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Locally Advanced Rectal Adenocarcinoma

MedGen UID:
1741687
Concept ID:
C5420598
Neoplastic Process

Definition

Rectal adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Rectal Adenocarcinoma

Professional guidelines

PubMed

Felder SI, Fleming JB, Gatenby RA
Adv Cancer Res 2021;151:39-67. Epub 2021 Apr 9 doi: 10.1016/bs.acr.2021.02.003. PMID: 34148619
Lukovic J, Kim JJ, Krzyzanowska M, Chadi SA, Taniguchi CM, Hosni A
JCO Oncol Pract 2020 Oct;16(10):635-640. doi: 10.1200/OP.20.00363. PMID: 33049179
Akce M, El-Rayes BF
J Oncol Pract 2019 Mar;15(3):123-131. doi: 10.1200/JOP.18.00769. PMID: 30861368

Recent clinical studies

Etiology

Conroy T, Castan F, Etienne PL, Rio E, Mesgouez-Nebout N, Evesque L, Vendrely V, Artignan X, Bouché O, Gargot D, Boige V, Bonichon-Lamichhane N, Louvet C, Morand C, de la Fouchardière C, Boilève A, Delaye M, Gourgou S, Pezzella V, Borg C
Ann Oncol 2024 Oct;35(10):873-881. Epub 2024 Jul 8 doi: 10.1016/j.annonc.2024.06.019. PMID: 38986769
Diefenhardt M, Martin D, Fleischmann M, Hofheinz RD, Ghadimi M, Rödel C, Fokas E
JAMA Netw Open 2023 Oct 2;6(10):e2340256. doi: 10.1001/jamanetworkopen.2023.40256. PMID: 37902752Free PMC Article
Yamazaki T, Gunderson AJ, Gilchrist M, Whiteford M, Kiely MX, Hayman A, O'Brien D, Ahmad R, Manchio JV, Fox N, McCarty K, Phillips M, Brosnan E, Vaccaro G, Li R, Simon M, Bernstein E, McCormick M, Yamasaki L, Wu Y, Drokin A, Carnahan T, To Y, Redmond WL, Lee B, Louie J, Hansen E, Solhjem MC, Cramer J, Urba WJ, Gough MJ, Crittenden MR, Young KH
Lancet Oncol 2022 Sep;23(9):1189-1200. Epub 2022 Aug 8 doi: 10.1016/S1470-2045(22)00446-6. PMID: 35952709
Bahadoer RR, Dijkstra EA, van Etten B, Marijnen CAM, Putter H, Kranenbarg EM, Roodvoets AGH, Nagtegaal ID, Beets-Tan RGH, Blomqvist LK, Fokstuen T, Ten Tije AJ, Capdevila J, Hendriks MP, Edhemovic I, Cervantes A, Nilsson PJ, Glimelius B, van de Velde CJH, Hospers GAP; RAPIDO collaborative investigators
Lancet Oncol 2021 Jan;22(1):29-42. Epub 2020 Dec 7 doi: 10.1016/S1470-2045(20)30555-6. PMID: 33301740
Pokharkar A, Kammar P, D'souza A, Bhamre R, Sugoor P, Saklani A
J Laparoendosc Adv Surg Tech A 2018 Dec;28(12):1489-1494. Epub 2018 May 9 doi: 10.1089/lap.2018.0147. PMID: 29741977

