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Locally Advanced Unresectable Rectal Adenocarcinoma

MedGen UID:
1699799
•Concept ID:
C5206480
•
Neoplastic Process

Definition

A rectal adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Unresectable Rectal Adenocarcinoma

Professional guidelines

PubMed

Preoperative treatment of patients with locally advanced unresectable rectal adenocarcinoma utilizing continuous chronobiologically shaped 5-fluorouracil infusion and radiation therapy.
Marsh RD, Chu NM, Vauthey JN, Mendenhall WM, Lauwers GY, Bewsher C, Copeland EM
Cancer 1996 Jul 15;78(2):217-25. doi: 10.1002/(SICI)1097-0142(19960715)78:2<217::AID-CNCR5>3.0.CO;2-I. PMID: 8673995

Recent clinical studies

Therapy

Neoadjuvant concurrent chemoradiotherapy using infusional gemcitabine in locally advanced rectal cancer: A phase II trial.
Bazarbashi S, Elshenawy MA, Badran A, Aljubran A, Alzahrani A, Almanea H, Alsuhaibani A, Alashwah A, Neimatallah M, Abduljabbar A, Ashari L, Alhomoud S, Ghebeh H, Elhassan T, Alsanea N, Mohiuddin M
Cancer Med 2022 May;11(10):2056-2066. Epub 2022 Feb 10 doi: 10.1002/cam4.4590. PMID: 35146939Free PMC Article
Intra-arterial chemoembolization with chemotherapy for unresectable locally advanced rectal cancer: a case report and literature review.
Meng W, Gao Y, Xie J, Wu S, Jian B, Li Q, Bai L
Ann Palliat Med 2021 Aug;10(8):9281-9287. doi: 10.21037/apm-21-1881. PMID: 34488414
Long-course neoadjuvant chemoradiotherapy with versus without a concomitant boost in locally advanced rectal cancer: a randomized, multicenter, phase II trial (FDRT-002).
Wang J, Guan Y, Gu W, Yan S, Zhou J, Huang D, Tong T, Li C, Cai S, Zhang Z, Zhu J
Radiat Oncol 2019 Nov 29;14(1):215. doi: 10.1186/s13014-019-1420-z. PMID: 31783766Free PMC Article
Role of pelvic radiotherapy for locally advanced rectal cancer and synchronous unresectable distant metastases.
Liu KT, Wan JF, Zhu J, Li GC, Sun WJ, Shen LJ, Cai SJ, Gu WL, Lian P, Zhang Z
Cancer Radiother 2016 Dec;20(8):805-810. Epub 2016 Oct 21 doi: 10.1016/j.canrad.2016.06.009. PMID: 27777027
Preoperative treatment of patients with locally advanced unresectable rectal adenocarcinoma utilizing continuous chronobiologically shaped 5-fluorouracil infusion and radiation therapy.
Marsh RD, Chu NM, Vauthey JN, Mendenhall WM, Lauwers GY, Bewsher C, Copeland EM
Cancer 1996 Jul 15;78(2):217-25. doi: 10.1002/(SICI)1097-0142(19960715)78:2<217::AID-CNCR5>3.0.CO;2-I. PMID: 8673995

