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Locally Advanced Clear Cell Renal Cell Carcinoma

MedGen UID:
1751253
Concept ID:
C5418297
Neoplastic Process

Definition

Clear cell renal cell carcinoma that has spread to nearby tissues or lymph nodes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Clear Cell Renal Cell Carcinoma

Professional guidelines

PubMed

Chen YW, Wang L, Panian J, Dhanji S, Derweesh I, Rose B, Bagrodia A, McKay RR
Curr Treat Options Oncol 2023 Dec;24(12):1889-1916. Epub 2023 Dec 28 doi: 10.1007/s11864-023-01161-5. PMID: 38153686Free PMC Article
Tannir NM, Signoretti S, Choueiri TK, McDermott DF, Motzer RJ, Flaifel A, Pignon JC, Ficial M, Frontera OA, George S, Powles T, Donskov F, Harrison MR, Barthélémy P, Tykodi SS, Kocsis J, Ravaud A, Rodriguez-Cid JR, Pal SK, Murad AM, Ishii Y, Saggi SS, McHenry MB, Rini BI
Clin Cancer Res 2021 Jan 1;27(1):78-86. Epub 2020 Sep 1 doi: 10.1158/1078-0432.CCR-20-2063. PMID: 32873572Free PMC Article
Rouprêt M, Babjuk M, Burger M, Capoun O, Cohen D, Compérat EM, Cowan NC, Dominguez-Escrig JL, Gontero P, Hugh Mostafid A, Palou J, Peyronnet B, Seisen T, Soukup V, Sylvester RJ, Rhijn BWGV, Zigeuner R, Shariat SF
Eur Urol 2021 Jan;79(1):62-79. Epub 2020 Jun 24 doi: 10.1016/j.eururo.2020.05.042. PMID: 32593530

Recent clinical studies

Etiology

Chen YW, Wang L, Panian J, Dhanji S, Derweesh I, Rose B, Bagrodia A, McKay RR
Curr Treat Options Oncol 2023 Dec;24(12):1889-1916. Epub 2023 Dec 28 doi: 10.1007/s11864-023-01161-5. PMID: 38153686Free PMC Article
Choueiri TK, McDermott DF, Merchan J, Bauer TM, Figlin R, Heath EI, Michaelson MD, Arrowsmith E, D'Souza A, Zhao S, Roy A, Perini R, Vickery D, Tykodi SS
Lancet Oncol 2023 May;24(5):553-562. Epub 2023 Mar 31 doi: 10.1016/S1470-2045(23)00097-9. PMID: 37011650
Rini BI, Signoretti S, Choueiri TK, McDermott DF, Motzer RJ, George S, Powles T, Donskov F, Tykodi SS, Pal SK, Gupta S, Lee CW, Jiang R, Tannir NM
J Immunother Cancer 2022 Dec;10(12) doi: 10.1136/jitc-2022-005445. PMID: 36549781Free PMC Article
Motzer RJ, McDermott DF, Escudier B, Burotto M, Choueiri TK, Hammers HJ, Barthélémy P, Plimack ER, Porta C, George S, Powles T, Donskov F, Gurney H, Kollmannsberger CK, Grimm MO, Barrios C, Tomita Y, Castellano D, Grünwald V, Rini BI, McHenry MB, Lee CW, McCarthy J, Ejzykowicz F, Tannir NM
Cancer 2022 Jun 1;128(11):2085-2097. Epub 2022 Apr 5 doi: 10.1002/cncr.34180. PMID: 35383908Free PMC Article
Hsieh JJ, Purdue MP, Signoretti S, Swanton C, Albiges L, Schmidinger M, Heng DY, Larkin J, Ficarra V
Nat Rev Dis Primers 2017 Mar 9;3:17009. doi: 10.1038/nrdp.2017.9. PMID: 28276433Free PMC Article

