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Locally Advanced Renal Cell Carcinoma

MedGen UID:
1717857
•Concept ID:
C5239295
•
Neoplastic Process

Definition

Renal cell carcinoma that has spread to nearby tissues or lymph nodes. [from NCI]

Professional guidelines

PubMed

Systemic therapy in the management of localized and locally advanced renal cell carcinoma: Current state and future perspectives.
Berquist SW, Yim K, Ryan ST, Patel SH, Eldefrawy A, Cotta BH, Bradshaw AW, Meagher MF, Bindayi A, McKay RR, Autorino R, Staehler M, Derweesh IH
Int J Urol 2019 May;26(5):532-542. Epub 2019 Apr 3 doi: 10.1111/iju.13943. PMID: 30943578
Neoadjuvant therapy of renal cell carcinoma: a novel treatment option in the era of targeted therapy?
Schrader AJ, Steffens S, Schnoeller TJ, Schrader M, Kuczyk MA
Int J Urol 2012 Oct;19(10):903-7. Epub 2012 May 28 doi: 10.1111/j.1442-2042.2012.03065.x. PMID: 22640774
Management of locally advanced renal cell carcinoma.
Rodriguez A, Sexton WJ
Cancer Control 2006 Jul;13(3):199-210. doi: 10.1177/107327480601300307. PMID: 16885916

Recent clinical studies

Etiology

Adjuvant immunotherapy for locally advanced renal cell carcinoma.
Alevizakos M, McDermott D
Expert Opin Biol Ther 2023 Jul-Dec;23(12):1265-1275. Epub 2023 Dec 28 doi: 10.1080/14712598.2023.2294001. PMID: 38069655
Preoperative prognostic model for localized and locally advanced renal cell carcinoma: Michinoku Japan Urological Cancer Study Group.
Horie S, Naito S, Hatakeyama S, Kandori S, Numakura K, Kato R, Koguchi T, Myoen S, Kawasaki Y, Ito A, Adachi H, Kojima Y, Obara W, Habuchi T, Nishiyama H, Ohyama C, Tsuchiya N
Int J Clin Oncol 2023 Nov;28(11):1538-1544. Epub 2023 Sep 22 doi: 10.1007/s10147-023-02401-2. PMID: 37740070
Adjuvant therapy for locally advanced renal cell carcinoma: A meta-analysis and systematic review.
Bai Y, Li S, Jia Z, Ding Y, Gu C, Yang J
Urol Oncol 2018 Feb;36(2):79.e1-79.e10. Epub 2017 Oct 31 doi: 10.1016/j.urolonc.2017.10.001. PMID: 29110942
Role of targeted therapy in combination with surgery in renal cell carcinoma.
Bex A, Powles T, Karam JA
Int J Urol 2016 Jan;23(1):5-12. Epub 2015 Aug 4 doi: 10.1111/iju.12891. PMID: 26238981
Systematic review of adrenalectomy and lymph node dissection in locally advanced renal cell carcinoma.
Bekema HJ, MacLennan S, Imamura M, Lam TB, Stewart F, Scott N, MacLennan G, McClinton S, Griffiths TR, Skolarikos A, MacLennan SJ, Sylvester R, Ljungberg B, N'Dow J
Eur Urol 2013 Nov;64(5):799-810. Epub 2013 Apr 23 doi: 10.1016/j.eururo.2013.04.033. PMID: 23643550

Diagnosis

Development and validation of a nomogram for predicting the impact of tumor size on cancer-specific survival of locally advanced renal cell carcinoma: a SEER-based study.
Bai J, Lu Q, Wen Y, Shangguan T, Ye Y, Lin J, Liu R, Cai W, Chen J
Aging (Albany NY) 2024 Feb 19;16(4):3823-3836. doi: 10.18632/aging.205562. PMID: 38376430Free PMC Article
Preoperative prognostic model for localized and locally advanced renal cell carcinoma: Michinoku Japan Urological Cancer Study Group.
Horie S, Naito S, Hatakeyama S, Kandori S, Numakura K, Kato R, Koguchi T, Myoen S, Kawasaki Y, Ito A, Adachi H, Kojima Y, Obara W, Habuchi T, Nishiyama H, Ohyama C, Tsuchiya N
Int J Clin Oncol 2023 Nov;28(11):1538-1544. Epub 2023 Sep 22 doi: 10.1007/s10147-023-02401-2. PMID: 37740070
Urologic cancer in China.
Pang C, Guan Y, Li H, Chen W, Zhu G
Jpn J Clin Oncol 2016 Jun;46(6):497-501. Epub 2016 Apr 4 doi: 10.1093/jjco/hyw034. PMID: 27049022
Role of targeted therapy in combination with surgery in renal cell carcinoma.
Bex A, Powles T, Karam JA
Int J Urol 2016 Jan;23(1):5-12. Epub 2015 Aug 4 doi: 10.1111/iju.12891. PMID: 26238981
Targeted therapy for locally advanced renal cell carcinoma.
Jonasch E, Tannir NM
Target Oncol 2010 Jun;5(2):113-8. Epub 2010 Jul 14 doi: 10.1007/s11523-010-0147-4. PMID: 20625844

