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Sinonasal Papilloma

MedGen UID:
137735
Concept ID:
C0334268
Neoplastic Process
Synonyms: Benign inverted transitional cell papilloma; Benign inverted transitional papilloma; Benign transitional cell papilloma, inverted; Benign transitional papilloma, inverted; Schneiderian Papilloma; Sinonasal Schneiderian Papilloma
SNOMED CT: Benign transitional cell papilloma, inverted (818954001); Benign transitional papilloma, inverted (818954001); Benign inverted transitional cell papilloma (818954001); Benign inverted transitional papilloma (818954001)

Definition

A benign neoplasm that arises from the ciliated respiratory mucosa that lines the nasal cavity and paranasal sinuses. It is classified as inverted papilloma, oncocytic papilloma, and exophytic papilloma. Clinical manifestations include nasal obstruction, epistaxis, and anosmia. [from NCI]

Professional guidelines

PubMed

Kuan EC, Wang EW, Adappa ND, Beswick DM, London NR Jr, Su SY, Wang MB, Abuzeid WM, Alexiev B, Alt JA, Antognoni P, Alonso-Basanta M, Batra PS, Bhayani M, Bell D, Bernal-Sprekelsen M, Betz CS, Blay JY, Bleier BS, Bonilla-Velez J, Callejas C, Carrau RL, Casiano RR, Castelnuovo P, Chandra RK, Chatzinakis V, Chen SB, Chiu AG, Choby G, Chowdhury NI, Citardi MJ, Cohen MA, Dagan R, Dalfino G, Dallan I, Dassi CS, de Almeida J, Dei Tos AP, DelGaudio JM, Ebert CS, El-Sayed IH, Eloy JA, Evans JJ, Fang CH, Farrell NF, Ferrari M, Fischbein N, Folbe A, Fokkens WJ, Fox MG, Lund VJ, Gallia GL, Gardner PA, Geltzeiler M, Georgalas C, Getz AE, Govindaraj S, Gray ST, Grayson JW, Gross BA, Grube JG, Guo R, Ha PK, Halderman AA, Hanna EY, Harvey RJ, Hernandez SC, Holtzman AL, Hopkins C, Huang Z, Huang Z, Humphreys IM, Hwang PH, Iloreta AM, Ishii M, Ivan ME, Jafari A, Kennedy DW, Khan M, Kimple AJ, Kingdom TT, Knisely A, Kuo YJ, Lal D, Lamarre ED, Lan MY, Le H, Lechner M, Lee NY, Lee JK, Lee VH, Levine CG, Lin JC, Lin DT, Lobo BC, Locke T, Luong AU, Magliocca KR, Markovic SN, Matnjani G, McKean EL, Meço C, Mendenhall WM, Michel L, Na'ara S, Nicolai P, Nuss DW, Nyquist GG, Oakley GM, Omura K, Orlandi RR, Otori N, Papagiannopoulos P, Patel ZM, Pfister DG, Phan J, Psaltis AJ, Rabinowitz MR, Ramanathan M Jr, Rimmer R, Rosen MR, Sanusi O, Sargi ZB, Schafhausen P, Schlosser RJ, Sedaghat AR, Senior BA, Shrivastava R, Sindwani R, Smith TL, Smith KA, Snyderman CH, Solares CA, Sreenath SB, Stamm A, Stölzel K, Sumer B, Surda P, Tajudeen BA, Thompson LDR, Thorp BD, Tong CCL, Tsang RK, Turner JH, Turri-Zanoni M, Udager AM, van Zele T, VanKoevering K, Welch KC, Wise SK, Witterick IJ, Won TB, Wong SN, Woodworth BA, Wormald PJ, Yao WC, Yeh CF, Zhou B, Palmer JN
Int Forum Allergy Rhinol 2024 Feb;14(2):149-608. Epub 2024 Jan 2 doi: 10.1002/alr.23262. PMID: 37658764
Israel AK, Cracolici V, Griffith CC
Semin Diagn Pathol 2023 Sep;40(5):321-332. Epub 2023 Apr 14 doi: 10.1053/j.semdp.2023.04.011. PMID: 37085435
Contrera KJ, Woody NM, Rahman M, Sindwani R, Burkey BB
Head Neck 2020 Aug;42(8):2202-2212. Epub 2020 Mar 25 doi: 10.1002/hed.26150. PMID: 32212360

