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Recurrent Malignant Head and Neck Neoplasm

MedGen UID:
1663644
•Concept ID:
C4726630
•
Neoplastic Process
Synonym: Recurrent Head and Neck Cancer

Definition

The reemergence of a malignant head and neck neoplasm after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Malignant Head and Neck Neoplasm

Professional guidelines

PubMed

Evidence-Based Clinical Practice Guidelines for Extramammary Paget Disease.
Kibbi N, Owen JL, Worley B, Wang JX, Harikumar V, Downing MB, Aasi SZ, Aung PP, Barker CA, Bolotin D, Bordeaux JS, Cartee TV, Chandra S, Cho NL, Choi JN, Chung KY, Cliby WA, Dorigo O, Eisen DB, Fujisawa Y, Golda N, Halfdanarson TR, Iavazzo C, Jiang SIB, Kanitakis J, Khan A, Kim JYS, Kuzel TM, Lawrence N, Leitao MM Jr, MacLean AB, Maher IA, Mittal BB, Nehal KS, Ozog DM, Pettaway CA, Ross JS, Rossi AM, Servaes S, Solomon MJ, Thomas VD, Tolia M, Voelzke BB, Waldman A, Wong MK, Zhou Y, Arai N, Brackett A, Ibrahim SA, Kang BY, Poon E, Alam M
JAMA Oncol 2022 Apr 1;8(4):618-628. doi: 10.1001/jamaoncol.2021.7148. PMID: 35050310
Management of locally recurrent nasopharyngeal carcinoma.
Lee AWM, Ng WT, Chan JYW, Corry J, Mäkitie A, Mendenhall WM, Rinaldo A, Rodrigo JP, Saba NF, Strojan P, Suárez C, Vermorken JB, Yom SS, Ferlito A
Cancer Treat Rev 2019 Sep;79:101890. Epub 2019 Aug 21 doi: 10.1016/j.ctrv.2019.101890. PMID: 31470314
Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment.
Marur S, Forastiere AA
Mayo Clin Proc 2016 Mar;91(3):386-96. doi: 10.1016/j.mayocp.2015.12.017. PMID: 26944243

Recent clinical studies

Etiology

A transcriptomic map of EGFR-induced epithelial-to-mesenchymal transition identifies prognostic and therapeutic targets for head and neck cancer.
Schinke H, Shi E, Lin Z, Quadt T, Kranz G, Zhou J, Wang H, Hess J, Heuer S, Belka C, Zitzelsberger H, Schumacher U, Genduso S, Riecken K, Gao Y, Wu Z, Reichel CA, Walz C, Canis M, Unger K, Baumeister P, Pan M, Gires O
Mol Cancer 2022 Sep 8;21(1):178. doi: 10.1186/s12943-022-01646-1. PMID: 36076232Free PMC Article
Update of Radiofrequency Ablation for Treating Benign and Malignant Thyroid Nodules. The Future Is Now.
Tufano RP, Pace-Asciak P, Russell JO, Suárez C, Randolph GW, López F, Shaha AR, Mäkitie A, Rodrigo JP, Kowalski LP, Zafereo M, Angelos P, Ferlito A
Front Endocrinol (Lausanne) 2021;12:698689. Epub 2021 Jun 24 doi: 10.3389/fendo.2021.698689. PMID: 34248853Free PMC Article
Pembrolizumab versus methotrexate, docetaxel, or cetuximab for recurrent or metastatic head-and-neck squamous cell carcinoma (KEYNOTE-040): a randomised, open-label, phase 3 study.
Cohen EEW, Soulières D, Le Tourneau C, Dinis J, Licitra L, Ahn MJ, Soria A, Machiels JP, Mach N, Mehra R, Burtness B, Zhang P, Cheng J, Swaby RF, Harrington KJ; KEYNOTE-040 investigators
Lancet 2019 Jan 12;393(10167):156-167. Epub 2018 Nov 30 doi: 10.1016/S0140-6736(18)31999-8. PMID: 30509740
Proton Therapy for Head and Neck Cancer.
Kim JK, Leeman JE, Riaz N, McBride S, Tsai CJ, Lee NY
Curr Treat Options Oncol 2018 May 9;19(6):28. doi: 10.1007/s11864-018-0546-9. PMID: 29744681
Mucosal melanomas.
Tomicic J, Wanebo HJ
Surg Clin North Am 2003 Apr;83(2):237-52. doi: 10.1016/S0039-6109(02)00100-7. PMID: 12744608