Therapy

Adjuvant immunotherapy for locally advanced renal cell carcinoma.
Alevizakos M, McDermott D
Expert Opin Biol Ther 2023 Jul-Dec;23(12):1265-1275. Epub 2023 Dec 28 doi: 10.1080/14712598.2023.2294001. PMID: 38069655
Neoadjuvant Therapy for Locally Advanced Renal Cell Carcinoma.
Westerman ME, Shapiro DD, Wood CG, Karam JA
Urol Clin North Am 2020 Aug;47(3):329-343. Epub 2020 Jun 11 doi: 10.1016/j.ucl.2020.04.010. PMID: 32600535
Systemic therapy in the management of localized and locally advanced renal cell carcinoma: Current state and future perspectives.
Berquist SW, Yim K, Ryan ST, Patel SH, Eldefrawy A, Cotta BH, Bradshaw AW, Meagher MF, Bindayi A, McKay RR, Autorino R, Staehler M, Derweesh IH
Int J Urol 2019 May;26(5):532-542. Epub 2019 Apr 3 doi: 10.1111/iju.13943. PMID: 30943578
Adjuvant therapy for locally advanced renal cell carcinoma: A meta-analysis and systematic review.
Bai Y, Li S, Jia Z, Ding Y, Gu C, Yang J
Urol Oncol 2018 Feb;36(2):79.e1-79.e10. Epub 2017 Oct 31 doi: 10.1016/j.urolonc.2017.10.001. PMID: 29110942
Neoadjuvant therapy for localized and locally advanced renal cell carcinoma.
Bindayi A, Hamilton ZA, McDonald ML, Yim K, Millard F, McKay RR, Campbell SC, Rini BI, Derweesh IH
Urol Oncol 2018 Jan;36(1):31-37. Epub 2017 Aug 10 doi: 10.1016/j.urolonc.2017.07.015. PMID: 28802883

Prognosis

Development and validation of a nomogram for predicting the impact of tumor size on cancer-specific survival of locally advanced renal cell carcinoma: a SEER-based study.
Bai J, Lu Q, Wen Y, Shangguan T, Ye Y, Lin J, Liu R, Cai W, Chen J
Aging (Albany NY) 2024 Feb 19;16(4):3823-3836. doi: 10.18632/aging.205562. PMID: 38376430Free PMC Article
Adjuvant immunotherapy for locally advanced renal cell carcinoma.
Alevizakos M, McDermott D
Expert Opin Biol Ther 2023 Jul-Dec;23(12):1265-1275. Epub 2023 Dec 28 doi: 10.1080/14712598.2023.2294001. PMID: 38069655
Preoperative prognostic model for localized and locally advanced renal cell carcinoma: Michinoku Japan Urological Cancer Study Group.
Horie S, Naito S, Hatakeyama S, Kandori S, Numakura K, Kato R, Koguchi T, Myoen S, Kawasaki Y, Ito A, Adachi H, Kojima Y, Obara W, Habuchi T, Nishiyama H, Ohyama C, Tsuchiya N
Int J Clin Oncol 2023 Nov;28(11):1538-1544. Epub 2023 Sep 22 doi: 10.1007/s10147-023-02401-2. PMID: 37740070
Renal cell carcinoma and pathologic nodal disease: Implications for American Joint Committee on Cancer staging.
Yu KJ, Keskin SK, Meissner MA, Petros FG, Wang X, Borregales LD, Gu C, Tamboli P, Matin SF, Wood CG, Karam JA
Cancer 2018 Oct 15;124(20):4023-4031. Epub 2018 Oct 1 doi: 10.1002/cncr.31661. PMID: 30276798
Chronic Kidney Disease Is More Common in Locally Advanced Renal Cell Carcinoma.
Dey S, Hamilton Z, Noyes SL, Tobert CM, Keeley J, Derweesh IH, Lane BR
Urology 2017 Jul;105:101-107. Epub 2017 Mar 30 doi: 10.1016/j.urology.2017.03.033. PMID: 28365357

