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Advanced Neuroendocrine Carcinoma

MedGen UID:
1652312
•Concept ID:
C4744427
•
Neoplastic Process

Definition

A neuroendocrine carcinoma that has metastasized from its original site of growth to distal anatomic sites or is no longer responding to treatment. [from NCI]

Professional guidelines

PubMed

Adverse event management in patients with advanced cancer receiving oral everolimus: focus on breast cancer.
Aapro M, Andre F, Blackwell K, Calvo E, Jahanzeb M, Papazisis K, Porta C, Pritchard K, Ravaud A
Ann Oncol 2014 Apr;25(4):763-773. doi: 10.1093/annonc/mdu021. PMID: 24667713
Practical management of everolimus-related toxicities in patients with advanced solid tumors.
Grünwald V, Weikert S, Pavel ME, Hörsch D, Lüftner D, Janni W, Geberth M, Weber MM
Onkologie 2013;36(5):295-302. Epub 2013 Apr 5 doi: 10.1159/000350625. PMID: 23689226

Recent clinical studies

Etiology

Paclitaxel-carboplatin plus bevacizumab therapy for advanced neuroendocrine carcinoma of the uterine cervix: A retrospective case series.
Kotaka S, Kondo E, Kawai Y, Okamoto K, Kishigami Y, Yamawaki T, Nagao K, Toru H, Suzuki S
J Obstet Gynaecol Res 2023 Dec;49(12):2868-2874. Epub 2023 Sep 2 doi: 10.1111/jog.15783. PMID: 37658751
Bevacizumab plus FOLFIRI after failure of platinum-etoposide first-line chemotherapy in patients with advanced neuroendocrine carcinoma (PRODIGE 41-BEVANEC): a randomised, multicentre, non-comparative, open-label, phase 2 trial.
Walter T, Lievre A, Coriat R, Malka D, Elhajbi F, Di Fiore F, Hentic O, Smith D, Hautefeuille V, Roquin G, Perrier M, Dahan L, Granger V, Sobhani I, Mineur L, Niccoli P, Assenat E, Scoazec JY, Le Malicot K, Lepage C, Lombard-Bohas C
Lancet Oncol 2023 Mar;24(3):297-306. Epub 2023 Feb 2 doi: 10.1016/S1470-2045(23)00001-3. PMID: 36739879
Effectiveness of Etoposide and Cisplatin vs Irinotecan and Cisplatin Therapy for Patients With Advanced Neuroendocrine Carcinoma of the Digestive System: The TOPIC-NEC Phase 3 Randomized Clinical Trial.
Morizane C, Machida N, Honma Y, Okusaka T, Boku N, Kato K, Nomura S, Hiraoka N, Sekine S, Taniguchi H, Okano N, Yamaguchi K, Sato T, Ikeda M, Mizuno N, Ozaka M, Kataoka T, Ueno M, Kitagawa Y, Terashima M, Furuse J; Japan Clinical Oncology Group (JCOG)
JAMA Oncol 2022 Oct 1;8(10):1447-1455. doi: 10.1001/jamaoncol.2022.3395. PMID: 35980649Free PMC Article
Radical Surgery After Neoadjuvant Chemotherapy for Locally Advanced Neuroendocrine Cancer of the Cervix.
Caruso G, Palaia I, DI Donato V, Pernazza A, Gallo R, Perniola G, Leopizzi M, Della Rocca C, Muzii L, Panici PB
Anticancer Res 2021 Sep;41(9):4431-4438. doi: 10.21873/anticanres.15250. PMID: 34475065
Multicenter retrospective analysis of systemic chemotherapy for advanced neuroendocrine carcinoma of the digestive system.
Yamaguchi T, Machida N, Morizane C, Kasuga A, Takahashi H, Sudo K, Nishina T, Tobimatsu K, Ishido K, Furuse J, Boku N, Okusaka T
Cancer Sci 2014 Sep;105(9):1176-81. Epub 2014 Sep 6 doi: 10.1111/cas.12473. PMID: 24975505Free PMC Article