Diagnosis

Leung G, Nishimura M, Hingorani N, Lin IH, Weiser MR, Garcia-Aguilar J, Pappou EP, Paty PB, Schattner MA
Gastrointest Endosc 2022 Aug;96(2):359-367. Epub 2022 Feb 17 doi: 10.1016/j.gie.2022.02.014. PMID: 35183541
Bahadoer RR, Dijkstra EA, van Etten B, Marijnen CAM, Putter H, Kranenbarg EM, Roodvoets AGH, Nagtegaal ID, Beets-Tan RGH, Blomqvist LK, Fokstuen T, Ten Tije AJ, Capdevila J, Hendriks MP, Edhemovic I, Cervantes A, Nilsson PJ, Glimelius B, van de Velde CJH, Hospers GAP; RAPIDO collaborative investigators
Lancet Oncol 2021 Jan;22(1):29-42. Epub 2020 Dec 7 doi: 10.1016/S1470-2045(20)30555-6. PMID: 33301740
Akce M, El-Rayes BF
J Oncol Pract 2019 Mar;15(3):123-131. doi: 10.1200/JOP.18.00769. PMID: 30861368
Pokharkar A, Kammar P, D'souza A, Bhamre R, Sugoor P, Saklani A
J Laparoendosc Adv Surg Tech A 2018 Dec;28(12):1489-1494. Epub 2018 May 9 doi: 10.1089/lap.2018.0147. PMID: 29741977
Conde-Muíño R, Cuadros M, Zambudio N, Segura-Jiménez I, Cano C, Palma P
Biomed Res Int 2015;2015:921435. Epub 2015 Oct 4 doi: 10.1155/2015/921435. PMID: 26504848Free PMC Article

Therapy

Conroy T, Castan F, Etienne PL, Rio E, Mesgouez-Nebout N, Evesque L, Vendrely V, Artignan X, Bouché O, Gargot D, Boige V, Bonichon-Lamichhane N, Louvet C, Morand C, de la Fouchardière C, Boilève A, Delaye M, Gourgou S, Pezzella V, Borg C
Ann Oncol 2024 Oct;35(10):873-881. Epub 2024 Jul 8 doi: 10.1016/j.annonc.2024.06.019. PMID: 38986769
Diefenhardt M, Martin D, Fleischmann M, Hofheinz RD, Ghadimi M, Rödel C, Fokas E
JAMA Netw Open 2023 Oct 2;6(10):e2340256. doi: 10.1001/jamanetworkopen.2023.40256. PMID: 37902752Free PMC Article
Yamazaki T, Gunderson AJ, Gilchrist M, Whiteford M, Kiely MX, Hayman A, O'Brien D, Ahmad R, Manchio JV, Fox N, McCarty K, Phillips M, Brosnan E, Vaccaro G, Li R, Simon M, Bernstein E, McCormick M, Yamasaki L, Wu Y, Drokin A, Carnahan T, To Y, Redmond WL, Lee B, Louie J, Hansen E, Solhjem MC, Cramer J, Urba WJ, Gough MJ, Crittenden MR, Young KH
Lancet Oncol 2022 Sep;23(9):1189-1200. Epub 2022 Aug 8 doi: 10.1016/S1470-2045(22)00446-6. PMID: 35952709
Felder SI, Fleming JB, Gatenby RA
Adv Cancer Res 2021;151:39-67. Epub 2021 Apr 9 doi: 10.1016/bs.acr.2021.02.003. PMID: 34148619
Bahadoer RR, Dijkstra EA, van Etten B, Marijnen CAM, Putter H, Kranenbarg EM, Roodvoets AGH, Nagtegaal ID, Beets-Tan RGH, Blomqvist LK, Fokstuen T, Ten Tije AJ, Capdevila J, Hendriks MP, Edhemovic I, Cervantes A, Nilsson PJ, Glimelius B, van de Velde CJH, Hospers GAP; RAPIDO collaborative investigators
Lancet Oncol 2021 Jan;22(1):29-42. Epub 2020 Dec 7 doi: 10.1016/S1470-2045(20)30555-6. PMID: 33301740