Recent clinical studies

Etiology

Kuan EC, Wang EW, Adappa ND, Beswick DM, London NR Jr, Su SY, Wang MB, Abuzeid WM, Alexiev B, Alt JA, Antognoni P, Alonso-Basanta M, Batra PS, Bhayani M, Bell D, Bernal-Sprekelsen M, Betz CS, Blay JY, Bleier BS, Bonilla-Velez J, Callejas C, Carrau RL, Casiano RR, Castelnuovo P, Chandra RK, Chatzinakis V, Chen SB, Chiu AG, Choby G, Chowdhury NI, Citardi MJ, Cohen MA, Dagan R, Dalfino G, Dallan I, Dassi CS, de Almeida J, Dei Tos AP, DelGaudio JM, Ebert CS, El-Sayed IH, Eloy JA, Evans JJ, Fang CH, Farrell NF, Ferrari M, Fischbein N, Folbe A, Fokkens WJ, Fox MG, Lund VJ, Gallia GL, Gardner PA, Geltzeiler M, Georgalas C, Getz AE, Govindaraj S, Gray ST, Grayson JW, Gross BA, Grube JG, Guo R, Ha PK, Halderman AA, Hanna EY, Harvey RJ, Hernandez SC, Holtzman AL, Hopkins C, Huang Z, Huang Z, Humphreys IM, Hwang PH, Iloreta AM, Ishii M, Ivan ME, Jafari A, Kennedy DW, Khan M, Kimple AJ, Kingdom TT, Knisely A, Kuo YJ, Lal D, Lamarre ED, Lan MY, Le H, Lechner M, Lee NY, Lee JK, Lee VH, Levine CG, Lin JC, Lin DT, Lobo BC, Locke T, Luong AU, Magliocca KR, Markovic SN, Matnjani G, McKean EL, Meço C, Mendenhall WM, Michel L, Na'ara S, Nicolai P, Nuss DW, Nyquist GG, Oakley GM, Omura K, Orlandi RR, Otori N, Papagiannopoulos P, Patel ZM, Pfister DG, Phan J, Psaltis AJ, Rabinowitz MR, Ramanathan M Jr, Rimmer R, Rosen MR, Sanusi O, Sargi ZB, Schafhausen P, Schlosser RJ, Sedaghat AR, Senior BA, Shrivastava R, Sindwani R, Smith TL, Smith KA, Snyderman CH, Solares CA, Sreenath SB, Stamm A, Stölzel K, Sumer B, Surda P, Tajudeen BA, Thompson LDR, Thorp BD, Tong CCL, Tsang RK, Turner JH, Turri-Zanoni M, Udager AM, van Zele T, VanKoevering K, Welch KC, Wise SK, Witterick IJ, Won TB, Wong SN, Woodworth BA, Wormald PJ, Yao WC, Yeh CF, Zhou B, Palmer JN
Int Forum Allergy Rhinol 2024 Feb;14(2):149-608. Epub 2024 Jan 2 doi: 10.1002/alr.23262. PMID: 37658764
Israel AK, Cracolici V, Griffith CC
Semin Diagn Pathol 2023 Sep;40(5):321-332. Epub 2023 Apr 14 doi: 10.1053/j.semdp.2023.04.011. PMID: 37085435
Viitasalo S, Ilmarinen T, Aaltonen LM, Hagström J, Hytönen M, Hammarén-Malmi S, Pietarinen P, Järvenpää P, Kinnari T, Geneid A, Lilja M
Laryngoscope 2023 Mar;133(3):506-511. Epub 2022 Apr 5 doi: 10.1002/lary.30128. PMID: 35383941
Archang M, Chew L, Han AY, Sajed D, Vorasubin N, Wang M
Am J Rhinol Allergy 2022 Nov;36(6):827-834. Epub 2022 Aug 2 doi: 10.1177/19458924221116441. PMID: 35915990
Zabolotnyi D, Zabolotna D, Zinchenko D, Tsvirinko I, Kizim Y
Georgian Med News 2020 Sep;(306):31-37. PMID: 33130642

Diagnosis

Yui R, Takahashi M, Noda K, Yoshida K, Sakurai R, Ohira S, Omura K, Otori N, Wada K, Kojima H
Sci Rep 2023 Aug 2;13(1):12439. doi: 10.1038/s41598-023-38913-0. PMID: 37532726Free PMC Article
Israel AK, Cracolici V, Griffith CC
Semin Diagn Pathol 2023 Sep;40(5):321-332. Epub 2023 Apr 14 doi: 10.1053/j.semdp.2023.04.011. PMID: 37085435
Viitasalo S, Ilmarinen T, Aaltonen LM, Hagström J, Hytönen M, Hammarén-Malmi S, Pietarinen P, Järvenpää P, Kinnari T, Geneid A, Lilja M
Laryngoscope 2023 Mar;133(3):506-511. Epub 2022 Apr 5 doi: 10.1002/lary.30128. PMID: 35383941
Sbrana MF, Borges RFR, Pinna FR, Neto DB, Voegels RL
Braz J Otorhinolaryngol 2021 Jan-Feb;87(1):80-84. Epub 2019 Aug 12 doi: 10.1016/j.bjorl.2019.07.003. PMID: 31455578Free PMC Article
Zabolotnyi D, Zabolotna D, Zinchenko D, Tsvirinko I, Kizim Y
Georgian Med News 2020 Sep;(306):31-37. PMID: 33130642

