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Recurrent Malignant Pharyngeal Neoplasm

MedGen UID:
1657662
•Concept ID:
C4725807
•
Neoplastic Process

Definition

Reemergence of a malignant pharyngeal neoplasm after a period of remission. [from NCI]

Professional guidelines

PubMed

Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy.
Parmar A, Macluskey M, Mc Goldrick N, Conway DI, Glenny AM, Clarkson JE, Worthington HV, Chan KK
Cochrane Database Syst Rev 2021 Dec 20;12(12):CD006386. doi: 10.1002/14651858.CD006386.pub4. PMID: 34929047Free PMC Article
SEOM clinical guidelines for the treatment of head and neck cancer (2020).
Mesia R, Iglesias L, Lambea J, Martínez-Trufero J, Soria A, Taberna M, Trigo J, Chaves M, García-Castaño A, Cruz J
Clin Transl Oncol 2021 May;23(5):913-921. Epub 2021 Feb 26 doi: 10.1007/s12094-020-02533-1. PMID: 33635468Free PMC Article
Management of locally recurrent nasopharyngeal carcinoma.
Lee AWM, Ng WT, Chan JYW, Corry J, Mäkitie A, Mendenhall WM, Rinaldo A, Rodrigo JP, Saba NF, Strojan P, Suárez C, Vermorken JB, Yom SS, Ferlito A
Cancer Treat Rev 2019 Sep;79:101890. Epub 2019 Aug 21 doi: 10.1016/j.ctrv.2019.101890. PMID: 31470314

Recent clinical studies

Etiology

International Recommendations on Reirradiation by Intensity Modulated Radiation Therapy for Locally Recurrent Nasopharyngeal Carcinoma.
Ng WT, Soong YL, Ahn YC, AlHussain H, Choi HCW, Corry J, Grégoire V, Harrington KJ, Hu CS, Jensen K, Kwong DL, Langendijk JA, Le QT, Lee NY, Lin JC, Lu TX, Mendenhall WM, O'Sullivan B, Ozyar E, Pan JJ, Peters LJ, Poh SS, Rosenthal DI, Sanguineti G, Tao Y, Wee JT, Yom SS, Chua MLK, Lee AWM
Int J Radiat Oncol Biol Phys 2021 Jul 1;110(3):682-695. Epub 2021 Feb 9 doi: 10.1016/j.ijrobp.2021.01.041. PMID: 33571626
Management of locally recurrent nasopharyngeal carcinoma.
Lee AWM, Ng WT, Chan JYW, Corry J, Mäkitie A, Mendenhall WM, Rinaldo A, Rodrigo JP, Saba NF, Strojan P, Suárez C, Vermorken JB, Yom SS, Ferlito A
Cancer Treat Rev 2019 Sep;79:101890. Epub 2019 Aug 21 doi: 10.1016/j.ctrv.2019.101890. PMID: 31470314
Parapharyngeal space primary tumours.
Grilli G, Suarez V, Muñoz MG, Costales M, Llorente JL
Acta Otorrinolaringol Esp (Engl Ed) 2017 May-Jun;68(3):138-144. doi: 10.1016/j.otorri.2016.06.003. PMID: 27663220
Nasopharyngeal carcinoma.
Chan AT
Ann Oncol 2010 Oct;21 Suppl 7:vii308-12. doi: 10.1093/annonc/mdq277. PMID: 20943634
Parapharyngeal space neoplasms.
Hughes KV 3rd, Olsen KD, McCaffrey TV
Head Neck 1995 Mar-Apr;17(2):124-30. doi: 10.1002/hed.2880170209. PMID: 7558809

Diagnosis

Management of locally recurrent nasopharyngeal carcinoma.
Lee AWM, Ng WT, Chan JYW, Corry J, Mäkitie A, Mendenhall WM, Rinaldo A, Rodrigo JP, Saba NF, Strojan P, Suárez C, Vermorken JB, Yom SS, Ferlito A
Cancer Treat Rev 2019 Sep;79:101890. Epub 2019 Aug 21 doi: 10.1016/j.ctrv.2019.101890. PMID: 31470314
Lymphangioma of the palatine tonsil.
Mardekian S, Karp JK
Arch Pathol Lab Med 2013 Dec;137(12):1837-42. doi: 10.5858/arpa.2012-0678-RS. PMID: 24283866
Reoperative maxillofacial oncology.
Petrisor D, Fernandes R
Oral Maxillofac Surg Clin North Am 2011 Feb;23(1):161-8, vii. doi: 10.1016/j.coms.2010.11.002. PMID: 21272772
Nasopharyngeal carcinoma.
Chan AT
Ann Oncol 2010 Oct;21 Suppl 7:vii308-12. doi: 10.1093/annonc/mdq277. PMID: 20943634
Hypopharyngeal cancer.
Wycliffe ND, Grover RS, Kim PD, Simental A Jr
Top Magn Reson Imaging 2007 Aug;18(4):243-58. doi: 10.1097/RMR.0b013e3181570c3f. PMID: 17893590

