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Colorectal Conventional Adenoma

MedGen UID:
1756401
Concept ID:
C5419783
Neoplastic Process
Synonym: Conventional Colorectal Adenoma

Definition

A benign, premalignant colorectal neoplasm composed of dysplastic epithelium. The descriptor ""conventional"" distinguishes this from lesions in the serrated pathway. (WHO 2019) [from NCI]

Professional guidelines

PubMed

Ferlitsch M, Hassan C, Bisschops R, Bhandari P, Dinis-Ribeiro M, Risio M, Paspatis GA, Moss A, Libânio D, Lorenzo-Zúñiga V, Voiosu AM, Rutter MD, Pellisé M, Moons LMG, Probst A, Awadie H, Amato A, Takeuchi Y, Repici A, Rahmi G, Koecklin HU, Albéniz E, Rockenbauer LM, Waldmann E, Messmann H, Triantafyllou K, Jover R, Gralnek IM, Dekker E, Bourke MJ
Endoscopy 2024 Jul;56(7):516-545. Epub 2024 Apr 26 doi: 10.1055/a-2304-3219. PMID: 38670139
Chu JE, Hamm J, Gentile L, Telford JJ, Schaeffer DF
J Clin Gastroenterol 2022 Mar 1;56(3):243-248. doi: 10.1097/MCG.0000000000001519. PMID: 33780220
Murakami T, Sakamoto N, Nagahara A
J Gastroenterol Hepatol 2019 Oct;34(10):1685-1695. Epub 2019 Jun 30 doi: 10.1111/jgh.14752. PMID: 31158302

Recent clinical studies

Etiology

Ferlitsch M, Hassan C, Bisschops R, Bhandari P, Dinis-Ribeiro M, Risio M, Paspatis GA, Moss A, Libânio D, Lorenzo-Zúñiga V, Voiosu AM, Rutter MD, Pellisé M, Moons LMG, Probst A, Awadie H, Amato A, Takeuchi Y, Repici A, Rahmi G, Koecklin HU, Albéniz E, Rockenbauer LM, Waldmann E, Messmann H, Triantafyllou K, Jover R, Gralnek IM, Dekker E, Bourke MJ
Endoscopy 2024 Jul;56(7):516-545. Epub 2024 Apr 26 doi: 10.1055/a-2304-3219. PMID: 38670139
Dunne PD, Arends MJ
Virchows Arch 2024 Feb;484(2):273-285. Epub 2024 Feb 6 doi: 10.1007/s00428-024-03746-3. PMID: 38319359Free PMC Article
Hang D, Wang L, Fang Z, Du M, Wang K, He X, Khandpur N, Rossato SL, Wu K, Hu Z, Shen H, Ogino S, Chan AT, Giovannucci EL, Zhang FF, Song M
J Natl Cancer Inst 2023 Feb 8;115(2):155-164. doi: 10.1093/jnci/djac221. PMID: 36477589Free PMC Article
Sninsky JA, Shore BM, Lupu GV, Crockett SD
Gastrointest Endosc Clin N Am 2022 Apr;32(2):195-213. Epub 2022 Feb 22 doi: 10.1016/j.giec.2021.12.008. PMID: 35361331
He X, Hang D, Wu K, Nayor J, Drew DA, Giovannucci EL, Ogino S, Chan AT, Song M
Gastroenterology 2020 Mar;158(4):852-861.e4. Epub 2019 Jul 11 doi: 10.1053/j.gastro.2019.06.039. PMID: 31302144Free PMC Article

