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Locally Advanced Unresectable Rectal Adenocarcinoma

MedGen UID:
1699799
•Concept ID:
C5206480
•
Neoplastic Process

Definition

A rectal adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Unresectable Rectal Adenocarcinoma

Professional guidelines

PubMed

Preoperative treatment of patients with locally advanced unresectable rectal adenocarcinoma utilizing continuous chronobiologically shaped 5-fluorouracil infusion and radiation therapy.
Marsh RD, Chu NM, Vauthey JN, Mendenhall WM, Lauwers GY, Bewsher C, Copeland EM
Cancer 1996 Jul 15;78(2):217-25. doi: 10.1002/(SICI)1097-0142(19960715)78:2<217::AID-CNCR5>3.0.CO;2-I. PMID: 8673995

Recent clinical studies

Etiology

Long-course neoadjuvant chemoradiotherapy with versus without a concomitant boost in locally advanced rectal cancer: a randomized, multicenter, phase II trial (FDRT-002).
Wang J, Guan Y, Gu W, Yan S, Zhou J, Huang D, Tong T, Li C, Cai S, Zhang Z, Zhu J
Radiat Oncol 2019 Nov 29;14(1):215. doi: 10.1186/s13014-019-1420-z. PMID: 31783766Free PMC Article
Role of pelvic radiotherapy for locally advanced rectal cancer and synchronous unresectable distant metastases.
Liu KT, Wan JF, Zhu J, Li GC, Sun WJ, Shen LJ, Cai SJ, Gu WL, Lian P, Zhang Z
Cancer Radiother 2016 Dec;20(8):805-810. Epub 2016 Oct 21 doi: 10.1016/j.canrad.2016.06.009. PMID: 27777027
Preoperative chemoradiation therapy and anal sphincter preservation with locally advanced rectal adenocarcinoma.
Luna-Pérez P, Rodríguez-Ramírez S, Rodriguez-Coria DF, Fernández A, Labastida S, Silva A, López MJ
World J Surg 2001 Aug;25(8):1006-11. doi: 10.1007/s00268-001-0071-y. PMID: 11571965
A phase I/II trial of three-dimensionally planned concurrent boost radiotherapy and protracted venous infusion of 5-FU chemotherapy for locally advanced rectal carcinoma.
Myerson RJ, Valentini V, Birnbaum EH, Cellini N, Coco C, Fleshman JW, Gambacorta MA, Genovesi D, Kodner IJ, Picus J, Ratkin GA, Read TE
Int J Radiat Oncol Biol Phys 2001 Aug 1;50(5):1299-308. doi: 10.1016/s0360-3016(01)01540-1. PMID: 11483342
Preoperative radiation with concurrent 5-fluorouracil continuous infusion for locally advanced unresectable rectal cancer.
Videtic GM, Fisher BJ, Perera FE, Bauman GS, Kocha WI, Taylor M, Vincent MD, Plewes EA, Engel CJ, Stitt LW
Int J Radiat Oncol Biol Phys 1998 Sep 1;42(2):319-24. doi: 10.1016/s0360-3016(98)00214-4. PMID: 9788410

