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Malignant childhood germ cell neoplasm

MedGen UID:
233150
•Concept ID:
C1334574
•
Neoplastic Process
Synonyms: Childhood Malignant Germ Cell Tumor; Malignant Childhood Germ Cell Neoplasm; malignant childhood germ cell neoplasm; malignant childhood germ cell tumor; malignant childhood germ cell tumour; malignant paediatric germ cell neoplasm; malignant paediatric germ cell tumour; Malignant Pediatric Germ Cell Neoplasm; malignant pediatric germ cell neoplasm; Malignant Pediatric Germ Cell Tumor; malignant pediatric germ cell tumor
 
Monarch Initiative: MONDO:0004479

Definition

A malignant germ cell tumor that occurs during childhood. [from NCI]

Professional guidelines

PubMed

National UK guidelines for the management of paediatric craniopharyngioma.
Gan HW, Morillon P, Albanese A, Aquilina K, Chandler C, Chang YC, Drimtzias E, Farndon S, Jacques TS, Korbonits M, Kuczynski A, Limond J, Robinson L, Simmons I, Thomas N, Thomas S, Thorp N, Vargha-Khadem F, Warren D, Zebian B, Mallucci C, Spoudeas HA
Lancet Diabetes Endocrinol 2023 Sep;11(9):694-706. Epub 2023 Aug 4 doi: 10.1016/S2213-8587(23)00162-6. PMID: 37549682
Modern treatment of retinoblastoma: A 2020 review.
Ancona-Lezama D, Dalvin LA, Shields CL
Indian J Ophthalmol 2020 Nov;68(11):2356-2365. doi: 10.4103/ijo.IJO_721_20. PMID: 33120616Free PMC Article
Updates in Diagnosis, Management, and Treatment of Neuroblastoma.
Swift CC, Eklund MJ, Kraveka JM, Alazraki AL
Radiographics 2018 Mar-Apr;38(2):566-580. doi: 10.1148/rg.2018170132. PMID: 29528815

Recent clinical studies

Etiology

Wilms Tumor.
Saltzman AF, Cost NG, Romao RLP
Urol Clin North Am 2023 Aug;50(3):455-464. Epub 2023 May 18 doi: 10.1016/j.ucl.2023.04.008. PMID: 37385707
Melanoma in children: A systematic review and individual patient meta-analysis.
Pampena R, Piccolo V, Muscianese M, Kyrgidis A, Lai M, Russo T, Briatico G, Di Brizzi EV, Cascone G, Pellerone S, Longo C, Moscarella E, Argenziano G
J Eur Acad Dermatol Venereol 2023 Sep;37(9):1758-1776. Epub 2023 Jun 2 doi: 10.1111/jdv.19220. PMID: 37210654
Mediastinal neuroblastoma, ganglioneuroblastoma, and ganglioneuroma: Pathology review and diagnostic approach.
Choi JH, Ro JY
Semin Diagn Pathol 2022 Mar;39(2):120-130. Epub 2021 Jun 15 doi: 10.1053/j.semdp.2021.06.007. PMID: 34167847
Neonatal Retinoblastoma.
Lin FY, Chintagumpala MM
Clin Perinatol 2021 Mar;48(1):53-70. doi: 10.1016/j.clp.2020.12.001. PMID: 33583507
Understanding medulloblastoma.
Quinlan A, Rizzolo D
JAAPA 2017 Oct;30(10):30-36. doi: 10.1097/01.JAA.0000524717.71084.50. PMID: 28953021

Diagnosis

Wilms Tumor.
Saltzman AF, Cost NG, Romao RLP
Urol Clin North Am 2023 Aug;50(3):455-464. Epub 2023 May 18 doi: 10.1016/j.ucl.2023.04.008. PMID: 37385707
Mediastinal neuroblastoma, ganglioneuroblastoma, and ganglioneuroma: Pathology review and diagnostic approach.
Choi JH, Ro JY
Semin Diagn Pathol 2022 Mar;39(2):120-130. Epub 2021 Jun 15 doi: 10.1053/j.semdp.2021.06.007. PMID: 34167847
Pediatric Brain Tumors.
Udaka YT, Packer RJ
Neurol Clin 2018 Aug;36(3):533-556. doi: 10.1016/j.ncl.2018.04.009. PMID: 30072070
Understanding medulloblastoma.
Quinlan A, Rizzolo D
JAAPA 2017 Oct;30(10):30-36. doi: 10.1097/01.JAA.0000524717.71084.50. PMID: 28953021
Retinoblastoma.
Rao R, Honavar SG
Indian J Pediatr 2017 Dec;84(12):937-944. Epub 2017 Jun 16 doi: 10.1007/s12098-017-2395-0. PMID: 28620731

