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Locally Advanced Unresectable Rectal Adenocarcinoma

MedGen UID:
1699799
Concept ID:
C5206480
Neoplastic Process

Definition

A rectal adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Unresectable Rectal Adenocarcinoma

Professional guidelines

PubMed

Marsh RD, Chu NM, Vauthey JN, Mendenhall WM, Lauwers GY, Bewsher C, Copeland EM
Cancer 1996 Jul 15;78(2):217-25. doi: 10.1002/(SICI)1097-0142(19960715)78:2<217::AID-CNCR5>3.0.CO;2-I. PMID: 8673995

Recent clinical studies

Etiology

Pratap Singh A, Kumar A, Dhar A, Agarwal S, Bhimaniya S
J Med Case Rep 2018 Oct 11;12(1):304. doi: 10.1186/s13256-018-1831-8. PMID: 30305152Free PMC Article
Liu KT, Wan JF, Zhu J, Li GC, Sun WJ, Shen LJ, Cai SJ, Gu WL, Lian P, Zhang Z
Cancer Radiother 2016 Dec;20(8):805-810. Epub 2016 Oct 21 doi: 10.1016/j.canrad.2016.06.009. PMID: 27777027
Madbouly KM, Mashhour AN, Omar W
Int J Surg 2015 Nov;23(Pt A):120-7. Epub 2015 Oct 24 doi: 10.1016/j.ijsu.2015.08.081. PMID: 26397210
Berut M, Mik M, Kędzia-Berut R, Kujawski R, Trzciński R, Dziki Ł, Dziki A
Pol Przegl Chir 2013 Aug;85(8):446-51. doi: 10.2478/pjs-2013-0068. PMID: 24009055
Lee WC, Yusof MM, Lau FN, Phua VC
Asian Pac J Cancer Prev 2013;14(6):3941-4. doi: 10.7314/apjcp.2013.14.6.3941. PMID: 23886211

Diagnosis

Bazarbashi S, Elshenawy MA, Badran A, Aljubran A, Alzahrani A, Almanea H, Alsuhaibani A, Alashwah A, Neimatallah M, Abduljabbar A, Ashari L, Alhomoud S, Ghebeh H, Elhassan T, Alsanea N, Mohiuddin M
Cancer Med 2022 May;11(10):2056-2066. Epub 2022 Feb 10 doi: 10.1002/cam4.4590. PMID: 35146939Free PMC Article
Meng W, Gao Y, Xie J, Wu S, Jian B, Li Q, Bai L
Ann Palliat Med 2021 Aug;10(8):9281-9287. doi: 10.21037/apm-21-1881. PMID: 34488414
Xue W, Li Y, Zhao Z, Li W, Wang S, Zhang M, Liu T, Wang M
Medicine (Baltimore) 2019 Apr;98(15):e15244. doi: 10.1097/MD.0000000000015244. PMID: 30985730Free PMC Article
Berut M, Mik M, Kędzia-Berut R, Kujawski R, Trzciński R, Dziki Ł, Dziki A
Pol Przegl Chir 2013 Aug;85(8):446-51. doi: 10.2478/pjs-2013-0068. PMID: 24009055
Lee WC, Yusof MM, Lau FN, Phua VC
Asian Pac J Cancer Prev 2013;14(6):3941-4. doi: 10.7314/apjcp.2013.14.6.3941. PMID: 23886211

Therapy

Bazarbashi S, Elshenawy MA, Badran A, Aljubran A, Alzahrani A, Almanea H, Alsuhaibani A, Alashwah A, Neimatallah M, Abduljabbar A, Ashari L, Alhomoud S, Ghebeh H, Elhassan T, Alsanea N, Mohiuddin M
Cancer Med 2022 May;11(10):2056-2066. Epub 2022 Feb 10 doi: 10.1002/cam4.4590. PMID: 35146939Free PMC Article
Madbouly KM, Mashhour AN, Omar W
Int J Surg 2015 Nov;23(Pt A):120-7. Epub 2015 Oct 24 doi: 10.1016/j.ijsu.2015.08.081. PMID: 26397210
Czito BG, Hong TJ, Cohen DP, Tyler DS, Lee CG, Anscher MS, Ludwig KA, Seigler HF, Mantyh C, Morse MA, Lockhart AC, Petros WP, Honeycutt W, Spector NL, Ertel PJ, Mangum SG, Hurwitz HI
Int J Radiat Oncol Biol Phys 2004 Mar 1;58(3):779-85. doi: 10.1016/S0360-3016(03)01567-0. PMID: 14967434
Di Bartolomeo M, Bajetta E, Buzzoni R, Bozzetti F, Artale S, Valvo F
Tumori 1999 May-Jun;85(3):211-3. doi: 10.1177/030089169908500313. PMID: 10426135
Galligioni E, Canobbio L, Figoli F, Fassio T, Frustaci S, Crivellari D, Vaccher E, Lo Re G, Gasparini G, Veronesi A
Eur J Cancer Clin Oncol 1987 Jun;23(6):657-61. doi: 10.1016/0277-5379(87)90260-4. PMID: 3653187

