;97(4):261-268. PMID: 29671528

Recent clinical studies

Etiology

Role of surgery in neuroblastoma.
Yoneda A
Pediatr Surg Int 2023 Apr 11;39(1):177. doi: 10.1007/s00383-023-05459-1. PMID: 37039977
Theranostics in Neuroblastoma.
Rafael MS, Cohen-Gogo S, Irwin MS, Vali R, Shammas A, Morgenstern DA
PET Clin 2021 Jul;16(3):419-427. doi: 10.1016/j.cpet.2021.03.006. PMID: 34053585
Viruses and esophageal cancer.
Chang C, Worrell SG
Dis Esophagus 2020 Dec 7;33(12) doi: 10.1093/dote/doaa036. PMID: 32462190
Update on neuroblastoma.
Newman EA, Abdessalam S, Aldrink JH, Austin M, Heaton TE, Bruny J, Ehrlich P, Dasgupta R, Baertschiger RM, Lautz TB, Rhee DS, Langham MR Jr, Malek MM, Meyers RL, Nathan JD, Weil BR, Polites S, Madonna MB; APSA Cancer committee
J Pediatr Surg 2019 Mar;54(3):383-389. Epub 2018 Sep 19 doi: 10.1016/j.jpedsurg.2018.09.004. PMID: 30305231
Epidemiology of Brain Tumors.
McNeill KA
Neurol Clin 2016 Nov;34(4):981-998. doi: 10.1016/j.ncl.2016.06.014. PMID: 27720005

Diagnosis

From patterns to patients: Advances in clinical machine learning for cancer diagnosis, prognosis, and treatment.
Swanson K, Wu E, Zhang A, Alizadeh AA, Zou J
Cell 2023 Apr 13;186(8):1772-1791. Epub 2023 Mar 10 doi: 10.1016/j.cell.2023.01.035. PMID: 36905928
Folate Receptor as a Biomarker and Therapeutic Target in Solid Tumors.
Young O, Ngo N, Lin L, Stanbery L, Creeden JF, Hamouda D, Nemunaitis J
Curr Probl Cancer 2023 Feb;47(1):100917. Epub 2022 Nov 17 doi: 10.1016/j.currproblcancer.2022.100917. PMID: 36508886
Congenital Neuroblastoma.
Minakova E, Lang J
Neoreviews 2020 Nov;21(11):e716-e727. doi: 10.1542/neo.21-11-e716. PMID: 33139509
Pediatric brain tumors.
Brandão LA, Poussaint TY
Neuroimaging Clin N Am 2013 Aug;23(3):499-525. Epub 2013 May 18 doi: 10.1016/j.nic.2013.03.003. PMID: 23928202
Solid tumor cytogenetics: current perspectives.
Nanjangud G, Amarillo I, Rao PN
Clin Lab Med 2011 Dec;31(4):785-811, xi. Epub 2011 Oct 21 doi: 10.1016/j.cll.2011.07.007. PMID: 22118748

Therapy

FDA Approval Summary: Sotorasib for KRAS G12C-Mutated Metastatic NSCLC.
Nakajima EC, Drezner N, Li X, Mishra-Kalyani PS, Liu Y, Zhao H, Bi Y, Liu J, Rahman A, Wearne E, Ojofeitimi I, Hotaki LT, Spillman D, Pazdur R, Beaver JA, Singh H
Clin Cancer Res 2022 Apr 14;28(8):1482-1486. doi: 10.1158/1078-0432.CCR-21-3074. PMID: 34903582Free PMC Article
Antibody-Drug Conjugate-Based Therapeutics: State of the Science.
Birrer MJ, Moore KN, Betella I, Bates RC
J Natl Cancer Inst 2019 Jun 1;111(6):538-549. doi: 10.1093/jnci/djz035. PMID: 30859213
Tumor-Agnostic Drug Development.
Offin M, Liu D, Drilon A
Am Soc Clin Oncol Educ Book 2018 May 23;38:184-187. doi: 10.1200/EDBK_200831. PMID: 30231313Free PMC Article
CARTs for Solid Tumors: Feasible or Infeasible?
Li W, Song X, Jin Y, Li F, Yu H, Cao C, Jiang Q
Oncol Res Treat 2017;40(9):540-546. Epub 2017 Aug 17 doi: 10.1159/000477095. PMID: 28813706
ErbB-targeted CAR T-cell immunotherapy of cancer.
Whilding LM, Maher J
Immunotherapy 2015;7(3):229-41. doi: 10.2217/imt.14.120. PMID: 25804476