Diagnosis

Chen YW, Wang L, Panian J, Dhanji S, Derweesh I, Rose B, Bagrodia A, McKay RR
Curr Treat Options Oncol 2023 Dec;24(12):1889-1916. Epub 2023 Dec 28 doi: 10.1007/s11864-023-01161-5. PMID: 38153686Free PMC Article
Sheng X, Yan X, Wang L, Shi Y, Yao X, Luo H, Shi B, Liu J, He Z, Yu G, Ying J, Han W, Hu C, Ling Y, Chi Z, Cui C, Si L, Fang J, Zhou A, Guo J
Clin Cancer Res 2021 Jan 1;27(1):43-51. Epub 2020 Oct 27 doi: 10.1158/1078-0432.CCR-20-2488. PMID: 33109737
Abbosh C, Birkbak NJ, Wilson GA, Jamal-Hanjani M, Constantin T, Salari R, Le Quesne J, Moore DA, Veeriah S, Rosenthal R, Marafioti T, Kirkizlar E, Watkins TBK, McGranahan N, Ward S, Martinson L, Riley J, Fraioli F, Al Bakir M, Grönroos E, Zambrana F, Endozo R, Bi WL, Fennessy FM, Sponer N, Johnson D, Laycock J, Shafi S, Czyzewska-Khan J, Rowan A, Chambers T, Matthews N, Turajlic S, Hiley C, Lee SM, Forster MD, Ahmad T, Falzon M, Borg E, Lawrence D, Hayward M, Kolvekar S, Panagiotopoulos N, Janes SM, Thakrar R, Ahmed A, Blackhall F, Summers Y, Hafez D, Naik A, Ganguly A, Kareht S, Shah R, Joseph L, Marie Quinn A, Crosbie PA, Naidu B, Middleton G, Langman G, Trotter S, Nicolson M, Remmen H, Kerr K, Chetty M, Gomersall L, Fennell DA, Nakas A, Rathinam S, Anand G, Khan S, Russell P, Ezhil V, Ismail B, Irvin-Sellers M, Prakash V, Lester JF, Kornaszewska M, Attanoos R, Adams H, Davies H, Oukrif D, Akarca AU, Hartley JA, Lowe HL, Lock S, Iles N, Bell H, Ngai Y, Elgar G, Szallasi Z, Schwarz RF, Herrero J, Stewart A, Quezada SA, Peggs KS, Van Loo P, Dive C, Lin CJ, Rabinowitz M, Aerts HJWL, Hackshaw A, Shaw JA, Zimmermann BG; TRACERx consortium; PEACE consortium, Swanton C
Nature 2017 Apr 26;545(7655):446-451. doi: 10.1038/nature22364. PMID: 28445469Free PMC Article
Hsieh JJ, Purdue MP, Signoretti S, Swanton C, Albiges L, Schmidinger M, Heng DY, Larkin J, Ficarra V
Nat Rev Dis Primers 2017 Mar 9;3:17009. doi: 10.1038/nrdp.2017.9. PMID: 28276433Free PMC Article
Capitanio U, Montorsi F
Lancet 2016 Feb 27;387(10021):894-906. Epub 2015 Aug 25 doi: 10.1016/S0140-6736(15)00046-X. PMID: 26318520

Therapy

Pal SK, Albiges L, Tomczak P, Suárez C, Voss MH, de Velasco G, Chahoud J, Mochalova A, Procopio G, Mahammedi H, Zengerling F, Kim C, Osawa T, Angel M, Gupta S, Khan O, Bergthold G, Liu B, Kalaitzidou M, Huseni M, Scheffold C, Powles T, Choueiri TK
Lancet 2023 Jul 15;402(10397):185-195. Epub 2023 Jun 5 doi: 10.1016/S0140-6736(23)00922-4. PMID: 37290461Free PMC Article
Choueiri TK, McDermott DF, Merchan J, Bauer TM, Figlin R, Heath EI, Michaelson MD, Arrowsmith E, D'Souza A, Zhao S, Roy A, Perini R, Vickery D, Tykodi SS
Lancet Oncol 2023 May;24(5):553-562. Epub 2023 Mar 31 doi: 10.1016/S1470-2045(23)00097-9. PMID: 37011650
Motzer RJ, McDermott DF, Escudier B, Burotto M, Choueiri TK, Hammers HJ, Barthélémy P, Plimack ER, Porta C, George S, Powles T, Donskov F, Gurney H, Kollmannsberger CK, Grimm MO, Barrios C, Tomita Y, Castellano D, Grünwald V, Rini BI, McHenry MB, Lee CW, McCarthy J, Ejzykowicz F, Tannir NM
Cancer 2022 Jun 1;128(11):2085-2097. Epub 2022 Apr 5 doi: 10.1002/cncr.34180. PMID: 35383908Free PMC Article
Hsieh JJ, Purdue MP, Signoretti S, Swanton C, Albiges L, Schmidinger M, Heng DY, Larkin J, Ficarra V
Nat Rev Dis Primers 2017 Mar 9;3:17009. doi: 10.1038/nrdp.2017.9. PMID: 28276433Free PMC Article
Jonasch E, Gao J, Rathmell WK
BMJ 2014 Nov 10;349:g4797. doi: 10.1136/bmj.g4797. PMID: 25385470Free PMC Article

