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Cardiac germ cell tumor

MedGen UID:
1633290
•Concept ID:
C4687640
•
Neoplastic Process
Synonyms: Cardiac Germ Cell Tumor; cardiac germ cell tumor; Heart Germ Cell Tumor; heart germ cell tumor; heart germ cell tumour
 
Monarch Initiative: MONDO:0020589

Definition

A germ cell tumor that arises within the myocardium or cardiac chambers. The reported cases have been teratomas and yolk sac tumors. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCardiac germ cell tumor

Professional guidelines

PubMed

Catecholamine-induced hypertensive crises: current insights and management.
Nazari MA, Hasan R, Haigney M, Maghsoudi A, Lenders JWM, Carey RM, Pacak K
Lancet Diabetes Endocrinol 2023 Dec;11(12):942-954. Epub 2023 Nov 6 doi: 10.1016/S2213-8587(23)00256-5. PMID: 37944546
Clinical consensus guideline on the management of phaeochromocytoma and paraganglioma in patients harbouring germline SDHD pathogenic variants.
Taïeb D, Wanna GB, Ahmad M, Lussey-Lepoutre C, Perrier ND, Nölting S, Amar L, Timmers HJLM, Schwam ZG, Estrera AL, Lim M, Pollom EL, Vitzthum L, Bourdeau I, Casey RT, Castinetti F, Clifton-Bligh R, Corssmit EPM, de Krijger RR, Del Rivero J, Eisenhofer G, Ghayee HK, Gimenez-Roqueplo AP, Grossman A, Imperiale A, Jansen JC, Jha A, Kerstens MN, Kunst HPM, Liu JK, Maher ER, Marchioni D, Mercado-Asis LB, Mete O, Naruse M, Nilubol N, Pandit-Taskar N, Sebag F, Tanabe A, Widimsky J, Meuter L, Lenders JWM, Pacak K
Lancet Diabetes Endocrinol 2023 May;11(5):345-361. Epub 2023 Mar 31 doi: 10.1016/S2213-8587(23)00038-4. PMID: 37011647Free PMC Article
Management of Small Bowel Neuroendocrine Tumors.
Scott AT, Howe JR
Surg Oncol Clin N Am 2020 Apr;29(2):223-241. doi: 10.1016/j.soc.2019.11.006. PMID: 32151357

Recent clinical studies

Etiology

Pheochromocytoma-induced cardiogenic shock.
Louis S, Selma H, Nicolas T
Acta Chir Belg 2023 Oct;123(5):573-576. Epub 2022 May 22 doi: 10.1080/00015458.2022.2079822. PMID: 35583372
GP2-enriched pancreatic progenitors give rise to functional beta cells in vivo and eliminate the risk of teratoma formation.
Aghazadeh Y, Sarangi F, Poon F, Nkennor B, McGaugh EC, Nunes SS, Nostro MC
Stem Cell Reports 2022 Apr 12;17(4):964-978. Epub 2022 Mar 31 doi: 10.1016/j.stemcr.2022.03.004. PMID: 35364010Free PMC Article
Is there an optimal preoperative management strategy for phaeochromocytoma/paraganglioma?
Challis BG, Casey RT, Simpson HL, Gurnell M
Clin Endocrinol (Oxf) 2017 Feb;86(2):163-167. Epub 2016 Oct 24 doi: 10.1111/cen.13252. PMID: 27696513
Cardiac paraganglioma.
El-Ashry AA, Cerfolio RJ, Singh SP, McGiffin D
J Card Surg 2015 Feb;30(2):135-9. Epub 2014 Dec 22 doi: 10.1111/jocs.12479. PMID: 25533017
Glioblastoma and other malignant gliomas: a clinical review.
Omuro A, DeAngelis LM
JAMA 2013 Nov 6;310(17):1842-50. doi: 10.1001/jama.2013.280319. PMID: 24193082