Diagnosis

Xu H, Tang RSY, Lam TYT, Zhao G, Lau JYW, Liu Y, Wu Q, Rong L, Xu W, Li X, Wong SH, Cai S, Wang J, Liu G, Ma T, Liang X, Mak JWY, Xu H, Yuan P, Cao T, Li F, Ye Z, Shutian Z, Sung JJY
Clin Gastroenterol Hepatol 2023 Feb;21(2):337-346.e3. Epub 2022 Jul 19 doi: 10.1016/j.cgh.2022.07.006. PMID: 35863686
Sninsky JA, Shore BM, Lupu GV, Crockett SD
Gastrointest Endosc Clin N Am 2022 Apr;32(2):195-213. Epub 2022 Feb 22 doi: 10.1016/j.giec.2021.12.008. PMID: 35361331
Chen B, Scurrah CR, McKinley ET, Simmons AJ, Ramirez-Solano MA, Zhu X, Markham NO, Heiser CN, Vega PN, Rolong A, Kim H, Sheng Q, Drewes JL, Zhou Y, Southard-Smith AN, Xu Y, Ro J, Jones AL, Revetta F, Berry LD, Niitsu H, Islam M, Pelka K, Hofree M, Chen JH, Sarkizova S, Ng K, Giannakis M, Boland GM, Aguirre AJ, Anderson AC, Rozenblatt-Rosen O, Regev A, Hacohen N, Kawasaki K, Sato T, Goettel JA, Grady WM, Zheng W, Washington MK, Cai Q, Sears CL, Goldenring JR, Franklin JL, Su T, Huh WJ, Vandekar S, Roland JT, Liu Q, Coffey RJ, Shrubsole MJ, Lau KS
Cell 2021 Dec 22;184(26):6262-6280.e26. Epub 2021 Dec 14 doi: 10.1016/j.cell.2021.11.031. PMID: 34910928Free PMC Article
He X, Hang D, Wu K, Nayor J, Drew DA, Giovannucci EL, Ogino S, Chan AT, Song M
Gastroenterology 2020 Mar;158(4):852-861.e4. Epub 2019 Jul 11 doi: 10.1053/j.gastro.2019.06.039. PMID: 31302144Free PMC Article
Schlemper RJ, Riddell RH, Kato Y, Borchard F, Cooper HS, Dawsey SM, Dixon MF, Fenoglio-Preiser CM, Fléjou JF, Geboes K, Hattori T, Hirota T, Itabashi M, Iwafuchi M, Iwashita A, Kim YI, Kirchner T, Klimpfinger M, Koike M, Lauwers GY, Lewin KJ, Oberhuber G, Offner F, Price AB, Rubio CA, Shimizu M, Shimoda T, Sipponen P, Solcia E, Stolte M, Watanabe H, Yamabe H
Gut 2000 Aug;47(2):251-5. doi: 10.1136/gut.47.2.251. PMID: 10896917Free PMC Article

Therapy

Schöler J, Alavanja M, de Lange T, Yamamoto S, Hedenström P, Varkey J
BMJ Open Gastroenterol 2024 Jan 30;11(1) doi: 10.1136/bmjgast-2023-001247. PMID: 38290758Free PMC Article
Mangira D, Raftopoulos S, Vogrin S, Hartley I, Mack A, Gazelakis K, Nalankilli K, Trinh A, Metz AJ, Appleyard M, Grimpen F, Elliott T, Brown G, Moss A
Endoscopy 2023 Jul;55(7):627-635. Epub 2023 Feb 7 doi: 10.1055/a-2029-9539. PMID: 36750222
Xu H, Tang RSY, Lam TYT, Zhao G, Lau JYW, Liu Y, Wu Q, Rong L, Xu W, Li X, Wong SH, Cai S, Wang J, Liu G, Ma T, Liang X, Mak JWY, Xu H, Yuan P, Cao T, Li F, Ye Z, Shutian Z, Sung JJY
Clin Gastroenterol Hepatol 2023 Feb;21(2):337-346.e3. Epub 2022 Jul 19 doi: 10.1016/j.cgh.2022.07.006. PMID: 35863686
Sui H, Zhang L, Gu K, Chai N, Ji Q, Zhou L, Wang Y, Ren J, Yang L, Zhang B, Hu J, Li Q
Cell Commun Signal 2020 Jul 16;18(1):113. doi: 10.1186/s12964-020-00596-9. PMID: 32677955Free PMC Article
Schmidt A, Meier B, Caca K
World J Gastroenterol 2015 Aug 21;21(31):9273-85. doi: 10.3748/wjg.v21.i31.9273. PMID: 26309354Free PMC Article