Therapy

Efficacy and Safety of Trametinib Monotherapy or in Combination With Dabrafenib in Pediatric BRAF V600-Mutant Low-Grade Glioma.
Bouffet E, Geoerger B, Moertel C, Whitlock JA, Aerts I, Hargrave D, Osterloh L, Tan E, Choi J, Russo M, Fox E
J Clin Oncol 2023 Jan 20;41(3):664-674. Epub 2022 Nov 14 doi: 10.1200/JCO.22.01000. PMID: 36375115Free PMC Article
Serial assessment of measurable residual disease in medulloblastoma liquid biopsies.
Liu APY, Smith KS, Kumar R, Paul L, Bihannic L, Lin T, Maass KK, Pajtler KW, Chintagumpala M, Su JM, Bouffet E, Fisher MJ, Gururangan S, Cohn R, Hassall T, Hansford JR, Klimo P Jr, Boop FA, Stewart CF, Harreld JH, Merchant TE, Tatevossian RG, Neale G, Lear M, Klco JM, Orr BA, Ellison DW, Gilbertson RJ, Onar-Thomas A, Gajjar A, Robinson GW, Northcott PA
Cancer Cell 2021 Nov 8;39(11):1519-1530.e4. Epub 2021 Oct 21 doi: 10.1016/j.ccell.2021.09.012. PMID: 34678152Free PMC Article
Pediatric melanoma.
Tracy ET, Aldrink JH
Semin Pediatr Surg 2016 Oct;25(5):290-298. Epub 2016 Sep 20 doi: 10.1053/j.sempedsurg.2016.09.010. PMID: 27955732
Craniopharyngioma.
Müller HL
Handb Clin Neurol 2014;124:235-53. doi: 10.1016/B978-0-444-59602-4.00016-2. PMID: 25248591
Childhood craniopharyngioma.
Müller HL
Pituitary 2013 Mar;16(1):56-67. doi: 10.1007/s11102-012-0401-0. PMID: 22678820

Prognosis

Childhood-onset Craniopharyngioma.
Otte A, Müller HL
J Clin Endocrinol Metab 2021 Sep 27;106(10):e3820-e3836. doi: 10.1210/clinem/dgab397. PMID: 34086900
Primary mediastinal germ cell tumors.
Rosti G, Secondino S, Necchi A, Fornarini G, Pedrazzoli P
Semin Oncol 2019 Apr;46(2):107-111. Epub 2019 Apr 24 doi: 10.1053/j.seminoncol.2019.04.001. PMID: 31076171
The management of retinoblastoma.
Fabian ID, Onadim Z, Karaa E, Duncan C, Chowdhury T, Scheimberg I, Ohnuma SI, Reddy MA, Sagoo MS
Oncogene 2018 Mar;37(12):1551-1560. Epub 2018 Jan 11 doi: 10.1038/s41388-017-0050-x. PMID: 29321667
Obesity and craniopharyngioma.
Iughetti L, Bruzzi P
Ital J Pediatr 2011 Aug 16;37:38. doi: 10.1186/1824-7288-37-38. PMID: 21846381Free PMC Article
Childhood medulloblastoma.
Massimino M, Giangaspero F, Garrè ML, Gandola L, Poggi G, Biassoni V, Gatta G, Rutkowski S
Crit Rev Oncol Hematol 2011 Jul;79(1):65-83. Epub 2010 Dec 3 doi: 10.1016/j.critrevonc.2010.07.010. PMID: 21129995