Diagnosis

Multimodality imaging appearance of intrapericardial paragangliomas.
Palacio D, Jo N, Del Pilar Gutierrez M, Shponka V, Betancourt S
Clin Radiol 2022 Dec;77(12):952-959. Epub 2022 Sep 26 doi: 10.1016/j.crad.2022.08.131. PMID: 36175258
Acute Stress Cardiomyopathy: Heart of pheochromocytoma.
Cornu E, Motiejunaite J, Belmihoub I, Vidal-Petiot E, Mirabel M, Amar L
Ann Endocrinol (Paris) 2021 Jun;82(3-4):201-205. Epub 2020 Mar 18 doi: 10.1016/j.ando.2020.03.011. PMID: 32988608
Neoplastic Pericardial Disease.
Maleszewski JJ, Anavekar NS
Cardiol Clin 2017 Nov;35(4):589-600. Epub 2017 Sep 6 doi: 10.1016/j.ccl.2017.07.011. PMID: 29025549
Cardiac paragangliomas.
Wang JG, Han J, Jiang T, Li YJ
J Card Surg 2015 Jan;30(1):55-60. Epub 2014 Oct 20 doi: 10.1111/jocs.12455. PMID: 25331372
Neonatal liver tumours.
von Schweinitz D
Semin Neonatol 2003 Oct;8(5):403-10. doi: 10.1016/S1084-2756(03)00092-7. PMID: 15001128

Therapy

Prognosis of Patients With Primary Melanoma Stage I and II According to American Joint Committee on Cancer Version 8 Validated in Two Independent Cohorts: Implications for Adjuvant Treatment.
Garbe C, Keim U, Amaral T, Berking C, Eigentler TK, Flatz L, Gesierich A, Leiter U, Stadler R, Sunderkötter C, Tüting T, Utikal J, Wollina U, Zimmer L, Zouboulis CC, Ascierto PA, Eggermont AMM, Grob JJ, Hauschild A, Sekulovic LK, Long GV, Luke JJ, Michielin O, Peris K, Schadendorf D, Kirkwood JM, Lorigan PC; Central Malignant Melanoma Registry (CMMR)
J Clin Oncol 2022 Nov 10;40(32):3741-3749. Epub 2022 Jun 16 doi: 10.1200/JCO.22.00202. PMID: 35709414Free PMC Article
Is there an optimal preoperative management strategy for phaeochromocytoma/paraganglioma?
Challis BG, Casey RT, Simpson HL, Gurnell M
Clin Endocrinol (Oxf) 2017 Feb;86(2):163-167. Epub 2016 Oct 24 doi: 10.1111/cen.13252. PMID: 27696513
Carcinoid tumor.
Kinova S, Duris I
Bratisl Lek Listy 2001;102(11):495-504. PMID: 11901706
Carcinoid tumours.
Janmohamed S, Bloom SR
Postgrad Med J 1997 Apr;73(858):207-14. doi: 10.1136/pgmj.73.858.207. PMID: 9156122Free PMC Article
Glucagon.
Br Med J 1971 Aug 26;3(5773):524-5. PMID: 4327680Free PMC Article

Prognosis

Hypertensive Heartbreak.
Lau ES, Scirica B, Schaefer IM, Miller AL, Loscalzo J
N Engl J Med 2021 Jun 3;384(22):2145-2152. doi: 10.1056/NEJMcps2018493. PMID: 34077647
Carcinoid heart disease.
Hassan SA, Banchs J, Iliescu C, Dasari A, Lopez-Mattei J, Yusuf SW
Heart 2017 Oct;103(19):1488-1495. Epub 2017 Jun 8 doi: 10.1136/heartjnl-2017-311261. PMID: 28596302
Cardiac paraganglioma.
El-Ashry AA, Cerfolio RJ, Singh SP, McGiffin D
J Card Surg 2015 Feb;30(2):135-9. Epub 2014 Dec 22 doi: 10.1111/jocs.12479. PMID: 25533017
Neonatal liver tumours.
von Schweinitz D
Semin Neonatol 2003 Oct;8(5):403-10. doi: 10.1016/S1084-2756(03)00092-7. PMID: 15001128
Carcinoid tumors.
Kulke MH, Mayer RJ
N Engl J Med 1999 Mar 18;340(11):858-68. doi: 10.1056/NEJM199903183401107. PMID: 10080850