Prognosis

Bazarbashi S, Elshenawy MA, Badran A, Aljubran A, Alzahrani A, Almanea H, Alsuhaibani A, Alashwah A, Neimatallah M, Abduljabbar A, Ashari L, Alhomoud S, Ghebeh H, Elhassan T, Alsanea N, Mohiuddin M
Cancer Med 2022 May;11(10):2056-2066. Epub 2022 Feb 10 doi: 10.1002/cam4.4590. PMID: 35146939Free PMC Article
Pratap Singh A, Kumar A, Dhar A, Agarwal S, Bhimaniya S
J Med Case Rep 2018 Oct 11;12(1):304. doi: 10.1186/s13256-018-1831-8. PMID: 30305152Free PMC Article
Liu KT, Wan JF, Zhu J, Li GC, Sun WJ, Shen LJ, Cai SJ, Gu WL, Lian P, Zhang Z
Cancer Radiother 2016 Dec;20(8):805-810. Epub 2016 Oct 21 doi: 10.1016/j.canrad.2016.06.009. PMID: 27777027
Berut M, Mik M, Kędzia-Berut R, Kujawski R, Trzciński R, Dziki Ł, Dziki A
Pol Przegl Chir 2013 Aug;85(8):446-51. doi: 10.2478/pjs-2013-0068. PMID: 24009055
Czito BG, Hong TJ, Cohen DP, Tyler DS, Lee CG, Anscher MS, Ludwig KA, Seigler HF, Mantyh C, Morse MA, Lockhart AC, Petros WP, Honeycutt W, Spector NL, Ertel PJ, Mangum SG, Hurwitz HI
Int J Radiat Oncol Biol Phys 2004 Mar 1;58(3):779-85. doi: 10.1016/S0360-3016(03)01567-0. PMID: 14967434

Clinical prediction guides

Berut M, Mik M, Kędzia-Berut R, Kujawski R, Trzciński R, Dziki Ł, Dziki A
Pol Przegl Chir 2013 Aug;85(8):446-51. doi: 10.2478/pjs-2013-0068. PMID: 24009055
Mawdsley S, Glynne-Jones R, Grainger J, Richman P, Makris A, Harrison M, Ashford R, Harrison RA, Osborne M, Livingstone JI, MacDonald P, Mitchell IC, Meyrick-Thomas J, Northover JM, Windsor A, Novell R, Wallace M
Int J Radiat Oncol Biol Phys 2005 Nov 1;63(3):745-52. doi: 10.1016/j.ijrobp.2005.03.003. PMID: 16199310
Beresford M, Glynne-Jones R, Richman P, Makris A, Mawdsley S, Stott D, Harrison M, Osborne M, Ashford R, Grainger J, Al-Jabbour J, Talbot I, Mitchell IC, Meyrick Thomas J, Livingstone JI, McCue J, MacDonald P, Northover JA, Windsor A, Novell R, Wallace M, Harrison RA
Clin Oncol (R Coll Radiol) 2005 Sep;17(6):448-55. doi: 10.1016/j.clon.2005.05.007. PMID: 16149289
Di Bartolomeo M, Bajetta E, Buzzoni R, Bozzetti F, Artale S, Valvo F
Tumori 1999 May-Jun;85(3):211-3. doi: 10.1177/030089169908500313. PMID: 10426135
Galligioni E, Canobbio L, Figoli F, Fassio T, Frustaci S, Crivellari D, Vaccher E, Lo Re G, Gasparini G, Veronesi A
Eur J Cancer Clin Oncol 1987 Jun;23(6):657-61. doi: 10.1016/0277-5379(87)90260-4. PMID: 3653187

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