Diagnosis

Radical Surgery After Neoadjuvant Chemotherapy for Locally Advanced Neuroendocrine Cancer of the Cervix.
Caruso G, Palaia I, DI Donato V, Pernazza A, Gallo R, Perniola G, Leopizzi M, Della Rocca C, Muzii L, Panici PB
Anticancer Res 2021 Sep;41(9):4431-4438. doi: 10.21873/anticanres.15250. PMID: 34475065
Neuroendocrine carcinoma of the stomach with peripancreatic lymph node metastases successfully treated with pancreaticoduodenectomy.
Ma J, Kimura W, Takeshita A, Hirai I, Moriya T, Mizutani M
Hepatogastroenterology 2007 Oct-Nov;54(79):1945-50. PMID: 18251134
Primary small cell undifferentiated (neuroendocrine) carcinoma of the maxillary sinus.
Georgiou AF, Walker DM, Collins AP, Morgan GJ, Shannon JA, Veness MJ
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2004 Nov;98(5):572-8. doi: 10.1016/j.tripleo.2004.04.003. PMID: 15529129

Therapy

Comparison of Efficacy and Safety between Carboplatin-Etoposide and Cisplatin-Etoposide Combination Therapy in Patients with Advanced Neuroendocrine Carcinoma: A Retrospective Study.
Imai H, Saijo K, Kawamura Y, Kodera S, Komine K, Iwasaki T, Takenaga N, Kasahara Y, Ouchi K, Shirota H, Takahashi M, Ishioka C
Oncology 2024;102(5):359-367. Epub 2023 Oct 30 doi: 10.1159/000534747. PMID: 37903486Free PMC Article
Paclitaxel-carboplatin plus bevacizumab therapy for advanced neuroendocrine carcinoma of the uterine cervix: A retrospective case series.
Kotaka S, Kondo E, Kawai Y, Okamoto K, Kishigami Y, Yamawaki T, Nagao K, Toru H, Suzuki S
J Obstet Gynaecol Res 2023 Dec;49(12):2868-2874. Epub 2023 Sep 2 doi: 10.1111/jog.15783. PMID: 37658751
Bevacizumab plus FOLFIRI after failure of platinum-etoposide first-line chemotherapy in patients with advanced neuroendocrine carcinoma (PRODIGE 41-BEVANEC): a randomised, multicentre, non-comparative, open-label, phase 2 trial.
Walter T, Lievre A, Coriat R, Malka D, Elhajbi F, Di Fiore F, Hentic O, Smith D, Hautefeuille V, Roquin G, Perrier M, Dahan L, Granger V, Sobhani I, Mineur L, Niccoli P, Assenat E, Scoazec JY, Le Malicot K, Lepage C, Lombard-Bohas C
Lancet Oncol 2023 Mar;24(3):297-306. Epub 2023 Feb 2 doi: 10.1016/S1470-2045(23)00001-3. PMID: 36739879
Effectiveness of Etoposide and Cisplatin vs Irinotecan and Cisplatin Therapy for Patients With Advanced Neuroendocrine Carcinoma of the Digestive System: The TOPIC-NEC Phase 3 Randomized Clinical Trial.
Morizane C, Machida N, Honma Y, Okusaka T, Boku N, Kato K, Nomura S, Hiraoka N, Sekine S, Taniguchi H, Okano N, Yamaguchi K, Sato T, Ikeda M, Mizuno N, Ozaka M, Kataoka T, Ueno M, Kitagawa Y, Terashima M, Furuse J; Japan Clinical Oncology Group (JCOG)
JAMA Oncol 2022 Oct 1;8(10):1447-1455. doi: 10.1001/jamaoncol.2022.3395. PMID: 35980649Free PMC Article
Case reports: chemoradiotherapy for locally advanced neuroendocrine carcinoma of the gallbladder.
Takeda Y, Kobayashi N, Kessoku T, Okubo N, Suzuki A, Tokuhisa M, Miwa H, Udaka N, Ichikawa Y
Clin J Gastroenterol 2022 Aug;15(4):803-808. Epub 2022 Jun 2 doi: 10.1007/s12328-022-01645-1. PMID: 35653037Free PMC Article

