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Advanced Soft Tissue Sarcoma

MedGen UID:
1701593
Concept ID:
C5206410
Neoplastic Process

Definition

A sarcoma of soft tissue that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Professional guidelines

PubMed

Hindi N, Haas RL
Surg Oncol Clin N Am 2022 Jul;31(3):547-558. doi: 10.1016/j.soc.2022.03.012. PMID: 35715149
Gamboa AC, Gronchi A, Cardona K
CA Cancer J Clin 2020 May;70(3):200-229. Epub 2020 Apr 10 doi: 10.3322/caac.21605. PMID: 32275330
Okuno SH, Maran A, Robinson SI
Expert Rev Anticancer Ther 2017 Oct;17(10):883-887. Epub 2017 Sep 8 doi: 10.1080/14737140.2017.1374857. PMID: 28862476

Recent clinical studies

Etiology

Saito Y, Shimoi T, Iwata S, Maejima A, Abe K, Udagawa R, Yonemori K, Furukawa T, Wakao F
J Chemother 2023 Dec;35(8):737-744. Epub 2023 Jan 12 doi: 10.1080/1120009X.2022.2164116. PMID: 36633925
Hindi N, Haas RL
Surg Oncol Clin N Am 2022 Jul;31(3):547-558. doi: 10.1016/j.soc.2022.03.012. PMID: 35715149
Tawbi HA, Burgess M, Bolejack V, Van Tine BA, Schuetze SM, Hu J, D'Angelo S, Attia S, Riedel RF, Priebat DA, Movva S, Davis LE, Okuno SH, Reed DR, Crowley J, Butterfield LH, Salazar R, Rodriguez-Canales J, Lazar AJ, Wistuba II, Baker LH, Maki RG, Reinke D, Patel S
Lancet Oncol 2017 Nov;18(11):1493-1501. Epub 2017 Oct 4 doi: 10.1016/S1470-2045(17)30624-1. PMID: 28988646Free PMC Article
Schöffski P, Chawla S, Maki RG, Italiano A, Gelderblom H, Choy E, Grignani G, Camargo V, Bauer S, Rha SY, Blay JY, Hohenberger P, D'Adamo D, Guo M, Chmielowski B, Le Cesne A, Demetri GD, Patel SR
Lancet 2016 Apr 16;387(10028):1629-37. Epub 2016 Feb 10 doi: 10.1016/S0140-6736(15)01283-0. PMID: 26874885
Judson I, Verweij J, Gelderblom H, Hartmann JT, Schöffski P, Blay JY, Kerst JM, Sufliarsky J, Whelan J, Hohenberger P, Krarup-Hansen A, Alcindor T, Marreaud S, Litière S, Hermans C, Fisher C, Hogendoorn PC, dei Tos AP, van der Graaf WT; European Organisation and Treatment of Cancer Soft Tissue and Bone Sarcoma Group
Lancet Oncol 2014 Apr;15(4):415-23. Epub 2014 Mar 5 doi: 10.1016/S1470-2045(14)70063-4. PMID: 24618336

Diagnosis

Hindi N, Haas RL
Surg Oncol Clin N Am 2022 Jul;31(3):547-558. doi: 10.1016/j.soc.2022.03.012. PMID: 35715149
Weiss AR, Chen YL, Scharschmidt TJ, Chi YY, Tian J, Black JO, Davis JL, Fanburg-Smith JC, Zambrano E, Anderson J, Arens R, Binitie O, Choy E, Davis JW, Hayes-Jordan A, Kao SC, Kayton ML, Kessel S, Lim R, Meyer WH, Million L, Okuno SH, Ostrenga A, Parisi MT, Pryma DA, Randall RL, Rosen MA, Schlapkohl M, Shulkin BL, Smith EA, Sorger JI, Terezakis S, Hawkins DS, Spunt SL, Wang D
Lancet Oncol 2020 Aug;21(8):1110-1122. Epub 2020 Jul 20 doi: 10.1016/S1470-2045(20)30325-9. PMID: 32702309Free PMC Article
Reichardt P
Future Oncol 2019 Sep;15(26s):1-3. Epub 2019 Sep 10 doi: 10.2217/fon-2019-0487. PMID: 31500457
Dayer LE, Hutchins LF, Johnson JT
J Oncol Pharm Pract 2015 Jun;21(3):224-31. Epub 2014 Feb 27 doi: 10.1177/1078155214524084. PMID: 24576945
D'Incalci M, Badri N, Galmarini CM, Allavena P
Br J Cancer 2014 Aug 12;111(4):646-50. Epub 2014 Apr 22 doi: 10.1038/bjc.2014.149. PMID: 24755886Free PMC Article