Therapy

Hyperfractionation compared with standard fractionation in intensity-modulated radiotherapy for patients with locally advanced recurrent nasopharyngeal carcinoma: a multicentre, randomised, open-label, phase 3 trial.
You R, Liu YP, Xie YL, Lin C, Duan CY, Chen DP, Pan Y, Qi B, Zou X, Guo L, Cao JY, Zhang YN, Wang ZQ, Liu YL, Ouyang YF, Wen K, Yang Q, Xie RQ, Li HF, Duan XT, Ding X, Peng L, Chen SY, Liang JL, Feng ZK, Xia TL, Xie RL, Jiang R, Gu CM, Liu RZ, Sun R, Yang X, Liu LZ, Ling L, Liu Q, Ng WT, Hua YJ, Huang PY, Chen MY
Lancet 2023 Mar 18;401(10380):917-927. Epub 2023 Feb 23 doi: 10.1016/S0140-6736(23)00269-6. PMID: 36842439
Camrelizumab Plus Apatinib in Patients With Recurrent or Metastatic Nasopharyngeal Carcinoma: An Open-Label, Single-Arm, Phase II Study.
Ding X, Zhang WJ, You R, Zou X, Wang ZQ, Ouyang YF, Peng L, Liu YP, Duan CY, Yang Q, Lin C, Xie YL, Chen SY, Liu YL, Gu CM, Xie RQ, Huang PY, Hong MH, Hua YJ, Chen MY
J Clin Oncol 2023 May 10;41(14):2571-2582. Epub 2023 Feb 3 doi: 10.1200/JCO.22.01450. PMID: 36735896Free PMC Article
Clinical trial data of Anti-PD-1/PD-L1 therapy for recurrent or metastatic nasopharyngeal Carcinoma: A review.
Adkins DR, Haddad RI
Cancer Treat Rev 2022 Sep;109:102428. Epub 2022 Jun 15 doi: 10.1016/j.ctrv.2022.102428. PMID: 35753157
Elective upper-neck versus whole-neck irradiation of the uninvolved neck in patients with nasopharyngeal carcinoma: an open-label, non-inferiority, multicentre, randomised phase 3 trial.
Tang LL, Huang CL, Zhang N, Jiang W, Wu YS, Huang SH, Mao YP, Liu Q, Li JB, Liang SQ, Qin GJ, Hu WH, Sun Y, Xie FY, Chen L, Zhou GQ, Ma J
Lancet Oncol 2022 Apr;23(4):479-490. Epub 2022 Feb 28 doi: 10.1016/S1470-2045(22)00058-4. PMID: 35240053
Efficacy, Safety, and Correlative Biomarkers of Toripalimab in Previously Treated Recurrent or Metastatic Nasopharyngeal Carcinoma: A Phase II Clinical Trial (POLARIS-02).
Wang FH, Wei XL, Feng J, Li Q, Xu N, Hu XC, Liao W, Jiang Y, Lin XY, Zhang QY, Yuan XL, Huang HX, Chen Y, Dai GH, Shi JH, Shen L, Yang SJ, Shu YQ, Liu YP, Wang W, Wu H, Feng H, Yao S, Xu RH
J Clin Oncol 2021 Mar 1;39(7):704-712. Epub 2021 Jan 25 doi: 10.1200/JCO.20.02712. PMID: 33492986Free PMC Article

Prognosis

Management of locally recurrent nasopharyngeal carcinoma.
Lee AWM, Ng WT, Chan JYW, Corry J, Mäkitie A, Mendenhall WM, Rinaldo A, Rodrigo JP, Saba NF, Strojan P, Suárez C, Vermorken JB, Yom SS, Ferlito A
Cancer Treat Rev 2019 Sep;79:101890. Epub 2019 Aug 21 doi: 10.1016/j.ctrv.2019.101890. PMID: 31470314
Lymphangioma of the palatine tonsil.
Mardekian S, Karp JK
Arch Pathol Lab Med 2013 Dec;137(12):1837-42. doi: 10.5858/arpa.2012-0678-RS. PMID: 24283866
Costs and effectiveness in the care of patients with oral and pharyngeal cancer: analysis of a paradox.
Mignogna MD, Fedele S, Lo Russo L, Ruoppo E, Lo Muzio L
Eur J Cancer Prev 2002 Jun;11(3):205-8. doi: 10.1097/00008469-200206000-00002. PMID: 12131652
Parapharyngeal space neoplasms.
Hughes KV 3rd, Olsen KD, McCaffrey TV
Head Neck 1995 Mar-Apr;17(2):124-30. doi: 10.1002/hed.2880170209. PMID: 7558809
Tumors and surgery of the parapharyngeal space.
Olsen KD
Laryngoscope 1994 May;104(5 Pt 2 Suppl 63):1-28. doi: 10.1288/00005537-199405000-00001. PMID: 8189998

