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Locally Advanced Liver Carcinoma

MedGen UID:
1756794
•Concept ID:
C5419077
•
Neoplastic Process

Definition

Liver carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes. [from NCI]

Professional guidelines

PubMed

Treatment landscape of metastatic pancreatic cancer.
De Dosso S, Siebenhüner AR, Winder T, Meisel A, Fritsch R, Astaras C, Szturz P, Borner M
Cancer Treat Rev 2021 May;96:102180. Epub 2021 Mar 17 doi: 10.1016/j.ctrv.2021.102180. PMID: 33812339
A global view of hepatocellular carcinoma: trends, risk, prevention and management.
Yang JD, Hainaut P, Gores GJ, Amadou A, Plymoth A, Roberts LR
Nat Rev Gastroenterol Hepatol 2019 Oct;16(10):589-604. Epub 2019 Aug 22 doi: 10.1038/s41575-019-0186-y. PMID: 31439937Free PMC Article
Neoadjuvant and adjuvant treatment strategies for hepatocellular carcinoma.
Akateh C, Black SM, Conteh L, Miller ED, Noonan A, Elliott E, Pawlik TM, Tsung A, Cloyd JM
World J Gastroenterol 2019 Jul 28;25(28):3704-3721. doi: 10.3748/wjg.v25.i28.3704. PMID: 31391767Free PMC Article

Recent clinical studies

Etiology

Predictors of early and late hepatocellular carcinoma recurrence.
Nevola R, Ruocco R, Criscuolo L, Villani A, Alfano M, Beccia D, Imbriani S, Claar E, Cozzolino D, Sasso FC, Marrone A, Adinolfi LE, Rinaldi L
World J Gastroenterol 2023 Feb 28;29(8):1243-1260. doi: 10.3748/wjg.v29.i8.1243. PMID: 36925456Free PMC Article
Personalised versus standard dosimetry approach of selective internal radiation therapy in patients with locally advanced hepatocellular carcinoma (DOSISPHERE-01): a randomised, multicentre, open-label phase 2 trial.
Garin E, Tselikas L, Guiu B, Chalaye J, Edeline J, de Baere T, Assenat E, Tacher V, Robert C, Terroir-Cassou-Mounat M, Mariano-Goulart D, Amaddeo G, Palard X, Hollebecque A, Kafrouni M, Regnault H, Boudjema K, Grimaldi S, Fourcade M, Kobeiter H, Vibert E, Le Sourd S, Piron L, Sommacale D, Laffont S, Campillo-Gimenez B, Rolland Y; DOSISPHERE-01 Study Group
Lancet Gastroenterol Hepatol 2021 Jan;6(1):17-29. Epub 2020 Nov 7 doi: 10.1016/S2468-1253(20)30290-9. PMID: 33166497
A global view of hepatocellular carcinoma: trends, risk, prevention and management.
Yang JD, Hainaut P, Gores GJ, Amadou A, Plymoth A, Roberts LR
Nat Rev Gastroenterol Hepatol 2019 Oct;16(10):589-604. Epub 2019 Aug 22 doi: 10.1038/s41575-019-0186-y. PMID: 31439937Free PMC Article
Hepatocellular carcinoma.
Llovet JM, Zucman-Rossi J, Pikarsky E, Sangro B, Schwartz M, Sherman M, Gores G
Nat Rev Dis Primers 2016 Apr 14;2:16018. doi: 10.1038/nrdp.2016.18. PMID: 27158749
Hepatocellular carcinoma.
Forner A, Llovet JM, Bruix J
Lancet 2012 Mar 31;379(9822):1245-55. Epub 2012 Feb 20 doi: 10.1016/S0140-6736(11)61347-0. PMID: 22353262