Prognosis

Dunne PD, Arends MJ
Virchows Arch 2024 Feb;484(2):273-285. Epub 2024 Feb 6 doi: 10.1007/s00428-024-03746-3. PMID: 38319359Free PMC Article
Hang D, Wang L, Fang Z, Du M, Wang K, He X, Khandpur N, Rossato SL, Wu K, Hu Z, Shen H, Ogino S, Chan AT, Giovannucci EL, Zhang FF, Song M
J Natl Cancer Inst 2023 Feb 8;115(2):155-164. doi: 10.1093/jnci/djac221. PMID: 36477589Free PMC Article
Sninsky JA, Shore BM, Lupu GV, Crockett SD
Gastrointest Endosc Clin N Am 2022 Apr;32(2):195-213. Epub 2022 Feb 22 doi: 10.1016/j.giec.2021.12.008. PMID: 35361331
He X, Hang D, Wu K, Nayor J, Drew DA, Giovannucci EL, Ogino S, Chan AT, Song M
Gastroenterology 2020 Mar;158(4):852-861.e4. Epub 2019 Jul 11 doi: 10.1053/j.gastro.2019.06.039. PMID: 31302144Free PMC Article
Schmidt A, Meier B, Caca K
World J Gastroenterol 2015 Aug 21;21(31):9273-85. doi: 10.3748/wjg.v21.i31.9273. PMID: 26309354Free PMC Article

Clinical prediction guides

Mangira D, Raftopoulos S, Vogrin S, Hartley I, Mack A, Gazelakis K, Nalankilli K, Trinh A, Metz AJ, Appleyard M, Grimpen F, Elliott T, Brown G, Moss A
Endoscopy 2023 Jul;55(7):627-635. Epub 2023 Feb 7 doi: 10.1055/a-2029-9539. PMID: 36750222
Hang D, Wang L, Fang Z, Du M, Wang K, He X, Khandpur N, Rossato SL, Wu K, Hu Z, Shen H, Ogino S, Chan AT, Giovannucci EL, Zhang FF, Song M
J Natl Cancer Inst 2023 Feb 8;115(2):155-164. doi: 10.1093/jnci/djac221. PMID: 36477589Free PMC Article
Zhou YJ, Lu XF, Chen H, Wang XY, Cheng W, Zhang QW, Chen JN, Wang XY, Jin JZ, Yan FR, Chen H, Li XB
Cell Mol Gastroenterol Hepatol 2023;15(2):393-424. Epub 2022 Oct 8 doi: 10.1016/j.jcmgh.2022.10.001. PMID: 36216310Free PMC Article
Schmidt A, Meier B, Caca K
World J Gastroenterol 2015 Aug 21;21(31):9273-85. doi: 10.3748/wjg.v21.i31.9273. PMID: 26309354Free PMC Article
Azzopardi D, Dallosso AR, Eliason K, Hendrickson BC, Jones N, Rawstorne E, Colley J, Moskvina V, Frye C, Sampson JR, Wenstrup R, Scholl T, Cheadle JP
Cancer Res 2008 Jan 15;68(2):358-63. doi: 10.1158/0008-5472.CAN-07-5733. PMID: 18199528

Recent systematic reviews

Adiwinata R, Tandarto K, Arifputra J, Waleleng BJ, Gosal F, Rotty L, Winarta J, Waleleng A, Simadibrata P, Simadibrata M
Asian Pac J Cancer Prev 2023 Nov 1;24(11):3655-3663. doi: 10.31557/APJCP.2023.24.11.3655. PMID: 38019222Free PMC Article
Mehta A, Kumar H, Yazji K, Wireko AA, Sivanandan Nagarajan J, Ghosh B, Nahas A, Morales Ojeda L, Anand A, Sharath M, Huang H, Garg T, Isik A
Int J Surg 2023 Apr 1;109(4):946-952. doi: 10.1097/JS9.0000000000000285. PMID: 36917126Free PMC Article
Jung YS, Park JH, Park CH
Clin Gastroenterol Hepatol 2022 Jan;20(1):31-43.e1. Epub 2020 Sep 30 doi: 10.1016/j.cgh.2020.09.051. PMID: 33007512
Castaneda D, Popov VB, Verheyen E, Wander P, Gross SA
Gastrointest Endosc 2018 Aug;88(2):209-222.e11. Epub 2018 Apr 1 doi: 10.1016/j.gie.2018.03.022. PMID: 29614263
Cohen J, Grunwald D, Grossberg LB, Sawhney MS
J Clin Gastroenterol 2017 Oct;51(9):818-824. doi: 10.1097/MCG.0000000000000695. PMID: 27683963Free PMC Article

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