Prognosis

Neoadjuvant concurrent chemoradiotherapy using infusional gemcitabine in locally advanced rectal cancer: A phase II trial.
Bazarbashi S, Elshenawy MA, Badran A, Aljubran A, Alzahrani A, Almanea H, Alsuhaibani A, Alashwah A, Neimatallah M, Abduljabbar A, Ashari L, Alhomoud S, Ghebeh H, Elhassan T, Alsanea N, Mohiuddin M
Cancer Med 2022 May;11(10):2056-2066. Epub 2022 Feb 10 doi: 10.1002/cam4.4590. PMID: 35146939Free PMC Article
Long-course neoadjuvant chemoradiotherapy with versus without a concomitant boost in locally advanced rectal cancer: a randomized, multicenter, phase II trial (FDRT-002).
Wang J, Guan Y, Gu W, Yan S, Zhou J, Huang D, Tong T, Li C, Cai S, Zhang Z, Zhu J
Radiat Oncol 2019 Nov 29;14(1):215. doi: 10.1186/s13014-019-1420-z. PMID: 31783766Free PMC Article
Role of pelvic radiotherapy for locally advanced rectal cancer and synchronous unresectable distant metastases.
Liu KT, Wan JF, Zhu J, Li GC, Sun WJ, Shen LJ, Cai SJ, Gu WL, Lian P, Zhang Z
Cancer Radiother 2016 Dec;20(8):805-810. Epub 2016 Oct 21 doi: 10.1016/j.canrad.2016.06.009. PMID: 27777027
Value of intraoperative radiotherapy in locally advanced rectal cancer.
Ferenschild FT, Vermaas M, Nuyttens JJ, Graveland WJ, Marinelli AW, van der Sijp JR, Wiggers T, Verhoef C, Eggermont AM, de Wilt JH
Dis Colon Rectum 2006 Sep;49(9):1257-65. doi: 10.1007/s10350-006-0651-x. PMID: 16912909
A Phase I trial of preoperative eniluracil plus 5-fluorouracil and radiation for locally advanced or unresectable adenocarcinoma of the rectum and colon.
Czito BG, Hong TJ, Cohen DP, Tyler DS, Lee CG, Anscher MS, Ludwig KA, Seigler HF, Mantyh C, Morse MA, Lockhart AC, Petros WP, Honeycutt W, Spector NL, Ertel PJ, Mangum SG, Hurwitz HI
Int J Radiat Oncol Biol Phys 2004 Mar 1;58(3):779-85. doi: 10.1016/S0360-3016(03)01567-0. PMID: 14967434

Clinical prediction guides

Long-course neoadjuvant chemoradiotherapy with versus without a concomitant boost in locally advanced rectal cancer: a randomized, multicenter, phase II trial (FDRT-002).
Wang J, Guan Y, Gu W, Yan S, Zhou J, Huang D, Tong T, Li C, Cai S, Zhang Z, Zhu J
Radiat Oncol 2019 Nov 29;14(1):215. doi: 10.1186/s13014-019-1420-z. PMID: 31783766Free PMC Article
Colorectal cancer in young and elderly patients.
Berut M, Mik M, Kędzia-Berut R, Kujawski R, Trzciński R, Dziki Ł, Dziki A
Pol Przegl Chir 2013 Aug;85(8):446-51. doi: 10.2478/pjs-2013-0068. PMID: 24009055
A phase I/II trial of three-dimensionally planned concurrent boost radiotherapy and protracted venous infusion of 5-FU chemotherapy for locally advanced rectal carcinoma.
Myerson RJ, Valentini V, Birnbaum EH, Cellini N, Coco C, Fleshman JW, Gambacorta MA, Genovesi D, Kodner IJ, Picus J, Ratkin GA, Read TE
Int J Radiat Oncol Biol Phys 2001 Aug 1;50(5):1299-308. doi: 10.1016/s0360-3016(01)01540-1. PMID: 11483342
Preoperative treatment of patients with locally advanced unresectable rectal adenocarcinoma utilizing continuous chronobiologically shaped 5-fluorouracil infusion and radiation therapy.
Marsh RD, Chu NM, Vauthey JN, Mendenhall WM, Lauwers GY, Bewsher C, Copeland EM
Cancer 1996 Jul 15;78(2):217-25. doi: 10.1002/(SICI)1097-0142(19960715)78:2<217::AID-CNCR5>3.0.CO;2-I. PMID: 8673995
Cisplatin and 5-fluorouracil combination chemotherapy in advanced and/or metastatic colorectal carcinoma: a phase II study.
Galligioni E, Canobbio L, Figoli F, Fassio T, Frustaci S, Crivellari D, Vaccher E, Lo Re G, Gasparini G, Veronesi A
Eur J Cancer Clin Oncol 1987 Jun;23(6):657-61. doi: 10.1016/0277-5379(87)90260-4. PMID: 3653187

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