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Spondyloarthritis

MedGen UID:
215416
•Concept ID:
C0949690
•
Disease or Syndrome
Synonyms: Arthritis, Spinal; Spinal Arthritides; Spinal Arthritis; Spondylarthritides; Spondylarthritis
SNOMED CT: Arthritis of spine (371082009); Spondarthritis (84172003); Spondyloarthritis syndrome (784332006); Spondyloarthritis (784332006); Inflammatory spondylopathy (371082009)

Definition

A group of disorders including ankylosing spondylitis, axial spondylarthritis, spondyloarthritis due to inflammatory bowel disease, and other conditions. They share the common features of inflammation of axial joints, asymmetric oligoarthritis, dactylitis, and enthesitis. [from SNOMEDCT_US]

Professional guidelines

PubMed

ASAS-EULAR recommendations for the management of axial spondyloarthritis: 2022 update.
Ramiro S, Nikiphorou E, Sepriano A, Ortolan A, Webers C, Baraliakos X, Landewé RBM, Van den Bosch FE, Boteva B, Bremander A, Carron P, Ciurea A, van Gaalen FA, Géher P, Gensler L, Hermann J, de Hooge M, Husakova M, Kiltz U, López-Medina C, Machado PM, Marzo-Ortega H, Molto A, Navarro-Compán V, Nissen MJ, Pimentel-Santos FM, Poddubnyy D, Proft F, Rudwaleit M, Telkman M, Zhao SS, Ziade N, van der Heijde D
Ann Rheum Dis 2023 Jan;82(1):19-34. Epub 2022 Oct 21 doi: 10.1136/ard-2022-223296. PMID: 36270658
Treatment of axial spondyloarthritis: an update.
Danve A, Deodhar A
Nat Rev Rheumatol 2022 Apr;18(4):205-216. Epub 2022 Mar 10 doi: 10.1038/s41584-022-00761-z. PMID: 35273385
2019 Update of the American College of Rheumatology/Spondylitis Association of America/Spondyloarthritis Research and Treatment Network Recommendations for the Treatment of Ankylosing Spondylitis and Nonradiographic Axial Spondyloarthritis.
Ward MM, Deodhar A, Gensler LS, Dubreuil M, Yu D, Khan MA, Haroon N, Borenstein D, Wang R, Biehl A, Fang MA, Louie G, Majithia V, Ng B, Bigham R, Pianin M, Shah AA, Sullivan N, Turgunbaev M, Oristaglio J, Turner A, Maksymowych WP, Caplan L
Arthritis Care Res (Hoboken) 2019 Oct;71(10):1285-1299. Epub 2019 Aug 21 doi: 10.1002/acr.24025. PMID: 31436026Free PMC Article

Recent clinical studies

Etiology

Psoriatic arthritis.
López-Ferrer A, Laiz A, Puig L
Med Clin (Barc) 2022 Jul 8;159(1):40-46. Epub 2022 May 4 doi: 10.1016/j.medcli.2022.01.024. PMID: 35525675
Understanding the Pathogenesis of Spondyloarthritis.
Sharip A, Kunz J
Biomolecules 2020 Oct 20;10(10) doi: 10.3390/biom10101461. PMID: 33092023Free PMC Article
Recent advances in ankylosing spondylitis: understanding the disease and management.
Garcia-Montoya L, Gul H, Emery P
F1000Res 2018;7 Epub 2018 Sep 21 doi: 10.12688/f1000research.14956.1. PMID: 30345001Free PMC Article
Epidemiology of axial spondyloarthritis: an update.
Wang R, Ward MM
Curr Opin Rheumatol 2018 Mar;30(2):137-143. doi: 10.1097/BOR.0000000000000475. PMID: 29227352Free PMC Article
Spondyloarthritis.
Dougados M, Baeten D
Lancet 2011 Jun 18;377(9783):2127-37. doi: 10.1016/S0140-6736(11)60071-8. PMID: 21684383

Diagnosis

Psoriatic arthritis.
López-Ferrer A, Laiz A, Puig L
Med Clin (Barc) 2022 Jul 8;159(1):40-46. Epub 2022 May 4 doi: 10.1016/j.medcli.2022.01.024. PMID: 35525675
Axial spondyloarthritis.
Navarro-Compán V, Sepriano A, El-Zorkany B, van der Heijde D
Ann Rheum Dis 2021 Dec;80(12):1511-1521. Epub 2021 Oct 6 doi: 10.1136/annrheumdis-2021-221035. PMID: 34615639
Clinical Manifestations and Diagnosis of Axial Spondyloarthritis.
Walsh JA, Magrey M
J Clin Rheumatol 2021 Dec 1;27(8):e547-e560. doi: 10.1097/RHU.0000000000001575. PMID: 33105312Free PMC Article
Axial spondyloarthritis.
Sieper J, Poddubnyy D
Lancet 2017 Jul 1;390(10089):73-84. Epub 2017 Jan 20 doi: 10.1016/S0140-6736(16)31591-4. PMID: 28110981
Axial spondyloarthritis.
Sieper J, Braun J, Dougados M, Baeten D
Nat Rev Dis Primers 2015 Jul 9;1:15013. doi: 10.1038/nrdp.2015.13. PMID: 27188328