Clinical prediction guides

Oncologic Outcomes After Clinically Node-Negative Salvage Laryngectomy.
Gross JH, Patel MR, Switchenko JM, Chan TG, Baddour HM, Kaka A, Boyce BJ, Saba NF, Beitler JJ, El-Deiry M
JAMA Otolaryngol Head Neck Surg 2023 Jan 1;149(1):24-33. doi: 10.1001/jamaoto.2022.3597. PMID: 36394866Free PMC Article
Clinical trial data of Anti-PD-1/PD-L1 therapy for recurrent or metastatic nasopharyngeal Carcinoma: A review.
Adkins DR, Haddad RI
Cancer Treat Rev 2022 Sep;109:102428. Epub 2022 Jun 15 doi: 10.1016/j.ctrv.2022.102428. PMID: 35753157
Maintenance metronomic chemotherapy for metastatic/recurrent nasopharyngeal carcinoma.
Twu CW, Lin PJ, Tsou HH, Liu YC, Jiang RS, Liang KL, Lin TY, Wang WY, Lin JC
Head Neck 2022 Jun;44(6):1453-1461. Epub 2022 Apr 1 doi: 10.1002/hed.27044. PMID: 35362634
Reirradiation of locally recurrent nasopharyngeal cancer: history, advances, and promises for the future.
Kong L, Lu JJ
Chin Clin Oncol 2016 Apr;5(2):26. doi: 10.21037/cco.2016.03.19. PMID: 27121886
Juvenile nasopharyngeal angiofibroma staging: An overview.
Alshaikh NA, Eleftheriadou A
Ear Nose Throat J 2015 Jun;94(6):E12-22. doi: 10.1177/014556131509400615. PMID: 26053985

Recent systematic reviews

Systematic review of neuroendocrine carcinomas of the oropharynx.
Froehlich MH, Shih MC, Shehee L, Kompelli AR, Aylward A, Nguyen SA, Kaczmar JM, Nathan CA, Day T, Neskey DM
Head Neck 2022 Jul;44(7):1725-1736. Epub 2022 Apr 18 doi: 10.1002/hed.27055. PMID: 35437851
Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy.
Parmar A, Macluskey M, Mc Goldrick N, Conway DI, Glenny AM, Clarkson JE, Worthington HV, Chan KK
Cochrane Database Syst Rev 2021 Dec 20;12(12):CD006386. doi: 10.1002/14651858.CD006386.pub4. PMID: 34929047Free PMC Article
Definition of locally recurrent head and neck squamous cell carcinoma: a systematic review and proposal for the Odense-Birmingham definition.
Rohde M, Rosenberg T, Pareek M, Nankivell P, Sharma N, Mehanna H, Godballe C
Eur Arch Otorhinolaryngol 2020 Jun;277(6):1593-1599. Epub 2020 Apr 7 doi: 10.1007/s00405-020-05953-5. PMID: 32266461
International Guideline on Dose Prioritization and Acceptance Criteria in Radiation Therapy Planning for Nasopharyngeal Carcinoma.
Lee AW, Ng WT, Pan JJ, Chiang CL, Poh SS, Choi HC, Ahn YC, AlHussain H, Corry J, Grau C, Grégoire V, Harrington KJ, Hu CS, Kwong DL, Langendijk JA, Le QT, Lee NY, Lin JC, Lu TX, Mendenhall WM, O'Sullivan B, Ozyar E, Peters LJ, Rosenthal DI, Sanguineti G, Soong YL, Tao Y, Yom SS, Wee JT
Int J Radiat Oncol Biol Phys 2019 Nov 1;105(3):567-580. Epub 2019 Jul 2 doi: 10.1016/j.ijrobp.2019.06.2540. PMID: 31276776
Salvage of recurrence after surgery and adjuvant therapy: A systematic review.
Zenga J, Gross J, Fowler S, Chen J, Vila P, Richmon JD, Varvares MA, Pipkorn P
Am J Otolaryngol 2018 Mar-Apr;39(2):223-227. Epub 2018 Feb 2 doi: 10.1016/j.amjoto.2018.01.009. PMID: 29398187

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