Clinical prediction guides

A rare case of chordoma cutis.
Jung D, Ko SM, Seo J, Park EJ, Kim KJ, Kim KH
J Cutan Pathol 2023 Nov;50(11):951-955. Epub 2023 Aug 31 doi: 10.1111/cup.14525. PMID: 37654082
Clinical consensus guideline on the management of phaeochromocytoma and paraganglioma in patients harbouring germline SDHD pathogenic variants.
Taïeb D, Wanna GB, Ahmad M, Lussey-Lepoutre C, Perrier ND, Nölting S, Amar L, Timmers HJLM, Schwam ZG, Estrera AL, Lim M, Pollom EL, Vitzthum L, Bourdeau I, Casey RT, Castinetti F, Clifton-Bligh R, Corssmit EPM, de Krijger RR, Del Rivero J, Eisenhofer G, Ghayee HK, Gimenez-Roqueplo AP, Grossman A, Imperiale A, Jansen JC, Jha A, Kerstens MN, Kunst HPM, Liu JK, Maher ER, Marchioni D, Mercado-Asis LB, Mete O, Naruse M, Nilubol N, Pandit-Taskar N, Sebag F, Tanabe A, Widimsky J, Meuter L, Lenders JWM, Pacak K
Lancet Diabetes Endocrinol 2023 May;11(5):345-361. Epub 2023 Mar 31 doi: 10.1016/S2213-8587(23)00038-4. PMID: 37011647Free PMC Article
Cardiac Imaging in Carcinoid Heart Disease.
Baron T, Bergsten J, Albåge A, Lundin L, Sörensen J, Öberg K, Flachskampf FA
JACC Cardiovasc Imaging 2021 Nov;14(11):2240-2253. Epub 2021 Apr 14 doi: 10.1016/j.jcmg.2020.12.030. PMID: 33865761
The theranostic promise for Neuroendocrine Tumors in the late 2010s - Where do we stand, where do we go?
Werner RA, Weich A, Kircher M, Solnes LB, Javadi MS, Higuchi T, Buck AK, Pomper MG, Rowe SP, Lapa C
Theranostics 2018;8(22):6088-6100. Epub 2018 Nov 29 doi: 10.7150/thno.30357. PMID: 30613284Free PMC Article
Cardiac paraganglioma.
Yadav PK, Baquero GA, Malysz J, Kelleman J, Gilchrist IC
Circ Cardiovasc Interv 2014 Dec;7(6):851-6. doi: 10.1161/CIRCINTERVENTIONS.114.001856. PMID: 25516760

Recent systematic reviews

Middle Meningeal Artery Embolization in Pediatric Patients.
Vazquez S, Zuckerman DA, Gandhi C, Al-Mufti F, Muh C, Santarelli J, Pisapia JM
Pediatr Neurosurg 2024;59(1):44-53. Epub 2023 Oct 30 doi: 10.1159/000534895. PMID: 37903471
Association between genetically determined telomere length and health-related outcomes: A systematic review and meta-analysis of Mendelian randomization studies.
Chen B, Yan Y, Wang H, Xu J
Aging Cell 2023 Jul;22(7):e13874. Epub 2023 May 26 doi: 10.1111/acel.13874. PMID: 37232505Free PMC Article
Diagnostic test accuracy meta-analysis of PRAME in distinguishing primary cutaneous melanomas from benign melanocytic lesions.
Kunc M, Żemierowska N, Skowronek F, Biernat W
Histopathology 2023 Jul;83(1):3-14. Epub 2023 Mar 21 doi: 10.1111/his.14904. PMID: 36942814
Increased risk of melanoma in organ transplant recipients: systematic review and meta-analysis of cohort studies.
Green AC, Olsen CM
Acta Derm Venereol 2015 Nov;95(8):923-7. doi: 10.2340/00015555-2148. PMID: 26012553
Pulmonary neuroendocrine (carcinoid) tumors: European Neuroendocrine Tumor Society expert consensus and recommendations for best practice for typical and atypical pulmonary carcinoids.
Caplin ME, Baudin E, Ferolla P, Filosso P, Garcia-Yuste M, Lim E, Oberg K, Pelosi G, Perren A, Rossi RE, Travis WD; ENETS consensus conference participants
Ann Oncol 2015 Aug;26(8):1604-20. Epub 2015 Feb 2 doi: 10.1093/annonc/mdv041. PMID: 25646366

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