Prognosis

Pembrolizumab in Patients With Microsatellite Instability-High Advanced Endometrial Cancer: Results From the KEYNOTE-158 Study.
O'Malley DM, Bariani GM, Cassier PA, Marabelle A, Hansen AR, De Jesus Acosta A, Miller WH Jr, Safra T, Italiano A, Mileshkin L, Xu L, Jin F, Norwood K, Maio M
J Clin Oncol 2022 Mar 1;40(7):752-761. Epub 2022 Jan 6 doi: 10.1200/JCO.21.01874. PMID: 34990208Free PMC Article
Epidemiology and Prevention of Prostate Cancer.
Gandaglia G, Leni R, Bray F, Fleshner N, Freedland SJ, Kibel A, Stattin P, Van Poppel H, La Vecchia C
Eur Urol Oncol 2021 Dec;4(6):877-892. Epub 2021 Oct 26 doi: 10.1016/j.euo.2021.09.006. PMID: 34716119
An Integrated Analysis of Dostarlimab Immunogenicity.
Lu S, Bowsher RR, Clancy A, Rosen A, Zhang M, Yang Y, Koeck K, Gao M, Potocka E, Guo W, Jen KY, Im E, Milton A
AAPS J 2021 Jul 29;23(5):96. doi: 10.1208/s12248-021-00624-7. PMID: 34324079Free PMC Article
Update on neuroblastoma.
Newman EA, Abdessalam S, Aldrink JH, Austin M, Heaton TE, Bruny J, Ehrlich P, Dasgupta R, Baertschiger RM, Lautz TB, Rhee DS, Langham MR Jr, Malek MM, Meyers RL, Nathan JD, Weil BR, Polites S, Madonna MB; APSA Cancer committee
J Pediatr Surg 2019 Mar;54(3):383-389. Epub 2018 Sep 19 doi: 10.1016/j.jpedsurg.2018.09.004. PMID: 30305231
Testicular cancer.
Cheng L, Albers P, Berney DM, Feldman DR, Daugaard G, Gilligan T, Looijenga LHJ
Nat Rev Dis Primers 2018 Oct 5;4(1):29. doi: 10.1038/s41572-018-0029-0. PMID: 30291251

Clinical prediction guides

Computational Analysis of High-Dimensional DNA Methylation Data for Cancer Prognosis.
Hu R, Zhou XJ, Li W
J Comput Biol 2022 Aug;29(8):769-781. Epub 2022 Jun 6 doi: 10.1089/cmb.2022.0002. PMID: 35671506Free PMC Article
TRPS1: a highly sensitive and specific marker for breast carcinoma, especially for triple-negative breast cancer.
Ai D, Yao J, Yang F, Huo L, Chen H, Lu W, Soto LMS, Jiang M, Raso MG, Wang S, Bell D, Liu J, Wang H, Tan D, Torres-Cabala C, Gan Q, Wu Y, Albarracin C, Hung MC, Meric-Bernstam F, Wistuba II, Prieto VG, Sahin AA, Ding Q
Mod Pathol 2021 Apr;34(4):710-719. Epub 2020 Oct 3 doi: 10.1038/s41379-020-00692-8. PMID: 33011748
Congenital Neuroblastoma.
Minakova E, Lang J
Neoreviews 2020 Nov;21(11):e716-e727. doi: 10.1542/neo.21-11-e716. PMID: 33139509
How Can Immune Checkpoint Inhibitors Cause Hyperprogression in Solid Tumors?
Denis M, Duruisseaux M, Brevet M, Dumontet C
Front Immunol 2020;11:492. Epub 2020 Mar 20 doi: 10.3389/fimmu.2020.00492. PMID: 32265935Free PMC Article
The Multinational Association for Supportive Care in Cancer risk index: A multinational scoring system for identifying low-risk febrile neutropenic cancer patients.
Klastersky J, Paesmans M, Rubenstein EB, Boyer M, Elting L, Feld R, Gallagher J, Herrstedt J, Rapoport B, Rolston K, Talcott J
J Clin Oncol 2000 Aug;18(16):3038-51. doi: 10.1200/JCO.2000.18.16.3038. PMID: 10944139

Recent systematic reviews

Circulating Tumor DNA in the Immediate Postoperative Setting.
Efthymiou V, Queenan N, Haas M, Naegele S, Goss D, Faden DL
Ann Surg Oncol 2024 Apr;31(4):2319-2325. Epub 2024 Jan 8 doi: 10.1245/s10434-023-14860-y. PMID: 38190058
Cutaneous metastasectomy: Is there a role in breast cancer? A systematic review and overview of current treatment modalities.
Huang S, Parekh V, Waisman J, Jones V, Yuan Y, Vora N, Li R, Jung J, Kruper L, Abdulla F, Fong Y, Li WY
J Surg Oncol 2022 Aug;126(2):217-238. Epub 2022 Apr 7 doi: 10.1002/jso.26870. PMID: 35389520Free PMC Article
PSMA-Targeting Positron Emission Agents for Imaging Solid Tumors Other Than Non-Prostate Carcinoma: A Systematic Review.
Van de Wiele C, Sathekge M, de Spiegeleer B, de Jonghe PJ, Beels L, Maes A
Int J Mol Sci 2019 Oct 2;20(19) doi: 10.3390/ijms20194886. PMID: 31581638Free PMC Article
Clinical efficacy of mTOR inhibitors in solid tumors: a systematic review.
Huang Z, Wu Y, Zhou X, Qian J, Zhu W, Shu Y, Liu P
Future Oncol 2015;11(11):1687-99. doi: 10.2217/fon.15.70. PMID: 26043220
Systematic review of hypofractionated radiation therapy for prostate cancer.
Zaorsky NG, Ohri N, Showalter TN, Dicker AP, Den RB
Cancer Treat Rev 2013 Nov;39(7):728-36. Epub 2013 Mar 1 doi: 10.1016/j.ctrv.2013.01.008. PMID: 23453861Free PMC Article

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