Prognosis

Yamazaki T, Gunderson AJ, Gilchrist M, Whiteford M, Kiely MX, Hayman A, O'Brien D, Ahmad R, Manchio JV, Fox N, McCarty K, Phillips M, Brosnan E, Vaccaro G, Li R, Simon M, Bernstein E, McCormick M, Yamasaki L, Wu Y, Drokin A, Carnahan T, To Y, Redmond WL, Lee B, Louie J, Hansen E, Solhjem MC, Cramer J, Urba WJ, Gough MJ, Crittenden MR, Young KH
Lancet Oncol 2022 Sep;23(9):1189-1200. Epub 2022 Aug 8 doi: 10.1016/S1470-2045(22)00446-6. PMID: 35952709
Felder SI, Fleming JB, Gatenby RA
Adv Cancer Res 2021;151:39-67. Epub 2021 Apr 9 doi: 10.1016/bs.acr.2021.02.003. PMID: 34148619
Bahadoer RR, Dijkstra EA, van Etten B, Marijnen CAM, Putter H, Kranenbarg EM, Roodvoets AGH, Nagtegaal ID, Beets-Tan RGH, Blomqvist LK, Fokstuen T, Ten Tije AJ, Capdevila J, Hendriks MP, Edhemovic I, Cervantes A, Nilsson PJ, Glimelius B, van de Velde CJH, Hospers GAP; RAPIDO collaborative investigators
Lancet Oncol 2021 Jan;22(1):29-42. Epub 2020 Dec 7 doi: 10.1016/S1470-2045(20)30555-6. PMID: 33301740
Pettit C, Walston S, Wald P, Webb A, Williams TM
Int J Oncol 2017 Aug;51(2):393-404. Epub 2017 Jun 14 doi: 10.3892/ijo.2017.4045. PMID: 28627602
Conde-Muíño R, Cuadros M, Zambudio N, Segura-Jiménez I, Cano C, Palma P
Biomed Res Int 2015;2015:921435. Epub 2015 Oct 4 doi: 10.1155/2015/921435. PMID: 26504848Free PMC Article

Clinical prediction guides

Bercz A, Park BK, Pappou E, Nemirovsky D, Sarkar R, Yamner M, Omer D, Verheij FS, Alvarez J, Atri P, Reyngold M, Yaeger R, Wei IH, Wu A, Raj N, Widmar M, Hajj C, Kim MJ, Rao D, Nash GM, Williams V, Shia J, Segal NH, Diaz L, Ganesh K, Weiser MR, Gollub MJ, Paty PB, Horvat N, Zinovoy M, Roth O'Brien D, Sanchez-Vega F, Saltz LB, Crane CH, Cercek A, Gonen M, Garcia-Aguilar J, Smith JJ, Romesser PB
Ann Oncol 2024 Nov;35(11):1003-1014. Epub 2024 Sep 11 doi: 10.1016/j.annonc.2024.07.729. PMID: 39266364Free PMC Article
Felder SI, Fleming JB, Gatenby RA
Adv Cancer Res 2021;151:39-67. Epub 2021 Apr 9 doi: 10.1016/bs.acr.2021.02.003. PMID: 34148619
Bahadoer RR, Dijkstra EA, van Etten B, Marijnen CAM, Putter H, Kranenbarg EM, Roodvoets AGH, Nagtegaal ID, Beets-Tan RGH, Blomqvist LK, Fokstuen T, Ten Tije AJ, Capdevila J, Hendriks MP, Edhemovic I, Cervantes A, Nilsson PJ, Glimelius B, van de Velde CJH, Hospers GAP; RAPIDO collaborative investigators
Lancet Oncol 2021 Jan;22(1):29-42. Epub 2020 Dec 7 doi: 10.1016/S1470-2045(20)30555-6. PMID: 33301740
Pettit C, Walston S, Wald P, Webb A, Williams TM
Int J Oncol 2017 Aug;51(2):393-404. Epub 2017 Jun 14 doi: 10.3892/ijo.2017.4045. PMID: 28627602
Conde-Muíño R, Cuadros M, Zambudio N, Segura-Jiménez I, Cano C, Palma P
Biomed Res Int 2015;2015:921435. Epub 2015 Oct 4 doi: 10.1155/2015/921435. PMID: 26504848Free PMC Article

Recent systematic reviews

Tan X, Zhang Y, Wu X, Fang Q, Xu Y, Li S, Yuan J, Peng X, Fu K, Xiao S
BMC Gastroenterol 2024 Aug 13;24(1):263. doi: 10.1186/s12876-024-03359-9. PMID: 39138423Free PMC Article
Petrelli F, Trevisan F, Tomasello G, De Stefani A, Viti M, Garrone O, Luciani A, Ghidini M
Crit Rev Oncol Hematol 2022 Dec;180:103853. Epub 2022 Oct 15 doi: 10.1016/j.critrevonc.2022.103853. PMID: 36252747
Rymer B, Curtis NJ, Siddiqui MR, Chand M
Clin Nucl Med 2016 May;41(5):371-5. doi: 10.1097/RLU.0000000000001166. PMID: 26914561

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