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Locally Advanced Unresectable Rectal Adenocarcinoma

MedGen UID:
1699799
Concept ID:
C5206480
Neoplastic Process

Definition

A rectal adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Unresectable Rectal Adenocarcinoma

Professional guidelines

PubMed

Marsh RD, Chu NM, Vauthey JN, Mendenhall WM, Lauwers GY, Bewsher C, Copeland EM
Cancer 1996 Jul 15;78(2):217-25. doi: 10.1002/(SICI)1097-0142(19960715)78:2<217::AID-CNCR5>3.0.CO;2-I. PMID: 8673995

Recent clinical studies

Etiology

Wang J, Guan Y, Gu W, Yan S, Zhou J, Huang D, Tong T, Li C, Cai S, Zhang Z, Zhu J
Radiat Oncol 2019 Nov 29;14(1):215. doi: 10.1186/s13014-019-1420-z. PMID: 31783766Free PMC Article
Liu KT, Wan JF, Zhu J, Li GC, Sun WJ, Shen LJ, Cai SJ, Gu WL, Lian P, Zhang Z
Cancer Radiother 2016 Dec;20(8):805-810. Epub 2016 Oct 21 doi: 10.1016/j.canrad.2016.06.009. PMID: 27777027
Pfeiffer P
Acta Oncol 2005;44(3):224-9. doi: 10.1080/02841860510029671. PMID: 16076693
Luna-Pérez P, Rodríguez-Ramírez S, Rodriguez-Coria DF, Fernández A, Labastida S, Silva A, López MJ
World J Surg 2001 Aug;25(8):1006-11. doi: 10.1007/s00268-001-0071-y. PMID: 11571965
Videtic GM, Fisher BJ, Perera FE, Bauman GS, Kocha WI, Taylor M, Vincent MD, Plewes EA, Engel CJ, Stitt LW
Int J Radiat Oncol Biol Phys 1998 Sep 1;42(2):319-24. doi: 10.1016/s0360-3016(98)00214-4. PMID: 9788410

Diagnosis

Bazarbashi S, Elshenawy MA, Badran A, Aljubran A, Alzahrani A, Almanea H, Alsuhaibani A, Alashwah A, Neimatallah M, Abduljabbar A, Ashari L, Alhomoud S, Ghebeh H, Elhassan T, Alsanea N, Mohiuddin M
Cancer Med 2022 May;11(10):2056-2066. Epub 2022 Feb 10 doi: 10.1002/cam4.4590. PMID: 35146939Free PMC Article
Meng W, Gao Y, Xie J, Wu S, Jian B, Li Q, Bai L
Ann Palliat Med 2021 Aug;10(8):9281-9287. doi: 10.21037/apm-21-1881. PMID: 34488414
Pratap Singh A, Kumar A, Dhar A, Agarwal S, Bhimaniya S
J Med Case Rep 2018 Oct 11;12(1):304. doi: 10.1186/s13256-018-1831-8. PMID: 30305152Free PMC Article
Berut M, Mik M, Kędzia-Berut R, Kujawski R, Trzciński R, Dziki Ł, Dziki A
Pol Przegl Chir 2013 Aug;85(8):446-51. doi: 10.2478/pjs-2013-0068. PMID: 24009055
Videtic GM, Fisher BJ, Perera FE, Bauman GS, Kocha WI, Taylor M, Vincent MD, Plewes EA, Engel CJ, Stitt LW
Int J Radiat Oncol Biol Phys 1998 Sep 1;42(2):319-24. doi: 10.1016/s0360-3016(98)00214-4. PMID: 9788410