Therapy

Inga P, Pavel T, Tatiana D, Svetlana S, Timur S, Irina A, Andrey B, Vladimir P, Anastasia K, Irada I
Braz J Otorhinolaryngol 2024 Sep-Oct;90(5):101449. Epub 2024 Jun 3 doi: 10.1016/j.bjorl.2024.101449. PMID: 38972285Free PMC Article
Chatelet F, Vinciguerra A, Marc M, Herman P, Verillaud B
Int Forum Allergy Rhinol 2024 Nov;14(11):1834-1837. Epub 2024 Jun 27 doi: 10.1002/alr.23399. PMID: 38934682
Fulla M, Szafarowski T, Frias-Gomez J, Quiros B, Clavero O, Gomà M, Pavon MA, Jurek-Matusiak O, Lares HR, Mañós M, Alemany L, Mena M, Gonzalez X
Head Neck Pathol 2020 Sep;14(3):758-767. Epub 2020 Jan 8 doi: 10.1007/s12105-019-01125-y. PMID: 31916205Free PMC Article

Prognosis

Kakkar A, Satapathy S, Sikka K, Tanwar P, Deo S, Jain D
Virchows Arch 2023 Sep;483(3):381-392. Epub 2023 Jul 15 doi: 10.1007/s00428-023-03601-x. PMID: 37452847
Archang M, Chew L, Han AY, Sajed D, Vorasubin N, Wang M
Am J Rhinol Allergy 2022 Nov;36(6):827-834. Epub 2022 Aug 2 doi: 10.1177/19458924221116441. PMID: 35915990
Wang H, Liu Q, Xu R, Zhang H, Zhai C, Sun X, Yu H, Wang D
Auris Nasus Larynx 2022 Feb;49(1):77-83. Epub 2021 Jun 11 doi: 10.1016/j.anl.2021.05.008. PMID: 34127313
Cabal VN, Menendez M, Vivanco B, Potes-Ares S, Riobello C, Suarez-Fernandez L, Garcia-Marin R, Blanco-Lorenzo V, Lopez F, Alvarez-Marcos C, Llorente JL, Hermsen MA
Rhinology 2020 Aug 1;58(4):368-376. doi: 10.4193/Rhin19.371. PMID: 32199023
Bishop JA
Head Neck Pathol 2017 Sep;11(3):269-277. Epub 2017 Mar 20 doi: 10.1007/s12105-017-0799-9. PMID: 28321771Free PMC Article

Clinical prediction guides

Yui R, Takahashi M, Noda K, Yoshida K, Sakurai R, Ohira S, Omura K, Otori N, Wada K, Kojima H
Sci Rep 2023 Aug 2;13(1):12439. doi: 10.1038/s41598-023-38913-0. PMID: 37532726Free PMC Article
Wang H, Liu Q, Xu R, Zhang H, Zhai C, Sun X, Yu H, Wang D
Auris Nasus Larynx 2022 Feb;49(1):77-83. Epub 2021 Jun 11 doi: 10.1016/j.anl.2021.05.008. PMID: 34127313
Cabal VN, Menendez M, Vivanco B, Potes-Ares S, Riobello C, Suarez-Fernandez L, Garcia-Marin R, Blanco-Lorenzo V, Lopez F, Alvarez-Marcos C, Llorente JL, Hermsen MA
Rhinology 2020 Aug 1;58(4):368-376. doi: 10.4193/Rhin19.371. PMID: 32199023
Bishop JA
Head Neck Pathol 2017 Sep;11(3):269-277. Epub 2017 Mar 20 doi: 10.1007/s12105-017-0799-9. PMID: 28321771Free PMC Article
Nomura K, Ogawa T, Sugawara M, Honkura Y, Oshima H, Arakawa K, Oshima T, Katori Y
Tohoku J Exp Med 2013 Dec;231(4):315-9. doi: 10.1620/tjem.231.315. PMID: 24366355

Recent systematic reviews

Trent MS, Goshtasbi K, Hui L, Stuyt JAG, Adappa ND, Palmer JN, Kuan EC
Otolaryngol Head Neck Surg 2022 Sep;167(3):425-433. Epub 2021 Oct 12 doi: 10.1177/01945998211051975. PMID: 34637363

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