Therapy

Martín-Broto J, Hindi N, Grignani G, Merlini A, Ibrahim T, Le Cesne A
Future Oncol 2022 Sep;18(30s):23-32. Epub 2022 Oct 6 doi: 10.2217/fon-2022-0519. PMID: 36200932
Reichardt P
Future Oncol 2019 Sep;15(26s):1-3. Epub 2019 Sep 10 doi: 10.2217/fon-2019-0487. PMID: 31500457
Tawbi HA, Burgess M, Bolejack V, Van Tine BA, Schuetze SM, Hu J, D'Angelo S, Attia S, Riedel RF, Priebat DA, Movva S, Davis LE, Okuno SH, Reed DR, Crowley J, Butterfield LH, Salazar R, Rodriguez-Canales J, Lazar AJ, Wistuba II, Baker LH, Maki RG, Reinke D, Patel S
Lancet Oncol 2017 Nov;18(11):1493-1501. Epub 2017 Oct 4 doi: 10.1016/S1470-2045(17)30624-1. PMID: 28988646Free PMC Article
Schöffski P, Chawla S, Maki RG, Italiano A, Gelderblom H, Choy E, Grignani G, Camargo V, Bauer S, Rha SY, Blay JY, Hohenberger P, D'Adamo D, Guo M, Chmielowski B, Le Cesne A, Demetri GD, Patel SR
Lancet 2016 Apr 16;387(10028):1629-37. Epub 2016 Feb 10 doi: 10.1016/S0140-6736(15)01283-0. PMID: 26874885
Judson I, Verweij J, Gelderblom H, Hartmann JT, Schöffski P, Blay JY, Kerst JM, Sufliarsky J, Whelan J, Hohenberger P, Krarup-Hansen A, Alcindor T, Marreaud S, Litière S, Hermans C, Fisher C, Hogendoorn PC, dei Tos AP, van der Graaf WT; European Organisation and Treatment of Cancer Soft Tissue and Bone Sarcoma Group
Lancet Oncol 2014 Apr;15(4):415-23. Epub 2014 Mar 5 doi: 10.1016/S1470-2045(14)70063-4. PMID: 24618336

Prognosis

Pan M, Zhou MY, Jiang C, Zhang Z, Bui NQ, Bien J, Siy A, Achacoso N, Solorzano AV, Tse P, Chung E, Thomas S, Habel LA, Ganjoo KN
Clin Cancer Res 2024 Jan 17;30(2):413-419. doi: 10.1158/1078-0432.CCR-23-1990. PMID: 37831066Free PMC Article
Gamboa AC, Gronchi A, Cardona K
CA Cancer J Clin 2020 May;70(3):200-229. Epub 2020 Apr 10 doi: 10.3322/caac.21605. PMID: 32275330
Tawbi HA, Burgess M, Bolejack V, Van Tine BA, Schuetze SM, Hu J, D'Angelo S, Attia S, Riedel RF, Priebat DA, Movva S, Davis LE, Okuno SH, Reed DR, Crowley J, Butterfield LH, Salazar R, Rodriguez-Canales J, Lazar AJ, Wistuba II, Baker LH, Maki RG, Reinke D, Patel S
Lancet Oncol 2017 Nov;18(11):1493-1501. Epub 2017 Oct 4 doi: 10.1016/S1470-2045(17)30624-1. PMID: 28988646Free PMC Article
Seddon B, Strauss SJ, Whelan J, Leahy M, Woll PJ, Cowie F, Rothermundt C, Wood Z, Benson C, Ali N, Marples M, Veal GJ, Jamieson D, Küver K, Tirabosco R, Forsyth S, Nash S, Dehbi HM, Beare S
Lancet Oncol 2017 Oct;18(10):1397-1410. Epub 2017 Sep 4 doi: 10.1016/S1470-2045(17)30622-8. PMID: 28882536Free PMC Article
Tobias A, O'brien MP, Agulnik M
Expert Rev Clin Pharmacol 2017 Jul;10(7):699-705. Epub 2017 May 5 doi: 10.1080/17512433.2017.1324295. PMID: 28447475