Prognosis

Motzer RJ, McDermott DF, Escudier B, Burotto M, Choueiri TK, Hammers HJ, Barthélémy P, Plimack ER, Porta C, George S, Powles T, Donskov F, Gurney H, Kollmannsberger CK, Grimm MO, Barrios C, Tomita Y, Castellano D, Grünwald V, Rini BI, McHenry MB, Lee CW, McCarthy J, Ejzykowicz F, Tannir NM
Cancer 2022 Jun 1;128(11):2085-2097. Epub 2022 Apr 5 doi: 10.1002/cncr.34180. PMID: 35383908Free PMC Article
Braun DA, Street K, Burke KP, Cookmeyer DL, Denize T, Pedersen CB, Gohil SH, Schindler N, Pomerance L, Hirsch L, Bakouny Z, Hou Y, Forman J, Huang T, Li S, Cui A, Keskin DB, Steinharter J, Bouchard G, Sun M, Pimenta EM, Xu W, Mahoney KM, McGregor BA, Hirsch MS, Chang SL, Livak KJ, McDermott DF, Shukla SA, Olsen LR, Signoretti S, Sharpe AH, Irizarry RA, Choueiri TK, Wu CJ
Cancer Cell 2021 May 10;39(5):632-648.e8. Epub 2021 Mar 11 doi: 10.1016/j.ccell.2021.02.013. PMID: 33711273Free PMC Article
Hsieh JJ, Purdue MP, Signoretti S, Swanton C, Albiges L, Schmidinger M, Heng DY, Larkin J, Ficarra V
Nat Rev Dis Primers 2017 Mar 9;3:17009. doi: 10.1038/nrdp.2017.9. PMID: 28276433Free PMC Article
Jonasch E, Gao J, Rathmell WK
BMJ 2014 Nov 10;349:g4797. doi: 10.1136/bmj.g4797. PMID: 25385470Free PMC Article
Rini BI, Campbell SC, Escudier B
Lancet 2009 Mar 28;373(9669):1119-32. Epub 2009 Mar 5 doi: 10.1016/S0140-6736(09)60229-4. PMID: 19269025

Clinical prediction guides

Choueiri TK, McDermott DF, Merchan J, Bauer TM, Figlin R, Heath EI, Michaelson MD, Arrowsmith E, D'Souza A, Zhao S, Roy A, Perini R, Vickery D, Tykodi SS
Lancet Oncol 2023 May;24(5):553-562. Epub 2023 Mar 31 doi: 10.1016/S1470-2045(23)00097-9. PMID: 37011650
Zhao W, Jin L, Chen P, Li D, Gao W, Dong G
Cancer Lett 2022 Oct 1;545:215816. Epub 2022 Jul 8 doi: 10.1016/j.canlet.2022.215816. PMID: 35810989
Motzer RJ, McDermott DF, Escudier B, Burotto M, Choueiri TK, Hammers HJ, Barthélémy P, Plimack ER, Porta C, George S, Powles T, Donskov F, Gurney H, Kollmannsberger CK, Grimm MO, Barrios C, Tomita Y, Castellano D, Grünwald V, Rini BI, McHenry MB, Lee CW, McCarthy J, Ejzykowicz F, Tannir NM
Cancer 2022 Jun 1;128(11):2085-2097. Epub 2022 Apr 5 doi: 10.1002/cncr.34180. PMID: 35383908Free PMC Article
Bailey C, Black JRM, Reading JL, Litchfield K, Turajlic S, McGranahan N, Jamal-Hanjani M, Swanton C
Cancer Discov 2021 Apr;11(4):916-932. doi: 10.1158/2159-8290.CD-20-1559. PMID: 33811124Free PMC Article
Hsieh JJ, Purdue MP, Signoretti S, Swanton C, Albiges L, Schmidinger M, Heng DY, Larkin J, Ficarra V
Nat Rev Dis Primers 2017 Mar 9;3:17009. doi: 10.1038/nrdp.2017.9. PMID: 28276433Free PMC Article

Recent systematic reviews

Siva S, Louie AV, Kotecha R, Barber MN, Ali M, Zhang Z, Guckenberger M, Kim MS, Scorsetti M, Tree AC, Slotman BJ, Sahgal A, Lo SS
Lancet Oncol 2024 Jan;25(1):e18-e28. doi: 10.1016/S1470-2045(23)00513-2. PMID: 38181809
Bolek H, Ürün Y
Crit Rev Oncol Hematol 2023 Dec;192:104144. Epub 2023 Sep 23 doi: 10.1016/j.critrevonc.2023.104144. PMID: 37748694
Yanagisawa T, Kawada T, Quhal F, Bekku K, Laukhtina E, Rajwa P, von Deimling M, Majdoub M, Chlosta M, Pradere B, Mori K, Kimura T, Schmidinger M, Karakiewicz PI, Shariat SF
World J Urol 2023 Jul;41(7):1763-1774. Epub 2023 May 20 doi: 10.1007/s00345-023-04412-0. PMID: 37209143Free PMC Article
Zalay O, Yan M, Sigurdson S, Malone S, Vera-Badillo FE, Mahmud A
Curr Oncol 2022 Dec 20;30(1):19-36. doi: 10.3390/curroncol30010002. PMID: 36661651Free PMC Article
Bai Y, Li S, Jia Z, Ding Y, Gu C, Yang J
Urol Oncol 2018 Feb;36(2):79.e1-79.e10. Epub 2017 Oct 31 doi: 10.1016/j.urolonc.2017.10.001. PMID: 29110942

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