Therapy

IL-23 and axial disease: do they come together?
Mease P, van den Bosch F
Rheumatology (Oxford) 2021 Oct 19;60(Suppl 4):iv28-iv33. doi: 10.1093/rheumatology/keab617. PMID: 34668015Free PMC Article
Axial spondyloarthritis.
Navarro-Compán V, Sepriano A, El-Zorkany B, van der Heijde D
Ann Rheum Dis 2021 Dec;80(12):1511-1521. Epub 2021 Oct 6 doi: 10.1136/annrheumdis-2021-221035. PMID: 34615639
JAK inhibitors, psoriatic arthritis, and axial spondyloarthritis: a critical review of clinical trials.
Keeling S, Maksymowych WP
Expert Rev Clin Immunol 2021 Jul;17(7):701-715. Epub 2021 May 13 doi: 10.1080/1744666X.2021.1925541. PMID: 33944642
Non-radiographic axial spondyloarthritis.
Kameda H, Kobayashi S, Tamura N, Kadono Y, Tada K, Yamamura M, Tomita T
Mod Rheumatol 2021 Mar;31(2):277-282. Epub 2020 Oct 12 doi: 10.1080/14397595.2020.1830512. PMID: 32996809
2019 Update of the American College of Rheumatology/Spondylitis Association of America/Spondyloarthritis Research and Treatment Network Recommendations for the Treatment of Ankylosing Spondylitis and Nonradiographic Axial Spondyloarthritis.
Ward MM, Deodhar A, Gensler LS, Dubreuil M, Yu D, Khan MA, Haroon N, Borenstein D, Wang R, Biehl A, Fang MA, Louie G, Majithia V, Ng B, Bigham R, Pianin M, Shah AA, Sullivan N, Turgunbaev M, Oristaglio J, Turner A, Maksymowych WP, Caplan L
Arthritis Care Res (Hoboken) 2019 Oct;71(10):1285-1299. Epub 2019 Aug 21 doi: 10.1002/acr.24025. PMID: 31436026Free PMC Article

Prognosis

Nutrition in Spondyloarthritis and Related Immune-Mediated Disorders.
Popa SL, Dumitrascu DI, Brata VD, Duse TA, Florea MD, Ismaiel A, Muntean LM, Grad S
Nutrients 2022 Mar 17;14(6) doi: 10.3390/nu14061278. PMID: 35334935Free PMC Article
Classification Criteria for Spondyloarthritis/HLA-B27-Associated Anterior Uveitis.
Standardization of Uveitis Nomenclature (SUN) Working Group
Am J Ophthalmol 2021 Aug;228:117-125. Epub 2021 Apr 15 doi: 10.1016/j.ajo.2021.03.049. PMID: 33845004Free PMC Article
Clinical Manifestations and Diagnosis of Axial Spondyloarthritis.
Walsh JA, Magrey M
J Clin Rheumatol 2021 Dec 1;27(8):e547-e560. doi: 10.1097/RHU.0000000000001575. PMID: 33105312Free PMC Article
Imaging of axial spondyloarthritis. New aspects and differential diagnoses.
Braun J, Baraliakos X, Buehring B, Kiltz U, Fruth M
Clin Exp Rheumatol 2018 Sep-Oct;36 Suppl 114(5):35-42. Epub 2018 Oct 1 PMID: 30296971
The classification and diagnostic criteria of ankylosing spondylitis.
Raychaudhuri SP, Deodhar A
J Autoimmun 2014 Feb-Mar;48-49:128-33. Epub 2014 Feb 16 doi: 10.1016/j.jaut.2014.01.015. PMID: 24534717