Prognosis

Comparison of Efficacy and Safety between Carboplatin-Etoposide and Cisplatin-Etoposide Combination Therapy in Patients with Advanced Neuroendocrine Carcinoma: A Retrospective Study.
Imai H, Saijo K, Kawamura Y, Kodera S, Komine K, Iwasaki T, Takenaga N, Kasahara Y, Ouchi K, Shirota H, Takahashi M, Ishioka C
Oncology 2024;102(5):359-367. Epub 2023 Oct 30 doi: 10.1159/000534747. PMID: 37903486Free PMC Article
Paclitaxel-carboplatin plus bevacizumab therapy for advanced neuroendocrine carcinoma of the uterine cervix: A retrospective case series.
Kotaka S, Kondo E, Kawai Y, Okamoto K, Kishigami Y, Yamawaki T, Nagao K, Toru H, Suzuki S
J Obstet Gynaecol Res 2023 Dec;49(12):2868-2874. Epub 2023 Sep 2 doi: 10.1111/jog.15783. PMID: 37658751
Multicenter retrospective analysis of systemic chemotherapy for advanced neuroendocrine carcinoma of the digestive system.
Yamaguchi T, Machida N, Morizane C, Kasuga A, Takahashi H, Sudo K, Nishina T, Tobimatsu K, Ishido K, Furuse J, Boku N, Okusaka T
Cancer Sci 2014 Sep;105(9):1176-81. Epub 2014 Sep 6 doi: 10.1111/cas.12473. PMID: 24975505Free PMC Article
A phase II clinical and pharmacodynamic study of temsirolimus in advanced neuroendocrine carcinomas.
Duran I, Kortmansky J, Singh D, Hirte H, Kocha W, Goss G, Le L, Oza A, Nicklee T, Ho J, Birle D, Pond GR, Arboine D, Dancey J, Aviel-Ronen S, Tsao MS, Hedley D, Siu LL
Br J Cancer 2006 Nov 6;95(9):1148-54. Epub 2006 Oct 10 doi: 10.1038/sj.bjc.6603419. PMID: 17031397Free PMC Article
Primary small cell undifferentiated (neuroendocrine) carcinoma of the maxillary sinus.
Georgiou AF, Walker DM, Collins AP, Morgan GJ, Shannon JA, Veness MJ
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2004 Nov;98(5):572-8. doi: 10.1016/j.tripleo.2004.04.003. PMID: 15529129

Clinical prediction guides

Case reports: chemoradiotherapy for locally advanced neuroendocrine carcinoma of the gallbladder.
Takeda Y, Kobayashi N, Kessoku T, Okubo N, Suzuki A, Tokuhisa M, Miwa H, Udaka N, Ichikawa Y
Clin J Gastroenterol 2022 Aug;15(4):803-808. Epub 2022 Jun 2 doi: 10.1007/s12328-022-01645-1. PMID: 35653037Free PMC Article
A phase II clinical and pharmacodynamic study of temsirolimus in advanced neuroendocrine carcinomas.
Duran I, Kortmansky J, Singh D, Hirte H, Kocha W, Goss G, Le L, Oza A, Nicklee T, Ho J, Birle D, Pond GR, Arboine D, Dancey J, Aviel-Ronen S, Tsao MS, Hedley D, Siu LL
Br J Cancer 2006 Nov 6;95(9):1148-54. Epub 2006 Oct 10 doi: 10.1038/sj.bjc.6603419. PMID: 17031397Free PMC Article

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