Clinical prediction guides

Development and validation of a nomogram for predicting the impact of tumor size on cancer-specific survival of locally advanced renal cell carcinoma: a SEER-based study.
Bai J, Lu Q, Wen Y, Shangguan T, Ye Y, Lin J, Liu R, Cai W, Chen J
Aging (Albany NY) 2024 Feb 19;16(4):3823-3836. doi: 10.18632/aging.205562. PMID: 38376430Free PMC Article
Adjuvant immunotherapy for locally advanced renal cell carcinoma.
Alevizakos M, McDermott D
Expert Opin Biol Ther 2023 Jul-Dec;23(12):1265-1275. Epub 2023 Dec 28 doi: 10.1080/14712598.2023.2294001. PMID: 38069655
Risk Factors and Patterns of Locoregional Recurrence after Radical Nephrectomy for Locally Advanced Renal Cell Carcinoma.
Yoo GS, Park W, Pyo H, Jeong BC, Jeon HG, Kang M, Seo SI, Jeon SS, Lee HM, Choi HY, Park BK, Kim CK, Park SY, Kwon GY
Cancer Res Treat 2022 Jan;54(1):218-225. Epub 2021 Apr 15 doi: 10.4143/crt.2020.1373. PMID: 33857365Free PMC Article
Adjuvant therapy for locally advanced renal cell carcinoma: A meta-analysis and systematic review.
Bai Y, Li S, Jia Z, Ding Y, Gu C, Yang J
Urol Oncol 2018 Feb;36(2):79.e1-79.e10. Epub 2017 Oct 31 doi: 10.1016/j.urolonc.2017.10.001. PMID: 29110942
Prediction of Pulmonary Metastasis in Renal Cell Carcinoma Patients with Indeterminate Pulmonary Nodules.
Adibi M, Kenney PA, Thomas AZ, Borregales LD, Nogueras-González GM, Wang X, Devine CE, Karam JA, Wood CG
Eur Urol 2016 Feb;69(2):352-60. Epub 2015 Sep 14 doi: 10.1016/j.eururo.2015.08.053. PMID: 26382085

Recent systematic reviews

The Efficacy of Adjuvant Targeted Therapy in Patients with Advanced Renal Cell Carcinoma: A Systematic Review and Meta-Analysis.
Yiu W, Chen J, Zhao B, Zhang W, Chen L, Liu H
Comput Math Methods Med 2022;2022:7341294. Epub 2022 Mar 29 doi: 10.1155/2022/7341294. PMID: 35392587Free PMC Article
Adjuvant therapy with tyrosine kinase inhibitors for localized and locally advanced renal cell carcinoma: an updated systematic review and meta-analysis.
Laukhtina E, Quhal F, Mori K, Sari Motlagh R, Pradere B, Schuettfort VM, Mostafaei H, Katayama S, Grossmann NС, Rajwa P, Resch I, Enikeev D, Karakiewicz PI, Shariat SF, Schmidinger M
Urol Oncol 2021 Nov;39(11):764-773. Epub 2021 Aug 14 doi: 10.1016/j.urolonc.2021.07.022. PMID: 34400065
Influence of lymph node dissection in patients undergoing radical nephrectomy for non-metastatic renal cell carcinoma: a systematic review and meta-analysis.
Luo X, Li JX, Liu YT, Zou G, Yao WX, Qing GQ, Yang RL, Ye XY, Facchini G, Rossetti S
Eur Rev Med Pharmacol Sci 2019 Jul;23(14):6079-6090. doi: 10.26355/eurrev_201907_18422. PMID: 31364109
Adjuvant therapy for locally advanced renal cell carcinoma: A meta-analysis and systematic review.
Bai Y, Li S, Jia Z, Ding Y, Gu C, Yang J
Urol Oncol 2018 Feb;36(2):79.e1-79.e10. Epub 2017 Oct 31 doi: 10.1016/j.urolonc.2017.10.001. PMID: 29110942
Systematic review of adrenalectomy and lymph node dissection in locally advanced renal cell carcinoma.
Bekema HJ, MacLennan S, Imamura M, Lam TB, Stewart F, Scott N, MacLennan G, McClinton S, Griffiths TR, Skolarikos A, MacLennan SJ, Sylvester R, Ljungberg B, N'Dow J
Eur Urol 2013 Nov;64(5):799-810. Epub 2013 Apr 23 doi: 10.1016/j.eururo.2013.04.033. PMID: 23643550

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