Diagnosis

SEOM clinical guidelines for the treatment of head and neck cancer (2020).
Mesia R, Iglesias L, Lambea J, Martínez-Trufero J, Soria A, Taberna M, Trigo J, Chaves M, García-Castaño A, Cruz J
Clin Transl Oncol 2021 May;23(5):913-921. Epub 2021 Feb 26 doi: 10.1007/s12094-020-02533-1. PMID: 33635468Free PMC Article
Clinicopathologic analysis of verrucous hyperplasia, verrucous carcinoma and squamous cell carcinoma as part of the clinicopathologic spectrum of oral proliferative verrucous leukoplakia: A literature review and analysis.
Akrish S, Eskander-Hashoul L, Rachmiel A, Ben-Izhak O
Pathol Res Pract 2019 Dec;215(12):152670. Epub 2019 Sep 25 doi: 10.1016/j.prp.2019.152670. PMID: 31630872
Proton Therapy for Head and Neck Cancer.
Kim JK, Leeman JE, Riaz N, McBride S, Tsai CJ, Lee NY
Curr Treat Options Oncol 2018 May 9;19(6):28. doi: 10.1007/s11864-018-0546-9. PMID: 29744681
Chondrosarcomas of the head and neck.
Coca-Pelaz A, Rodrigo JP, Triantafyllou A, Hunt JL, Fernández-Miranda JC, Strojan P, de Bree R, Rinaldo A, Takes RP, Ferlito A
Eur Arch Otorhinolaryngol 2014 Oct;271(10):2601-9. Epub 2013 Nov 10 doi: 10.1007/s00405-013-2807-3. PMID: 24213203
Mucosal melanomas.
Tomicic J, Wanebo HJ
Surg Clin North Am 2003 Apr;83(2):237-52. doi: 10.1016/S0039-6109(02)00100-7. PMID: 12744608

Therapy

SEOM clinical guidelines for the treatment of head and neck cancer (2020).
Mesia R, Iglesias L, Lambea J, Martínez-Trufero J, Soria A, Taberna M, Trigo J, Chaves M, García-Castaño A, Cruz J
Clin Transl Oncol 2021 May;23(5):913-921. Epub 2021 Feb 26 doi: 10.1007/s12094-020-02533-1. PMID: 33635468Free PMC Article
Management of recurrent and metastatic oral cavity cancer: Raising the bar a step higher.
Szturz P, Vermorken JB
Oral Oncol 2020 Feb;101:104492. Epub 2019 Dec 11 doi: 10.1016/j.oraloncology.2019.104492. PMID: 31837576
Pembrolizumab versus methotrexate, docetaxel, or cetuximab for recurrent or metastatic head-and-neck squamous cell carcinoma (KEYNOTE-040): a randomised, open-label, phase 3 study.
Cohen EEW, Soulières D, Le Tourneau C, Dinis J, Licitra L, Ahn MJ, Soria A, Machiels JP, Mach N, Mehra R, Burtness B, Zhang P, Cheng J, Swaby RF, Harrington KJ; KEYNOTE-040 investigators
Lancet 2019 Jan 12;393(10167):156-167. Epub 2018 Nov 30 doi: 10.1016/S0140-6736(18)31999-8. PMID: 30509740
Proton Therapy for Head and Neck Cancer.
Kim JK, Leeman JE, Riaz N, McBride S, Tsai CJ, Lee NY
Curr Treat Options Oncol 2018 May 9;19(6):28. doi: 10.1007/s11864-018-0546-9. PMID: 29744681
Defining risk levels in locally advanced head and neck cancers: a comparative analysis of concurrent postoperative radiation plus chemotherapy trials of the EORTC (#22931) and RTOG (# 9501).
Bernier J, Cooper JS, Pajak TF, van Glabbeke M, Bourhis J, Forastiere A, Ozsahin EM, Jacobs JR, Jassem J, Ang KK, Lefèbvre JL
Head Neck 2005 Oct;27(10):843-50. doi: 10.1002/hed.20279. PMID: 16161069

Prognosis

A transcriptomic map of EGFR-induced epithelial-to-mesenchymal transition identifies prognostic and therapeutic targets for head and neck cancer.
Schinke H, Shi E, Lin Z, Quadt T, Kranz G, Zhou J, Wang H, Hess J, Heuer S, Belka C, Zitzelsberger H, Schumacher U, Genduso S, Riecken K, Gao Y, Wu Z, Reichel CA, Walz C, Canis M, Unger K, Baumeister P, Pan M, Gires O
Mol Cancer 2022 Sep 8;21(1):178. doi: 10.1186/s12943-022-01646-1. PMID: 36076232Free PMC Article
Leiomyosarcoma: Prognostic outline of a rare head and neck malignancy.
Saluja TS, Iyer J, Singh SK
Oral Oncol 2019 Aug;95:100-105. Epub 2019 Jun 13 doi: 10.1016/j.oraloncology.2019.06.010. PMID: 31345375
Re-irradiation for head and neck squamous cell carcinoma.
Benson R, Giridhar P, Venkatesulu BP, Mallick S, Raza MW, Rath GK
J Egypt Natl Canc Inst 2017 Mar;29(1):1-9. Epub 2016 Aug 29 doi: 10.1016/j.jnci.2016.07.002. PMID: 27595192
Safety and clinical activity of pembrolizumab for treatment of recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-012): an open-label, multicentre, phase 1b trial.
Seiwert TY, Burtness B, Mehra R, Weiss J, Berger R, Eder JP, Heath K, McClanahan T, Lunceford J, Gause C, Cheng JD, Chow LQ
Lancet Oncol 2016 Jul;17(7):956-965. Epub 2016 May 27 doi: 10.1016/S1470-2045(16)30066-3. PMID: 27247226
Chondrosarcomas of the head and neck.
Coca-Pelaz A, Rodrigo JP, Triantafyllou A, Hunt JL, Fernández-Miranda JC, Strojan P, de Bree R, Rinaldo A, Takes RP, Ferlito A
Eur Arch Otorhinolaryngol 2014 Oct;271(10):2601-9. Epub 2013 Nov 10 doi: 10.1007/s00405-013-2807-3. PMID: 24213203