Diagnosis

Neoadjuvant concurrent chemoradiotherapy using infusional gemcitabine in locally advanced rectal cancer: A phase II trial.
Bazarbashi S, Elshenawy MA, Badran A, Aljubran A, Alzahrani A, Almanea H, Alsuhaibani A, Alashwah A, Neimatallah M, Abduljabbar A, Ashari L, Alhomoud S, Ghebeh H, Elhassan T, Alsanea N, Mohiuddin M
Cancer Med 2022 May;11(10):2056-2066. Epub 2022 Feb 10 doi: 10.1002/cam4.4590. PMID: 35146939Free PMC Article
Intra-arterial chemoembolization with chemotherapy for unresectable locally advanced rectal cancer: a case report and literature review.
Meng W, Gao Y, Xie J, Wu S, Jian B, Li Q, Bai L
Ann Palliat Med 2021 Aug;10(8):9281-9287. doi: 10.21037/apm-21-1881. PMID: 34488414
Advanced colorectal carcinoma with testicular metastasis in an adolescent: a case report.
Pratap Singh A, Kumar A, Dhar A, Agarwal S, Bhimaniya S
J Med Case Rep 2018 Oct 11;12(1):304. doi: 10.1186/s13256-018-1831-8. PMID: 30305152Free PMC Article
Transanal Minimally Invasive Surgery for Local Excision of Benign and Malignant Rectal Neoplasia: Outcomes From 200 Consecutive Cases With Midterm Follow Up.
Lee L, Burke JP, deBeche-Adams T, Nassif G, Martin-Perez B, Monson JRT, Albert MR, Atallah SB
Ann Surg 2018 May;267(5):910-916. doi: 10.1097/SLA.0000000000002190. PMID: 28252517
Preoperative radiation with concurrent 5-fluorouracil continuous infusion for locally advanced unresectable rectal cancer.
Videtic GM, Fisher BJ, Perera FE, Bauman GS, Kocha WI, Taylor M, Vincent MD, Plewes EA, Engel CJ, Stitt LW
Int J Radiat Oncol Biol Phys 1998 Sep 1;42(2):319-24. doi: 10.1016/s0360-3016(98)00214-4. PMID: 9788410

Therapy

Neoadjuvant concurrent chemoradiotherapy using infusional gemcitabine in locally advanced rectal cancer: A phase II trial.
Bazarbashi S, Elshenawy MA, Badran A, Aljubran A, Alzahrani A, Almanea H, Alsuhaibani A, Alashwah A, Neimatallah M, Abduljabbar A, Ashari L, Alhomoud S, Ghebeh H, Elhassan T, Alsanea N, Mohiuddin M
Cancer Med 2022 May;11(10):2056-2066. Epub 2022 Feb 10 doi: 10.1002/cam4.4590. PMID: 35146939Free PMC Article
Intra-arterial chemoembolization with chemotherapy for unresectable locally advanced rectal cancer: a case report and literature review.
Meng W, Gao Y, Xie J, Wu S, Jian B, Li Q, Bai L
Ann Palliat Med 2021 Aug;10(8):9281-9287. doi: 10.21037/apm-21-1881. PMID: 34488414
Long-course neoadjuvant chemoradiotherapy with versus without a concomitant boost in locally advanced rectal cancer: a randomized, multicenter, phase II trial (FDRT-002).
Wang J, Guan Y, Gu W, Yan S, Zhou J, Huang D, Tong T, Li C, Cai S, Zhang Z, Zhu J
Radiat Oncol 2019 Nov 29;14(1):215. doi: 10.1186/s13014-019-1420-z. PMID: 31783766Free PMC Article
Role of pelvic radiotherapy for locally advanced rectal cancer and synchronous unresectable distant metastases.
Liu KT, Wan JF, Zhu J, Li GC, Sun WJ, Shen LJ, Cai SJ, Gu WL, Lian P, Zhang Z
Cancer Radiother 2016 Dec;20(8):805-810. Epub 2016 Oct 21 doi: 10.1016/j.canrad.2016.06.009. PMID: 27777027
Hyperthermia combined with radiation therapy for primarily unresectable and recurrent colorectal cancer.
Nishimura Y, Hiraoka M, Akuta K, Jo S, Nagata Y, Masunaga S, Takahashi M, Abe M
Int J Radiat Oncol Biol Phys 1992;23(4):759-68. doi: 10.1016/0360-3016(92)90649-3. PMID: 1618669