Diagnosis

Conversion therapy and maintenance therapy for primary hepatocellular carcinoma.
Zhou H, Song T
Biosci Trends 2021 Jul 6;15(3):155-160. Epub 2021 May 27 doi: 10.5582/bst.2021.01091. PMID: 34039818
Systemic therapy of advanced hepatocellular carcinoma.
Galle PR, Dufour JF, Peck-Radosavljevic M, Trojan J, Vogel A
Future Oncol 2021 Apr;17(10):1237-1251. Epub 2020 Dec 14 doi: 10.2217/fon-2020-0758. PMID: 33307782
Hepatocellular carcinoma.
Forner A, Reig M, Bruix J
Lancet 2018 Mar 31;391(10127):1301-1314. Epub 2018 Jan 5 doi: 10.1016/S0140-6736(18)30010-2. PMID: 29307467
Hepatocellular carcinoma.
Llovet JM, Zucman-Rossi J, Pikarsky E, Sangro B, Schwartz M, Sherman M, Gores G
Nat Rev Dis Primers 2016 Apr 14;2:16018. doi: 10.1038/nrdp.2016.18. PMID: 27158749
Hepatocellular carcinoma.
Forner A, Llovet JM, Bruix J
Lancet 2012 Mar 31;379(9822):1245-55. Epub 2012 Feb 20 doi: 10.1016/S0140-6736(11)61347-0. PMID: 22353262

Therapy

Tumor Immune Microenvironment and Immunosuppressive Therapy in Hepatocellular Carcinoma: A Review.
Oura K, Morishita A, Tani J, Masaki T
Int J Mol Sci 2021 May 28;22(11) doi: 10.3390/ijms22115801. PMID: 34071550Free PMC Article
Conversion therapy and maintenance therapy for primary hepatocellular carcinoma.
Zhou H, Song T
Biosci Trends 2021 Jul 6;15(3):155-160. Epub 2021 May 27 doi: 10.5582/bst.2021.01091. PMID: 34039818
Locoregional therapies in the era of molecular and immune treatments for hepatocellular carcinoma.
Llovet JM, De Baere T, Kulik L, Haber PK, Greten TF, Meyer T, Lencioni R
Nat Rev Gastroenterol Hepatol 2021 May;18(5):293-313. Epub 2021 Jan 28 doi: 10.1038/s41575-020-00395-0. PMID: 33510460
Hepatocellular carcinoma.
Forner A, Reig M, Bruix J
Lancet 2018 Mar 31;391(10127):1301-1314. Epub 2018 Jan 5 doi: 10.1016/S0140-6736(18)30010-2. PMID: 29307467
Hepatocellular carcinoma.
Llovet JM, Zucman-Rossi J, Pikarsky E, Sangro B, Schwartz M, Sherman M, Gores G
Nat Rev Dis Primers 2016 Apr 14;2:16018. doi: 10.1038/nrdp.2016.18. PMID: 27158749

Prognosis

Tumor Immune Microenvironment and Immunosuppressive Therapy in Hepatocellular Carcinoma: A Review.
Oura K, Morishita A, Tani J, Masaki T
Int J Mol Sci 2021 May 28;22(11) doi: 10.3390/ijms22115801. PMID: 34071550Free PMC Article
Conversion therapy and maintenance therapy for primary hepatocellular carcinoma.
Zhou H, Song T
Biosci Trends 2021 Jul 6;15(3):155-160. Epub 2021 May 27 doi: 10.5582/bst.2021.01091. PMID: 34039818
Advances in immunotherapy for hepatocellular carcinoma.
Sangro B, Sarobe P, Hervás-Stubbs S, Melero I
Nat Rev Gastroenterol Hepatol 2021 Aug;18(8):525-543. Epub 2021 Apr 13 doi: 10.1038/s41575-021-00438-0. PMID: 33850328Free PMC Article
Hepatocellular carcinoma.
Llovet JM, Zucman-Rossi J, Pikarsky E, Sangro B, Schwartz M, Sherman M, Gores G
Nat Rev Dis Primers 2016 Apr 14;2:16018. doi: 10.1038/nrdp.2016.18. PMID: 27158749
Hepatocellular carcinoma.
Forner A, Llovet JM, Bruix J
Lancet 2012 Mar 31;379(9822):1245-55. Epub 2012 Feb 20 doi: 10.1016/S0140-6736(11)61347-0. PMID: 22353262