Clinical prediction guides

Enthesitis in Psoriatic Arthritis, the Sonographic Perspective.
Smerilli G, Di Matteo A, Cipolletta E, Grassi W, Filippucci E
Curr Rheumatol Rep 2021 Aug 24;23(9):75. doi: 10.1007/s11926-021-01039-1. PMID: 34427783Free PMC Article
Modified stoke ankylosing spondylitis spinal score as an outcome measure to assess the impact of treatment on structural progression in ankylosing spondylitis.
van der Heijde D, Braun J, Deodhar A, Baraliakos X, Landewé R, Richards HB, Porter B, Readie A
Rheumatology (Oxford) 2019 Mar 1;58(3):388-400. doi: 10.1093/rheumatology/key128. PMID: 29860356Free PMC Article
Imaging of axial spondyloarthritis. New aspects and differential diagnoses.
Braun J, Baraliakos X, Buehring B, Kiltz U, Fruth M
Clin Exp Rheumatol 2018 Sep-Oct;36 Suppl 114(5):35-42. Epub 2018 Oct 1 PMID: 30296971
Reliability of a consensus-based ultrasound definition and scoring for enthesitis in spondyloarthritis and psoriatic arthritis: an OMERACT US initiative.
Balint PV, Terslev L, Aegerter P, Bruyn GAW, Chary-Valckenaere I, Gandjbakhch F, Iagnocco A, Jousse-Joulin S, Möller I, Naredo E, Schmidt WA, Wakefield RJ, D'Agostino MA; OMERACT Ultrasound Task Force members
Ann Rheum Dis 2018 Dec;77(12):1730-1735. Epub 2018 Aug 3 doi: 10.1136/annrheumdis-2018-213609. PMID: 30076154
Treating axial spondyloarthritis and peripheral spondyloarthritis, especially psoriatic arthritis, to target: 2017 update of recommendations by an international task force.
Smolen JS, Schöls M, Braun J, Dougados M, FitzGerald O, Gladman DD, Kavanaugh A, Landewé R, Mease P, Sieper J, Stamm T, Wit M, Aletaha D, Baraliakos X, Betteridge N, Bosch FVD, Coates LC, Emery P, Gensler LS, Gossec L, Helliwell P, Jongkees M, Kvien TK, Inman RD, McInnes IB, Maccarone M, Machado PM, Molto A, Ogdie A, Poddubnyy D, Ritchlin C, Rudwaleit M, Tanew A, Thio B, Veale D, Vlam K, van der Heijde D
Ann Rheum Dis 2018 Jan;77(1):3-17. Epub 2017 Jul 6 doi: 10.1136/annrheumdis-2017-211734. PMID: 28684559Free PMC Article

Recent systematic reviews

Efficacy and safety of biological DMARDs: a systematic literature review informing the 2022 update of the ASAS-EULAR recommendations for the management of axial spondyloarthritis.
Webers C, Ortolan A, Sepriano A, Falzon L, Baraliakos X, Landewé RBM, Ramiro S, van der Heijde D, Nikiphorou E
Ann Rheum Dis 2023 Jan;82(1):130-141. Epub 2022 Oct 21 doi: 10.1136/ard-2022-223298. PMID: 36270657
2022 American College of Rheumatology/American Association of Hip and Knee Surgeons Guideline for the Perioperative Management of Antirheumatic Medication in Patients With Rheumatic Diseases Undergoing Elective Total Hip or Total Knee Arthroplasty.
Goodman SM, Springer BD, Chen AF, Davis M, Fernandez DR, Figgie M, Finlayson H, George MD, Giles JT, Gilliland J, Klatt B, MacKenzie R, Michaud K, Miller A, Russell L, Sah A, Abdel MP, Johnson B, Mandl LA, Sculco P, Turgunbaev M, Turner AS, Yates A Jr, Singh JA
Arthritis Care Res (Hoboken) 2022 Sep;74(9):1399-1408. Epub 2022 Jun 19 doi: 10.1002/acr.24893. PMID: 35718887
Effects of diet on the outcomes of rheumatic and musculoskeletal diseases (RMDs): systematic review and meta-analyses informing the 2021 EULAR recommendations for lifestyle improvements in people with RMDs.
Gwinnutt JM, Wieczorek M, Rodríguez-Carrio J, Balanescu A, Bischoff-Ferrari HA, Boonen A, Cavalli G, de Souza S, de Thurah A, Dorner TE, Moe RH, Putrik P, Silva-Fernández L, Stamm T, Walker-Bone K, Welling J, Zlatković-Švenda M, Guillemin F, Verstappen SMM
RMD Open 2022 Jun;8(2) doi: 10.1136/rmdopen-2021-002167. PMID: 35654458Free PMC Article
Ankylosing spondylitis risk factors: a systematic literature review.
Hwang MC, Ridley L, Reveille JD
Clin Rheumatol 2021 Aug;40(8):3079-3093. Epub 2021 Mar 22 doi: 10.1007/s10067-021-05679-7. PMID: 33754220Free PMC Article
Immunogenicity of Biologics in Chronic Inflammatory Diseases: A Systematic Review.
Strand V, Balsa A, Al-Saleh J, Barile-Fabris L, Horiuchi T, Takeuchi T, Lula S, Hawes C, Kola B, Marshall L
BioDrugs 2017 Aug;31(4):299-316. doi: 10.1007/s40259-017-0231-8. PMID: 28612180Free PMC Article

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