Clinical prediction guides

A transcriptomic map of EGFR-induced epithelial-to-mesenchymal transition identifies prognostic and therapeutic targets for head and neck cancer.
Schinke H, Shi E, Lin Z, Quadt T, Kranz G, Zhou J, Wang H, Hess J, Heuer S, Belka C, Zitzelsberger H, Schumacher U, Genduso S, Riecken K, Gao Y, Wu Z, Reichel CA, Walz C, Canis M, Unger K, Baumeister P, Pan M, Gires O
Mol Cancer 2022 Sep 8;21(1):178. doi: 10.1186/s12943-022-01646-1. PMID: 36076232Free PMC Article
Opportunities and challenges in combining immunotherapy and radiotherapy in head and neck cancers.
Wong KCW, Johnson D, Hui EP, Lam RCT, Ma BBY, Chan ATC
Cancer Treat Rev 2022 Apr;105:102361. Epub 2022 Feb 16 doi: 10.1016/j.ctrv.2022.102361. PMID: 35231870
Clinicopathologic analysis of verrucous hyperplasia, verrucous carcinoma and squamous cell carcinoma as part of the clinicopathologic spectrum of oral proliferative verrucous leukoplakia: A literature review and analysis.
Akrish S, Eskander-Hashoul L, Rachmiel A, Ben-Izhak O
Pathol Res Pract 2019 Dec;215(12):152670. Epub 2019 Sep 25 doi: 10.1016/j.prp.2019.152670. PMID: 31630872
Leiomyosarcoma: Prognostic outline of a rare head and neck malignancy.
Saluja TS, Iyer J, Singh SK
Oral Oncol 2019 Aug;95:100-105. Epub 2019 Jun 13 doi: 10.1016/j.oraloncology.2019.06.010. PMID: 31345375
Cetuximab in metastatic or recurrent head and neck cancer: the EXTREME trial.
Rivera F, García-Castaño A, Vega N, Vega-Villegas ME, Gutiérrez-Sanz L
Expert Rev Anticancer Ther 2009 Oct;9(10):1421-8. doi: 10.1586/era.09.113. PMID: 19828002

Recent systematic reviews

Interventions for head and neck cancer survivors: Systematic review.
Margalit DN, Salz T, Venchiarutti R, Milley K, McNamara M, Chima S, Wong J, Druce P, Nekhlyudov L
Head Neck 2022 Nov;44(11):2579-2599. Epub 2022 Jul 18 doi: 10.1002/hed.27142. PMID: 35848095Free PMC Article
A systematic review of proteomic biomarkers in oral squamous cell cancer.
Pillai J, Chincholkar T, Dixit R, Pandey M
World J Surg Oncol 2021 Oct 28;19(1):315. doi: 10.1186/s12957-021-02423-y. PMID: 34711249Free PMC Article
Anti-PD-1 and Anti-PD-L1 in Head and Neck Cancer: A Network Meta-Analysis.
Botticelli A, Cirillo A, Strigari L, Valentini F, Cerbelli B, Scagnoli S, Cerbelli E, Zizzari IG, Rocca CD, D'Amati G, Polimeni A, Nuti M, Merlano MC, Mezi S, Marchetti P
Front Immunol 2021;12:705096. Epub 2021 Aug 9 doi: 10.3389/fimmu.2021.705096. PMID: 34434192Free PMC Article
A systematic review of secretory carcinoma of the salivary gland: where are we?
Alves LDB, de Melo AC, Farinha TA, de Lima Araujo LH, Thiago LS, Dias FL, Antunes HS, Amaral Eisenberg AL, Santos Thuler LC, Cohen Goldemberg D
Oral Surg Oral Med Oral Pathol Oral Radiol 2021 Oct;132(4):e143-e152. Epub 2020 May 31 doi: 10.1016/j.oooo.2020.04.007. PMID: 32493686
American Cancer Society Head and Neck Cancer Survivorship Care Guideline.
Cohen EE, LaMonte SJ, Erb NL, Beckman KL, Sadeghi N, Hutcheson KA, Stubblefield MD, Abbott DM, Fisher PS, Stein KD, Lyman GH, Pratt-Chapman ML
CA Cancer J Clin 2016 May;66(3):203-39. Epub 2016 Mar 22 doi: 10.3322/caac.21343. PMID: 27002678

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