Clinical prediction guides

Childhood-onset Craniopharyngioma.
Otte A, Müller HL
J Clin Endocrinol Metab 2021 Sep 27;106(10):e3820-e3836. doi: 10.1210/clinem/dgab397. PMID: 34086900
Congenital Neuroblastoma.
Minakova E, Lang J
Neoreviews 2020 Nov;21(11):e716-e727. doi: 10.1542/neo.21-11-e716. PMID: 33139509
Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort.
Waszak SM, Northcott PA, Buchhalter I, Robinson GW, Sutter C, Groebner S, Grund KB, Brugières L, Jones DTW, Pajtler KW, Morrissy AS, Kool M, Sturm D, Chavez L, Ernst A, Brabetz S, Hain M, Zichner T, Segura-Wang M, Weischenfeldt J, Rausch T, Mardin BR, Zhou X, Baciu C, Lawerenz C, Chan JA, Varlet P, Guerrini-Rousseau L, Fults DW, Grajkowska W, Hauser P, Jabado N, Ra YS, Zitterbart K, Shringarpure SS, De La Vega FM, Bustamante CD, Ng HK, Perry A, MacDonald TJ, Hernáiz Driever P, Bendel AE, Bowers DC, McCowage G, Chintagumpala MM, Cohn R, Hassall T, Fleischhack G, Eggen T, Wesenberg F, Feychting M, Lannering B, Schüz J, Johansen C, Andersen TV, Röösli M, Kuehni CE, Grotzer M, Kjaerheim K, Monoranu CM, Archer TC, Duke E, Pomeroy SL, Shelagh R, Frank S, Sumerauer D, Scheurlen W, Ryzhova MV, Milde T, Kratz CP, Samuel D, Zhang J, Solomon DA, Marra M, Eils R, Bartram CR, von Hoff K, Rutkowski S, Ramaswamy V, Gilbertson RJ, Korshunov A, Taylor MD, Lichter P, Malkin D, Gajjar A, Korbel JO, Pfister SM
Lancet Oncol 2018 Jun;19(6):785-798. Epub 2018 May 9 doi: 10.1016/S1470-2045(18)30242-0. PMID: 29753700Free PMC Article
Biological and Genetic Features of Neuroblastoma and Their Clinical Importance.
Aygun N
Curr Pediatr Rev 2018;14(2):73-90. doi: 10.2174/1573396314666180129101627. PMID: 29380702
Childhood medulloblastoma.
Massimino M, Giangaspero F, Garrè ML, Gandola L, Poggi G, Biassoni V, Gatta G, Rutkowski S
Crit Rev Oncol Hematol 2011 Jul;79(1):65-83. Epub 2010 Dec 3 doi: 10.1016/j.critrevonc.2010.07.010. PMID: 21129995

Recent systematic reviews

Agricultural exposures and risk of childhood neuroblastoma: a systematic review and meta-analysis.
Hymel E, Degarege A, Fritch J, Farazi E, Napit K, Coulter D, Schmidt C, Watanabe-Galloway S
Environ Sci Pollut Res Int 2023 Nov;30(53):113193-113204. Epub 2023 Oct 19 doi: 10.1007/s11356-023-30315-z. PMID: 37858025
Melanoma in children: A systematic review and individual patient meta-analysis.
Pampena R, Piccolo V, Muscianese M, Kyrgidis A, Lai M, Russo T, Briatico G, Di Brizzi EV, Cascone G, Pellerone S, Longo C, Moscarella E, Argenziano G
J Eur Acad Dermatol Venereol 2023 Sep;37(9):1758-1776. Epub 2023 Jun 2 doi: 10.1111/jdv.19220. PMID: 37210654
Systematic review of the receptor tyrosine kinase superfamily in neuroblastoma pathophysiology.
Rozen EJ, Shohet JM
Cancer Metastasis Rev 2022 Mar;41(1):33-52. Epub 2021 Oct 30 doi: 10.1007/s10555-021-10001-7. PMID: 34716856Free PMC Article
Maternal smoking during pregnancy and risk of childhood neuroblastoma: Systematic review and meta-analysis.
Chu P, Wang H, Han S, Jin Y, Lu J, Han W, Shi J, Guo Y, Ni X
J Cancer Res Ther 2016 Apr-Jun;12(2):999-1005. doi: 10.4103/0973-1482.171367. PMID: 27461688
Malignant melanoma as second malignant neoplasm in long-term childhood cancer survivors: a systematic review.
Braam KI, Overbeek A, Kaspers GJ, Ronckers CM, Schouten-van Meeteren AY, Van Dulmen-Den Broeder E, Veening MA
Pediatr Blood Cancer 2012 May;58(5):665-74. Epub 2012 Jan 9 doi: 10.1002/pbc.24023. PMID: 22232079

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