Prognosis

Neoadjuvant concurrent chemoradiotherapy using infusional gemcitabine in locally advanced rectal cancer: A phase II trial.
Bazarbashi S, Elshenawy MA, Badran A, Aljubran A, Alzahrani A, Almanea H, Alsuhaibani A, Alashwah A, Neimatallah M, Abduljabbar A, Ashari L, Alhomoud S, Ghebeh H, Elhassan T, Alsanea N, Mohiuddin M
Cancer Med 2022 May;11(10):2056-2066. Epub 2022 Feb 10 doi: 10.1002/cam4.4590. PMID: 35146939Free PMC Article
Long-course neoadjuvant chemoradiotherapy with versus without a concomitant boost in locally advanced rectal cancer: a randomized, multicenter, phase II trial (FDRT-002).
Wang J, Guan Y, Gu W, Yan S, Zhou J, Huang D, Tong T, Li C, Cai S, Zhang Z, Zhu J
Radiat Oncol 2019 Nov 29;14(1):215. doi: 10.1186/s13014-019-1420-z. PMID: 31783766Free PMC Article
Role of pelvic radiotherapy for locally advanced rectal cancer and synchronous unresectable distant metastases.
Liu KT, Wan JF, Zhu J, Li GC, Sun WJ, Shen LJ, Cai SJ, Gu WL, Lian P, Zhang Z
Cancer Radiother 2016 Dec;20(8):805-810. Epub 2016 Oct 21 doi: 10.1016/j.canrad.2016.06.009. PMID: 27777027
Value of intraoperative radiotherapy in locally advanced rectal cancer.
Ferenschild FT, Vermaas M, Nuyttens JJ, Graveland WJ, Marinelli AW, van der Sijp JR, Wiggers T, Verhoef C, Eggermont AM, de Wilt JH
Dis Colon Rectum 2006 Sep;49(9):1257-65. doi: 10.1007/s10350-006-0651-x. PMID: 16912909
A Phase I trial of preoperative eniluracil plus 5-fluorouracil and radiation for locally advanced or unresectable adenocarcinoma of the rectum and colon.
Czito BG, Hong TJ, Cohen DP, Tyler DS, Lee CG, Anscher MS, Ludwig KA, Seigler HF, Mantyh C, Morse MA, Lockhart AC, Petros WP, Honeycutt W, Spector NL, Ertel PJ, Mangum SG, Hurwitz HI
Int J Radiat Oncol Biol Phys 2004 Mar 1;58(3):779-85. doi: 10.1016/S0360-3016(03)01567-0. PMID: 14967434

Clinical prediction guides

Long-course neoadjuvant chemoradiotherapy with versus without a concomitant boost in locally advanced rectal cancer: a randomized, multicenter, phase II trial (FDRT-002).
Wang J, Guan Y, Gu W, Yan S, Zhou J, Huang D, Tong T, Li C, Cai S, Zhang Z, Zhu J
Radiat Oncol 2019 Nov 29;14(1):215. doi: 10.1186/s13014-019-1420-z. PMID: 31783766Free PMC Article
Transanal Minimally Invasive Surgery for Local Excision of Benign and Malignant Rectal Neoplasia: Outcomes From 200 Consecutive Cases With Midterm Follow Up.
Lee L, Burke JP, deBeche-Adams T, Nassif G, Martin-Perez B, Monson JRT, Albert MR, Atallah SB
Ann Surg 2018 May;267(5):910-916. doi: 10.1097/SLA.0000000000002190. PMID: 28252517
Colorectal cancer in young and elderly patients.
Berut M, Mik M, Kędzia-Berut R, Kujawski R, Trzciński R, Dziki Ł, Dziki A
Pol Przegl Chir 2013 Aug;85(8):446-51. doi: 10.2478/pjs-2013-0068. PMID: 24009055
High-dose radiotherapy and concurrent UFT plus l-leucovorin in locally advanced rectal cancer: a phase I trial.
Pfeiffer P
Acta Oncol 2005;44(3):224-9. doi: 10.1080/02841860510029671. PMID: 16076693
A phase I/II trial of three-dimensionally planned concurrent boost radiotherapy and protracted venous infusion of 5-FU chemotherapy for locally advanced rectal carcinoma.
Myerson RJ, Valentini V, Birnbaum EH, Cellini N, Coco C, Fleshman JW, Gambacorta MA, Genovesi D, Kodner IJ, Picus J, Ratkin GA, Read TE
Int J Radiat Oncol Biol Phys 2001 Aug 1;50(5):1299-308. doi: 10.1016/s0360-3016(01)01540-1. PMID: 11483342

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