Therapy

Bazarbashi S, Elshenawy MA, Badran A, Aljubran A, Alzahrani A, Almanea H, Alsuhaibani A, Alashwah A, Neimatallah M, Abduljabbar A, Ashari L, Alhomoud S, Ghebeh H, Elhassan T, Alsanea N, Mohiuddin M
Cancer Med 2022 May;11(10):2056-2066. Epub 2022 Feb 10 doi: 10.1002/cam4.4590. PMID: 35146939Free PMC Article
Meng W, Gao Y, Xie J, Wu S, Jian B, Li Q, Bai L
Ann Palliat Med 2021 Aug;10(8):9281-9287. doi: 10.21037/apm-21-1881. PMID: 34488414
Wang J, Guan Y, Gu W, Yan S, Zhou J, Huang D, Tong T, Li C, Cai S, Zhang Z, Zhu J
Radiat Oncol 2019 Nov 29;14(1):215. doi: 10.1186/s13014-019-1420-z. PMID: 31783766Free PMC Article
Liu KT, Wan JF, Zhu J, Li GC, Sun WJ, Shen LJ, Cai SJ, Gu WL, Lian P, Zhang Z
Cancer Radiother 2016 Dec;20(8):805-810. Epub 2016 Oct 21 doi: 10.1016/j.canrad.2016.06.009. PMID: 27777027
Mathis KL, Nelson H, Pemberton JH
Adv Surg 2009;43:211-9. doi: 10.1016/j.yasu.2009.02.006. PMID: 19845180

Prognosis

Bazarbashi S, Elshenawy MA, Badran A, Aljubran A, Alzahrani A, Almanea H, Alsuhaibani A, Alashwah A, Neimatallah M, Abduljabbar A, Ashari L, Alhomoud S, Ghebeh H, Elhassan T, Alsanea N, Mohiuddin M
Cancer Med 2022 May;11(10):2056-2066. Epub 2022 Feb 10 doi: 10.1002/cam4.4590. PMID: 35146939Free PMC Article
Wang J, Guan Y, Gu W, Yan S, Zhou J, Huang D, Tong T, Li C, Cai S, Zhang Z, Zhu J
Radiat Oncol 2019 Nov 29;14(1):215. doi: 10.1186/s13014-019-1420-z. PMID: 31783766Free PMC Article
Liu KT, Wan JF, Zhu J, Li GC, Sun WJ, Shen LJ, Cai SJ, Gu WL, Lian P, Zhang Z
Cancer Radiother 2016 Dec;20(8):805-810. Epub 2016 Oct 21 doi: 10.1016/j.canrad.2016.06.009. PMID: 27777027
Ferenschild FT, Vermaas M, Nuyttens JJ, Graveland WJ, Marinelli AW, van der Sijp JR, Wiggers T, Verhoef C, Eggermont AM, de Wilt JH
Dis Colon Rectum 2006 Sep;49(9):1257-65. doi: 10.1007/s10350-006-0651-x. PMID: 16912909
Pfeiffer P
Acta Oncol 2005;44(3):224-9. doi: 10.1080/02841860510029671. PMID: 16076693

Clinical prediction guides

Wang J, Guan Y, Gu W, Yan S, Zhou J, Huang D, Tong T, Li C, Cai S, Zhang Z, Zhu J
Radiat Oncol 2019 Nov 29;14(1):215. doi: 10.1186/s13014-019-1420-z. PMID: 31783766Free PMC Article
Berut M, Mik M, Kędzia-Berut R, Kujawski R, Trzciński R, Dziki Ł, Dziki A
Pol Przegl Chir 2013 Aug;85(8):446-51. doi: 10.2478/pjs-2013-0068. PMID: 24009055
Pfeiffer P
Acta Oncol 2005;44(3):224-9. doi: 10.1080/02841860510029671. PMID: 16076693
Myerson RJ, Valentini V, Birnbaum EH, Cellini N, Coco C, Fleshman JW, Gambacorta MA, Genovesi D, Kodner IJ, Picus J, Ratkin GA, Read TE
Int J Radiat Oncol Biol Phys 2001 Aug 1;50(5):1299-308. doi: 10.1016/s0360-3016(01)01540-1. PMID: 11483342
Marsh RD, Chu NM, Vauthey JN, Mendenhall WM, Lauwers GY, Bewsher C, Copeland EM
Cancer 1996 Jul 15;78(2):217-25. doi: 10.1002/(SICI)1097-0142(19960715)78:2<217::AID-CNCR5>3.0.CO;2-I. PMID: 8673995

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