Clinical prediction guides

Predictors of early and late hepatocellular carcinoma recurrence.
Nevola R, Ruocco R, Criscuolo L, Villani A, Alfano M, Beccia D, Imbriani S, Claar E, Cozzolino D, Sasso FC, Marrone A, Adinolfi LE, Rinaldi L
World J Gastroenterol 2023 Feb 28;29(8):1243-1260. doi: 10.3748/wjg.v29.i8.1243. PMID: 36925456Free PMC Article
Knowledge Mapping of Immunotherapy for Hepatocellular Carcinoma: A Bibliometric Study.
Shen J, Shen H, Ke L, Chen J, Dang X, Liu B, Hua Y
Front Immunol 2022;13:815575. Epub 2022 Jan 31 doi: 10.3389/fimmu.2022.815575. PMID: 35173728Free PMC Article
Tumor Immune Microenvironment and Immunosuppressive Therapy in Hepatocellular Carcinoma: A Review.
Oura K, Morishita A, Tani J, Masaki T
Int J Mol Sci 2021 May 28;22(11) doi: 10.3390/ijms22115801. PMID: 34071550Free PMC Article
Advances in immunotherapy for hepatocellular carcinoma.
Sangro B, Sarobe P, Hervás-Stubbs S, Melero I
Nat Rev Gastroenterol Hepatol 2021 Aug;18(8):525-543. Epub 2021 Apr 13 doi: 10.1038/s41575-021-00438-0. PMID: 33850328Free PMC Article
Fontan-associated liver disease: A review.
Gordon-Walker TT, Bove K, Veldtman G
J Cardiol 2019 Sep;74(3):223-232. Epub 2019 Mar 28 doi: 10.1016/j.jjcc.2019.02.016. PMID: 30928109

Recent systematic reviews

Sarcomatoid hepatocellular carcinoma versus conventional hepatocellular carcinoma: a systematic review and meta-analysis.
Lv TR, Hu HJ, Regmi P, Liu F, Li FY
J Cancer Res Clin Oncol 2022 Jul;148(7):1685-1696. Epub 2022 Feb 24 doi: 10.1007/s00432-022-03949-8. PMID: 35201426
Effect of sarcopenia on survival in patients with cirrhosis: A meta-analysis.
Tantai X, Liu Y, Yeo YH, Praktiknjo M, Mauro E, Hamaguchi Y, Engelmann C, Zhang P, Jeong JY, van Vugt JLA, Xiao H, Deng H, Gao X, Ye Q, Zhang J, Yang L, Cai Y, Liu Y, Liu N, Li Z, Han T, Kaido T, Sohn JH, Strassburg C, Berg T, Trebicka J, Hsu YC, IJzermans JNM, Wang J, Su GL, Ji F, Nguyen MH
J Hepatol 2022 Mar;76(3):588-599. Epub 2021 Nov 14 doi: 10.1016/j.jhep.2021.11.006. PMID: 34785325
Adjuvant chemotherapy after liver transplantation for hepatocellular carcinoma: a systematic review and a meta-analysis.
Lin HS, Wan RH, Gao LH, Li JF, Shan RF, Shi J
Hepatobiliary Pancreat Dis Int 2015 Jun;14(3):236-45. doi: 10.1016/s1499-3872(15)60373-3. PMID: 26063023
Systematic review of novel ablative methods in locally advanced pancreatic cancer.
Keane MG, Bramis K, Pereira SP, Fusai GK
World J Gastroenterol 2014 Mar 7;20(9):2267-78. doi: 10.3748/wjg.v20.i9.2267. PMID: 24605026Free PMC Article
Efficacy and safety of microwave ablation for primary and secondary liver malignancies: a systematic review.
Ong SL, Gravante G, Metcalfe MS, Strickland AD, Dennison AR, Lloyd DM
Eur J Gastroenterol Hepatol 2009 Jun;21(6):599-605. doi: 10.1097/MEG.0b013e328318ed04. PMID: 19282763

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