Clinical prediction guides

Weiss AR, Chen YL, Scharschmidt TJ, Chi YY, Tian J, Black JO, Davis JL, Fanburg-Smith JC, Zambrano E, Anderson J, Arens R, Binitie O, Choy E, Davis JW, Hayes-Jordan A, Kao SC, Kayton ML, Kessel S, Lim R, Meyer WH, Million L, Okuno SH, Ostrenga A, Parisi MT, Pryma DA, Randall RL, Rosen MA, Schlapkohl M, Shulkin BL, Smith EA, Sorger JI, Terezakis S, Hawkins DS, Spunt SL, Wang D
Lancet Oncol 2020 Aug;21(8):1110-1122. Epub 2020 Jul 20 doi: 10.1016/S1470-2045(20)30325-9. PMID: 32702309Free PMC Article
Tap WD, Wagner AJ, Schöffski P, Martin-Broto J, Krarup-Hansen A, Ganjoo KN, Yen CC, Abdul Razak AR, Spira A, Kawai A, Le Cesne A, Van Tine BA, Naito Y, Park SH, Fedenko A, Pápai Z, Soldatenkova V, Shahir A, Mo G, Wright J, Jones RL; ANNOUNCE Investigators
JAMA 2020 Apr 7;323(13):1266-1276. doi: 10.1001/jama.2020.1707. PMID: 32259228Free PMC Article
Zobniw CM, Trinh VA, Posey K, Somaiah N
J Oncol Pharm Pract 2019 Mar;25(2):442-448. Epub 2018 Jul 22 doi: 10.1177/1078155218788135. PMID: 30032714
Calvani N, Orlando L, Nacci A, Sponziello F, Cinefra M, Cinieri S
Tumori 2009 Nov-Dec;95(6):843-5. doi: 10.1177/030089160909500635. PMID: 20210257
Judson I, Radford JA, Harris M, Blay JY, van Hoesel Q, le Cesne A, van Oosterom AT, Clemons MJ, Kamby C, Hermans C, Whittaker J, Donato di Paola E, Verweij J, Nielsen S
Eur J Cancer 2001 May;37(7):870-7. doi: 10.1016/s0959-8049(01)00050-8. PMID: 11313175

Recent systematic reviews

Liu XX, Han YH, Kuang BH, Lin GH, Wang BC
Medicine (Baltimore) 2023 Aug 18;102(33):e34902. doi: 10.1097/MD.0000000000034902. PMID: 37603507Free PMC Article
Hayashi K, Hiraoka K, Akiyama T, Iwata S, Tsuchiya H, Kawai A
Jpn J Clin Oncol 2021 Jul 1;51(7):1088-1093. doi: 10.1093/jjco/hyab049. PMID: 33822987
Zer A, Prince RM, Amir E, Abdul Razak AR
Cancer Treat Rev 2018 Feb;63:71-78. Epub 2017 Dec 6 doi: 10.1016/j.ctrv.2017.12.003. PMID: 29253836
Sharma S, Takyar S, Manson SC, Powell S, Penel N
BMC Cancer 2013 Aug 13;13:385. doi: 10.1186/1471-2407-13-385. PMID: 23937858Free PMC Article
Penel N, Cousin S, Duhamel A, Kramar A
Crit Rev Oncol Hematol 2013 Nov;88(2):309-17. Epub 2013 May 22 doi: 10.1016/j.critrevonc.2013.05.004. PMID: 23706377

Supplemental Content

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